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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Pain, Intractable Clear all
Completed Phase 2 Interventional

Docetaxel in Treating Patients With Stage IV Prostate Cancer

NCT00003781
View directory record Official record
Conditions
Pain, Prostate Cancer
Interventions
docetaxel, pain therapy, quality-of-life assessment
Drug · Procedure
Lead sponsor
OHSU Knight Cancer Institute
Other
Eligibility
18 Years to 120 Years · Male only
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2003
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 27, 2017 · Synced Sep 15, 2026, 10:07 PM EDT
No Longer Available No phase listed Expanded access

Lixivaptan in a Single Subject With Intractable Pain Due to Polycystic Kidney Disease

NCT03717181
View directory record Official record
Conditions
Polycystic Kidney
Interventions
Lixivaptan
Drug
Lead sponsor
Palladio Biosciences
Industry
Eligibility
15 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 13, 2021 · Synced Sep 15, 2026, 10:07 PM EDT
Terminated Phase 1 Interventional

Oxcarbazepine Plus Morphine in Patients With Refractory Cancer Pain

NCT02078089
View directory record Official record
Conditions
Cancer
Interventions
Morphine, Oxcarbazepine
Drug
Lead sponsor
Costantine Albany
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
2
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 30, 2017 · Synced Sep 15, 2026, 10:07 PM EDT
Completed No phase listed Observational

Psychosocial, Behavioral, and Radiologic Changes Following Radiosurgery for Benign Neurologic Disease

NCT04688554
View directory record Official record
Conditions
Obsessive-Compulsive Disorder, Pain, Intractable, Depression
Interventions
fMRI and DTI, Behavioral questionnaires, Disease-Specific Patient-Reported Outcomes, Behavioral tests
Diagnostic Test · Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 5, 2024 · Synced Sep 15, 2026, 10:07 PM EDT
Terminated Phase 3 Interventional

A Randomized Multicenter Double-Blind CT to Evaluate the Efficacy and Safety of Mycophenolate Mofetil . . .

NCT00451867
View directory record Official record
Conditions
Interstitial Cystitis, Painful Bladder Syndrome
Interventions
Mycophenolate Mofetil, Mycofenolate Mofetil (MMF), Placebo
Drug
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years and older
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
10
States / cities
San Diego, California • Stanford, California • Maywood, Illinois + 7 more
Source: ClinicalTrials.gov public record
Updated Jan 13, 2010 · Synced Sep 15, 2026, 10:07 PM EDT
Completed Phase 2 Interventional Results available

ACT34-CMI -- Adult Autologous CD34+ Cells

NCT00300053
View directory record Official record
Conditions
Myocardial Ischemia
Interventions
CLBS14 (low-dose), CLBS14 (high-dose), placebo injection
Biological
Lead sponsor
Lisata Therapeutics, Inc.
Industry
Eligibility
21 Years to 80 Years
Enrollment
321 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
26
States / cities
Birmingham, Alabama • Phoenix, Arizona • La Jolla, California + 18 more
Source: ClinicalTrials.gov public record
Updated Jan 25, 2021 · Synced Sep 15, 2026, 10:07 PM EDT
Completed Phase 1Phase 2 Interventional

Epicardial Delivery of XC001 Gene Therapy for Refractory Angina Coronary Treatment (The EXACT Trial)

NCT04125732
View directory record Official record
Conditions
Coronary Artery Disease, Ischemia, Angina Refractory, Cardiovascular Diseases, Heart Diseases
Interventions
AdVEGFXC1
Biological
Lead sponsor
XyloCor Therapeutics, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
16
States / cities
Stanford, California • Washington D.C., District of Columbia • Daytona Beach, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Jan 29, 2024 · Synced Sep 15, 2026, 10:07 PM EDT
Completed Phase 3 Interventional Results available

An Implantable Spinal Cord Stimulation Pain Management System

NCT00205855
View directory record Official record
Conditions
Chronic Pain, Pain, Intractable, Pain, Back Pain, Failed Back Surgery Syndrome
Interventions
Precision SCS
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
9
States / cities
Huntsville, Alabama • Los Angeles, California • San Francisco, California + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 25, 2012 · Synced Sep 15, 2026, 10:07 PM EDT
Completed Phase 1 Interventional

Study to Evaluate Safety and MTD of Epidural Resiniferatoxin Injection for Treatment of Intractable Cancer Pain

NCT03226574
View directory record Official record
Conditions
Intractable Cancer Pain
Interventions
Resiniferatoxin
Drug
Lead sponsor
Sorrento Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
4
States / cities
Miami, Florida • Boston, Massachusetts • Durham, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Sep 15, 2026, 10:07 PM EDT
Recruiting Not applicable Interventional

Sensory Spinal Cord Stimulation

NCT07095036
View directory record Official record
Conditions
Pain Management, Pain, Intractable, Pain, Chronic Disease
Interventions
Spinal cord stimulation (SCS)
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 85 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Sep 15, 2026, 10:07 PM EDT
Completed No phase listed Observational

Implantable Systems Performance Registry

NCT00959296
View directory record Official record
Conditions
Spinal Cord Stimulation, Deep Brain Stimulation, Drug Infusion (Implantable Pumps), Sacral Neuromodulation
Interventions
Various
Device
Lead sponsor
MedtronicNeuro
Industry
Eligibility
Not listed
Enrollment
10,981 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2016
U.S. locations
43
States / cities
Huntsville, Alabama • Scottsdale, Arizona • Aliso Viejo, California + 40 more
Source: ClinicalTrials.gov public record
Updated Apr 20, 2017 · Synced Sep 15, 2026, 10:07 PM EDT
Completed Not applicable Interventional Results available

BurstDR™ micrOdosing stimuLation in De-novo Patients

NCT03350256
View directory record Official record
Conditions
Pain, Intractable, Pain, Back
Interventions
Stimulation will be delivered at with different microdosing setting to identify the optimal parameter values for each patient.
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
19 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
5
States / cities
Santa Rosa, California • Reno, Nevada • Asheville, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 18, 2020 · Synced Sep 15, 2026, 10:07 PM EDT
Completed Not applicable Interventional Results available

Wave Crossover ECP Study for Simplified Therapy

NCT06571370
View directory record Official record
Conditions
Chronic Stable Angina, Refractory Angina
Interventions
External Counterpulsation
Device
Lead sponsor
Pression
Industry
Eligibility
35 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Monroe, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Sep 15, 2026, 10:07 PM EDT
Not listed Phase 2 Interventional

Light-Emitting Diode Therapy in Preventing Mucositis in Children Receiving Chemotherapy With or Without Radiation Therapy Before Bone Marrow Transplantation

NCT00036712
View directory record Official record
Conditions
Chronic Myeloproliferative Disorders, Kidney Cancer, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms, Neuroblastoma, Oral Complications, Ovarian Cancer, Pain, Sarcoma
Interventions
management of therapy complications, pain therapy
Procedure
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
2 Years to 18 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2002
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 19, 2013 · Synced Sep 15, 2026, 10:07 PM EDT
Recruiting Not applicable Interventional

Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control

NCT07190807
View directory record Official record
Conditions
Chronic Pain, Intractable Pain, Low Back Pain, Chronic Low-back Pain, Chronic Leg Pain, Leg Pain
Interventions
Boston Scientific WaveWriter Alpha™ SCS Systems
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
7
States / cities
Greenwood, Colorado • Clermont, Florida • New Orleans, Louisiana + 4 more
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Sep 15, 2026, 10:07 PM EDT
Recruiting Not applicable Interventional

Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain

NCT04144972
View directory record Official record
Conditions
Spinal Cord Injuries, Nerve Injury, Pain, Postoperative, Post Herpetic Neuralgia, Complex Regional Pain Syndromes, Post-Stroke Pain, Post Radiation Brain Injury, Post Radiation Plexopathy, Nerve Root Avulsion
Interventions
Medtronic Summit RC+S or Percept RC
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
22 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2030
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Sep 15, 2026, 10:07 PM EDT
Completed Phase 4 Interventional Results available

Ticagrelor Therapy for RefrACTORy Migraine Study

NCT02518464
View directory record Official record
Conditions
Migraine, Headache, Migraine Headache
Interventions
Ticagrelor 90 mg twice per day
Drug
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 3, 2019 · Synced Sep 15, 2026, 10:07 PM EDT
Completed Phase 1 Interventional

Gene Transfer for Cancer Pain

NCT00804076
View directory record Official record
Conditions
Cancer Pain
Interventions
NP2
Biological
Lead sponsor
Diamyd Inc
Industry
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
5
States / cities
Miami, Florida • New Orleans, Louisiana • Ann Arbor, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 18, 2014 · Synced Sep 15, 2026, 10:07 PM EDT
Withdrawn Phase 4 Interventional

Transitioning to a Valve -Gated Intrathecal Drug Delivery System (IDDS)

NCT03876158
View directory record Official record
Conditions
Chronic Pain, Intractable Pain, Back Pain
Interventions
Prometra II Programmable Pump system(Flowonix Medical)
Device
Lead sponsor
Rush University Medical Center
Other
Eligibility
22 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 11, 2020 · Synced Sep 15, 2026, 10:07 PM EDT
Terminated Not applicable Interventional

Home Hypnotherapy for Refractory Functional Chest Pain: A Pilot Study

NCT01284179
View directory record Official record
Conditions
Functional Chest Pain
Interventions
Home Hypnotherapy, Educational
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 80 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 19, 2016 · Synced Sep 15, 2026, 10:07 PM EDT
Terminated No phase listed Observational

Quality of Life and Pain Changes Due to DRG Stimulation for Chronic Pain

NCT03417973
View directory record Official record
Conditions
Spinal; Nerve Root, Pain, Pelvic Pain, Regional Pain Syndrome, Chronic Pain Syndrome, Complex Regional Pain Syndromes
Interventions
dorsal root ganglion neuromodulation
Device
Lead sponsor
KM Clinical Research Group
Industry
Eligibility
18 Years to 85 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Murrieta, California
Source: ClinicalTrials.gov public record
Updated Mar 18, 2020 · Synced Sep 15, 2026, 10:07 PM EDT
Active, not recruiting Not applicable Interventional

CardiAMP Cell Therapy Chronic Myocardial Ischemia Trial

NCT03455725
View directory record Official record
Conditions
Refractory Angina, Chronic Myocardial Ischemia
Interventions
CardiAMP Cell Therapy System, Sham Treatment
Device · Other
Lead sponsor
BioCardia, Inc.
Industry
Eligibility
21 Years to 80 Years
Enrollment
343 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
2
States / cities
Gainesville, Florida • Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 5, 2026 · Synced Sep 15, 2026, 10:07 PM EDT
Active, not recruiting Not applicable Interventional

PDN Post Market, Multicenter, Prospective, Global Clinical Study

NCT05301816
View directory record Official record
Conditions
Diabetic Neuropathy, Painful
Interventions
Spinal Cord Stimulator (SCS)
Device
Lead sponsor
Nevro Corp
Industry
Eligibility
18 Years and older
Enrollment
497 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
8
States / cities
Anchorage, Alaska • Ann Arbor, Michigan • West Bloomfield, Michigan + 5 more
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Sep 15, 2026, 10:07 PM EDT
Terminated No phase listed Observational

Change in Pain and Quality of Life Following SCS for Chronic Pain

NCT03421951
View directory record Official record
Conditions
Pain, Chronic, Pain, Radiating, Pain, Back, Pain Syndrome
Interventions
Not listed
Lead sponsor
KM Clinical Research Group
Industry
Eligibility
18 Years to 85 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Murrieta, California
Source: ClinicalTrials.gov public record
Updated Mar 18, 2020 · Synced Sep 15, 2026, 10:07 PM EDT