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Showing 1–24 of 117 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Panic Disorder Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

Evaluation of Substance P Neurotransmission in Panic Disorder by PET Imaging of NK1 Receptors With [18F]SPA-RQ

NCT00088738
View directory record Official record
Conditions
Panic Disorder, Healthy
Interventions
[18F] SPA-RQ
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 65 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Jul 21, 2026, 10:55 AM EDT
Completed Phase 1 Interventional Results available

Exposure Therapy for Veterans With PTSD and Panic Attacks (Phase 1)

NCT01551199
View directory record Official record
Conditions
PTSD, Panic Attacks
Interventions
Multiple Channel Exposure Therapy- Veterans
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 64 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 22, 2017 · Synced Jul 21, 2026, 10:55 AM EDT
Completed Not applicable Interventional Results available

Relaxation and Heart Rate Variability

NCT00735618
View directory record Official record
Conditions
Cancer
Interventions
Guided Relaxation
Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 18, 2011 · Synced Jul 21, 2026, 10:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Breathing Regulation Training for Individuals With Panic Disorder

NCT00183521
View directory record Official record
Conditions
Panic Disorder
Interventions
Raise-CO2 breathing regulation training, Lower-CO2 breathing regulation training, Control
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 60 Years
Enrollment
136 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Dec 1, 2011 · Synced Jul 21, 2026, 10:55 AM EDT
Completed Not applicable Interventional Results available

Exposure Therapy For Veterans With PTSD And Panic Attacks

NCT01033136
View directory record Official record
Conditions
PTSD, Panic Attacks
Interventions
Multiple Channel Exposure Therapy - Veterans, Cognitive Processing Therapy
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 75 Years
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 16, 2018 · Synced Jul 21, 2026, 10:55 AM EDT
Completed Not applicable Interventional

Youth Mayo Clinic Anxiety Coach Randomized Controlled Trial

NCT02205203
View directory record Official record
Conditions
Anxiety
Interventions
Mayo Clinic Anxiety Coach, Treatment as Usual
Device · Other
Lead sponsor
Stephen Whiteside
Other
Eligibility
7 Years to 17 Years
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 28, 2021 · Synced Jul 21, 2026, 10:55 AM EDT
Completed Phase 4 Interventional

A Study of Risperidone Monotherapy in Bipolar Anxiety

NCT00167479
View directory record Official record
Conditions
Bipolar Disorder, Panic Disorder, Generalized Anxiety Disorder
Interventions
risperidone (Risperdal)
Drug
Lead sponsor
University of South Florida
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2006
U.S. locations
3
States / cities
Tampa, Florida • Cincinnati, Ohio • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 10, 2006 · Synced Jul 21, 2026, 10:55 AM EDT
Completed Not applicable Interventional

Building an Outcomes Assessment Infrastructure to Assess Anxiety Treatment

NCT02305537
View directory record Official record
Conditions
Social Anxiety Disorder, Specific Phobia, Separation Anxiety Disorder, Panic Disorder, Agoraphobia, Obsessive-Compulsive Disorder
Interventions
McLean Anxiety Mastery Program
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
6 Years to 19 Years
Enrollment
559 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2024
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 19, 2025 · Synced Jul 21, 2026, 10:55 AM EDT
Completed Phase 4 Interventional Results available

A Study of Quetiapine SR (Seroquel SR) to Treat SSRI-Resistant, Comorbid Panic Disorder Patients

NCT00619892
View directory record Official record
Conditions
Panic Disorder
Interventions
quetiapine XR, placebo
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 65 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 20, 2016 · Synced Jul 21, 2026, 10:55 AM EDT
Completed Not applicable Interventional

Efficacy and Mechanisms of Psychosocial Treatments for Panic Disorder

NCT04366011
View directory record Official record
Conditions
Panic Disorder
Interventions
Cognitive Behavioral Therapy (CBT), Capnometry Assisted Respiratory Training (CART)
Behavioral
Lead sponsor
Southern Methodist University
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 27, 2020 · Synced Jul 21, 2026, 10:55 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

A Randomized Controlled Test of the Effects of CHI-554 on Fear.

NCT04577612
View directory record Official record
Conditions
Anxiety, Fear, Panic
Interventions
CHI-554
Drug
Lead sponsor
Canopy Growth Corporation
Industry
Eligibility
18 Years to 55 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Fayetteville, Arkansas
Source: ClinicalTrials.gov public record
Updated Jun 2, 2021 · Synced Jul 21, 2026, 10:55 AM EDT
Active, not recruiting Not applicable Interventional

Patient-centered Treatment of Anxiety After Low-Risk Chest Pain in the Emergency Room

NCT04811521
View directory record Official record
Conditions
Generalized Anxiety Disorder, Chest Pain, Panic
Interventions
Primary care follow-up, Online Self-Administered Anxiety Management Program plus Peer Support Guidance, Therapist-Administered Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
375 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
5
States / cities
Avon, Indiana • Carmel, Indiana • Fishers, Indiana + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 29, 2024 · Synced Jul 21, 2026, 10:55 AM EDT
Completed Not applicable Interventional

Optimizing Exposure Therapy for Anxiety Disorders

NCT04048824
View directory record Official record
Conditions
Social Anxiety Disorder, Panic Disorder
Interventions
Inhibitory Learning-Based Exposure, Habituation-Based Exposure
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 5, 2025 · Synced Jul 21, 2026, 10:55 AM EDT
Completed Phase 4 Interventional

Aripiprazole for the Treatment of Refractory Anxiety

NCT00438386
View directory record Official record
Conditions
Generalized Anxiety Disorder, Panic Disorder
Interventions
Aripiprazole
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 9, 2009 · Synced Jul 21, 2026, 10:55 AM EDT
Recruiting Not applicable Interventional

Mindful Self-compassion for Anxiety and Depression: Impact of Delivery Method

NCT07028216
View directory record Official record
Conditions
Anxiety Disorders, Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder, Agoraphobia, Major Depressive Disorder, Persistent Depressive Disorder (Dysthymia)
Interventions
Mindful Self-Compassion
Behavioral
Lead sponsor
Georgetown University
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Jul 21, 2026, 10:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Expectation of Unpleasant Events in Anxiety Disorders

NCT00055224
View directory record Official record
Conditions
Anxiety Disorders
Interventions
Threat of shock
Device
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 50 Years
Enrollment
921 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2022
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 8, 2024 · Synced Jul 21, 2026, 10:55 AM EDT
Completed Not applicable Interventional Results available

Neurofeedback Enhanced Cognitive Reappraisal Training

NCT06132659
View directory record Official record
Conditions
Anxiety, Social Anxiety Disorder, Panic Disorder, Generalized Anxiety Disorder
Interventions
Functional magnetic resonance imaging (fMRI) with Veritable-NF, fMRI with Sham-NF
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 55 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 10, 2025 · Synced Jul 21, 2026, 10:55 AM EDT
Not listed Not applicable Interventional

Improving Access to Child Anxiety Treatment

NCT03528109
View directory record Official record
Conditions
Obsessive-Compulsive Disorder, Anxiety Disorders, Pediatric Disorder, Anxiety, OCD, Phobia, Agoraphobia, Generalized Anxiety, Generalized Anxiety Disorder, Selective Mutism, Separation Anxiety, Social Anxiety, Social Anxiety Disorder, Panic Disorder
Interventions
Exposure Therapy
Behavioral
Lead sponsor
Bradley Hospital
Other
Eligibility
5 Years to 18 Years
Enrollment
379 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Riverside, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 2, 2022 · Synced Jul 21, 2026, 10:55 AM EDT
Completed Not applicable Interventional

Addressing Help-Seeking Barriers in Developing an Intensive Treatment for Veterans With Panic Disorder

NCT00628979
View directory record Official record
Conditions
Panic Disorder
Interventions
CBT
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 74 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 2, 2009 · Synced Jul 21, 2026, 10:55 AM EDT
Recruiting Not applicable Interventional

Neurofeedback Enhanced Cognitive Reappraisal Training - Phase 4

NCT06563310
View directory record Official record
Conditions
Anxiety, Social Anxiety Disorder, Panic Disorder, Generalized Anxiety Disorder
Interventions
Functional magnetic resonance imaging (fMRI) with Veritable-NF, fMRI with Sham-NF
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 24 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Jul 21, 2026, 10:55 AM EDT
Not listed Not applicable Interventional

Neuroimaging of Pavlovian Fear Conditioning Processes in Patients With Pathological Anxiety

NCT03498599
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Anxiety Disorders, Panic Disorder, Social Phobia, Phobia
Interventions
Novelty facilitated extinction, Standard Extinction
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 50 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 12, 2018 · Synced Jul 21, 2026, 10:55 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Therapies for Treatment-Resistant Panic Disorder Symptoms

NCT00118417
View directory record Official record
Conditions
Panic Disorder
Interventions
Clonazepam, Sertraline, Cognitive behavioral therapy
Drug · Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2007
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 10, 2014 · Synced Jul 21, 2026, 10:55 AM EDT
Not listed No phase listed Observational

Measuring Physiology to Determine if Pre-panic Attack Detection is Possible

NCT03360578
View directory record Official record
Conditions
Panic Disorder
Interventions
Garmin
Device
Lead sponsor
Medical Psychology Center
Other
Eligibility
18 Years to 65 Years
Enrollment
46 participants
Timeline
2018 – 2022
U.S. locations
1
States / cities
Beverly, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 12, 2022 · Synced Jul 21, 2026, 10:55 AM EDT
Completed Not applicable Interventional

Investigations of Amygdala Function Using Neurophysiological Recording and Stimulation

NCT03958903
View directory record Official record
Conditions
Fear, PTSD, Panic Disorder
Interventions
Amygdala recording and stimulation using Neuropace RNS, Behavioral tasks
Device · Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 65 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 25, 2023 · Synced Jul 21, 2026, 10:55 AM EDT