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Showing 1–24 of 120 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Otitis Media Clear all
Terminated Phase 3 Interventional

Bioequivalence of Two Ciprofloxacin 0.3%/Dexamethasone 0.1% Sterile Otic Suspensions in Otitis Media in Children With Tympanostomy Tubes

NCT01994642
View directory record Official record
Conditions
Otitis Media in Patients With Tympanostomy Tubes
Interventions
Ciprofloxacin 0.3%/dexamethasone 0.1% sterile otic suspension, CIPRODEX® (ciprofloxacin 0.3%/dexamethasone 0.1%), Placebo Sterile Otic Suspension
Drug
Lead sponsor
Par Pharmaceutical, Inc.
Industry
Eligibility
6 Months to 12 Years
Enrollment
203 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
23
States / cities
Birmingham, Alabama • Mesa, Arizona • Phoenix, Arizona + 17 more
Source: ClinicalTrials.gov public record
Updated Sep 25, 2017 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Phase 2 Interventional

Nervous System Manipulation and Botanicals for the Treatment of Recurrent Ear Infections in Children

NCT00010465
View directory record Official record
Conditions
Otitis Media
Interventions
Craniosacral Osteopathic Manipulative Treatment, Botanicals
Procedure · Drug
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
12 Months to 60 Months
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2002
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 21, 2013 · Synced Jul 21, 2026, 9:50 AM EDT
Active, not recruiting No phase listed Observational

Reducing Antibiotic Use by Implementation of Stewardship in Primary and Urgent Care

NCT07217002
View directory record Official record
Conditions
Community Acquired Pneumonia (CAP), Sinusitis, Strep Pharyngitis, Acute Otitis Media (AOM)
Interventions
Online Educational Modules, Prescribing Feedback Reports, Clinical Decision Support, Live, hybrid in-person and online educational sessions
Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
6 Months to 12 Years
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Jul 21, 2026, 9:50 AM EDT
Recruiting No phase listed Observational

Evaluation of Outcomes Following In-office Tympanostomy Using the Tula® System: a Prospective, Multi-center Registry

NCT05915078
View directory record Official record
Conditions
Otitis Media With Effusion, Acute Otitis Media, Otitis Media
Interventions
Iontophoresis and tube placement
Combination Product
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
6 Months to 17 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
6
States / cities
Louisville, Kentucky • Cherry Hill, New Jersey • New Brunswick, New Jersey + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 22, 2024 · Synced Jul 21, 2026, 9:50 AM EDT
Withdrawn Phase 4 Interventional

Otiprio Versus Ciprodex Tympanostomy Tube Outcomes

NCT03347461
View directory record Official record
Conditions
Otorrhea, Otitis Media With Effusion in Children
Interventions
Otiprio, Ciprodex
Drug
Lead sponsor
Boston Medical Center
Other
Eligibility
6 Months to 10 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 13, 2018 · Synced Jul 21, 2026, 9:50 AM EDT
Recruiting Not applicable Interventional

Coherent Optical Detection of Middle Ear Disease

NCT05353569
View directory record Official record
Conditions
Otitis Media, Otitis Media With Effusion, Otitis Media Acute
Interventions
OCT Device(s)
Diagnostic Test
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
12 Months to 6 Years
Enrollment
235 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
2
States / cities
Wauwatosa, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pediatric Emergency Department Smartphone Otoscope Study (PED-Oto)

NCT02918773
View directory record Official record
Conditions
Acute Otitis Media, Acute Otitis Externa
Interventions
Smartphone otoscope, Conventional otoscope
Device
Lead sponsor
Emory University
Other
Eligibility
Not listed
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
2
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 12, 2018 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Not applicable Interventional

Balloon Dilation in Selected Subjects With Refractory Eustachian Tube Dysfunction

NCT02114762
View directory record Official record
Conditions
Eustachian Tube Dysfunction
Interventions
Balloon dilation of the Eustachian tube
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 50 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 10, 2017 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Not applicable Interventional Results available

Homeopathic Ear Drops for Otitis Media Study

NCT01003210
View directory record Official record
Conditions
Otitis Media
Interventions
Hyland's earache drops
Drug
Lead sponsor
University of Washington
Other
Eligibility
6 Months to 11 Years
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
3
States / cities
Mercer Island, Washington • Renton, Washington • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 7, 2018 · Synced Jul 21, 2026, 9:50 AM EDT
Completed No phase listed Observational Results available

Comparative Effectiveness of Antibiotics for Respiratory Infections

NCT02297815
View directory record Official record
Conditions
Acute Otitis Media, Acute Sinusitis, Group A Streptococcal Pharyngitis
Interventions
Broad-spectrum antibiotics, Narrow-spectrum antibiotics
Drug
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
6 Months to 12 Years
Enrollment
2,472 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 7, 2019 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Not applicable Interventional Results available

Hummingbird TTS Ear Tube Delivery Study

NCT02165384
View directory record Official record
Conditions
Otitis Media
Interventions
Ear tube placement with the Hummingbird TTS
Device
Lead sponsor
Preceptis Medical, Inc.
Industry
Eligibility
6 Months and older
Enrollment
199 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
4
States / cities
Maple Grove, Minnesota • Minneapolis, Minnesota • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 2, 2019 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Phase 3 Interventional Results available

Short Term Relief of Eustachian Tube Dysfunction and Serous Otitis Media Using Intranasal Steroid Sprays

NCT00279916
View directory record Official record
Conditions
Otitis Media, Serous, Negative Middle Ear Pressure, Rhinitis, Otitis Media With Effusion, Otitis Media, Secretory
Interventions
Triamcinolone acetonide nasal spray, Placebo nasal spray
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
6 Years to 100 Years
Enrollment
91 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 29, 2017 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Safety Study of a Single Dose of Pneumococcal Whole-Cell Vaccine in Healthy Adults

NCT07059182
View directory record Official record
Conditions
PREVENTION OF INVASIVE PNEUMOCOCCAL DISEASE, Prevention of Pneumococcal-induced Acute Otitis Media
Interventions
Inactivated whole-cell Streptococcus pneumoniae vaccine, Placebo
Biological · Drug
Lead sponsor
Serum Life Science Europe GmbH
Industry
Eligibility
18 Years to 49 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 23, 2025 · Synced Jul 21, 2026, 9:50 AM EDT
Not yet recruiting Not applicable Interventional

Osteopathic Manipulative Treatment for Children With Chronic or Recurrent Otitis Media

NCT07639775
View directory record Official record
Conditions
Otitis Media, Otitis Media Effusion, Otitis Media Recurrent, Otitis Media With Effusion in Children, Otitis Media Chronic, Otitis Media in Children, Tympanostomy Tube Insertion, Osteopathic Manipulative Treatment (OMT)
Interventions
Experimental Osteopathic Manipulative Treatment (OMT) Protocol, Control Osteopathic Manipulative Treatment (OMT) Protocol
Other
Lead sponsor
Sarah Vidal
Other
Eligibility
6 Months to 6 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Lynchburg, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Phase 2 Interventional Results available

Dose Ranging Study of OTO-201 in AOMT

NCT02719158
View directory record Official record
Conditions
Acute Otitis Media, AOMT
Interventions
6 mg ciprofloxacin, 12 mg ciprofloxacin, Sham
Drug · Other
Lead sponsor
Otonomy, Inc.
Industry
Eligibility
6 Months to 17 Years
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Oct 18, 2020 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Not applicable Interventional Results available

A Clinical Trial of Proton Pump Inhibitors to Treat Children With Chronic Otitis Media With Effusion

NCT00546117
View directory record Official record
Conditions
Otitis Media With Effusion
Interventions
lansoprazole, placebo
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
2 Years to 12 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 31, 2018 · Synced Jul 21, 2026, 9:50 AM EDT
Completed No phase listed Observational

Antibiotic Concentration After Delivery to Middle Ear for Chronic Suppurative Otitis Media

NCT05133258
View directory record Official record
Conditions
Chronic Suppurative Otitis Media
Interventions
Aspiration of middle ear fluid following standard-of-care delivery of ciprofloxacin and dexamethasone suspension
Other
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 31, 2023 · Synced Jul 21, 2026, 9:50 AM EDT
Completed No phase listed Observational Results available

Evaluation of Moderate to Severe Influenza Outcomes in Children

NCT02979626
View directory record Official record
Conditions
Influenza, Otitis Media, Lower Resp Tract Infection, Encephalitic Infection, Myositis Viral, Fever
Interventions
Respiratory nasal swab
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
6 Months to 8 Years
Enrollment
1,478 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
2
States / cities
Aurora, Colorado • Broomfield, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 3, 2021 · Synced Jul 21, 2026, 9:50 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Eustachian Tube Growth and Development

NCT00422929
View directory record Official record
Conditions
Otitis Media
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
3 Years to 3 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2018
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 21, 2019 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Phase 3 Interventional

Phase III Study Evaluating Topical Benzocaine for Treatment of Acute Otitis Media in Children

NCT03116737
View directory record Official record
Conditions
Pain, Acute Otitis Media
Interventions
Benzocaine Otic Solution, Placebo
Drug
Lead sponsor
Lachlan Pharma Holdings
Industry
Eligibility
5 Years to 12 Years
Enrollment
141 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Gresham, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 12, 2017 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Phase 2Phase 3 Interventional

Safety and Efficacy Study of Cefdinir Oral Suspension, in Pediatric Subjects to Treat Acute Otitis Media

NCT00645203
View directory record Official record
Conditions
Acute Otitis Media
Interventions
cefdinir
Drug
Lead sponsor
Abbott
Industry
Eligibility
6 Months to 4 Years
Enrollment
447 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2002
U.S. locations
13
States / cities
Scottsdale, Arizona • Clovis, California • Dinuba, California + 9 more
Source: ClinicalTrials.gov public record
Updated Mar 26, 2008 · Synced Jul 21, 2026, 9:50 AM EDT
Not listed Not applicable Interventional

Clinical Study of the Solo+ Tympanostomy Tube Device

NCT04148417
View directory record Official record
Conditions
Ear Infection, Otitis Media
Interventions
Solo+ Tympanostomy Tube Device
Device
Lead sponsor
AventaMed DAC
Industry
Eligibility
6 Months to 15 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Jul 21, 2026, 9:50 AM EDT
Recruiting Phase 4 Interventional

Trimethoprim-sulfamethoxazole vs. Clindamycin for the Treatment of Children With Invasive MRSA Infections

NCT06982105
View directory record Official record
Conditions
Methicillin Resistant Staphylococcus Aureus, Osteomyelitis Acute, Septic Arthritis, Orbital Cellulitis, Facial Cellulitis, Mastoiditis, Cervical Adenitis, Retropharyngeal Abscess, Peritonsillar Abscess
Interventions
Trimethoprim Sulfamethoxazole
Drug
Lead sponsor
Indiana University
Other
Eligibility
2 Months to 18 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 3, 2025 · Synced Jul 21, 2026, 9:50 AM EDT
Completed Phase 2 Interventional Results available

Open-Label Study of OTO-201 for Treatment of AOMT

NCT02408796
View directory record Official record
Conditions
Acute Otitis Media, AOMT
Interventions
OTO-201
Drug
Lead sponsor
Otonomy, Inc.
Industry
Eligibility
6 Months to 17 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
5
States / cities
Fresno, California • Fort Lauderdale, Florida • Charlotte, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 18, 2020 · Synced Jul 21, 2026, 9:50 AM EDT