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Showing 1–24 of 52 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Patellofemoral Pain Syndrome Clear all
Completed Not applicable Interventional

Maladaptive Psychosocial Beliefs and Adolescents With Patellofemoral Pain

NCT04752501
View directory record Official record
Conditions
Patellofemoral Pain Syndrome, Knee Pain Chronic, Patellofemoral Syndrome, Anterior Knee Pain Syndrome
Interventions
Psychologically Informed Education, Biomedical Education (Control)
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
12 Years to 18 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 2, 2023 · Synced Jul 21, 2026, 6:59 PM EDT
Terminated Not applicable Interventional

Blood Flow Restriction Therapy in Patellofemoral Pain Syndrome

NCT03717532
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Placebo, Personalized Tourniquet System for Blood Flow Restriction
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 27, 2020 · Synced Jul 21, 2026, 6:59 PM EDT
Completed Not applicable Interventional Results available

Effectiveness Trial for Evaluating IAHA for PFPS

NCT01811654
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Intra-Articular Hyaluronic Acid-Euflexxa
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 40 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 25, 2020 · Synced Jul 21, 2026, 6:59 PM EDT
Completed No phase listed Observational

Muscle Strength Loss and Its Effect on Knee Cap Motion in Volunteers With Anterior Knee Pain

NCT01862731
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Not listed
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
18 Years to 55 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2013
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Jul 21, 2026, 6:59 PM EDT
Completed Not applicable Interventional

Comparison Study of Two Chiropractic Treatment Protocols for Knee Pain Due to Patellofemoral Pain Syndrome

NCT00401050
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
chiropractic manipulative therapy, knee exercises, Graston Instrument Soft Tissue Mobilization (GISTM)
Procedure
Lead sponsor
Cleveland Chiropractic College
Other
Eligibility
18 Years to 45 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 19, 2010 · Synced Jul 21, 2026, 6:59 PM EDT
Completed Not applicable Interventional

Effect of Lower Back Treatment in People With Patellofemoral Pain Syndrome.

NCT01975311
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Lumbopelvic Manipulation, Passive lumbar spine flexion and extension
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
18 Years to 50 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 11, 2015 · Synced Jul 21, 2026, 6:59 PM EDT
Completed No phase listed Observational Results available

In Vivo Arthroscopic Behavior of the Infrapatellar Plica of the Knee

NCT00643487
View directory record Official record
Conditions
Anterior Knee Pain Syndrome
Interventions
observation of the behavior of the infrapatellar plica
Procedure
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 80 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Apr 23, 2018 · Synced Jul 21, 2026, 6:59 PM EDT
Terminated Not applicable Interventional

Running Study for Runners With Chronic Knee Pain

NCT02567123
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Experimental
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years to 44 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Mar 11, 2024 · Synced Jul 21, 2026, 6:59 PM EDT
Terminated Not applicable Interventional

Knee Isometric Program (KIP) Home Exercise Programs (HEP) Physical Therapy (PT) Study

NCT06536426
View directory record Official record
Conditions
Anterior Knee Pain Syndrome
Interventions
Knee Isometric Program (KIP)
Behavioral
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 30, 2025 · Synced Jul 21, 2026, 6:59 PM EDT
Terminated Early Phase 1 Interventional

Neural Mechanisms of Muscle Control in Individuals With Knee Pain

NCT02854774
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Muscle activation exercises
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 4, 2020 · Synced Jul 21, 2026, 6:59 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Internet Enhanced, Patient-Centered Orthopedic Care: A Prospective, Randomized, Controlled Pilot Trial

NCT02025400
View directory record Official record
Conditions
Knee Injuries, Shoulder Injuries, Rotator Cuff Disease, Meniscus Tear, Patellofemoral Pain
Interventions
eRehab, Formal Physical Therapy
Other
Lead sponsor
Charlotte Sports Medicine Institute, PA
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
2
States / cities
Prince Frederick, Maryland • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 31, 2013 · Synced Jul 21, 2026, 6:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Protonics Knee Brace Versus Hamstring Resisted Exercise (HRE) on Individuals With Patellofemoral Pain Syndrome

NCT03042559
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Protonics Knee brace, Sports Cords
Device
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 45 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated May 14, 2020 · Synced Jul 21, 2026, 6:59 PM EDT
Terminated Not applicable Interventional

Manual Therapy to Treat Gluteus Medius Trigger Points

NCT02333617
View directory record Official record
Conditions
Anterior Knee Pain Syndrome, Patellofemoral Pain Syndrome
Interventions
Dry Needling, Soft Tissue Mobilization, Placebo Control, Hip and core strengthening exercises
Other
Lead sponsor
Mitchell Selhorst
Other
Eligibility
13 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 23, 2018 · Synced Jul 21, 2026, 6:59 PM EDT
Enrolling by invitation Not applicable Interventional

A Self-Directed Web-Based Education for Boston Marathon Runners With Patellofemoral Pain

NCT07266922
View directory record Official record
Conditions
Patellofemoral Pain
Interventions
Education Platform-MyKneeCap.com
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Waltham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Jul 21, 2026, 6:59 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Limited Ankle Dorsiflexion and Effect on Single Limb Squats in Individuals With Patellofemoral Pain

NCT05285007
View directory record Official record
Conditions
Patellofemoral Pain
Interventions
Mobilization with Movement, No mobilization with movement and education
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 59 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Jul 21, 2026, 6:59 PM EDT
Completed Not applicable Interventional

Strength Training in Female Runners With Patellofemoral Pain

NCT04480528
View directory record Official record
Conditions
Patellofemoral Syndrome
Interventions
Blood Flow Restriction Training (BFRT), Sham Blood Flow Restriction Training (Sham BFRT)
Other
Lead sponsor
Lauren Erickson
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 3, 2022 · Synced Jul 21, 2026, 6:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Utilizing the Trunk as a Proximal Lever to Strengthen the Hip Musculature and Alter Lower Extremity Function

NCT03285464
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Triplanar Rotary Resistance
Other
Lead sponsor
High Point University
Other
Eligibility
18 Years and older · Female only
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 25, 2018 · Synced Jul 21, 2026, 6:59 PM EDT
Recruiting Not applicable Interventional

Modulating Cortical Excitability to Improve Functional Movements in Individuals With Patellofemoral Pain

NCT06565520
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
transcranial direct current stimulator
Device
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years to 45 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Aug 21, 2024 · Synced Jul 21, 2026, 6:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Strength and Coordination Training on Biomechanics and Injury in New Runners

NCT03293121
View directory record Official record
Conditions
Injuries, Patellofemoral Pain Syndrome, Iliotibial Band Syndrome
Interventions
Strength and Coordination Training, Walking
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 60 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 17, 2019 · Synced Jul 21, 2026, 6:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Hip Activation Compared to Hip Plus Balance Training on the Forward-Step-Down Test

NCT06298903
View directory record Official record
Conditions
Control of Frontal Plane Biomechanics, Patellofemoral Pain Syndrome
Interventions
Hip Activation, Hip activation + Single leg balance
Other
Lead sponsor
Louisiana State University Health Sciences Center Shreveport
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Shreveport, Louisiana
Source: ClinicalTrials.gov public record
Updated Dec 12, 2024 · Synced Jul 21, 2026, 6:59 PM EDT
Completed Not applicable Interventional

Digital Home-Exercise Therapy Application For Patients With Non-Surgical Knee Injuries

NCT04323267
View directory record Official record
Conditions
Knee Injuries, Knee Osteoarthritis, Patellofemoral Syndrome
Interventions
Limber Digital Application, Physical therapy Therapy
Device · Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 28, 2020 · Synced Jul 21, 2026, 6:59 PM EDT
Completed Not applicable Interventional

Dynamic Quadriceps Muscle Stimulation for Treatment of Patellofemoral Pain

NCT02243332
View directory record Official record
Conditions
Patellofemoral Pain Syndrome, Anterior Knee Pain Syndrome
Interventions
KneeStim mobile rehabilitation assistance device
Device
Lead sponsor
Articulate Labs
Industry
Eligibility
18 Years to 40 Years · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 26, 2017 · Synced Jul 21, 2026, 6:59 PM EDT
Completed Not applicable Interventional

Neural Correlates of Knee Sensorimotor Control in Patients With Patellofemoral Pain Syndrome

NCT04099004
View directory record Official record
Conditions
Patellofemoral Pain Syndrome, Patellofemoral Pain
Interventions
Neural Imaging
Other
Lead sponsor
Emory University
Other
Eligibility
7 Years to 40 Years · Female only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
2
States / cities
Flowery Branch, Georgia • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 12, 2024 · Synced Jul 21, 2026, 6:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparing Rehabilitation Programs for Patellofemoral Pain Syndrome

NCT00445224
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Hip Progressive Resistive Exercise, Quad Progressive Resistive Exercises
Other
Lead sponsor
Timothy Uhl
Other
Eligibility
15 Years to 35 Years · Female only
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 27, 2017 · Synced Jul 21, 2026, 6:59 PM EDT