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Showing 1–24 of 66 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Pain Modulation Clear all
Not listed Phase 4 Interventional

Randomized Trial of Narcotic vs Non-Narcotic Pain Modulation After Labrum Repair

NCT05974423
View directory record Official record
Conditions
Postoperative Pain, Acute, Opioid Use, Labral Tear, Glenoid
Interventions
Tylenol, Ibuprofen, and Oxycodone, Tylenol and Ibuprofen only
Drug
Lead sponsor
The Cooper Health System
Other
Eligibility
15 Years to 25 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Camden, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 2, 2023 · Synced Jul 22, 2026, 10:04 AM EDT
Completed Not applicable Interventional

Vestibular Caloric Stimulation and the Modulation of Pain in Fibromyalgia

NCT05004194
View directory record Official record
Conditions
Fibromyalgia
Interventions
Vestibular Caloric Stimulation
Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 18, 2021 · Synced Jul 22, 2026, 10:04 AM EDT
Not yet recruiting Not applicable Interventional

Yoga, Education, and Nidra (YEN) for Chronic Low Back Pain: A Pilot Study on Pain Modulation, Well-Being, and Sleep

NCT06979713
View directory record Official record
Conditions
Low Back Pain
Interventions
yoga, pain education, yoga nidra, yoga, pain education, relaxing music
Other
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated May 19, 2025 · Synced Jul 22, 2026, 10:04 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Study of Pain Perception Between Males and Females Following Laparoscopic Cholecystectomy

NCT00575276
View directory record Official record
Conditions
Cholecystitis, Acute, Cholecystitis, Chronic
Interventions
Not listed
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 90 Years
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 7, 2012 · Synced Jul 22, 2026, 10:04 AM EDT
Terminated Not applicable Interventional

Modulating Neuropathic Pain With Transcranial Direct Current Stimulation

NCT04581525
View directory record Official record
Conditions
Pain, Neuropathic, Complex Regional Pain Syndromes, Phantom Limb Pain, Spinal Cord Injuries
Interventions
transcranial direct current stimulation
Device
Lead sponsor
Susan McDowell
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2020
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 13, 2021 · Synced Jul 22, 2026, 10:04 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Breathing and Attention Training (BAT) on Pain Modulation

NCT05773482
View directory record Official record
Conditions
Fibromyalgia
Interventions
Breathing and Attention Training (BAT), Breathing Control
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Jul 22, 2026, 10:04 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Determining How the Nervous System Processes Pain in Adults With Fibromyalgia

NCT00496886
View directory record Official record
Conditions
Fibromyalgia, Rheumatoid Arthritis
Interventions
Not listed
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
137 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2011
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 1, 2015 · Synced Jul 22, 2026, 10:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mechanisms and Modulation of Pain Modulatory Capacity

NCT04441619
View directory record Official record
Conditions
Musculoskeletal Pain
Interventions
Delayed onset muscle soreness.
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 70 Years
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Jul 22, 2026, 10:04 AM EDT
Completed Phase 2 Interventional

Mind and Body Approaches to Pain Reduction in Youth With Migraine

NCT03472092
View directory record Official record
Conditions
Headache, Migraine, Migraine, Migraine Disorders, Headache
Interventions
Cognitive Behavioral Therapy (CBT), Placebo, Amitriptyline, Biofeedback-Assisted Relaxation Training (BART), Cognitive Reappraisal Training (CR)
Behavioral · Drug
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
10 Years to 17 Years
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 25, 2025 · Synced Jul 22, 2026, 10:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pain Modulation Effectiveness (PME)

NCT05783362
View directory record Official record
Conditions
Healthy People
Interventions
Conditioned Pain Modulation (CPM)
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 30, 2023 · Synced Jul 22, 2026, 10:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Isometric Exercise and Endogenous Pain Inhibition

NCT03778476
View directory record Official record
Conditions
Fibromyalgia
Interventions
Isometric Exercise
Other
Lead sponsor
Marquette University
Other
Eligibility
18 Years to 75 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 23, 2021 · Synced Jul 22, 2026, 10:04 AM EDT
Completed Not applicable Interventional Results available

A Safety and Effectiveness Trial of Spinal Cord Stimulation of the Dorsal Root Ganglion for Chronic Lower Limb Pain

NCT01923285
View directory record Official record
Conditions
Chronic Lower Limb Pain
Interventions
AXIUM Neurostimulator System, Control Spinal Cord Stimulation Device
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
22 Years to 75 Years
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
22
States / cities
Phoenix, Arizona • Aptos, California • Carlsbad, California + 19 more
Source: ClinicalTrials.gov public record
Updated Nov 23, 2020 · Synced Jul 22, 2026, 10:04 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

In Vitro Studies on Pharmacological Regulation and Genetic Risk Factors of Peripheral Human Nociceptors

NCT00223366
View directory record Official record
Conditions
Pain
Interventions
Not listed
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
16 Years to 90 Years
Enrollment
2,007 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2019
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Nov 2, 2020 · Synced Jul 22, 2026, 10:04 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Investigation and Modulation of the Mu-Opioid Mechanisms in Migraine (in Vivo)

NCT02964741
View directory record Official record
Conditions
Migraine
Interventions
Active Comparator, Sham Comparator
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 25, 2022 · Synced Jul 22, 2026, 10:04 AM EDT
Terminated Not applicable Interventional Results available

Irritable Bowel Syndrome (IBS) Functional Magnetic Resonance Imaging (fMRI) With Desipramine

NCT00880594
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
Desipramine
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 90 Years · Female only
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Jul 22, 2026, 10:04 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Selective Nerve Stimulation (SNS) Pilot Study

NCT01259271
View directory record Official record
Conditions
Healthy, Pain
Interventions
Selective Nerve Stimulation (SNS) stimulator device
Device
Lead sponsor
Codman & Shurtleff
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Raynham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 17, 2019 · Synced Jul 22, 2026, 10:04 AM EDT
Not yet recruiting Not applicable Interventional

TRANScriptional Pathways Of Surgical Pain Modulated by Music Therapy Exposure (TRANSPOSE)

NCT07653594
View directory record Official record
Conditions
Surgery, Stomach Cancer, Pancreas Cancer, Bile Duct Cancer, Liver Cancer, Peritoneal Cancer
Interventions
Music-assisted relaxation and imagery (MARI)
Behavioral
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
50 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Jul 22, 2026, 10:04 AM EDT
Recruiting Not applicable Interventional

Placebo Impacts Sleep and Pain Modulation in Chronic Pain

NCT06225817
View directory record Official record
Conditions
Chronic Pain, Headache
Interventions
Open-label placebo pills
Dietary Supplement
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 88 Years
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Jul 22, 2026, 10:04 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

NEPAL (Neuromodulatory Examination of Pain and Mobility Across the Lifespan)

NCT02488863
View directory record Official record
Conditions
Musculoskeletal Pain, Pain, Chronic
Interventions
MRI Neuroimaging, Quantitative Sensory Testing, Questionnaires, Physical and Cognitive Function Testing
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2024
U.S. locations
4
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 17, 2025 · Synced Jul 22, 2026, 10:04 AM EDT
Not yet recruiting Phase 4 Interventional

Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation

NCT07644923
View directory record Official record
Conditions
Postoperative Pain
Interventions
Bupivacaine, Lidocaine, Thrombin, Tranexamic acid, Aminocaproic acid
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Jul 22, 2026, 10:04 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Memory & Conditioning Under Anesthesia

NCT04062123
View directory record Official record
Conditions
Anesthesia, Pain
Interventions
Dexmedetomidine, Propofol, Fentanyl, Peripheral Nerve Stimulation, Placebo
Drug · Device
Lead sponsor
Keith M Vogt
Other
Eligibility
18 Years to 39 Years
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 17, 2025 · Synced Jul 22, 2026, 10:04 AM EDT
Recruiting Not applicable Interventional

Modulating Cortical Excitability to Improve Functional Movements in Individuals With Patellofemoral Pain

NCT06565520
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
transcranial direct current stimulator
Device
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years to 45 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Aug 21, 2024 · Synced Jul 22, 2026, 10:04 AM EDT
Completed Not applicable Interventional Results available

Effects of Transcranial Direct Current Stimulation (tDCS) on Neuropathic Symptoms Following Burn Injury

NCT01795079
View directory record Official record
Conditions
Burn Injury, Chronic Pain, Pruritus, Itching
Interventions
Transcranial direct current stimulation (tDCS)
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 16, 2021 · Synced Jul 22, 2026, 10:04 AM EDT
Completed Not applicable Interventional

Effects of Transcranial Direct Current Stimulation (tDCS) on Neuropathic Symptoms Due to Burn Injury

NCT01404026
View directory record Official record
Conditions
Pain, Burn Injury
Interventions
Transcranial Direct Current Stimulation (tDCS)
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 23, 2020 · Synced Jul 22, 2026, 10:04 AM EDT