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Showing 1–24 of 69 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Pediatric Critical Illness Clear all
Completed No phase listed Observational

Comparing Cardiac Output Measurements in Critically Ill Children Using USCOM and Transthoracic ECHO

NCT01460329
View directory record Official record
Conditions
Critical Illness, Pediatrics
Interventions
Ultrasonic Cardiac Output Monitor (USCOM).
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
1 Day to 17 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 5, 2013 · Synced Sep 12, 2026, 6:50 AM EDT
Withdrawn Phase 4 Interventional

Dexmedetomidine Cycling and Sleep in the Pediatric ICU

NCT05003102
View directory record Official record
Conditions
Critical Illness, Sedation Complication, Delirium
Interventions
Dexmedetomidine Hydrochloride - Cycling, Fentanyl - PICU Standard, Dexmedetomidine Hydrochloride - PICU Standard
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
12 Years to 17 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 9, 2022 · Synced Sep 12, 2026, 6:50 AM EDT
Withdrawn No phase listed Observational

Clinical Pediatric Pneumonia Score in Critically Ill Children

NCT02139384
View directory record Official record
Conditions
Community Acquired Pneumonia
Interventions
Not listed
Lead sponsor
Loma Linda University
Other
Eligibility
1 Day to 21 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Apr 24, 2017 · Synced Sep 12, 2026, 6:50 AM EDT
Completed No phase listed Observational

Improvement Project To Optimizing Nutrition With Higher Protein and Calorie Pediatric Tube Feeding

NCT03017664
View directory record Official record
Conditions
Critically Ill Children
Interventions
Peptide-based enteral formula, Retrospective review of enteral tube feeding formula
Other
Lead sponsor
Société des Produits Nestlé (SPN)
Industry
Eligibility
1 Year to 13 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
2
States / cities
Chicago, Illinois • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 26, 2020 · Synced Sep 12, 2026, 6:50 AM EDT
Completed No phase listed Observational

Blood Culture Improvement Guidelines and Diagnostic Stewardship for Antibiotic Reduction in Critically Ill Children

NCT03441126
View directory record Official record
Conditions
Sepsis, Bacteremia
Interventions
Multicenter Quality Improvement program
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
Not listed
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
5
States / cities
St Louis, Missouri • Cleveland, Ohio • Portland, Oregon + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 10, 2022 · Synced Sep 12, 2026, 6:50 AM EDT
Terminated Not applicable Interventional

Use of Biomarkers to Optimize Fluid Dosing,CRRT Initiation and Discontinuation in Pediatric ICU Patients With AKI

NCT01416298
View directory record Official record
Conditions
Acute Kidney Injury, Fluid Overload
Interventions
Continuous Renal Replacement Therapy
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
1 Year to 25 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 19, 2018 · Synced Sep 12, 2026, 6:50 AM EDT
Completed No phase listed Observational

Methionine Metabolism in Parenterally Fed Pediatric Sepsis

NCT01891682
View directory record Official record
Conditions
Sepsis, Critical Illness
Interventions
Observational
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
1 Month to 19 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 21, 2017 · Synced Sep 12, 2026, 6:50 AM EDT
Completed Not applicable Interventional

Pediatric Continuity Care Intensivist

NCT02146573
View directory record Official record
Conditions
Critical Illness
Interventions
Continuity Care Intensivist Communication Training, Continuity Care Intensivist (CCI) Provider Program
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
Not listed
Enrollment
276 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 15, 2020 · Synced Sep 12, 2026, 6:50 AM EDT
Recruiting Phase 2Phase 3 Interventional

Azithromycin for Critical Asthma - Pediatrics

NCT06223828
View directory record Official record
Conditions
Pediatric Asthma, Critical Illness
Interventions
Azithromycin
Drug
Lead sponsor
Johns Hopkins All Children's Hospital
Other
Eligibility
3 Years to 17 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
St. Petersburg, Florida
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Sep 12, 2026, 6:50 AM EDT
Withdrawn Not applicable Interventional

Use of NGAL for Fluid Dosing and CRRT Initiation in Pediatric and Neonatal AKI

NCT05114057
View directory record Official record
Conditions
Acute Kidney Injury, Acute Kidney Injury Due to Sepsis, Neonatal Sepsis
Interventions
Renal Angina Index (RAI)
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
Up to 25 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Sep 12, 2026, 6:50 AM EDT
Completed Phase 2Phase 3 Interventional

Lorazepam Sedation for Critically Ill Children

NCT00109395
View directory record Official record
Conditions
Critical Illness
Interventions
Lorazepam, Midazolam, Lorazepam CI
Drug
Lead sponsor
The Emmes Company, LLC
Industry
Eligibility
1 Day to 18 Years
Enrollment
179 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 19, 2023 · Synced Sep 12, 2026, 6:50 AM EDT
Completed No phase listed Observational

Methionine Metabolism in Enterally Fed Pediatric Sepsis

NCT01889264
View directory record Official record
Conditions
Sepsis, Critical Illness
Interventions
Observational
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
1 Month to 19 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 21, 2017 · Synced Sep 12, 2026, 6:50 AM EDT
Terminated No phase listed Observational

Prospective Evaluation of the Incidence of PICS

NCT03584399
View directory record Official record
Conditions
Metabolism and Nutrition Disorder
Interventions
PICS in critically ill pediatric population
Other
Lead sponsor
Indiana University
Other
Eligibility
Up to 18 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 24, 2023 · Synced Sep 12, 2026, 6:50 AM EDT
Recruiting Phase 2 Interventional

The "What Is Important to Us" Communication Intervention Pilot Clinical Trial

NCT06208332
View directory record Official record
Conditions
Critical Illness, Neurologic Disorder
Interventions
"What Is Important to Us" Communication Intervention
Behavioral
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
6 Months and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 12, 2026, 6:50 AM EDT
Suspended Not applicable Interventional

Pediatric Prehospital Airway Resuscitation Trial

NCT06364280
View directory record Official record
Conditions
Heart Arrest, Out-Of-Hospital, Wounds and Injuries, Respiratory Insufficiency in Children, Child, Only, Critical Illness
Interventions
BVM, SGA, ETI
Device
Lead sponsor
Ohio State University
Other
Eligibility
24 Hours to 17 Years
Enrollment
3,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
10
States / cities
Tucson, Arizona • Los Angeles, California • Sacramento, California + 7 more
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Sep 12, 2026, 6:50 AM EDT
Enrolling by invitation No phase listed Observational

A Multi-Center Diagnostic Stewardship Program to Improve Respiratory Culture Utilization in Critically Ill Children

NCT04987840
View directory record Official record
Conditions
Ventilator Associated Pneumonia, Tracheobronchitis
Interventions
Not listed
Lead sponsor
Johns Hopkins University
Other
Eligibility
Not listed
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
8
States / cities
Baltimore, Maryland • Boston, Massachusetts • Minneapolis, Minnesota + 5 more
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Sep 12, 2026, 6:50 AM EDT
Withdrawn No phase listed Observational

Comparison of Techniques for Assessing Cardiac Output and Preload in Critically Ill Pediatric Patients

NCT00167440
View directory record Official record
Conditions
Low Cardiac Output
Interventions
Not listed
Lead sponsor
University of Rochester
Other
Eligibility
Up to 16 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Nov 25, 2015 · Synced Sep 12, 2026, 6:50 AM EDT
Completed No phase listed Observational Results available

Ultrasound Guided Vascular Access in Pediatric Intensive Care Patients

NCT00207883
View directory record Official record
Conditions
Critical Illness
Interventions
Not listed
Lead sponsor
Children's Healthcare of Atlanta
Other
Eligibility
1 Month to 18 Years
Enrollment
212 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 17, 2017 · Synced Sep 12, 2026, 6:50 AM EDT
Enrolling by invitation Not applicable Interventional

Enhancing Parent/Caregiver Engagement in the Pediatric Intensive Care Unit (PICU): A PICU Journal

NCT06117345
View directory record Official record
Conditions
Critical Illness
Interventions
PICU Journal
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Sep 12, 2026, 6:50 AM EDT
Completed Phase 2 Interventional

Sedation Management in Pediatric Patients Supported on Mechanical Ventilation

NCT00142766
View directory record Official record
Conditions
Respiratory Failure
Interventions
Nurse Implemented Goal-Directed Comfort Algorithm
Behavioral
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
2 Weeks to 18 Years
Enrollment
245 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
3
States / cities
Washington D.C., District of Columbia • Boston, Massachusetts • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 6, 2015 · Synced Sep 12, 2026, 6:50 AM EDT
Not listed Phase 2 Interventional

Improving Blood Glucose Control With a Computerized Decision Support Tool: Phase 2

NCT00654797
View directory record Official record
Conditions
Critically Ill, Hyperglycemia
Interventions
glucose control with computer generated recommendations
Procedure
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
1 Month and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2018
U.S. locations
10
States / cities
Madera, California • Saint Paul, Minnesota • Lebanon, New Hampshire + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 25, 2015 · Synced Sep 12, 2026, 6:50 AM EDT
Completed No phase listed Observational

Study of the Prediction of Acute Kidney Injury in Children Using Risk Stratification and Biomarkers

NCT01735162
View directory record Official record
Conditions
Renal Angina, Acute Kidney Injury
Interventions
Not listed
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
Not listed
Enrollment
184 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 2, 2015 · Synced Sep 12, 2026, 6:50 AM EDT
Completed No phase listed Observational

IPV and Lung Compliance in Invasively Ventilated Children

NCT06836050
View directory record Official record
Conditions
Pediatric Acute Respiratory Distress Syndrome (PARDS), Pediatric Respiratory Diseases, Lung Compliance
Interventions
Not listed
Lead sponsor
Northwell Health
Other
Eligibility
0 Days to 18 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New Hyde Park, New York
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Sep 12, 2026, 6:50 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Examining Health Literacy in Biorepository Consents

NCT04953169
View directory record Official record
Conditions
Pediatric, Critical Illness, Consent
Interventions
Biobank Video, Non-Video
Other
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 18, 2024 · Synced Sep 12, 2026, 6:50 AM EDT