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ClinicalTrials.gov public records Last synced May 21, 2026, 7:39 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 120 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Osteonecrosis Clear all
Terminated Not applicable Interventional Results available
View directory record Official record
Conditions
Osteoarthritis, Osteoarthritis, Knee, Osteonecrosis
Interventions
Signature Custom Guides, Conventional Instrumentation
Device · Procedure
Lead sponsor
Zimmer Biomet
Industry
Eligibility
21 Years and older
Enrollment
266 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
7
States / cities
Elkhart, Indiana • Rockville, Maryland • Columbia, Missouri + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 22, 2021 · Synced May 21, 2026, 7:39 PM EDT
Terminated Phase 2 Interventional Results available
View directory record Official record
Conditions
Avascular Necrosis
Interventions
Atorvastatin, MRI, Venipuncture, Placebo
Drug · Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 75 Years · Female only
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 22, 2018 · Synced May 21, 2026, 7:39 PM EDT
Recruiting No phase listed Observational
View directory record Official record
Conditions
Mandibular Reconstruction, Segmental Mandibular Defects
Interventions
Surgical Resection and Reconstruction
Procedure
Lead sponsor
AO Innovation Translation Center
Other
Eligibility
18 Years and older
Enrollment
300 participants
Timeline
2022 – 2030
U.S. locations
5
States / cities
Jacksonville, Florida • Chicago, Illinois • New Hyde Park, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 3, 2025 · Synced May 21, 2026, 7:39 PM EDT
Completed Phase 2 Interventional Results available
View directory record Official record
Conditions
Hypertension, Osteonecrosis, Osteonecrosis Due to Drug
Interventions
Intensive Antihypertensive Therapy, Conventional Antihypertensive Therapy, Symptom Survey, Semi-structured interview
Drug · Other
Lead sponsor
St. Jude Children's Research Hospital
Other
Eligibility
10 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
2
States / cities
Charlotte, North Carolina • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 2, 2025 · Synced May 21, 2026, 7:39 PM EDT
Enrolling by invitation No phase listed Observational
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Revision Knee implants
Device
Lead sponsor
MicroPort Orthopedics Inc.
Industry
Eligibility
21 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2033
U.S. locations
1
States / cities
Englewood, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 19, 2024 · Synced May 21, 2026, 7:39 PM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Osteoarthritis, Rheumatoid Arthritis, Other Inflammatory Arthritis, Post-Traumatic Arthritis, Juvenile Rheumatoid Arthritis, Avascular Necrosis
Interventions
Total Knee Arthroplasty, Total knee replacement
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
18 Years to 75 Years
Enrollment
149 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2007
U.S. locations
3
States / cities
Greensboro, North Carolina • Austin, Texas • Lakewood, Washington
Source: ClinicalTrials.gov public record
Updated May 2, 2023 · Synced May 21, 2026, 7:39 PM EDT
Completed No phase listed Observational Results available
View directory record Official record
Conditions
Noninflammatory Degenerative Joint Disease, Rheumatoid Arthritis
Interventions
Metal on Polyethylene articulation, Ceramic on Polyethylene articulation, Ceramic on Ceramic articulation
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2025
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced May 21, 2026, 7:39 PM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Non-inflammatory Degenerative Joint Disease, Osteoarthritis, Avascular Necrosis, Post-Traumatic Osteoarthritis of Hip
Interventions
COC 36mm
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
21 Years to 75 Years
Enrollment
172 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2023
U.S. locations
9
States / cities
Sacramento, California • Denver, Colorado • Tampa, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 15, 2025 · Synced May 21, 2026, 7:39 PM EDT
Active, not recruiting Not applicable Interventional Results available
View directory record Official record
Conditions
Sickle Cell Disease, Sickle Cell Anemia, Low Bone Density, Osteoporosis, Osteopenia, Vertebral Fracture, Vertebral Compression, Osteonecrosis, Ischemic Necrosis, Avascular Necrosis
Interventions
Dual-energy X-ray absorptiometry, Vertebral fracture analysis, Adult Sickle Cell Quality of Life Measurement System pain impact questionnaire
Other
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 80 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Aug 23, 2025 · Synced May 21, 2026, 7:39 PM EDT
Completed Phase 3 Interventional Results available
View directory record Official record
Conditions
Inflammatory Tissue Disorder, Osteoarthritis, Avascular Necrosis, Post-traumatic Arthritis, Secondary Arthritis
Interventions
Encore Mobile-Bearing Knee
Device
Lead sponsor
Encore Medical, L.P.
Industry
Eligibility
18 Years and older
Enrollment
419 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2008
U.S. locations
8
States / cities
Phoenix, Arizona • Fountain Valley, California • Miami, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated May 10, 2011 · Synced May 21, 2026, 7:39 PM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Osteoarthritis, Hip, Rheumatoid Arthritis, Avascular Necrosis
Interventions
Not listed
Lead sponsor
Biomet Orthopedics, LLC
Industry
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2013
U.S. locations
4
States / cities
Chicago, Illinois • Pittsburgh, Pennsylvania • Fredericksburg, Virginia + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 20, 2017 · Synced May 21, 2026, 7:39 PM EDT
Completed Phase 4 Interventional Results available
View directory record Official record
Conditions
Osteoarthritis, Rheumatoid Arthritis, Post Traumatic Arthritis, Varus Deformity, Avascular Necrosis
Interventions
3DKnee
Device
Lead sponsor
Encore Medical, L.P.
Industry
Eligibility
18 Years and older
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
City of Saint Peters, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 1, 2011 · Synced May 21, 2026, 7:39 PM EDT
Active, not recruiting Not applicable Interventional
View directory record Official record
Conditions
Hip Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Post-traumatic Osteoarthritis, Femoral Neck Fractures, Trochanteric Fractures, Surgery
Interventions
Insignia uncemented Hip Stem
Device
Lead sponsor
Stryker Orthopaedics
Industry
Eligibility
18 Years and older
Enrollment
313 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2034
U.S. locations
11
States / cities
Phoenix, Arizona • San Francisco, California • Chicago, Illinois + 8 more
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced May 21, 2026, 7:39 PM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Osteoarthritis, Hip, Femoroacetabular Impingement, Osteonecrosis, Legg-Calvé-Perthes Disease, Osteochondral Lesion, Hip Dysplasia
Interventions
ReNew Hip Implant
Device
Lead sponsor
Cytex Therapeutics, Inc.
Other
Eligibility
14 Years to 64 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2031
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced May 21, 2026, 7:39 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Osteoarthritis, Traumatic Arthritis, Rheumatoid Arthritis, Congenital Hip Dysplasia, Avascular Necrosis of the Femoral Head, Acute Traumatic Fracture of the Femoral Head or Neck, Certain Cases of Ankylosis, Non-union of Femoral Neck Fractures, Certain High Sub-Capital & Femoral Neck Fractures in Elderly
Interventions
Actis Total Hip System
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
21 Years and older
Enrollment
266 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2024
U.S. locations
9
States / cities
Louisville, Kentucky • Boston, Massachusetts • Rochester, Minnesota + 6 more
Source: ClinicalTrials.gov public record
Updated Aug 14, 2025 · Synced May 21, 2026, 7:39 PM EDT
Completed Phase 1 Interventional
View directory record Official record
Conditions
Osteopenia, Osteoporosis, Osteonecrosis
Interventions
LLP2A-ALENDRONATE, Placebo
Drug
Lead sponsor
Nancy E. Lane, MD
Other
Eligibility
20 Years to 85 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
4
States / cities
Cypress, California • Walnut Creek, California • Duncansville, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 5, 2021 · Synced May 21, 2026, 7:39 PM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Osteoarthritis, Avascular Necrosis
Interventions
Oxford® Meniscal Unicompartmental Knee System
Device
Lead sponsor
Biomet Orthopedics, LLC
Industry
Eligibility
18 Years and older
Enrollment
388 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2021
U.S. locations
6
States / cities
Schaumburg, Illinois • New Albany, Ohio • Cordova, Tennessee + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 20, 2021 · Synced May 21, 2026, 7:39 PM EDT
Withdrawn No phase listed Observational
View directory record Official record
Conditions
Joint Disease
Interventions
Not listed
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2023
U.S. locations
1
States / cities
Rochester Hills, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 20, 2017 · Synced May 21, 2026, 7:39 PM EDT
Not listed Not applicable Interventional
View directory record Official record
Conditions
Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, CDH
Interventions
Trinity CoC Total Hip System, Trinity Ceramic-on-Poly THR
Device
Lead sponsor
Corin
Industry
Eligibility
18 Years to 80 Years
Enrollment
342 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2021
U.S. locations
9
States / cities
Little Rock, Arkansas • Parker, Colorado • Hartford, Connecticut + 5 more
Source: ClinicalTrials.gov public record
Updated Mar 10, 2021 · Synced May 21, 2026, 7:39 PM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Bone Diseases, Metastases, Osteonecrosis, Bisphosphonate-Associated Osteonecrosis of the Jaw
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
21 Years and older
Enrollment
271 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 1, 2014 · Synced May 21, 2026, 7:39 PM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Hip Arthropathy, Avascular Necrosis of Bone, Subchondral Cysts
Interventions
Bone Marrow Collection
Device
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 50 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced May 21, 2026, 7:39 PM EDT
Terminated Phase 1 Interventional
View directory record Official record
Conditions
Osteonecrosis
Interventions
Lactated Ringers, The Celution 800/GP System (Cytori Therapeutics), Adipose Derived Regenerative Cells (ADRC)
Other · Device · Biological
Lead sponsor
Mayo Clinic
Other
Eligibility
22 Years to 70 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 10, 2022 · Synced May 21, 2026, 7:39 PM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Osteoarthritis
Interventions
Reflection Ceramic-Ceramic Total Hip Replacement, Reflection FSO V Total Hip Replacement
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
21 Years to 80 Years
Enrollment
456 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2014
U.S. locations
7
States / cities
Augusta, Georgia • Flint, Michigan • New York, New York + 4 more
Source: ClinicalTrials.gov public record
Updated Oct 12, 2022 · Synced May 21, 2026, 7:39 PM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Osteoarthritis, Avascular Necrosis, Congenital Hip Dysplasia, Traumatic Arthritis
Interventions
C2a - Taper™ Acetabular System
Device
Lead sponsor
Biomet Orthopedics, LLC
Industry
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2015
U.S. locations
2
States / cities
Cedar Rapids, Iowa • Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 20, 2017 · Synced May 21, 2026, 7:39 PM EDT