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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Osteo Arthritis Knee Clear all
Recruiting Not applicable Interventional

Effects of Home Base Whole-body Vibration in Osteoarthritis. (VIBE-Rx2)

NCT06058169
View directory record Official record
Conditions
Whole Body Vibration, Osteo Arthritis Knee
Interventions
Sub Acute Whole Body Vibration Training
Device
Lead sponsor
Augusta University
Other
Eligibility
40 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Jul 22, 2026, 12:57 AM EDT
Completed Not applicable Interventional

Use of a Self-Guided Mindfulness Mobile Application to Improve Pain Outcomes in Individuals With Knee Osteoarthritis

NCT03936088
View directory record Official record
Conditions
Osteo Arthritis Knee, Pain
Interventions
Intervention -- "Headspace" mindfulness application, Control -- "My Water Balance" application
Device
Lead sponsor
jilliansylvester
Federal
Eligibility
18 Years to 74 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Scott Air Force Base, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 12, 2022 · Synced Jul 22, 2026, 12:57 AM EDT
Not listed No phase listed Observational

Prospective Post Approval Clinical Follow-Up Study of the Commercially Available U2 Knee™ System - "U-Propel Study"

NCT03060057
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
U2 Knee™ System
Device
Lead sponsor
United Orthopedic Corporation
Industry
Eligibility
18 Years to 75 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2026
U.S. locations
4
States / cities
Bradenton, Florida • Jacksonville, Florida • Vero Beach, Florida + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2023 · Synced Jul 22, 2026, 12:57 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Sustained Acoustic Medicine (SAM) for Symptomatic Treatment of Knee Pain Related to Osteoarthritis

NCT05882812
View directory record Official record
Conditions
Osteo Arthritis Knee, Arthritis
Interventions
Sustained Acoustic Device with 2.5% Diclofenac Patch, Sustained Acoustic Device with 0% Diclofenac Patch, 2.5% Diclofenac Patches
Device · Drug
Lead sponsor
ZetrOZ, Inc.
Industry
Eligibility
35 Years to 80 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
3
States / cities
Stamford, Connecticut • Trumbull, Connecticut • Dryden, New York
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Jul 22, 2026, 12:57 AM EDT
Completed Not applicable Interventional Results available

Comparison of Alignment Achieved Using the VELYS Robotic-Assisted Solution Versus Manual Instrumentation in Total Knee Arthroplasty

NCT04730271
View directory record Official record
Conditions
Osteo Arthritis Knee, Osteoarthritis
Interventions
Total Knee Replacement
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
22 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
5
States / cities
Baltimore, Maryland • Crosby, Minnesota • Charlotte, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 26, 2025 · Synced Jul 22, 2026, 12:57 AM EDT
Completed No phase listed Observational

A Retrospective Study to Evaluate the ConforMIS iTotal® Posterior Stabilized (PS) Knee Replacement System

NCT03289000
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
iTotal Posterior Stabilized (PS) Knee Replacement System
Device
Lead sponsor
Restor3D
Industry
Eligibility
18 Years and older
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
2
States / cities
Nashville, Tennessee • Huntington, West Virginia
Source: ClinicalTrials.gov public record
Updated Oct 24, 2023 · Synced Jul 22, 2026, 12:57 AM EDT
Withdrawn Phase 2 Interventional

Conventional Platelet-Rich Plasma Versus Concentrated Bone Marrow Stem Cell Injections for Osteoarthritis of the Knee

NCT03271229
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Concentrated Bone Marrow Aspirate (BMAC), Platelet-Rich Plasma (PRP)
Biological
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Dec 23, 2019 · Synced Jul 22, 2026, 12:57 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Energy Status and Protein Intake As Prognostic Indicators of Rehabilitative Outcomes

NCT06734845
View directory record Official record
Conditions
Orthopedic, Osteo Arthritis Knee, Hip Osteoarthritis, Protein-Energy Malnutrition, Energy Malnutrition Protein
Interventions
Total Knee Arthroplasty, Total Joint Arthroplasty
Procedure
Lead sponsor
University of Connecticut
Other
Eligibility
50 Years to 70 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 15, 2024 · Synced Jul 22, 2026, 12:57 AM EDT
Recruiting Not applicable Interventional

Gait Rehabilitation to Treat FastOA

NCT05848622
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, Knee Osteoarthritis, Osteo Arthritis Knee, Knee Injuries, Cartilage, Articular, Gait
Interventions
Real-time gait biofeedback, Sham real-time gait biofeedback
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
16 Years to 35 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Jul 22, 2026, 12:57 AM EDT
Completed No phase listed Observational Results available

In Vivo Kinematics for Subjects Implanted With Klassic Total Knee Arthroplasty (TKA)

NCT04113785
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteo Arthritis Knee, Knee Implant, Knee Injuries
Interventions
Klassic Knee System
Device
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 14, 2019 · Synced Jul 22, 2026, 12:57 AM EDT
Suspended Not applicable Interventional

Low Frequency Ultrasound for Osteoarthritis Healing and Rehabilitation

NCT06562374
View directory record Official record
Conditions
Osteo Arthritis Knee, Age Related Osteoporosis, Pain, Knee Joint Contracture
Interventions
Low Frequency Ultrasound Therapy
Device
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
40 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Jul 22, 2026, 12:57 AM EDT
Completed Phase 2 Interventional Results available

To Determine the Safety, Tolerability, Pharmacokinetics and Effect on Pain of a Single Intra-articular Administration of Canakinumab in Patients With Osteoarthritis in the Knee

NCT01160822
View directory record Official record
Conditions
Osteoarthritis
Interventions
Canakinumab, Placebo to canakinumab, Naproxen, Placebo to Naproxen
Biological · Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
40 Years to 80 Years
Enrollment
169 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
8
States / cities
Anniston, Alabama • Mesa, Arizona • San Diego, California + 5 more
Source: ClinicalTrials.gov public record
Updated Oct 29, 2012 · Synced Jul 22, 2026, 12:57 AM EDT
Recruiting Phase 1Phase 2 Interventional

The Role of Vitamin K on Knee Osteoarthritis Outcomes

NCT06385275
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Vitamin K1 500 µg, K1 1000 µg, Vitamin K2 (MK-7) 300 µg, Placebo
Drug · Other
Lead sponsor
Boston University
Other
Eligibility
60 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Jul 22, 2026, 12:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparing Surgical and Economical Parameters of Total Knee Replacement.

NCT03427047
View directory record Official record
Conditions
Osteo Arthritis Knee, Total Knee Arthroplasty
Interventions
MyKnee with single use Efficiency Instrument, Stryker Navigational with conventional metal instruments
Device
Lead sponsor
Medacta USA
Industry
Eligibility
16 Years to 75 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 12, 2023 · Synced Jul 22, 2026, 12:57 AM EDT
Withdrawn Not applicable Interventional

Utilization of a Knee Brace With Extension Swing

NCT05179044
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Guardian Sport Rehabilitator knee brace
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 23, 2023 · Synced Jul 22, 2026, 12:57 AM EDT
Completed Phase 3 Interventional

Evaluation of Clinical Endpoints of Two Diclofenac Sodium Gel 1%

NCT01456611
View directory record Official record
Conditions
Osteo Arthritis of the Knee
Interventions
Diclofenac, Placebo
Drug
Lead sponsor
Anchen Pharmaceuticals, Inc
Industry
Eligibility
35 Years and older
Enrollment
749 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
57
States / cities
Birmingham, Alabama • Huntsville, Alabama • Chandler, Arizona + 54 more
Source: ClinicalTrials.gov public record
Updated Jul 11, 2012 · Synced Jul 22, 2026, 12:57 AM EDT
Completed Not applicable Interventional Results available

Geniculate Artery Embolization for Knee Pain Secondary to Osteoarthritis (OA)

NCT03362957
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Geniculate Artery Embolization, Sham Procedure
Device · Diagnostic Test
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
40 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Woodbridge, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 21, 2021 · Synced Jul 22, 2026, 12:57 AM EDT
Completed Not applicable Interventional Results available

Home-based tDCS and Mindfulness-based Meditation for Self-management of Clinical Pain and Symptoms

NCT04375072
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
active tDCS paired with active MBM, sham tDCS paired with active MBM, active tDCS paired with sham MBM, sham tDCS paired with sham MBM
Device
Lead sponsor
University of Arizona
Other
Eligibility
50 Years to 85 Years
Enrollment
208 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 11, 2025 · Synced Jul 22, 2026, 12:57 AM EDT
Recruiting Not applicable Interventional

MISHA Post-Market Clinical Study

NCT06118892
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
MISHA Knee System
Device
Lead sponsor
Moximed
Industry
Eligibility
25 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2030
U.S. locations
4
States / cities
Sonoma, California • Raleigh, North Carolina • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Jul 22, 2026, 12:57 AM EDT
Completed Not applicable Interventional Results available

Knee Biofeedback Rehabilitation Interface for Game-based Home Therapy for Patients With Knee Osteoarthritis

NCT04187092
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
KneeBright Group, Standard Rehabilitation group
Other
Lead sponsor
University of Virginia
Other
Eligibility
40 Years to 75 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 20, 2023 · Synced Jul 22, 2026, 12:57 AM EDT
Recruiting Not applicable Interventional

Home-Based Leg Dexterity Trainer for Management of Knee Osteoarthritis

NCT07397806
View directory record Official record
Conditions
Osteo Arthritis of the Knee
Interventions
Lex Dexterity Trainer, Wobble Board
Device
Lead sponsor
Steadman Philippon Research Institute
Other
Eligibility
40 Years to 85 Years
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Vail, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Jul 22, 2026, 12:57 AM EDT
Completed Not applicable Interventional Results available

Study of Pain Catastrophizing

NCT03836586
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Cognitive-Behavioral Intervention, Pain Education
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
45 Years to 85 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 18, 2024 · Synced Jul 22, 2026, 12:57 AM EDT
Active, not recruiting Not applicable Interventional

Effects of Vitamin K on Lower-extremity Function in Adults With Osteoarthritis:

NCT05505552
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Vitamin K, Placebo
Dietary Supplement
Lead sponsor
Tufts University
Other
Eligibility
50 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
3
States / cities
Boston, Massachusetts • Worcester, Massachusetts • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 16, 2025 · Synced Jul 22, 2026, 12:57 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Osteoarthritis Care Tools for Primary Care Providers

NCT06988163
View directory record Official record
Conditions
Arthritis, Osteo Arthritis Knee
Interventions
OACareTools+
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 99 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 27, 2025 · Synced Jul 22, 2026, 12:57 AM EDT