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ClinicalTrials.gov public records Last synced May 21, 2026, 9:06 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Nicotine Dependence Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Smoking Cessation
Interventions
GENERIC, eTARGET
Behavioral
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
2,896 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Feb 22, 2022 · Synced May 21, 2026, 9:06 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Nicotine Dependence, Nicotine Vaping
Interventions
(S)-Nicotine, (R)- nicotine, Racemic nicotine
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced May 21, 2026, 9:06 PM EDT
Withdrawn Not applicable Interventional
View directory record Official record
Conditions
Cocaine Dependence, Nicotine Dependence
Interventions
Progesterone, Placebo
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 5, 2019 · Synced May 21, 2026, 9:06 PM EDT
Completed Phase 4 Interventional
View directory record Official record
Conditions
Smoking Cessation
Interventions
Nicotine patch, nicotine inhaler, bupropion, Nicotine patch
Drug
Lead sponsor
University of Medicine and Dentistry of New Jersey
Other
Eligibility
18 Years and older
Enrollment
127 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 9, 2008 · Synced May 21, 2026, 9:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Nicotine Dependence, Smoking Cessation
Interventions
Varenicline and smoking cessation counseling, Exercise or relaxation treatment
Other · Behavioral
Lead sponsor
UConn Health
Other
Eligibility
45 Years and older · Female only
Enrollment
301 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2017
U.S. locations
2
States / cities
Farmington, Connecticut • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 30, 2017 · Synced May 21, 2026, 9:06 PM EDT
Completed Phase 2Phase 3 Interventional Results available
View directory record Official record
Conditions
Alcohol Dependence, Nicotine Dependence
Interventions
Low-Dose Topiramate, Placebo, High-Dose Topiramate
Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
236 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
4
States / cities
La Jolla, California • Houston, Texas • Charlottesville, Virginia + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced May 21, 2026, 9:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Substance Withdrawal Syndrome
Interventions
Abstinence from e-cigarettes
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
147 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
2
States / cities
Baltimore, Maryland • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Nov 19, 2018 · Synced May 21, 2026, 9:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Cardiovascular Risk Factor, Nicotine Dependence
Interventions
Electronic Cigarette
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 70 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 14, 2025 · Synced May 21, 2026, 9:06 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Varenicline, Nicotine patch, Placebo Patch, Placebo Pill
Drug · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
1,251 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
2
States / cities
Madison, Wisconsin • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 22, 2023 · Synced May 21, 2026, 9:06 PM EDT
Completed Phase 3 Interventional Results available
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Varenicline, Placebo, Smoking Cessation Counseling
Drug · Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
207 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
2
States / cities
Chicago, Illinois • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 29, 2019 · Synced May 21, 2026, 9:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Tobacco Dependence
Interventions
varenicline, placebo
Drug
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years to 60 Years
Enrollment
163 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Dec 15, 2013 · Synced May 21, 2026, 9:06 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Tobacco Use Disorder, Tobacco Dependence
Interventions
Quitbuddy, Control, SDoH Augmentation, SDoH Control
Other
Lead sponsor
Bryan W. Heckman
Other
Eligibility
21 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 7, 2024 · Synced May 21, 2026, 9:06 PM EDT
Active, not recruiting Phase 4 Interventional
View directory record Official record
Conditions
Nicotine Dependence, Electronic Cigarette Use
Interventions
Electronic Cigarette, Nicotine Lozenge
Drug
Lead sponsor
Butler Hospital
Other
Eligibility
21 Years to 65 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Nov 14, 2024 · Synced May 21, 2026, 9:06 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Tobacco Use, Tobacco Use Cessation, Smoking Cessation, Nicotine Addiction, Tobacco Smoking
Interventions
ELEVATE, ELEVATE-S
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
5,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced May 21, 2026, 9:06 PM EDT
Withdrawn Phase 1 Interventional
View directory record Official record
Conditions
Alcohol Abuse, Cannabis Abuse, Nicotine Dependence
Interventions
c-ASBI
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
9 Years to 20 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
6
States / cities
Boston, Massachusetts • Cambridge, Massachusetts • Lexington, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 6, 2016 · Synced May 21, 2026, 9:06 PM EDT
Completed Phase 4 Interventional Results available
View directory record Official record
Conditions
Vaping, Nicotine Dependence
Interventions
Double Blind Varenicline, Double Blind Placebo, QuitVaping, This Is Quitting
Drug · Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
16 Years to 25 Years
Enrollment
261 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 26, 2025 · Synced May 21, 2026, 9:06 PM EDT
Not listed Not applicable Interventional
View directory record Official record
Conditions
Smoking, Cigarette, Nicotine Dependence
Interventions
Nicotine (electronic cigarette), Nicotine (nicotine pouch)
Other
Lead sponsor
Brown University
Other
Eligibility
21 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 25, 2023 · Synced May 21, 2026, 9:06 PM EDT
Completed Phase 2 Interventional
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Cotinine fumarate
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 45 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1995 – 2001
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced May 21, 2026, 9:06 PM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Nicotine Dependence, Cigarettes
Interventions
Nicotine Corrective Messages
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
794 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Dec 1, 2022 · Synced May 21, 2026, 9:06 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Amphetamine
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 55 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 1, 2023 · Synced May 21, 2026, 9:06 PM EDT
Completed Phase 1 Interventional
View directory record Official record
Conditions
Nicotine Addiction
Interventions
Cycloserine, Placebo
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 55 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 26, 2012 · Synced May 21, 2026, 9:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Marijuana Dependence
Interventions
Progesterone, placebo
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 60 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 25, 2020 · Synced May 21, 2026, 9:06 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Internet-based smoking treatment, Individual Counseling, self-help
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
207 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2011
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 26, 2012 · Synced May 21, 2026, 9:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Tobacco Dependence
Interventions
repetitive transcranial magnetic stimulation (rTMS) 10 Hertz (Hz), repetitive transcranial magnetic stimulation (rTMS) 20Hz, SHAM repetitive transcranial magnetic stimulation (rTMS)
Device
Lead sponsor
University of Arkansas
Other
Eligibility
19 Years to 55 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Sep 23, 2013 · Synced May 21, 2026, 9:06 PM EDT