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Showing 1–24 of 103 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Osteoporosis Fracture Clear all
Recruiting Not applicable Interventional

U.S. Prospective Evaluation of EPIONE Device for Percutaneous MSK Procedures

NCT07325578
View directory record Official record
Conditions
Bone Tumor, Osteoporosis, Traumatic Fracture
Interventions
Percutaneous procedure in the MSK structures of the pelvis and/or the spine
Device
Lead sponsor
Precision IO Group
Industry
Eligibility
22 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
3
States / cities
San Diego, California • Miami, Florida • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Jul 21, 2026, 11:36 PM EDT
Completed No phase listed Observational

Validation of a Revised Food Frequency Questionnaire

NCT02693184
View directory record Official record
Conditions
Osteoporosis, Nutrition
Interventions
Full length Block 2014 Food Frequency Questionnaire, Revised Calcium, Vitamin D and Protein Screener
Other
Lead sponsor
University of Nebraska
Other
Eligibility
65 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 28, 2023 · Synced Jul 21, 2026, 11:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CT-Based Modeling of Bone Micro-Architecture and Fracture-Risk in COPD

NCT03534934
View directory record Official record
Conditions
Pulmonary Disease, Chronic Obstructive, Osteoporosis
Interventions
Vital signs, Urine Pregnancy Test, Questionnaires, Blood Test, Duel-energy X-ray absorptiometry scan, Multi-detector computed tomography, Dual-energy X-ray absorptiometry scan
Diagnostic Test · Other
Lead sponsor
Punam K Saha
Other
Eligibility
45 Years to 90 Years
Enrollment
560 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
2
States / cities
Iowa City, Iowa • New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Jul 21, 2026, 11:36 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Does Omeprazole Decrease Intestinal Calcium Absorption?

NCT00582972
View directory record Official record
Conditions
Osteoporosis, Achlorhydria, GERD, Hip Fracture
Interventions
Omeprazole
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
Female only
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 14, 2013 · Synced Jul 21, 2026, 11:36 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Outcomes for Quality of Life and Activities of Daily Living for BKP in the Treatment of VCFs

NCT01871519
View directory record Official record
Conditions
Compression Fracture of Vertebral Body, Osteoporosis, Cancer
Interventions
Balloon kyphoplasty
Device
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
65 Years and older
Enrollment
354 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
25
States / cities
Birmingham, Alabama • Fremont, California • Sacramento, California + 20 more
Source: ClinicalTrials.gov public record
Updated Mar 28, 2017 · Synced Jul 21, 2026, 11:36 PM EDT
Completed Phase 3 Interventional Results available

Early Effects of Abaloparatide on Tissue-Based Indices of Bone Formation and Resorption

NCT03710889
View directory record Official record
Conditions
Osteoporosis, Postmenopausal, Osteoporosis, Osteoporosis Vertebral, Osteoporosis Risk, Osteoporosis Fracture, Osteoporosis Localized to Spine, Osteoporosis, Age-Related, Osteoporosis Senile, Osteoporosis of Vertebrae
Interventions
Abaloparatide
Drug
Lead sponsor
Radius Health, Inc.
Industry
Eligibility
50 Years to 85 Years · Female only
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
4
States / cities
Golden, Colorado • Gainesville, Georgia • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 14, 2021 · Synced Jul 21, 2026, 11:36 PM EDT
Active, not recruiting Not applicable Interventional Results available

Sickle Cell Disease (SCD) Bone Pain Study

NCT05283148
View directory record Official record
Conditions
Sickle Cell Disease, Sickle Cell Anemia, Low Bone Density, Osteoporosis, Osteopenia, Vertebral Fracture, Vertebral Compression, Osteonecrosis, Ischemic Necrosis, Avascular Necrosis
Interventions
Dual-energy X-ray absorptiometry, Vertebral fracture analysis, Adult Sickle Cell Quality of Life Measurement System pain impact questionnaire
Other
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 80 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Aug 23, 2025 · Synced Jul 21, 2026, 11:36 PM EDT
Recruiting No phase listed Observational

The Osteoporotic Fracture Classification-based Scoring System for Treatment Decision in Thoracolumbar Osteoporotic Fractures

NCT07027306
View directory record Official record
Conditions
Osteoporotic Fractures, Osteoporosis
Interventions
Posterior stabilization (pedicle screws)
Procedure
Lead sponsor
AO Foundation, AO Spine
Other
Eligibility
50 Years and older
Enrollment
648 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
2
States / cities
San Francisco, California • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Jul 21, 2026, 11:36 PM EDT
Completed No phase listed Observational Results available

Longitudinal Effects of Denosumab on Trabecular Bone Score and Femur Strength Index

NCT02435147
View directory record Official record
Conditions
Osteoporosis, Bone Fracture
Interventions
denosumab
Drug
Lead sponsor
HealthEast Care System
Other
Eligibility
40 Years to 90 Years · Female only
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 28, 2018 · Synced Jul 21, 2026, 11:36 PM EDT
Completed Phase 3 Interventional

Evaluating the Ability of Zoledronic Acid to Reduce the Rate of Subsequent Osteoporotic Fractures After a Hip Fracture

NCT00046254
View directory record Official record
Conditions
Osteoporosis, Hip Fracture
Interventions
Zoledronic Acid
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
50 Years and older
Enrollment
2,127 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2007
U.S. locations
27
States / cities
Birmingham, Alabama • Eureka, California • La Mesa, California + 24 more
Source: ClinicalTrials.gov public record
Updated May 1, 2012 · Synced Jul 21, 2026, 11:36 PM EDT
Completed Phase 2 Interventional Results available

Safety and Efficacy of Alendronate (Fosamax) in Children With Osteoporosis

NCT00259857
View directory record Official record
Conditions
Osteoporosis
Interventions
Alendronate
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
5 Years to 15 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2009
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 18, 2011 · Synced Jul 21, 2026, 11:36 PM EDT
Completed Phase 4 Interventional

Impact of Vertebral Fracture Knowledge on Persistence in Subjects Taking Glucocorticoid Therapy

NCT00616694
View directory record Official record
Conditions
Osteoporosis
Interventions
Actonel
Drug
Lead sponsor
Sanofi
Industry
Eligibility
30 Years to 85 Years
Enrollment
248 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2004
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 20, 2008 · Synced Jul 21, 2026, 11:36 PM EDT
Active, not recruiting Phase 4 Interventional

Romosozumab Use to Build Skeletal Integrity

NCT05058976
View directory record Official record
Conditions
Osteoporosis, Osteoporosis, Postmenopausal, Osteoporosis Fracture
Interventions
Romosozumab, Placebo, Zoledronic acid, Calcium and Vitamin D
Drug · Dietary Supplement
Lead sponsor
Susan L. Greenspan
Other
Eligibility
65 Years and older · Female only
Enrollment
184 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Jul 21, 2026, 11:36 PM EDT
Completed Phase 3 Interventional Results available

Zoledronate in Preventing Osteoporosis and Bone Fractures in Patients With Locally Advanced Nonmetastatic Prostate Cancer Undergoing Radiation Therapy and Hormone Therapy

NCT00329797
View directory record Official record
Conditions
Osteoporosis, Prostate Cancer
Interventions
Calcium, Zoledronic acid, radiation therapy, LHRH, Vitamin D
Dietary Supplement · Radiation · Drug
Lead sponsor
Radiation Therapy Oncology Group
Network
Eligibility
18 Years and older · Male only
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2014
U.S. locations
80
States / cities
Chico, California • Los Angeles, California • Pomona, California + 66 more
Source: ClinicalTrials.gov public record
Updated Nov 28, 2017 · Synced Jul 21, 2026, 11:36 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Forteo for the Treatment of Unexplained Osteoporosis in Premenopausal Women

NCT00697463
View directory record Official record
Conditions
Menopause, Fracture, Osteoporosis
Interventions
Teriparatide (PTH 1-34)
Drug
Lead sponsor
Columbia University
Other
Eligibility
20 Years to 48 Years · Female only
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
2
States / cities
Omaha, Nebraska • New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 25, 2018 · Synced Jul 21, 2026, 11:36 PM EDT
Recruiting Not applicable Interventional

OsteoPorotic fracTure preventION System (OPTIONS) Research Study

NCT06731608
View directory record Official record
Conditions
Osteoporosis, Lower Limb Fracture
Interventions
OPTIONS, Enhanced usual care
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
65 Years and older
Enrollment
1,344 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
2
States / cities
Baltimore, Maryland • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Jul 21, 2026, 11:36 PM EDT
Completed No phase listed Observational Results available

A Comparison of Serum and Urine N-telopeptide Marker

NCT05326815
View directory record Official record
Conditions
Osteoporosis, Fractures, Bone
Interventions
N-Telopeptide, Bone Marker
Diagnostic Test
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 23, 2024 · Synced Jul 21, 2026, 11:36 PM EDT
Completed Phase 3 Interventional Results available

Vertebroplasty for the Treatment of Fractures Due to Osteoporosis

NCT00068822
View directory record Official record
Conditions
Spinal Fractures, Osteoporosis
Interventions
Percutaneous vertebroplasty, Sham vertebroplasty
Device · Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
50 Years and older
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2009
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 26, 2012 · Synced Jul 21, 2026, 11:36 PM EDT
Completed No phase listed Observational

Bone MicroArchitecture in Acromegaly

NCT03225040
View directory record Official record
Conditions
Acromegaly, Osteoporosis Risk
Interventions
Pegvisomant
Drug
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 12, 2021 · Synced Jul 21, 2026, 11:36 PM EDT
Completed Phase 4 Interventional Results available

Preventing Osteoporosis Using Denosumab

NCT02753283
View directory record Official record
Conditions
Osteoporosis, Postmenopausal, Osteoporosis, Osteoporotic Fractures
Interventions
denosumab, Placebo, Calcium and Vitamin D
Drug · Dietary Supplement
Lead sponsor
Susan L. Greenspan
Other
Eligibility
65 Years and older
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jul 21, 2026, 11:36 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Biomarker Identification in Orthopaedic & Oral Maxillofacial Surgery Subjects to Identify Risks of Bisphosphonate Use

NCT01875458
View directory record Official record
Conditions
Osteoporosis, With or Without Treatment, Bisphosphonate Treatment, Atypical Femur Fracture, Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ), Healthy Volunteers
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
314 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 12, 2023 · Synced Jul 21, 2026, 11:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Assessment of Vertebral Fracture Risk for First Time Liver Transplant Candidates

NCT03811873
View directory record Official record
Conditions
Metabolic Bone Disease, Transplant-Related Disorder, Secondary Osteoporosis
Interventions
Dual x-ray absorptiometry, Vertebral Fracture Assessment
Diagnostic Test · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated May 5, 2023 · Synced Jul 21, 2026, 11:36 PM EDT
Completed No phase listed Observational Results available

Study of FORTEO Use in Subjects in the Community Setting

NCT01078805
View directory record Official record
Conditions
Osteoporosis
Interventions
FORTEO
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
Not listed
Enrollment
4,167 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2011
U.S. locations
1
States / cities
Lakewood, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 25, 2012 · Synced Jul 21, 2026, 11:36 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

A Safety and Efficacy Study for Treatment of Painful Vertebral Compression Fractures Caused by Osteoporosis

NCT00290862
View directory record Official record
Conditions
Spinal Fractures
Interventions
Percutaneous Vertebral Augmentation of compression fractures
Device
Lead sponsor
Orthovita d/b/a Stryker
Industry
Eligibility
18 Years and older
Enrollment
256 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2009
U.S. locations
18
States / cities
Scottsdale, Arizona • Encinitas, California • Rancho Mirage, California + 14 more
Source: ClinicalTrials.gov public record
Updated Oct 14, 2008 · Synced Jul 21, 2026, 11:36 PM EDT