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Showing 1–24 of 95 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Polyphenols Clear all
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Berries, Inflammation, and Gut Microbiome

NCT04100200
View directory record Official record
Conditions
Overweight or Obesity, Healthy
Interventions
Mixed berries, FOS, Control, Combination
Dietary Supplement
Lead sponsor
Clinical Nutrition Research Center, Illinois Institute of Technology
Industry
Eligibility
20 Years to 60 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Sep 7, 2026, 5:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Acute and Chronic Effects of Fruit Polyphenols on Chronic Disease (PPF)

NCT01729949
View directory record Official record
Conditions
Nutritional and Metabolic Disease, Overweight
Interventions
Active Treatment Beverage, Placebo Treatment Beverage
Dietary Supplement
Lead sponsor
Clinical Nutrition Research Center, Illinois Institute of Technology
Industry
Eligibility
40 Years to 65 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2018
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 26, 2021 · Synced Sep 7, 2026, 5:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Aronia Berries on Vascular Endothelial Function and the Gut Microbiota in Middle-Aged/Older Adults

NCT03824041
View directory record Official record
Conditions
Endothelial Dysfunction, Aging
Interventions
Aronia full spectrum - half dose, Aronia full spectrum - full dose, Placebo
Dietary Supplement
Lead sponsor
Colorado State University
Other
Eligibility
45 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 2, 2023 · Synced Sep 7, 2026, 5:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of a Single Dose of Cranberry Beverage on Inflammation and Oxidative Stress

NCT01780922
View directory record Official record
Conditions
Inflammation
Interventions
Low Calorie Cranberry Juice Cocktail, Cranberry Extract Beverage, Non-Cranberry Beverage
Other
Lead sponsor
Washington State University
Other
Eligibility
18 Years to 35 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Pullman, Washington
Source: ClinicalTrials.gov public record
Updated Jul 7, 2014 · Synced Sep 7, 2026, 5:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Scavenging of Reactive Carbonyl Species by Dietary Flavonoids in Humans

NCT05773794
View directory record Official record
Conditions
Human Health, Reactive Carbonyl Species, Polyphenols
Interventions
Soymilk, green tea, or blueberry, Control group
Dietary Supplement
Lead sponsor
North Carolina Agriculture & Technical State University
Other
Eligibility
25 Years to 70 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Sep 7, 2026, 5:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intake-dependent Effect of Cocoa Flavanol Absorption, Metabolism and Excretion in Humans

NCT03201822
View directory record Official record
Conditions
Healthy
Interventions
100 mg of Cocoa Flavanols/70 kg BW, 200 mg of Cocoa Flavanols/70 kg BW, 400 mg of Cocoa Flavanols/70 kg BW, 1000 mg of Cocoa Flavanols/70 kg BW
Other
Lead sponsor
University of California, Davis
Other
Eligibility
25 Years to 40 Years · Male only
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Jun 27, 2017 · Synced Sep 7, 2026, 5:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Blackberry Polyphenol Intake and Fuel Management

NCT01932879
View directory record Official record
Conditions
Fuel Management
Interventions
Blackberry, Jello
Other
Lead sponsor
USDA Beltsville Human Nutrition Research Center
Federal
Eligibility
25 Years to 75 Years · Male only
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Beltsville, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 6, 2016 · Synced Sep 7, 2026, 5:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Adaptation in Polyphenol Bioavailability and Bioactivity During Long Term Exposure to Polyphenol-Rich Foods

NCT02197754
View directory record Official record
Conditions
Healthy
Interventions
Controlled diet
Other
Lead sponsor
USDA Beltsville Human Nutrition Research Center
Federal
Eligibility
25 Years to 75 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Beltsville, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 15, 2015 · Synced Sep 7, 2026, 5:30 AM EDT
Completed Not applicable Interventional

Cocoa Polyphenols and Postprandial Metabolism in Type 2 Diabetes

NCT01886989
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Cocoa polyphenols
Dietary Supplement
Lead sponsor
Arpita Basu
Other
Eligibility
21 Years to 60 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Stillwater, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jan 22, 2018 · Synced Sep 7, 2026, 5:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Food Matrix Effect on Flavanol Absorption, Metabolism and Excretion: Methylxanthines

NCT03526107
View directory record Official record
Conditions
Healthy
Interventions
CF Control, CF-Theobromine, CF-Caffeine
Other
Lead sponsor
University of California, Davis
Other
Eligibility
25 Years to 60 Years · Male only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
2
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Oct 9, 2022 · Synced Sep 7, 2026, 5:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Fruit-based Chewing Gums for Improving Oral Health

NCT05755152
View directory record Official record
Conditions
Oral Health
Interventions
polyphenol-lecithin precipitate (PLP), control formulation
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Nov 1, 2023 · Synced Sep 7, 2026, 5:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Short-term Curcumin and Multi-polyphenol Supplementation on the Anti-inflammatory Properties of HDL

NCT02998918
View directory record Official record
Conditions
Inflammation, Atherosclerosis, Cardiovascular Disease
Interventions
PolyResveratrol Supplementation, Curcumin Supplementation
Dietary Supplement
Lead sponsor
University of South Carolina
Other
Eligibility
18 Years to 60 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Sep 7, 2026, 5:30 AM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Effects of Hesperidin on Insulin Sensitivity

NCT01773486
View directory record Official record
Conditions
Obesity, Insulin Resistance
Interventions
Hesperidin, Placebo
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
21 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2022 · Synced Sep 7, 2026, 5:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Strawberry Consumption on the Microbiome

NCT04217122
View directory record Official record
Conditions
Microbiome
Interventions
strawberry powder, placebo powder
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 6, 2020 · Synced Sep 7, 2026, 5:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effectiveness of a Butyrate Formulation and Butyrate + Polyphenol Formulation on Gut Health, Permeability and Associated Symptoms

NCT06419231
View directory record Official record
Conditions
Gut Health
Interventions
Butyrate Formulation, Butyrate + Polyphenol Formulation, Placebo
Dietary Supplement
Lead sponsor
Supplement Formulators, Inc.
Industry
Eligibility
21 Years to 70 Years
Enrollment
143 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Sep 7, 2026, 5:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Suppression of Postprandial Monocyte Activation by Blueberries or Docosahexaenoic Acid in Humans

NCT02472171
View directory record Official record
Conditions
Inflammation
Interventions
High saturated fat meal, placebo powder and sunflower oil, High saturated fat meal, blueberry powder and sunflower oil, High saturated fat meal, placebo powder and DHA
Dietary Supplement
Lead sponsor
USDA, Western Human Nutrition Research Center
Federal
Eligibility
18 Years to 60 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Oct 29, 2018 · Synced Sep 7, 2026, 5:30 AM EDT
Completed Not applicable Interventional

Cocoa and Metabolic Health in Prediabetes

NCT02203240
View directory record Official record
Conditions
Prediabetes
Interventions
Cocoa, Placebo
Other
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
40 Years to 75 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Blacksburg, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 20, 2023 · Synced Sep 7, 2026, 5:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Bioavailability of Aronia Berry Polyphenols

NCT05488886
View directory record Official record
Conditions
Gut Health, Metabolism, Polyphenols
Interventions
Whole Aronia Berry Powder Applesauce, Aronia Berry Extract Applesauce, Phospholipid-Polyphenol Applesauce, Low-Polyphenol Control Applesauce
Dietary Supplement · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 30, 2023 · Synced Sep 7, 2026, 5:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

MINDSpeed Food and Brain Training RCT

NCT03419052
View directory record Official record
Conditions
Low Education, Cognition, Cognitive Training, Polyphenols
Interventions
Speed of processing training, MIND foods, Cognitive training control, Control foods
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
60 Years and older
Enrollment
212 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 6, 2025 · Synced Sep 7, 2026, 5:30 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Metabolism of Bioactive Dietary Polyphenol Preparation (BDPP)

NCT04421079
View directory record Official record
Conditions
Healthy Control
Interventions
Trans-resveratrol, Concord grape juice, Grape seed polyphenol extract, Placebo
Dietary Supplement · Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 55 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 2, 2025 · Synced Sep 7, 2026, 5:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effect of Concord Grape Polyphenol-soy Protein Isolate Complex (GP-SPI) on Gut Microbiota

NCT04018066
View directory record Official record
Conditions
Mechanisms, Defense
Interventions
GP-SPI
Dietary Supplement
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 35 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Sep 7, 2026, 5:30 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Olive Oil Polyphenols and Cardiovascular Health Biomarkers

NCT04149288
View directory record Official record
Conditions
Healthy, Normal Weight, Overweight, Obese
Interventions
High-polyphenol olive oil, Low-polyphenol olive oil
Dietary Supplement
Lead sponsor
University of California, Davis
Other
Eligibility
20 Years to 45 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Sep 7, 2026, 5:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Oral Pomegranate Extract on the Microbiome and Skin Biophysical Properties

NCT04596722
View directory record Official record
Conditions
Human Microbiome
Interventions
Pomella, Placebo
Dietary Supplement · Other
Lead sponsor
Integrative Skin Science and Research
Industry
Eligibility
25 Years to 55 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Apr 12, 2021 · Synced Sep 7, 2026, 5:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude

NCT04111263
View directory record Official record
Conditions
Gastrointestinal Injury, Acute Mountain Sickness
Interventions
FP, Placebo, High altitude, Sea level
Dietary Supplement · Other
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
17 Years to 39 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 22, 2022 · Synced Sep 7, 2026, 5:30 AM EDT