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Conditions: Pregnancy; Proteinuria, With Hypertension (Severe Pre-eclampsia), Delivery; Proteinuria, With Gestational Hypertension (Pre-eclampsia, Severe), Pregnancy; Hypertension, Gestational Hypertension, With Albuminuria (Severe Pre-eclampsia)
Interventions: Not listed
Lead sponsor: University of Mississippi Medical Center; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Jackson, Mississippi

Conditions: Obesity, Pre-hypertension, Hypertension
Interventions: Stretching Training; Other
Lead sponsor: Florida State University; Other
Eligibility: 50 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011
U.S. locations: 1
States / cities: Tallahassee, Florida

Conditions: Preeclampsia
Interventions: Pravastatin, Placebo; Drug
Lead sponsor: The University of Texas Medical Branch, Galveston; Other
Eligibility: 18 Years and older · Female only
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2024
U.S. locations: 3
States / cities: Chicago, Illinois • Pittsburgh, Pennsylvania • Galveston, Texas

Conditions: Pre-Eclampsia, Obesity, Gestational Diabetes, Gestational Hypertension
Interventions: Women's Health Delaware Food Farmacy, Usual Standard of Care; Other
Lead sponsor: Christiana Care Health Services; Other
Eligibility: 18 Years and older · Female only
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Newark, Delaware

Conditions: Preeclampsia, Anxiety, Hypertension, Pregnancy, Eclampsia, HELLP
Interventions: Graphic card, Video; Other
Lead sponsor: Geisinger Clinic; Other
Eligibility: Female only
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 2
States / cities: Danville, Pennsylvania • Forty Fort, Pennsylvania

Conditions: Pregnant Women With Singleton Pregnancies
Interventions: Food Kit; Other
Lead sponsor: Texas A&M University; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 800 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 3
States / cities: College Station, Texas • Dallas, Texas • Mansfield, Texas

Conditions: Preeclampsia, Severe Preeclampsia, Eculizumab, HELLP, HELLP Syndrome, HELLP Syndrome Second Trimester, Pregnancy Related, AHUS, PNH, Complement Regulatory Factor Defect, Complement Abnormality, HELLP Syndrome Third Trimester
Interventions: Eculizumab; Drug
Lead sponsor: Cedars-Sinai Medical Center; Other
Eligibility: 13 Years and older · Female only
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Gestational Hypertension, Preeclampsia, Chronic Hypertension Complicating Pregnancy
Interventions: App-based remote blood pressure monitoring, text-message based remote blood pressure monitoring; Behavioral
Lead sponsor: Women and Infants Hospital of Rhode Island; Other
Eligibility: 18 Years to 55 Years · Female only
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Preeclampsia, Gestational Hypertension
Interventions: spironolactone 25 mg orally once daily, Placebo tablet to match spironolactone; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older · Female only
Enrollment: 204 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 3
States / cities: Boston, Massachusetts • Pittsburgh, Pennsylvania

Conditions: Preeclampsia, Hypertension in Pregnancy
Interventions: Labetalol, Nifedipine; Drug
Lead sponsor: Medical College of Wisconsin; Other
Eligibility: 18 Years and older · Female only
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2026
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Cardiovascular Risk Factor, Insulin Resistance, PreDiabetes, Diabetes, Coronary Artery Disease, Hypertension, Prehypertension, Dyslipidemias
Interventions: Use of HealthPals (Telemedicine supported by digital health platform); Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 38 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Stanford, California

Conditions: Pre-Eclampsia
Interventions: L-arginine supplementation in a medical food, Vitamin C and E supplementation in a medical food; Procedure
Lead sponsor: Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes; Government
Eligibility: 19 Years to 32 Years · Female only
Enrollment: 585 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2006
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Obesity, Pre-Hypertension, Hyperuricemia
Interventions: Allopurinol, Probenecid, Placebo; Drug
Lead sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); NIH
Eligibility: 11 Years to 18 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Preeclampsia, Maternal, Hypertension, Pregnancy
Interventions: Sphygmomanometer; Device
Lead sponsor: University of California, Irvine; Other
Eligibility: 18 Years and older · Female only
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Orange, California

Conditions: Pre-hypertension
Interventions: carvedilol phosphate, lisinopril, carvedilol phosphate and lisinopril, placebo and placebo; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 19 Years and older
Enrollment: 101 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Diabetes, Pre-diabetes, Hypertension, Overweight and Obesity
Interventions: Multi-level, community-digital health promotion intervention; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 664 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 2
States / cities: Washington D.C., District of Columbia • Baltimore, Maryland

Conditions: Heart Diseases, Hypertension, Pulmonary
Interventions: tezosentan, placebo; Drug
Lead sponsor: Idorsia Pharmaceuticals Ltd.; Industry
Eligibility: 18 Years and older
Enrollment: 274 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 9
States / cities: Stanford, California • New York, New York • Durham, North Carolina + 5 more

Conditions: Prehypertension
Interventions: Marealis refined peptide concentrate, Placebo; Dietary Supplement
Lead sponsor: KGK Science Inc.; Industry
Eligibility: 30 Years to 75 Years
Enrollment: 144 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Addison, Illinois

Conditions: Blood Pressure
Interventions: Internet-enabled automated self-management program, BP cuff at workplace; Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 30 Years to 65 Years
Enrollment: 404 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Pregnancy, Preeclampsia (PE)
Interventions: 17 OHPC; Drug
Lead sponsor: University of Mississippi Medical Center; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2027
U.S. locations: 1
States / cities: Jackson, Mississippi

Conditions: Prehypertension (elevated Blood Pressure) or Hypertension
Interventions: H1 receptor blockade: 540 mg (Allegra), H2 receptor blockade: 40 mg (Pepcid AC); Genetic
Lead sponsor: California Baptist University; Other
Eligibility: 18 Years to 30 Years · Male only
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Riverside, California

Conditions: Hypertension in Pregnancy, Gestational Hypertension, Preeclampsia, Chronic Hypertension With Pre-Eclampsia, Eclampsia, Chronic Hypertension in Obstetric Context
Interventions: virtual cardiac wellness program, Placebo comparator; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older · Female only
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Prediabetes, Prehypertension
Interventions: Vitamin D supplementation; Other
Lead sponsor: Pennington Biomedical Research Center; Other
Eligibility: 18 Years and older
Enrollment: 18 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2013
U.S. locations: 7
States / cities: Baton Rouge, Louisiana • Covington, Louisiana • Durham, North Carolina + 1 more

Conditions: High Blood Pressure, Metabolic Syndrome, Insulin Resistance, Endothelial Dysfunction
Interventions: Aliskiren, Amlodipine, Placebo Aliskiren, Placebo Amlodipine; Drug
Lead sponsor: Novartis Pharmaceuticals; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Santa Monica, California

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Impedance Cardiographic (ICG) Assessment of Pregnant Women With Severe Hypertension to Assess Impact of Standard Therapy

The Effects of Stretching Training on Arterial Function and Autonomic Control

Pravastatin for Prevention of Preeclampsia

Evaluating the Effectiveness of a Food is Medicine Community Health Worker Program for Pregnant Women

Comparing Different Methods of Patient Education on Preeclampsia

Harvesting Health: Advancing Nutrition and Wellness for Moms and Babies

Complement Regulation to Undo Systemic Harm in Preeclampsia

App-based Remote Blood Pressure Monitoring

Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories

Preeclampsia Postpartum Antihypertensive Treatment

Chronic Cardiovascular Risk Outpatient Management in South Asians Using Digital Health Technology

L-Arginine and Antioxidant Vitamins During Pregnancy to Reduce Preeclampsia

Primary Prevention of Hypertension in Obese Adolescents

A Comparison of BNP Levels Using the Nexfin Device in Healthy Pregnant and Preeclamptic Women

Efficacy of Coreg CR and Lisinopril on Markers for Cardiovascular Functional and Structural Disease

Community Engagement Alliance Against Disparities

Study of the Efficacy and Safety of Tezosentan in Patients With Pre-operative Pulmonary Hypertension, Due to Left Heart Disease, Undergoing Open Heart Surgery

Effect and Safety of Marealis RPC (Refined Peptide Concentrate) in Mild or Moderate Hypertensive Subjects

Blood Pressure Self Management for Hypertension & Prehypertension Using an Internet Enabled, Automated Self Management Program

Progesterone to Enhance the Efficacy and Success of Expectantly Managed Preterm Severe/Superimposed Preeclampsia

Effect of Aerobic Exercise with Blood Flow Restriction on Post-exercise Hypotension in Young Adults: the Role of Histamine Receptors

Virtual Cardiac Wellness Program Following Hypertensive Disorders of Pregnancy

Prediabetes, Prehypertension and Vitamin D Supplementation - A Practice Based Clinical Intervention Pilot Study

Comparison of Aliskiren and Amlodipine on Insulin Resistance and Endothelial Dysfunction in Patients With Hypertension and Metabolic Syndrome