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Showing 1–24 of 42 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Opioid Craving Clear all
Recruiting Phase 2 Interventional

Ketamine for Opioid Use Disorder

NCT06943859
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Treatment with Ketamine, Treatment with Very Low Dose Ketamine
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 12, 2026 · Synced Jul 23, 2026, 4:30 AM EDT
Completed Not applicable Interventional

Neurofeedback During Naturalistic Stimuli to Reduce Craving in Heroin Addiction

NCT07344233
View directory record Official record
Conditions
Opioid Use Disorder, Substance Use Disorder, Heroin Use Disorder
Interventions
Real-time fMRI Neurofeedback, Sham Real-time fMRI Neurofeedback
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 64 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Jul 23, 2026, 4:30 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders

NCT02322047
View directory record Official record
Conditions
Alcohol Use Disorder, Posttraumatic Stress Disorder (PTSD)
Interventions
Prazosin, Naltrexone, Placebo (Prazosin), Placebo (Naltrexone)
Drug
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years to 80 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 28, 2020 · Synced Jul 23, 2026, 4:30 AM EDT
Completed Phase 2 Interventional Results available

Acute and Short-term Effects of CBD on Cue-induced Craving in Drug-abstinent Heroin-dependent Humans

NCT02539823
View directory record Official record
Conditions
Opiate Addiction
Interventions
CBD 400 mg, CBD 800 mg, Control (placebo)
Drug
Lead sponsor
Hurd,Yasmin, Ph.D.
Individual
Eligibility
21 Years to 65 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 31, 2022 · Synced Jul 23, 2026, 4:30 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Dexmedetomidine in the Treatment of Symptoms Of Acute Opioid Withdrawal

NCT04470050
View directory record Official record
Conditions
Opioid Withdrawal
Interventions
Dexmedetomidine, Placebo
Drug
Lead sponsor
BioXcel Therapeutics Inc
Industry
Eligibility
18 Years to 65 Years
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
3
States / cities
Miami Lakes, Florida • Marlton, New Jersey • New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Jul 23, 2026, 4:30 AM EDT
Completed Not applicable Interventional Results available

tDCS to Decrease Opioid Relapse (UG3)

NCT03842137
View directory record Official record
Conditions
Opioid Dependence, Craving
Interventions
tDCS, sham tDCS
Device
Lead sponsor
Butler Hospital
Other
Eligibility
21 Years to 50 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 23, 2024 · Synced Jul 23, 2026, 4:30 AM EDT
Recruiting Phase 2 Interventional

Assessing a Clinically-meaningful Opioid Withdrawal Phenotype

NCT05027919
View directory record Official record
Conditions
Opioid Withdrawal, Opioid Use Disorder, Opioid Craving
Interventions
Hydromorphone, Naloxone + lofexidine pretreatment, Naloxone + placebo pretreatment, Lofexidine
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 11, 2025 · Synced Jul 23, 2026, 4:30 AM EDT
Completed Not applicable Interventional

Frontoparietal Synchronization to Modulate Drug Craving in Opioid Use Disorder

NCT03907644
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Transcranial Alternating Current Stimulation (tACS)
Device
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 61 Years · Male only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jul 10, 2023 · Synced Jul 23, 2026, 4:30 AM EDT
Completed Phase 2 Interventional Results available

Acute and Short-term Effects of Cannabidiol Admin on Cue-induced Craving in Drug-abstinent Heroin Dependent Humans

NCT01605539
View directory record Official record
Conditions
Opiate Addiction
Interventions
Cannabidiol 400, Cannabidiol 800, Control
Drug
Lead sponsor
Hurd,Yasmin, Ph.D.
Individual
Eligibility
21 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 10, 2020 · Synced Jul 23, 2026, 4:30 AM EDT
Completed Phase 1 Interventional Results available

Oxytocin, Stress, Craving, Opioid Use Disorder

NCT04051619
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
intranasal oxytocin, 40 IU, twice a day for 7 days
Drug
Lead sponsor
Brown University
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated May 24, 2025 · Synced Jul 23, 2026, 4:30 AM EDT
Withdrawn Not applicable Interventional

Use of Transcranial Magnetic Stimulation to Reduce Craving for Individuals With Opioid Use Disorder Taking Buprenorphine

NCT03653169
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Transcranial Magnetic Stimulation
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 13, 2022 · Synced Jul 23, 2026, 4:30 AM EDT
Completed Phase 2 Interventional Results available

Cannabidiol Effects on Craving and Relapse Prevention in Opioid Use Disorder

NCT03787628
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Cannabidiol (CBD) 600 mg, Placebo
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Tarzana, California
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Jul 23, 2026, 4:30 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Developing a Clinical Outcome Assessment for Opioid Craving

NCT05109429
View directory record Official record
Conditions
Opioid Craving, Opioid Use Disorder, Measure Development
Interventions
Neutral Cue-induced Craving, Visual Opioid Cue-induced Craving, Visual and Tactile Opioid Cue-induced Craving
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced Jul 23, 2026, 4:30 AM EDT
Completed Early Phase 1 Interventional

Endocannabinoids, Stress, Craving And Pain Effects Study

NCT05480072
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Palmitoylethanolamide, Placebo
Drug · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 19, 2025 · Synced Jul 23, 2026, 4:30 AM EDT
Completed Not applicable Interventional

Evaluating the Feasibility, Acceptability, and Preliminary Outcomes of Heart Rate Variability Biofeedback for Individuals With Opioid Use Disorder.

NCT07361731
View directory record Official record
Conditions
Autonomic Nervous System Imbalance, Heart Rate Variability (HRV), Opioid Use Disorder, Breathing Techniques, Opioid Craving, Recovery, Emotional Regulation, Positive and Negative Affect, Stress, Biofeedback
Interventions
Heart rate variability biofeedback
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
18 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Jul 23, 2026, 4:30 AM EDT
Terminated Not applicable Interventional Results available

Repetitive Transcranial Magnetic Stimulation for Opiate Use Disorder

NCT03538444
View directory record Official record
Conditions
Opiate Dependence, Chronic Pain
Interventions
Repetitive Transcranial Magnetic Stimulation, Sham rTMS
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 13, 2022 · Synced Jul 23, 2026, 4:30 AM EDT
Completed Not applicable Interventional

The Feasibility of VR for OUD

NCT06255119
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
3D Therapy Thrive
Device
Lead sponsor
3D Therapy, LLC
Industry
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Quincy, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 12, 2024 · Synced Jul 23, 2026, 4:30 AM EDT
Terminated Not applicable Interventional Results available

Pain Catastrophizing and Prescription Opioid Craving

NCT04097743
View directory record Official record
Conditions
Chronic Pain
Interventions
Coping Statement
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Jul 23, 2026, 4:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Resonance Breathing Intervention Opioid Use Disorder

NCT05830773
View directory record Official record
Conditions
Substance-Related Disorders
Interventions
Resonance Breathing Exercises
Other
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jan 8, 2024 · Synced Jul 23, 2026, 4:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Minds and Mentors Program (MiMP)- R61

NCT04233671
View directory record Official record
Conditions
Opioid-use Disorder, Medication Assisted Treatment, Substance Use Disorders
Interventions
Mindfulness based relapse prevention and peer mentoring
Behavioral
Lead sponsor
University of Alabama, Tuscaloosa
Other
Eligibility
19 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
2
States / cities
Birmingham, Alabama • Homewood, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 20, 2023 · Synced Jul 23, 2026, 4:30 AM EDT
Not listed Phase 2 Interventional

Computerized Chemosensory-Based Orbitofrontal Cortex (CBOT) for Opioid Use Disorder

NCT04850664
View directory record Official record
Conditions
Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe, Withdrawal Symptoms, Craving, Negative Affectivity
Interventions
CBOT + TAU, Sham + TAU
Drug
Lead sponsor
Evon Medics LLC
Industry
Eligibility
18 Years to 70 Years
Enrollment
190 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
4
States / cities
Washington D.C., District of Columbia • Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 5, 2021 · Synced Jul 23, 2026, 4:30 AM EDT
Completed Phase 1 Interventional

Effect of Clonidine on Responses to Imagery Scripts

NCT00318760
View directory record Official record
Conditions
Cocaine Abuse, Heroin Abuse
Interventions
Clonidine, Placebo
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 55 Years
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 4, 2018 · Synced Jul 23, 2026, 4:30 AM EDT
Completed Not applicable Interventional

Transcranial Photobiomodulation for the Treatment of Opioid Cravings

NCT04417738
View directory record Official record
Conditions
Opioid-use Disorder, Depression, Anxiety, Craving
Interventions
unilateral transcranial photobiomodulation, near infrared mode, Sham treatment
Device
Lead sponsor
MindLight, LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Newton Highlands, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 25, 2021 · Synced Jul 23, 2026, 4:30 AM EDT
Recruiting Not applicable Interventional

tDCS to Decrease Opioid Relapse (UH3)

NCT06432465
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
active tDCS, sham tDCS
Device
Lead sponsor
Butler Hospital
Other
Eligibility
21 Years to 60 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Jul 23, 2026, 4:30 AM EDT