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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Night Waking Clear all
Completed Phase 1 Interventional

Effect of Honey and Dextromethorphan on Nocturnal Cough and Sleep

NCT00127686
View directory record Official record
Conditions
Cough, Respiratory Tract Infections
Interventions
Dextromethorphan, Buckwheat Honey
Drug
Lead sponsor
Penn State University
Other
Eligibility
2 Years to 18 Years
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 23, 2017 · Synced Jul 22, 2026, 2:27 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Effects of Night Call on Intellectual Performance

NCT02697266
View directory record Official record
Conditions
Sleep Deprivation
Interventions
No intervention
Other
Lead sponsor
Haleh Saadat
Other
Eligibility
Not listed
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 8, 2016 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Not applicable Interventional Results available

Validation of Safety and Efficacy for Night Shift Therapy

NCT02032706
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Deliver therapy when the supine position is detected
Device
Lead sponsor
Advanced Brain Monitoring, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Murrieta, California
Source: ClinicalTrials.gov public record
Updated Mar 31, 2016 · Synced Jul 22, 2026, 2:27 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pilot Trial in Sleep Laboratory Setting to Compare the Physiology of Night Time Bladder Function in Subjects With Overactive Bladder (OAB) Versus Subjects That Have Insomnia and Healthy Normal Subjects

NCT01029015
View directory record Official record
Conditions
Bladder Function
Interventions
cystometry, polysomnography
Procedure
Lead sponsor
Astellas Pharma Inc
Industry
Eligibility
45 Years and older
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 6, 2011 · Synced Jul 22, 2026, 2:27 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Effect of a Daily Magnesium and Melatonin Supplement on Sleep Quality in People With Nighttime Leg Cramps

NCT07651514
View directory record Official record
Conditions
Poor Sleep Quality, Leg Cramps, Nocturnal
Interventions
Magnesium and melatonin based multi-ingredient dietary supplementation, Placebo
Dietary Supplement · Other
Lead sponsor
StudySetGo
Network
Eligibility
40 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Palm Beach Gardens, Florida
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Phase 3 Interventional

Efficacy and Safety of Eplivanserin Treatment for Sleep Maintenance Insomnia Followed by Optional Extension up to 1 Year

NCT00253903
View directory record Official record
Conditions
Sleep Initiation and Maintenance Disorders, Insomnia
Interventions
eplivanserin (SR46349), placebo
Drug
Lead sponsor
Sanofi
Industry
Eligibility
18 Years and older
Enrollment
1,155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated Nov 29, 2010 · Synced Jul 22, 2026, 2:27 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Effect of Melatonin on Sleep Patterns of Resident Trainees During Night Float Shift

NCT05701969
View directory record Official record
Conditions
Sleep Disorders, Circadian Rhythm
Interventions
Melatonin, Placebo
Dietary Supplement · Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Jul 22, 2026, 2:27 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Hyperandrogenemia and Altered Day-night LH Pulse Patterns

NCT03068910
View directory record Official record
Conditions
Hyperandrogenism, Polycystic Ovary Syndrome, Puberty
Interventions
Micronized progesterone, Spironolactone, Placebo
Drug
Lead sponsor
University of Virginia
Other
Eligibility
10 Years to 17 Years · Female only
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2025
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 4, 2025 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Phase 3 Interventional

Efficacy and Safety of M100907 on Sleep Maintenance Insomnia With a Sub-study in Stable Type II Diabetes Mellitus

NCT00495885
View directory record Official record
Conditions
Sleep Initiation and Maintenance Disorders
Interventions
volinanserin (M100907), Placebo
Drug
Lead sponsor
Sanofi
Industry
Eligibility
18 Years and older
Enrollment
848 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated May 25, 2016 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Phase 2 Interventional Results available

Exploratory Subjective Sleep Study of a Prototype Nasal Dilator

NCT01122849
View directory record Official record
Conditions
Sleep Disorders, Congestion, Nasal
Interventions
Prototype Nasal Dilator, Marketed Nasal Strip, Placebo Nasal Strip
Device
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
2
States / cities
Paramus, New Jersey • Bethlehem, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 8, 2018 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Effects of Naltrexone on Nocturnal Breathing Patterns at Altitude

NCT05037032
View directory record Official record
Conditions
Altitude, Sleep Apnea, Central
Interventions
Naltrexone Pill, Placebo
Drug
Lead sponsor
VA Loma Linda Health Care System
Federal
Eligibility
18 Years to 35 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Apr 25, 2023 · Synced Jul 22, 2026, 2:27 PM EDT
Suspended Not applicable Interventional Accepts healthy volunteers

Light Exposure to Treat Sleep Disruption in Older People

NCT00427323
View directory record Official record
Conditions
Sleep Initiation and Maintenance Disorders, Circadian Rhythm Sleep Disorders, Hypersomnia
Interventions
light exposure
Procedure
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
55 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 10, 2009 · Synced Jul 22, 2026, 2:27 PM EDT
Suspended No phase listed Observational Accepts healthy volunteers

Human Plasma Fatty Acid Oscillations

NCT02502435
View directory record Official record
Conditions
Nocturnal Eating-Drinking Syndrome, Healthy
Interventions
Observation
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Toileting at Night in Older Adults: Light to Maximize Balance, Minimize Insomnia

NCT01350505
View directory record Official record
Conditions
Falls, Balance, Insomnia, Aging
Interventions
White light exposure, Dim white light exposure, Very dim white light exposure, Dim orange light exposure
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
55 Years to 85 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Feb 14, 2019 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Phase 3 Interventional Results available

A Study of Dexlansoprazole Modified Release Formulation to Treat Night Heartburn

NCT00627016
View directory record Official record
Conditions
Gastroesophageal Reflux
Interventions
Dexlansoprazole, Placebo
Drug
Lead sponsor
Takeda
Industry
Eligibility
18 Years to 65 Years
Enrollment
305 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
43
States / cities
Tucson, Arizona • Anaheim, California • Garden Grove, California + 40 more
Source: ClinicalTrials.gov public record
Updated Apr 27, 2011 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Not applicable Interventional Results available

Positive Airway Pressure for the Treatment of Asthma

NCT01154699
View directory record Official record
Conditions
Asthma, Sleep Apnea
Interventions
Bilevel PAP (4 weeks), Usual Care (4 weeks), Washout Period (4 weeks)
Device · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 16, 2017 · Synced Jul 22, 2026, 2:27 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Improving Metabolic & Mental Health in Female Healthcare Shift Workers

NCT06158204
View directory record Official record
Conditions
Sleep, Inadequate, Overweight and Obesity, Work Related Stress, Healthy Lifestyle
Interventions
Lifestyle Intervention
Behavioral
Lead sponsor
Auburn University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 7, 2025 · Synced Jul 22, 2026, 2:27 PM EDT
Terminated No phase listed Observational Results available

A Sensor-enhanced Mouth Guard to Quantitatively Measure Bite Compression Forces.

NCT06688474
View directory record Official record
Conditions
Bruxism, Sleep-Related
Interventions
Not listed
Lead sponsor
Otis Dental, LLC
Industry
Eligibility
18 Years to 50 Years · Male only
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Not applicable Interventional

Using Behavioral Programs to Treat Sleep Problems in Individuals With Alzheimer's Disease

NCT00183378
View directory record Official record
Conditions
Alzheimer Disease, Sleep Initiation and Maintenance Disorders
Interventions
Walking Program, Light Exposure Program, Combined Education, Walking and Light Exposure Program, Routine Medical Care with Education
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
55 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2011
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 12, 2012 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Study of Paxil Use in Menopausal Women

NCT00225914
View directory record Official record
Conditions
Menopause
Interventions
Paroxetine, placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
40 Years and older · Female only
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2006
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 23, 2010 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Not applicable Interventional

Effect of Agave Syrup, Placebo, and No Treatment on Nocturnal Cough and Sleep Quality for Coughing Infants/Toddlers and Their Parents

NCT01721395
View directory record Official record
Conditions
Cough
Interventions
Agave Syrup
Dietary Supplement
Lead sponsor
Penn State University
Other
Eligibility
2 Months to 48 Months
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 22, 2015 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Pharmacodynamic Profile of SPD489 in Healthy Adult Males Undergoing a Nocturnal Period of Acute Sleep Loss

NCT01096680
View directory record Official record
Conditions
Sleep Deprivation
Interventions
SPD489 20 mg, SPD489 50 mg, SPD489 70 mg, Armodafinil, Placebo
Drug
Lead sponsor
Shire
Industry
Eligibility
18 Years to 40 Years · Male only
Enrollment
135 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 13, 2021 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Not applicable Interventional

Cognitive Behavioral Therapy for Insomnia and Nocturnal Hot Flashes in Menopause

NCT02092844
View directory record Official record
Conditions
Menopause, Insomnia, Hot Flashes
Interventions
CBT for Menopausal Insomnia (CBTMI)
Behavioral
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
40 Years to 65 Years · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated May 11, 2017 · Synced Jul 22, 2026, 2:27 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Wake and Sleep State Transitions on a Portable Electroencephalogram (EEG) Device in Narcolepsy Type 1 (NT1) and Healthy Participants

NCT04445129
View directory record Official record
Conditions
Healthy Volunteers, Narcolepsy Type 1
Interventions
Portable EEG Device, Portable ECG Device, Accelerometry
Device
Lead sponsor
Takeda
Industry
Eligibility
16 Years to 60 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
13
States / cities
Redwood City, California • Colorado Springs, Colorado • Clearwater, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated May 6, 2021 · Synced Jul 22, 2026, 2:27 PM EDT