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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Pain, Leg Clear all
Completed Not applicable Interventional

Comparison of Prosthetic Femoropopliteal Bypass Versus Viabahn Endoprosthesis for Treatment of Symptomatic Femoral Artery Occlusive Disease

NCT00693823
View directory record Official record
Conditions
Atherosclerosis, Lower Extremity Ischemia, Claudication, Rest Pain
Interventions
Femoral-popliteal Bypass, Angioplasty and stent placement with Viabahn covered stent-graft(W.L. Gore & Associates, Flagstff, Arizona) of superficial femoral artery
Procedure · Device
Lead sponsor
Texas Vascular Associates
Other
Eligibility
18 Years and older
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jun 8, 2008 · Synced Sep 24, 2026, 11:37 PM EDT
Completed Phase 2 Interventional

ALGRX 4975 After Total Knee Replacement

NCT00132392
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Knee Injuries
Interventions
ALGRX 4975
Drug
Lead sponsor
AlgoRx Pharmaceuticals
Industry
Eligibility
35 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 19, 2006 · Synced Sep 24, 2026, 11:37 PM EDT
Completed Not applicable Interventional

Manual Therapy as a Form of Sensory Discrimination in Chronic Low Back Pain

NCT02757378
View directory record Official record
Conditions
Low Back Pain
Interventions
Neuroplasticity Explanation (Experimental), Biomechanical Explanation (Control)
Procedure
Lead sponsor
Kevin Farrell
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
5
States / cities
Moline, Illinois • Silvis, Illinois • Woodridge, Illinois + 1 more
Source: ClinicalTrials.gov public record
Updated May 1, 2016 · Synced Sep 24, 2026, 11:37 PM EDT
Completed Not applicable Interventional

Post-market, Randomized, Controlled, Prospective Study Evaluating Intrathecal Pain Medication (IT) Versus Conventional Medical Management (CMM) in the Non-cancer, Refractory, Chronic Pain Population

NCT04096391
View directory record Official record
Conditions
Chronic Nonmalignant Pain, Pain, Intractable, Pain, Chronic
Interventions
Flowonix Prometra® II Programmable Infusion System, Pain Medicine
Device · Drug
Lead sponsor
Evolve Restorative Center
Other
Eligibility
22 Years and older
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Santa Rosa, California
Source: ClinicalTrials.gov public record
Updated May 17, 2022 · Synced Sep 24, 2026, 11:37 PM EDT
Completed Phase 3 Interventional

HKT-500 in Adult Patients With Ankle Sprain

NCT00680784
View directory record Official record
Conditions
Ankle Sprain
Interventions
HKT-500 Ketoprofen Topical Patch, Placebo Patch
Drug · Other
Lead sponsor
Hisamitsu Pharmaceutical Co., Inc.
Industry
Eligibility
18 Years and older
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
30
States / cities
Birmingham, Alabama • Montgomery, Alabama • Anaheim, California + 26 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2015 · Synced Sep 24, 2026, 11:37 PM EDT
Terminated Not applicable Interventional Results available

Efficacy Study of Femoral Nerve Block in Children With a Femur Fracture

NCT01294098
View directory record Official record
Conditions
Femoral Fractures, Pain, Postoperative
Interventions
Marcaine
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
7 Years to 14 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
2
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 29, 2018 · Synced Sep 24, 2026, 11:37 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Study to Assess the Efficacy of Direct Observation and Mental Visualization of Foot Movements to Treat Bilateral Lower Limb Phantom Limb Pain

NCT00639431
View directory record Official record
Conditions
Phantom Limb Pain
Interventions
direct observation, mental visualization
Behavioral
Lead sponsor
Walter Reed Army Medical Center
Federal
Eligibility
18 Years to 70 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2014
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 11, 2014 · Synced Sep 24, 2026, 11:37 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effects of Lumbosacral Joint Mobilization/Manipulation on Lower Extremity Muscle Neuromuscular Response

NCT00601341
View directory record Official record
Conditions
Knee Pain, Hip Pain, Ankle Pain, Lumbopelvic Pain
Interventions
lumbosacral joint manipulation, lumbar passive range of motion, No active intervention
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 50 Years
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 23, 2010 · Synced Sep 24, 2026, 11:37 PM EDT
Completed Not applicable Interventional Results available

Dual Field PEMF Therapy in Lower Extremity Painful Diabetic Distal Symmetric Peripheral Neuropathy

NCT03455543
View directory record Official record
Conditions
Diabetic Neuropathy Peripheral
Interventions
Active Provant Therapy System, Inactive (sham) Provant Therapy System
Device
Lead sponsor
Regenesis Biomedical, Inc.
Industry
Eligibility
22 Years to 80 Years
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
18
States / cities
Mesa, Arizona • Northridge, California • Sacramento, California + 15 more
Source: ClinicalTrials.gov public record
Updated Jul 14, 2020 · Synced Sep 24, 2026, 11:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Aspiration for Pain Relief Following Ankle Fracture

NCT01484535
View directory record Official record
Conditions
Ankle Fracture
Interventions
Ankle Aspiration, Ankle aspiration Standard Anterolateral
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 16, 2015 · Synced Sep 24, 2026, 11:37 PM EDT
Completed Not applicable Interventional Results available

Cryoanalgesia to Treat Phantom Limb Pain Following Above-Knee Amputation

NCT06071715
View directory record Official record
Conditions
Amputation, Surgical, Amputation, Traumatic, Phantom Limb Pain, Phantom Pain Following Amputation of Lower Limb
Interventions
ACTIVE cryoneurolysis, SHAM cryoneurolysis
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Sep 24, 2026, 11:37 PM EDT
Completed Phase 3 Interventional

Evaluating Two Exercise Training Programs to Reduce Leg Pain in People With Peripheral Arterial Disease (The EXERT Study)

NCT00895635
View directory record Official record
Conditions
Intermittent Claudication, Peripheral Vascular Diseases
Interventions
Treadmill Exercise Training, Arm Ergometry Exercise Training, Usual Care
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 90 Years
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 31, 2019 · Synced Sep 24, 2026, 11:37 PM EDT
Withdrawn Phase 1Phase 2 Interventional

A Study of Postsurgical Pain Control for Lower Extremity Fractures

NCT02214810
View directory record Official record
Conditions
Lower Extremity Fractures.
Interventions
Bupivacaine/Exparel
Drug
Lead sponsor
Broward Health
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Feb 18, 2016 · Synced Sep 24, 2026, 11:37 PM EDT
Terminated Phase 4 Interventional Results available

Botox for the Treatment of Recurrent Chronic Exertional Compartment Syndrome

NCT05006417
View directory record Official record
Conditions
Compartment Syndrome of Leg
Interventions
Botox
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 17, 2024 · Synced Sep 24, 2026, 11:37 PM EDT
Completed Not applicable Interventional

Telehealth Delivered Physical Rehabilitation for an Ankle Sprain

NCT04520854
View directory record Official record
Conditions
Ankle Sprains, Telerehabilitation, Analgesic, Opioid, Analgesics, Non-narcotic, Anti-Inflammatory Agents, Non-Steroidal, Implementation Science, Acute Pain, Quality of Life
Interventions
Telehealth Protocol, Usual Care
Other
Lead sponsor
Kyle Kosik
Other
Eligibility
15 Years to 35 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 27, 2025 · Synced Sep 24, 2026, 11:37 PM EDT
Terminated Not applicable Interventional Results available

Effectiveness of Precision Spinal Cord Stimulation With Artisan Paddle Electrode

NCT00386724
View directory record Official record
Conditions
Back Pain, Chronic Pain, Pain in Leg, Unspecified
Interventions
Precision Spinal Cord Stimulation System, Artisan Surgical Lead
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
2
States / cities
Charleston, South Carolina • Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 16, 2020 · Synced Sep 24, 2026, 11:37 PM EDT
Completed Not applicable Interventional

Physical Therapy Treatments, Including Neural Mobilization and Hip/Back Stretches for People Between 50-89 With Lumbar Spinal Stenosis and Leg Pain Provoked by Walking

NCT03368638
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Physical therapy intervention
Other
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
50 Years to 89 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Amarillo, Texas
Source: ClinicalTrials.gov public record
Updated Jan 24, 2021 · Synced Sep 24, 2026, 11:37 PM EDT
Completed Phase 4 Interventional Results available

Effectiveness of Intensive Lipid Modification Medication in Preventing the Progression of Peripheral Arterial Disease (The ELIMIT Study)

NCT00687076
View directory record Official record
Conditions
Peripheral Arterial Disease
Interventions
Ezetimibe, Niaspan, Statin therapy, Standard care, Aspirin, Clopidogrel, Placebo Niaspan, Placebo Ezetimibe, Percutaneous transluminal angioplasty (PTA)
Drug · Behavioral · Procedure
Lead sponsor
Baylor College of Medicine
Other
Eligibility
40 Years to 80 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 5, 2020 · Synced Sep 24, 2026, 11:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Spine Position and Neural Sensitivity

NCT05313217
View directory record Official record
Conditions
Sciatic Nerve, Postural Lordosis, Nerve Pain
Interventions
Knee extension angle, Straight Leg Raise, Slump Test, Extended slump test
Diagnostic Test
Lead sponsor
University of Hartford
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
West Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated May 9, 2023 · Synced Sep 24, 2026, 11:37 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis

NCT00405691
View directory record Official record
Conditions
Low Back Pain, Leg Pain, Spondylolisthesis, Lumbar Spinal Stenosis
Interventions
"TOPS System" - Total Posterior Arthroplasty Implant
Device
Lead sponsor
Impliant, Ltd.
Industry
Eligibility
40 Years to 75 Years
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2006
U.S. locations
16
States / cities
Beverly Hills, California • Daly City, California • New Haven, Connecticut + 12 more
Source: ClinicalTrials.gov public record
Updated May 17, 2011 · Synced Sep 24, 2026, 11:37 PM EDT
Completed Phase 2 Interventional

Safety and Efficacy Study of Ad2/Hypoxia Inducible Factor (HIF)-1α/VP16 Gene Transfer in Patients With Intermittent Claudication

NCT00117650
View directory record Official record
Conditions
Intermittent Claudication, Peripheral Vascular Disease, Atherosclerosis
Interventions
Ad2/HIF-1α/VP16, Saline (Placebo Control)
Biological · Other
Lead sponsor
Genzyme, a Sanofi Company
Industry
Eligibility
40 Years to 80 Years
Enrollment
289 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
35
States / cities
Birmingham, Alabama • Palo Alto, California • Sacramento, California + 28 more
Source: ClinicalTrials.gov public record
Updated Apr 2, 2015 · Synced Sep 24, 2026, 11:37 PM EDT
Withdrawn Phase 4 Interventional

Effects of Dexmedetomidine on Tourniquet Pain Associated With Lower Extremity Surgeries Under General Anesthesia

NCT00932386
View directory record Official record
Conditions
Orthopedic/Podiatry Procedures
Interventions
Dexmedetomidine Hcl infusion, normal saline
Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2009
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 23, 2015 · Synced Sep 24, 2026, 11:37 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic ACL Surgery

NCT04246554
View directory record Official record
Conditions
ACL Injury, Postoperative Pain
Interventions
Ketorolac, Oxycodone-Acetaminophen
Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 20, 2021 · Synced Sep 24, 2026, 11:37 PM EDT
Terminated Not applicable Interventional Results available

Spinal Cord Stimulation for Restoration of Function in Lower-Limb Amputees, 90-Day

NCT04547582
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity, Phantom Limb Pain
Interventions
Spinal cord stimulator
Device
Lead sponsor
Lee Fisher, PhD
Other
Eligibility
22 Years to 70 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Sep 24, 2026, 11:37 PM EDT