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ClinicalTrials.gov public records Last synced Jul 21, 2026, 7:29 PM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Physical Impairments Clear all
Completed Early Phase 1 Interventional Accepts healthy volunteers

Pilot Study of GLY-LOW Supplementation in Postmenopausal Women With Obesity

NCT06242535
View directory record Official record
Conditions
Insulin Resistance, Obesity, Cardiovascular Diseases, Cognitive Impairment, Physical Disability, Depression, Inflammation, Hormone Deficiency, Physical Inactivity, Hyperlipidemias, Hypertension, Overeating
Interventions
GLY-LOW
Biological
Lead sponsor
Hoskinson Health and Wellness Clinic
Industry
Eligibility
56 Years and older · Female only
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Gillette, Wyoming
Source: ClinicalTrials.gov public record
Updated Jun 9, 2025 · Synced Jul 21, 2026, 7:29 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Evaluation of Assessments of Motor Performance, Physical Impairments and Functional Abilities

NCT00747955
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Not listed
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
Not listed
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2017
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 16, 2019 · Synced Jul 21, 2026, 7:29 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Project Gnosis: the Neurophysical and Psychosocial Health Outcomes of Tai Chi for Older Adults with Cognitive Concerns or Mild Cognitive Impairment

NCT06828926
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI), Sarcopenia
Interventions
Tai Chi
Behavioral
Lead sponsor
Ohio University
Other
Eligibility
60 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Athens, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 16, 2025 · Synced Jul 21, 2026, 7:29 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Assess the Effect of Metaxalone 640 mg (M640) Compared to Tizanidine 8 mg on Truck Driving Ability and Cognition

NCT06382662
View directory record Official record
Conditions
Cognitive Impairment
Interventions
metaxalone m640, tizanidine
Drug
Lead sponsor
Primus Pharmaceuticals
Industry
Eligibility
20 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Peoria, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 21, 2025 · Synced Jul 21, 2026, 7:29 PM EDT
Not yet recruiting Not applicable Interventional

FES: Effect on Walking in the Real World and Participation in Daily Life in People With Multiple Sclerosis.

NCT07706114
View directory record Official record
Conditions
Multiple Sclerosis, Impaired Gait
Interventions
Use of functional electrical stimulation for extended duration on the participants' weaker limb
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
22 Years to 75 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Jul 21, 2026, 7:29 PM EDT
Active, not recruiting Not applicable Interventional

STAT: Standard Therapy Plus Active Therapy

NCT04368117
View directory record Official record
Conditions
Burn Injury, Physical Injury, Thermal Burn
Interventions
Physical Therapy
Behavioral
Lead sponsor
American Burn Association
Other
Eligibility
18 Years to 65 Years
Enrollment
166 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
7
States / cities
Phoenix, Arizona • Sacramento, California • Maywood, Illinois + 4 more
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Jul 21, 2026, 7:29 PM EDT
Completed Not applicable Interventional Results available

Promoting Adaptive Neuroplasticity in Mild Cognitive Impairment

NCT02155946
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer's Disease
Interventions
Transcranial direct current stimulation (tDCS) Soterix Medical Inc. tDCS unit
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years to 88 Years
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 29, 2023 · Synced Jul 21, 2026, 7:29 PM EDT
Terminated Not applicable Interventional Results available

Impact of Physical Activity on Cognitive Outcomes in Youth With Pediatric-Onset Multiple Sclerosis (POMS)

NCT03933020
View directory record Official record
Conditions
Pediatric Onset Multiple Sclerosis (POMS)
Interventions
VR active video game intervention, Educational session, Standard Management of Physical Activity
Device · Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
15 Years to 25 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 18, 2022 · Synced Jul 21, 2026, 7:29 PM EDT
Not listed Not applicable Interventional

FE-SaLiR: Function Improvement Exercise

NCT04284137
View directory record Official record
Conditions
Disability Physical, Cognitive Impairment
Interventions
Modified FE-SaLiR, Unmodified Chinese Medicine Exercise, Active Control
Behavioral
Lead sponsor
The University of Texas at San Antonio
Other
Eligibility
60 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 24, 2020 · Synced Jul 21, 2026, 7:29 PM EDT
Active, not recruiting Phase 2 Interventional Accepts healthy volunteers

A Novel Computer-Based Functional Skills Assessment and Training Program

NCT04679441
View directory record Official record
Conditions
Mild Cognitive Impairment, Healthy Aging
Interventions
The Computerized Functional Skills Assessment and Training Program, Brain HQ Double Decision
Device
Lead sponsor
i-Function, Inc.
Industry
Eligibility
60 Years to 100 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
2
States / cities
Miami, Florida • New York, New York
Source: ClinicalTrials.gov public record
Updated May 7, 2023 · Synced Jul 21, 2026, 7:29 PM EDT
Completed Not applicable Interventional

A Physical Activity Intervention to Promote Cognitive Health, Cardiovascular Health and Sleep in Older Latinos

NCT05030948
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Tiempo Juntos Intervention
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
55 Years and older
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Jul 21, 2026, 7:29 PM EDT
Completed Phase 2 Interventional Results available

A Study of LY3372689 to Assess the Safety, Tolerability, and Efficacy in Participants With Alzheimer's Disease

NCT05063539
View directory record Official record
Conditions
Alzheimer Disease
Interventions
LY3372689, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
60 Years to 85 Years
Enrollment
327 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
35
States / cities
Canoga Park, California • Fresno, California • Irvine, California + 30 more
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Jul 21, 2026, 7:29 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

The MObile AssessMENT of Behavioral and Psychological Symptoms of Dementia in Amnestic MCI and AD (MOMENT) Study

NCT04482036
View directory record Official record
Conditions
Alzheimer Disease, Mild Memory Disturbance, Mild Cognitive Impairment
Interventions
Mobile Phone Application Assessments, Standard Assessments
Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 120 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 31, 2023 · Synced Jul 21, 2026, 7:29 PM EDT
Recruiting Not applicable Interventional

Physical Therapy for Montana Children With NMD Using Hippotherapy and the Equine Environment

NCT06887647
View directory record Official record
Conditions
Neuromotor Impairments
Interventions
Physical Therapy Using Hippotherapy and the Equine Environment, Standard Play-Based Physical Therapy
Other
Lead sponsor
University of Montana
Other
Eligibility
6 Years to 17 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Missoula, Montana
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Jul 21, 2026, 7:29 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Wearable Sensors for Quantitative Assessment of Motor Impairment in Huntington's Disease Huntington's Disease

NCT03599076
View directory record Official record
Conditions
Huntington Disease
Interventions
HD Wear
Other
Lead sponsor
BioSensics
Industry
Eligibility
Not listed
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jan 23, 2019 · Synced Jul 21, 2026, 7:29 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

UCLA Fitness and Memory Study of Activity In Mild Cognitive Impairment (AIM)

NCT02001441
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Not listed
Lead sponsor
University of California, Los Angeles
Other
Eligibility
60 Years to 89 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 1, 2018 · Synced Jul 21, 2026, 7:29 PM EDT
Completed Phase 2 Interventional Results available

NeuroCognition After Carotid Recanalization

NCT04219774
View directory record Official record
Conditions
Cognition Disorder, Stroke, Occlusion Carotid
Interventions
Endovascular intervention, Aspirin and Clopidogrel (maximal medical Therapy)
Procedure · Drug
Lead sponsor
Duke University
Other
Eligibility
21 Years to 90 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
2
States / cities
Iowa City, Iowa • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 8, 2025 · Synced Jul 21, 2026, 7:29 PM EDT
Active, not recruiting Early Phase 1 Interventional

Safety and Feasibility of Exablate Blood-Brain Barrier Disruption for Mild Cognitive Impairment or Mild Alzheimer's Disease Undergoing Standard of Care Monoclonal Antibody (mAb) Therapy

NCT05469009
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer Disease 1
Interventions
Aducanumab, Exablate Model 4000 Type 2, Lecanemab
Drug · Device
Lead sponsor
Ali Rezai
Other
Eligibility
50 Years to 85 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2029
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Jul 21, 2026, 7:29 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Arlington Longitudinal Optimal Healthy Aging Study (ALOHA)

NCT07180147
View directory record Official record
Conditions
Alzheimer Disease (AD), Cardio Vascular Disease, Mild Cognitive Impairment (MCI), Frailty Syndrome, Disability Physical, Hypertension, Metabolic Syndrome (MetS), Healthy Aging, Obesity &Amp; Overweight
Interventions
Not listed
Lead sponsor
Marymount University
Other
Eligibility
50 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2031
U.S. locations
1
States / cities
Arlington, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 8, 2026 · Synced Jul 21, 2026, 7:29 PM EDT
Completed No phase listed Observational

Assessment of Cognitive and Functional Impairment in Older Patients After ERCP

NCT03762954
View directory record Official record
Conditions
Cognitive Impairment
Interventions
Neurocognitive function assessment
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
60 Years and older
Enrollment
215 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 28, 2024 · Synced Jul 21, 2026, 7:29 PM EDT
Completed Not applicable Interventional

Dual-task Training for Function in MCI

NCT04059705
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Dual-Task Training
Behavioral
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
65 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Nov 29, 2023 · Synced Jul 21, 2026, 7:29 PM EDT
Completed Not applicable Interventional

Managing Pain and Cognitions in Older Adults With Early Cognitive Decline and Chronic Pain

NCT05373745
View directory record Official record
Conditions
Chronic Pain, Mild Cognitive Impairment, Older Adults, Physical Activity
Interventions
Active Brains 1, Active Brains 2
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
60 Years and older
Enrollment
267 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Jul 21, 2026, 7:29 PM EDT
Recruiting No phase listed Observational

FOXP1 Syndrome: The Seaver Autism Center for Research and Treatment is Characterizing FOXP1-related Neurodevelopmental Disorders Using Genetic, Medical, and Neuropsychological Measures.

NCT03718923
View directory record Official record
Conditions
FOXP1, Mental Retardation With Language Impairment and With or Without Autistic Features, Autism Spectrum Disorder
Interventions
Not listed
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
2 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Jul 21, 2026, 7:29 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

An Objective Assessment Tool for Evaluating Functioning in Older Adults

NCT06489847
View directory record Official record
Conditions
Alzheimer Disease
Interventions
SPPB++ Application
Diagnostic Test
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Jul 21, 2026, 7:29 PM EDT