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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Polypharmacy Clear all
Completed Not applicable Interventional

Deprescribing for Older Adults After Hospital Discharge in Home Health Care

NCT05630144
View directory record Official record
Conditions
Polypharmacy
Interventions
HomeMed
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
65 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 15, 2025 · Synced Jul 22, 2026, 5:53 AM EDT
Not listed No phase listed Observational

Simulation of Risk of Adverse Drug Events Associated With the Initiation of Drugs Repurposed for the Treatment of COVID-19 in Adults With Polypharmacy Using Data From Large Medicare and Commercially Insured Populations

NCT04378881
View directory record Official record
Conditions
COVID, Drug Effect, Drug Interaction, Adverse Drug Event
Interventions
Not listed
Lead sponsor
Tabula Rasa HealthCare
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Sep 1, 2022 · Synced Jul 22, 2026, 5:53 AM EDT
Completed Not applicable Interventional

Deprescribing in Outpatient Internal Medicine Practices

NCT07226960
View directory record Official record
Conditions
Deprescribing
Interventions
medication review
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
75 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Jul 22, 2026, 5:53 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Measuring the Impact of an Interdisciplinary Polypharmacy Clinic Within a Patient-centered Medical Home

NCT02077725
View directory record Official record
Conditions
Polypharmacy
Interventions
interdisciplinary polypharmacy clinic visit
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2013
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 29, 2022 · Synced Jul 22, 2026, 5:53 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

e-ALIGN: A Patient Portal-based Intervention to Align Medications With What Matters Most

NCT07454824
View directory record Official record
Conditions
Dementia, Potentially Inappropriate Medication Use, Mild Cognitive Impairment (MCI)
Interventions
e-ALIGN Patient-Portal Deprescribing
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
65 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Jul 22, 2026, 5:53 AM EDT
Withdrawn Not applicable Interventional

Reducing High-Risk Geriatric Polypharmacy Via EHR Nudges: Pilot Phase

NCT03791580
View directory record Official record
Conditions
Fall, Congestive Heart Failure, Chronic Kidney Failure, Adverse Drug Event
Interventions
Commitment nudge, Justification nudge
Behavioral
Lead sponsor
RAND
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Jul 22, 2026, 5:53 AM EDT
Completed No phase listed Observational

Simulation of Risk of Adverse Drug Events Associated With the Initiation of Drugs Repurposed for the Treatment of COVID-19 in Frail Elderly Adults With Polypharmacy

NCT04339634
View directory record Official record
Conditions
COVID, Drug Effect, Drug Interaction, Adverse Drug Event
Interventions
Simulation of Repurposed Drugs for COVID-19
Other
Lead sponsor
Tabula Rasa HealthCare
Industry
Eligibility
55 Years and older
Enrollment
12,873 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jan 30, 2023 · Synced Jul 22, 2026, 5:53 AM EDT
Completed Not applicable Interventional

Optimal Medication Management in Alzheimer's Disease and Dementia

NCT03984396
View directory record Official record
Conditions
Dementia
Interventions
Educational Materials - Patient & Clinician
Other
Lead sponsor
Kaiser Permanente
Other
Eligibility
65 Years and older
Enrollment
7,398 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 31, 2024 · Synced Jul 22, 2026, 5:53 AM EDT
Recruiting Phase 4 Interventional

LDL-C Optimization Using Inclisiran in Patients in Which Drug-Drug Interactions Limit LDL Lowering

NCT06865885
View directory record Official record
Conditions
Drug Interactions, Primary Prevention, Cardiometabolic Syndrome, LDL-Cholersterol Lowering
Interventions
Inclisiran sodium 300 mg (equivalent to 284 mg inclisiran) in 1.5 mL
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Jul 22, 2026, 5:53 AM EDT
Completed Not applicable Interventional

Reducing Costs by Deprescribing Medications

NCT04553107
View directory record Official record
Conditions
Polypharmacy, Deprescribing, Adverse Drug Reaction
Interventions
Deprescribing Intervention, Usual Care
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
65 Years and older
Enrollment
419 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 21, 2022 · Synced Jul 22, 2026, 5:53 AM EDT
Completed No phase listed Observational Results available

Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population

NCT03468309
View directory record Official record
Conditions
Pharmacogenetic Testing
Interventions
Genecept Assay and G-DIG decision tool
Genetic
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years to 75 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Apr 22, 2024 · Synced Jul 22, 2026, 5:53 AM EDT
Completed Not applicable Interventional

Tailored Medication Management Intervention

NCT04717297
View directory record Official record
Conditions
Medication Non Adherence, Polypharmacy
Interventions
Medication Management Remote Intervention, Waitlist Control, Medication Management In-Person Intervention
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
65 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 28, 2023 · Synced Jul 22, 2026, 5:53 AM EDT
Not listed No phase listed Observational

Pharmacogenomic Testing in a Program of All-inclusive Care for the Elderly (PACE) Setting

NCT05053815
View directory record Official record
Conditions
Pharmacogenomics, Polypharmacy
Interventions
Pharmacogenomic Testing
Other
Lead sponsor
Tabula Rasa HealthCare
Industry
Eligibility
18 Years and older
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Sep 1, 2022 · Synced Jul 22, 2026, 5:53 AM EDT
Completed No phase listed Observational

Older Adults' Readiness to Stop Prescribed Medications

NCT05996237
View directory record Official record
Conditions
Polypharmacy, Decision-making
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
65 Years and older
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 8, 2025 · Synced Jul 22, 2026, 5:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Bundled Hyperpolypharmacy Deprescribing

NCT05616689
View directory record Official record
Conditions
Polypharmacy
Interventions
Bundled hyperpolypharmacy
Other
Lead sponsor
Kaiser Permanente
Other
Eligibility
76 Years and older
Enrollment
2,471 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated Dec 14, 2023 · Synced Jul 22, 2026, 5:53 AM EDT
Not listed Not applicable Interventional

Acute Care for Elders (ACE) Program at OHSU Hospital

NCT02119078
View directory record Official record
Conditions
Delirium, Age-Related Cognitive Decline, Frail Elderly, Hospital Acquired Pressure Ulcer, Drug-Related Side Effects and Adverse Reactions
Interventions
Acute Care of Elders focused geriatric care
Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
Not listed
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 3, 2019 · Synced Jul 22, 2026, 5:53 AM EDT
Active, not recruiting Not applicable Interventional Results available

Pharmacist Intervention to Reduce Post-Hospitalization Utilization

NCT04071951
View directory record Official record
Conditions
Nonadherence, Patient, Polypharmacy, Readmission
Interventions
Pharmacist-led Hospital Discharge Care Intervention
Behavioral
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
55 Years and older
Enrollment
6,478 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
2
States / cities
Los Angeles, California • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Jul 22, 2026, 5:53 AM EDT
Recruiting Not applicable Interventional

Safety and Effectiveness of Minimally Invasive Micro Sclerostomy (MIMS®) to Reduce Intraocular Pressure in Open-Angle Glaucoma Which is Not Controlled Despite Polypharmacy

NCT06313749
View directory record Official record
Conditions
Primary Open Angle Glaucoma, Open Angle Glaucoma
Interventions
Minimally Invasive Micro Sclerostomy Device
Device
Lead sponsor
Sanoculis Ltd
Industry
Eligibility
40 Years to 85 Years
Enrollment
129 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 6, 2024 · Synced Jul 22, 2026, 5:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Medication Management at Home Via Pharmacy Home Televisits

NCT04340570
View directory record Official record
Conditions
Polypharmacy, Deprescribing, Telemedicine
Interventions
Medication management via televisit to home
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
65 Years and older
Enrollment
304 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
2
States / cities
Bedford, Massachusetts • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Jul 22, 2026, 5:53 AM EDT
Completed Not applicable Interventional

Drug & Gene Interaction Risk Analysis With & Without Genetic Testing Among Patients Undergoing MTM

NCT02428660
View directory record Official record
Conditions
Cytochrome P450 CYP2D6 Enzyme Deficiency, Poor Metabolizer Due to Cytochrome P450 CYP2D6 Variant, Ultrarapid Metabolizer Due to Cytochrome P450 CYP2D6 Variant, Extensive Metabolizer Due to Cytochrome P450 CYP2D6 Variant, Cytochrome P450 CYP2C9 Enzyme Deficiency, Cytochrome P450 CYP2C19 Enzyme Deficiency, Drug Metabolism, Poor, CYP2D6-RELATED, Drug Metabolism, Poor, CYP2C19-RELATED, CYP2D6 Polymorphism
Interventions
Pharmacogenetic testing, Software-based drug & gene interaction risk analysis, MTM
Genetic · Other
Lead sponsor
Genelex Corporation
Industry
Eligibility
65 Years and older
Enrollment
341 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Feb 22, 2017 · Synced Jul 22, 2026, 5:53 AM EDT
Active, not recruiting Not applicable Interventional

Reducing High-Risk Geriatric Polypharmacy Via EHR Nudges R01 Trial

NCT05656560
View directory record Official record
Conditions
Polypharmacy
Interventions
Clinical decision support (CDS)-Commitment nudge, Clinician education, Clinical decision support (CDS)-Justification nudge
Behavioral · Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
786 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
2
States / cities
Chicago, Illinois • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 25, 2026 · Synced Jul 22, 2026, 5:53 AM EDT
Completed Not applicable Interventional

Decreasing Harms and Improving Child Health

NCT07392489
View directory record Official record
Conditions
Psychotropic Drugs, Psychiatric Drugs, Children, Shared Decision Making, Patient Decision Aid
Interventions
AWARE Shared Decision Making Medication Review
Behavioral
Lead sponsor
Glyn Jones-Elwyn
Other
Eligibility
6 Years to 17 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
4
States / cities
Hanover, New Hampshire • Lebanon, New Hampshire • Auburn, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Jul 22, 2026, 5:53 AM EDT
Not listed No phase listed Observational

Bictegravir in the Elderly Living With HIV (BICEP)

NCT05064020
View directory record Official record
Conditions
HIV-1-infection
Interventions
Bictegravir/Emtricitabine/Tenofovir Alafenamide 50 MG-200 MG-25 MG Oral Tablet [BIKTARVY]
Drug
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years and older
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jun 3, 2024 · Synced Jul 22, 2026, 5:53 AM EDT
Completed Not applicable Interventional Results available

A Randomized Controlled Trial to Deprescribe for Older Patients With Polypharmacy

NCT02979353
View directory record Official record
Conditions
Polypharmacy, Care Transitions, Geriatric Syndromes
Interventions
Shed-Meds: A Patient-Centered Deprescribing Intervention
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
50 Years and older
Enrollment
372 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 18, 2023 · Synced Jul 22, 2026, 5:53 AM EDT