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Conditions: Healthy
Interventions: Methylphenidate, Triazolam, Project: EVO, Placebo; Drug · Other
Lead sponsor: Akili Interactive Labs, Inc.; Industry
Eligibility: 40 Years to 55 Years
Enrollment: 18 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Parkinson Disease, Mild Cognitive Impairment, Old Age; Dementia
Interventions: Adaptango Performance Process (APP) program; Other
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Seasonal Influenza
Interventions: mRNA-1010, Fluarix Quadrivalent; Biological
Lead sponsor: ModernaTX, Inc.; Industry
Eligibility: 50 Years and older
Enrollment: 22,502 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 134
States / cities: Athens, Alabama • Glendale, Arizona • Phoenix, Arizona + 110 more

Conditions: Influenza Vaccine
Interventions: Sing2016 M2SR H3N2 influenza vaccine, Placebo; Biological · Other
Lead sponsor: FluGen Inc; Industry
Eligibility: 50 Years to 85 Years
Enrollment: 122 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021
U.S. locations: 3
States / cities: Anaheim, California • DeLand, Florida • Lenexa, Kansas

Conditions: Old Adults, Sleep Quality, Kava, Mobility Impairment, Physical Activity and Stress, Physical Impairment, Sedentary Lifestyle in Patients Over 70
Interventions: AB-free kava, Placebo; Drug · Other
Lead sponsor: University of Florida; Other
Eligibility: 70 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 2
States / cities: Gainesville, Florida

Conditions: ADHD
Interventions: Not listed
Lead sponsor: BioBehavioral Diagnostics Company; Industry
Eligibility: 15 Years to 55 Years
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011
U.S. locations: 1
States / cities: Clinton, Utah

Conditions: Healthy Volunteer
Interventions: BIIB144, Placebo; Drug
Lead sponsor: Biogen; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Epilepsy
Interventions: Keppra XR; Drug
Lead sponsor: UCB BIOSCIENCES, Inc.; Industry
Eligibility: 12 Years to 55 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 6
States / cities: Mobile, Alabama • Phoenix, Arizona • Little Rock, Arkansas + 3 more

Conditions: Pneumonia, Pneumocystis Carinii, HIV Infections
Interventions: Trimetrexate glucuronate, Leucovorin calcium; Drug
Lead sponsor: U.S. Bioscience; Industry
Eligibility: 13 Years and older
Healthy volunteers: Healthy volunteers not accepted
U.S. locations: 1
States / cities: West Conshohocken, Pennsylvania

Conditions: Deaf, Fall, American Sign Language, Old Age
Interventions: Balance in Motion Exercise class; Behavioral
Lead sponsor: Gallaudet University; Other
Eligibility: 60 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: MDD
Interventions: Brexpiprazole; Drug
Lead sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.; Industry
Eligibility: 18 Years to 35 Years
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 24
States / cities: Cerritos, California • Costa Mesa, California • Garden Grove, California + 21 more

Conditions: Aging, Fall, Old Age; Debility, Muscle Weakness
Interventions: Exercise Program; Other
Lead sponsor: College of Staten Island, the City University of New York; Other
Eligibility: 60 Years and older
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Brooklyn, New York

Conditions: Respiratory Syncytial Virus Prevention
Interventions: Ad26.RSV.preF-based vaccine; Biological
Lead sponsor: Janssen Vaccines & Prevention B.V.; Industry
Eligibility: 60 Years to 75 Years
Enrollment: 250 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 9
States / cities: San Diego, California • Lakeland, Florida • Melbourne, Florida + 4 more

Conditions: Accidental Fall, Neurologic Disorder, Old Age; Debility, Healthy Aging
Interventions: Falls Prevention Program; Other
Lead sponsor: University of St. Augustine for Health Sciences; Other
Eligibility: 18 Years to 100 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2026
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Type 2 Diabetes Mellitus, Obesity
Interventions: Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention; Procedure · Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 25 Years to 55 Years
Enrollment: 69 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2028
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Type 1 Diabetes Mellitus
Interventions: Spotlight AQ Survey platform; Other
Lead sponsor: Children's Mercy Hospital Kansas City; Other
Eligibility: 16 Years to 25 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Kansas City, Missouri

Conditions: Respiratory Syncytial Virus Infections
Interventions: MVA-BN-RSV, Placebo; Biological · Other
Lead sponsor: Bavarian Nordic; Industry
Eligibility: 55 Years and older
Enrollment: 420 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 12
States / cities: Redding, California • San Diego, California • The Villages, Florida + 9 more

Conditions: Sarcopenia
Interventions: High intensity aerobic exercise, Resistance exercise training, Combined; Behavioral
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 80 Years
Enrollment: 72 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2017
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: SARS-CoV-2, Influenza, RSV
Interventions: mRNA-1010, mRNA-1345, mRNA-1273.214, mRNA-1045, mRNA-1230; Biological
Lead sponsor: ModernaTX, Inc.; Industry
Eligibility: 50 Years to 75 Years
Enrollment: 392 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 14
States / cities: DeLand, Florida • Hollywood, Florida • St. Petersburg, Florida + 11 more

Conditions: Acute Vaso Occlusive Crisis (VOC)
Interventions: L-citrulline, D5 1/2NS; Drug · Other
Lead sponsor: Asklepion Pharmaceuticals, LLC; Industry
Eligibility: 6 Years to 21 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 2
States / cities: Washington D.C., District of Columbia • Jackson, Mississippi

Conditions: Parkinson's Disease (PD), Alzheimer's Disease (AD) and Related Disorders, Older Adults (60 - 85 Years Old)
Interventions: Complex Rhythmic Movement Sequences (CRMS) Sessions; Other
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 79 Years
Enrollment: 210 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2028
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Depression in Old Age
Interventions: Peers plus; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 50 Years and older
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Stroke, Old Age
Interventions: Subject-specific optimized RAS, Active walking; Other · Behavioral
Lead sponsor: Boston University Charles River Campus; Other
Eligibility: 18 Years to 80 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Influenza
Interventions: Cell Culture-Derived H5N1 Subunit Influenza Vaccine, 3.75_0%MF59, Cell Culture-Derived H5N1 Subunit Influenza Vaccine, 3.75_25%MF59, Cell Culture-Derived H5N1 Subunit Influenza Vaccine, 3.75_50%MF59, Cell Culture-Derived H5N1 Subunit Influenza Vaccine, 3.75_100%MF59, Cell Culture-Derived H5N1 Subunit Influenza Vaccine, 7.5_0%MF59, Cell Culture-Derived H5N1 Subunit Influenza Vaccine, 7.5_25%MF59, Cell Culture-Derived H5N1 Subunit Influenza Vaccine, 7.5_50%MF59, Cell Culture-Derived H5N1 Subunit Influenza Vaccine, 7.5_100%MF59, Cell Culture-Derived H5N1 Subunit Influenza Vaccine, 15_0%MF59, Cell Culture-Derived H5N1 Subunit Influenza Vaccine, 15_25%MF59, Cell Culture-Derived H5N1 Subunit Influenza Vaccine, 15_50%MF59, Cell Culture-Derived H5N1 Subunit Influenza Vaccine, 15_100%MF59; Biological
Lead sponsor: Seqirus; Industry
Eligibility: 18 Years to 40 Years
Enrollment: 753 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Houston, Texas

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Sensitivity of Project: EVO Monitor Cognitive Measurements to Pharmacological Agents

Adaptango Performance PRocess for Older Adults Community reHabilitation

A Study of mRNA-1010 Seasonal Influenza Vaccine in Adults 50 Years Old and Older

Safety and Immunogenicity of the Sing2016 M2SR H3N2 Monovalent Influenza Vaccine in Adults Ages 50 to 85 Years Old

Kava Aging and Mobility Study

Adult Normative Performance of the Quotient ADHD System

A Study to Learn More About the Safety of a Single Dose of BIIB144 and How it is Processed in the Body of Healthy Adult Participants Ages 18 to 55 Years Old as Compared to a Placebo

Study Evaluating the Pharmacokinetics of Keppra Extended Release (XR) in Children and Adults With Epilepsy

A Compassionate Treatment Protocol for the Use of Trimetrexate Glucuronate (Neutrexin) With Leucovorin Protection for European Adult Patients (>= 13 Years Old) With Pneumocystis Carinii Pneumonia

Exercise Program for Deaf Seniors to Increase Their Balance and Fitness

Brexpiprazole (OPC-34712) as an Adjunctive Treatment in Active Adults, 18 to 35 Years Old, With Major Depressive Disorder Who Are in a School or Work Environment

Hydraulic Resistance and Older Adults

A Study Evaluating the Immunogenicity of Different Clinical Trial Materials of Ad26.RSV.preF- Based Vaccine in Adults Aged 60 - 75 Years Old

A Community-Based Falls Prevention Program for Adults At-Risk for Falls

The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes

Implementing the Spotlight AQ Platform in Adolescent/ Young Adult (16-25 Years Old) Type 1 Diabetics (T1D)

RSV-MVA-BN Vaccine Phase II Trial in ≥ 55 Year Old Adults

Effects of Aerobic and Resistance Training on Accumulation of Old, Modified Proteins in Young and Older Adults

A Safety, Reactogenicity, and Immunogenicity Study of mRNA-1045 (Influenza and Respiratory Syncytial Virus [RSV]) or mRNA-1230 (Influenza, RSV, and Severe Acute Respiratory Syndrome Coronavirus 2 [SARS-CoV-2]) Vaccine in Adults 50 to 75 Years Old

L-citrulline Injection in Patients Aged 6-21 Years Old with Sickle Cell Disease Presenting with Vaso-Occlusive Crisis (VOC)

Moving Yourself in Space and Time: MYSTIC

PEERS Plus mHealth Enhanced Peer Support

Responders to Rhythmic Auditory Stimulation in Individuals Post-Stroke and Older Adults

Dose Ranging Study to Evaluate Immunogenicity and Safety of Adjuvanted or Non-adjuvanted Cell Culture-derived H5N1 Influenza Vaccine in Young Adults (18-40 Years Old)