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ClinicalTrials.gov public records Last synced Oct 1, 2026, 5:22 PM EDT

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Showing 25–48 of 85 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Osteo Arthritis Knee Clear all
Not listed Not applicable Interventional

Post-op Ketamine Study

NCT03865550
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Isotonic saline, Ketamine Injectable Solution
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
Not listed
Enrollment
75 participants
Timeline
2016 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 7, 2019 · Synced Oct 1, 2026, 5:22 PM EDT
Recruiting Not applicable Interventional

Adipose-Derived Biocellular Regenerative Therapy for Osteoarthritis

NCT04238143
View directory record Official record
Conditions
Osteoarthritis, Osteo Arthritis Knee, Osteo Arthritis Shoulders, Osteoarthritis of Multiple Joints, Osteoarthritis, Hip, Osteoarthritis - Ankle/Foot
Interventions
Tissue Stromal Vascular Fraction (tSVF) Arm 1, PRP Concentrate Arm 1, Tissue Stromal Vascular Fraction (tSVF) Arm 2, PRP Concentrate Arm 2, Cellular Stromal Vascular Fraction (cSVF) Arm 2, Cellular Stromal Vascular Fraction (cSVF) Arm 3, Sterile Normal Saline (IV Solution)
Procedure · Biological · Drug
Lead sponsor
Healeon Medical Inc
Industry
Eligibility
18 Years to 90 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
2
States / cities
Valencia, California • Stevensville, Montana
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Oct 1, 2026, 5:22 PM EDT
Not listed Early Phase 1 Interventional

Biofeedback Retention in Individuals With AKA

NCT05126485
View directory record Official record
Conditions
Amputation of Knee, Back Pain, Osteo Arthritis Knee
Interventions
Haptic Biofeedback from SageMotion Biofeedback System
Device
Lead sponsor
San Jose State University
Other
Eligibility
18 Years to 70 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
2
States / cities
Palo Alto, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 2, 2023 · Synced Oct 1, 2026, 5:22 PM EDT
Completed Not applicable Interventional Results available

Analgesic Value of Adductor Canal vs Femoral Block After Total Knee Arthroplasty

NCT03395990
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Active comparator: chloroprocaine, Sham comparator: saline
Procedure
Lead sponsor
Duke University
Other
Eligibility
56 Years to 85 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 17, 2020 · Synced Oct 1, 2026, 5:22 PM EDT
Withdrawn Not applicable Interventional

Utilization of a Knee Brace With Extension Swing

NCT05179044
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Guardian Sport Rehabilitator knee brace
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 24, 2023 · Synced Oct 1, 2026, 5:22 PM EDT
Completed Not applicable Interventional Results available

Comparison of Alignment Achieved Using the VELYS Robotic-Assisted Solution Versus Manual Instrumentation in Total Knee Arthroplasty

NCT04730271
View directory record Official record
Conditions
Osteo Arthritis Knee, Osteoarthritis
Interventions
Total Knee Replacement
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
22 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
5
States / cities
Baltimore, Maryland • Crosby, Minnesota • Charlotte, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 27, 2025 · Synced Oct 1, 2026, 5:22 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Use of Bone Growth Stimulators for Osteoarthritis of the Knee.

NCT03476382
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Ultrasound Bone Growth Stimulator
Device
Lead sponsor
Coastal Carolinas Integrated Medicine
Other
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Supply, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 31, 2019 · Synced Oct 1, 2026, 5:22 PM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Surgical Joint Registry MBJRF

NCT03484325
View directory record Official record
Conditions
Osteoarthritis, Knee, Osteoarthritis, Hip
Interventions
Not listed
Lead sponsor
Memorial Bone and Joint Research Foundation
Other
Eligibility
18 Years to 100 Years
Enrollment
990 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2030
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 15, 2019 · Synced Oct 1, 2026, 5:22 PM EDT
Completed Not applicable Interventional

OrthoCor Advanced Trial for Knee Osteoarthritis

NCT06475677
View directory record Official record
Conditions
Osteoarthritis, Knee, Osteo Arthritis Knee
Interventions
OrthoCor Advanced System
Device
Lead sponsor
Caerus Corporation
Industry
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Gulf Breeze, Florida
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Oct 1, 2026, 5:22 PM EDT
Not listed No phase listed Observational

Prospective Post Approval Clinical Follow-Up Study of the Commercially Available U2 Knee™ System - "U-Propel Study"

NCT03060057
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
U2 Knee™ System
Device
Lead sponsor
United Orthopedic Corporation
Industry
Eligibility
18 Years to 75 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2026
U.S. locations
4
States / cities
Bradenton, Florida • Jacksonville, Florida • Vero Beach, Florida + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 5, 2023 · Synced Oct 1, 2026, 5:22 PM EDT
Completed Not applicable Interventional Results available

Geniculate Artery Embolization for Knee Pain Secondary to Osteoarthritis (OA)

NCT03362957
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Geniculate Artery Embolization, Sham Procedure
Device · Diagnostic Test
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
40 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Woodbridge, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 22, 2021 · Synced Oct 1, 2026, 5:22 PM EDT
Active, not recruiting Not applicable Interventional

Geniculate Artery Embolization for Osteoarthritis

NCT04456569
View directory record Official record
Conditions
Osteo Arthritis Knee, Arthritis, Osteoarthritis, Osteoarthritis, Knee
Interventions
Geniculate Artery Embolization
Device
Lead sponsor
University of Minnesota
Other
Eligibility
40 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 1, 2026, 5:22 PM EDT
Completed Not applicable Interventional Results available

Self-Administered Transcranial Direct Current Stimulation for Pain in Older Adults With Knee Osteoarthritis

NCT04016272
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Active tDCS, Sham tDCS
Device
Lead sponsor
Florida State University
Other
Eligibility
50 Years to 85 Years
Enrollment
123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 10, 2023 · Synced Oct 1, 2026, 5:22 PM EDT
Completed Not applicable Interventional

Use of a Self-Guided Mindfulness Mobile Application to Improve Pain Outcomes in Individuals With Knee Osteoarthritis

NCT03936088
View directory record Official record
Conditions
Osteo Arthritis Knee, Pain
Interventions
Intervention -- "Headspace" mindfulness application, Control -- "My Water Balance" application
Device
Lead sponsor
jilliansylvester
Federal
Eligibility
18 Years to 74 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Scott Air Force Base, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 13, 2022 · Synced Oct 1, 2026, 5:22 PM EDT
Enrolling by invitation Phase 3 Interventional

Extended Oral Tranexamic Acid After Total Knee Arthroplasty

NCT06618820
View directory record Official record
Conditions
Osteo Arthritis Knee, Pain, Postoperative
Interventions
Tranexamic acid, Placebo
Drug
Lead sponsor
Campbell Clinic
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Germantown, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Oct 1, 2026, 5:22 PM EDT
Active, not recruiting Phase 3 Interventional

Microfragmented Adipose Tissue Compared to Saline Injection for the Treatment of Knee Osteoarthritis

NCT06121882
View directory record Official record
Conditions
Knee Osteoarthritis, Osteo Arthritis Knee
Interventions
Microfragmented Adipose Tissue derived using the Lipogems® System, Saline Injection
Device · Drug
Lead sponsor
Lipogems International spa
Industry
Eligibility
18 Years and older
Enrollment
173 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
16
States / cities
Phoenix, Arizona • Encinitas, California • La Mesa, California + 13 more
Source: ClinicalTrials.gov public record
Updated Jun 12, 2025 · Synced Oct 1, 2026, 5:22 PM EDT
Not yet recruiting Not applicable Interventional

Developing a Nonpharmacological Pain Intervention for Community-dwelling Older Adults With Dementia

NCT06264362
View directory record Official record
Conditions
Pain, Chronic, Dementia, Mild, Mobility Limitation, Physical Disability, Osteo Arthritis Knee, Mild Cognitive Impairment
Interventions
Tailored Physical Activity Program
Behavioral
Lead sponsor
Drexel University
Other
Eligibility
60 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 11, 2025 · Synced Oct 1, 2026, 5:22 PM EDT
Withdrawn Not applicable Interventional

rTMS for Relieving Chronic OA Pain

NCT05097729
View directory record Official record
Conditions
Chronic Pain, Osteo Arthritis Knee
Interventions
Transcranial Magnetic Stimulation
Device
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 3, 2023 · Synced Oct 1, 2026, 5:22 PM EDT
No Longer Available No phase listed Expanded access

Individual Patient Expanded Access IND of Autologous HB-adMSCS for the Treatment of Bilateral Knee Pain.

NCT04604288
View directory record Official record
Conditions
Knee Pain Chronic, Osteo Arthritis Knee
Interventions
HB-adMSC
Biological
Lead sponsor
Hope Biosciences Research Foundation
Industry
Eligibility
Not listed
U.S. locations
1
States / cities
Sugar Land, Texas
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Oct 1, 2026, 5:22 PM EDT
Recruiting Not applicable Interventional

Bone Marrow Aspirate Concentrate (BMAC)Treatment for Knee Osteoarthritis

NCT04716803
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Bone Marrow Aspirate Concentrate, Angel Concentrated Platelet Rich Plasma (cPRP) System
Biological · Device
Lead sponsor
University of California, San Diego
Other
Eligibility
45 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jan 26, 2022 · Synced Oct 1, 2026, 5:22 PM EDT
Completed Not applicable Interventional Results available

Study of Pain Catastrophizing

NCT03836586
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Cognitive-Behavioral Intervention, Pain Education
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
45 Years to 85 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 19, 2024 · Synced Oct 1, 2026, 5:22 PM EDT
Active, not recruiting Not applicable Interventional

Pain & Aging: Combined Interventions for Fitness in the Community Study

NCT04099394
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Behavioral Health, Health Education
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
65 Years and older
Enrollment
280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 28, 2025 · Synced Oct 1, 2026, 5:22 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparing Surgical and Economical Parameters of Total Knee Replacement.

NCT03427047
View directory record Official record
Conditions
Osteo Arthritis Knee, Total Knee Arthroplasty
Interventions
MyKnee with single use Efficiency Instrument, Stryker Navigational with conventional metal instruments
Device
Lead sponsor
Medacta USA
Industry
Eligibility
16 Years to 75 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 13, 2023 · Synced Oct 1, 2026, 5:22 PM EDT
Active, not recruiting Not applicable Interventional

SakuraBead Used as Resorbable Embolic for Genicular Artery Embolization

NCT06550024
View directory record Official record
Conditions
Osteo Arthritis Knee, Joint Diseases, Musculoskeletal Diseases, Rheumatic Diseases, Arthritis, Osteoarthritis
Interventions
SakuraBead Resorbable Microspheres, Corticosteroid Injection
Device · Drug
Lead sponsor
CrannMed
Industry
Eligibility
40 Years to 79 Years
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
5
States / cities
Birmingham, Alabama • Torrance, California • Panama City, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Oct 1, 2026, 5:22 PM EDT