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Showing 1–24 of 167 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Prediabetes (Insulin Resistance, Impaired Glucose Tolerance) Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Fuel Utilization, Diet Composition, and Exercise in African American Women

NCT04293367
View directory record Official record
Conditions
Obesity, Diabetes, Insulin Resistance
Interventions
High Intensity Interval Training (HIIT)
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
20 Years to 40 Years · Female only
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 2, 2020 · Synced Jul 23, 2026, 8:13 PM EDT
Recruiting Not applicable Interventional

Stand up for Your Health With a Sit-stand Desk

NCT05585190
View directory record Official record
Conditions
Pre Diabetes, Obesity, Metabolic Syndrome, Sedentary Behavior
Interventions
Control, Sit-Stand Desk at Work
Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 79 Years
Enrollment
198 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Jul 23, 2026, 8:13 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Vitamin K and Glucose Metabolism in Children at Risk for Diabetes (Vita-K 'n' Kids Study)

NCT01972113
View directory record Official record
Conditions
Obesity, Insulin Resistance, Insulin Sensitivity, Prediabetes, Dyslipidemia, Diabetes
Interventions
Placebo-Control, Low-Dose Vitamin K2 (menaquinone-7; 45 mcg/d), High-Dose Vitamin K2 (menaquinone-7; 90 mcg/d)
Dietary Supplement
Lead sponsor
Augusta University
Other
Eligibility
8 Years to 17 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2020
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 18, 2019 · Synced Jul 23, 2026, 8:13 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Physical Activity Following Surgery Induced Weight Loss

NCT00692367
View directory record Official record
Conditions
Obesity
Interventions
Physical Activity
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
21 Years to 60 Years
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2012
U.S. locations
2
States / cities
Greenville, North Carolina • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 3, 2014 · Synced Jul 23, 2026, 8:13 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Weight Loss Using a Feedback Device in Obese People With the Metabolic Syndrome

NCT03491930
View directory record Official record
Conditions
Weight Loss, Obesity, Pre-Diabetes, Metabolic Syndrome
Interventions
VA MOVE! Coach app, Telephone Coaching, Standard of Care for weight loss.
Device · Behavioral
Lead sponsor
Rockefeller University
Other
Eligibility
40 Years to 70 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 23, 2018 · Synced Jul 23, 2026, 8:13 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Fructose: Substrate, Stimulus, or Both?

NCT04168372
View directory record Official record
Conditions
Insulin Resistance, Insulin Sensitivity, Pre Diabetes
Interventions
High fructose, fructose labeled meal, High fructose, pyruvate labeled meal, Low fructose, fructose labeled meal, Low fructose, pyruvate labeled meal
Other
Lead sponsor
Touro University, California
Other
Eligibility
20 Years to 55 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
Vallejo, California
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Jul 23, 2026, 8:13 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Metformin and Muscle in Insulin-resistant Older Veterans

NCT01804049
View directory record Official record
Conditions
Prediabetes
Interventions
metformin, placebo
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
65 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 10, 2020 · Synced Jul 23, 2026, 8:13 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Cognitive Effects of Aerobic Exercise for IGT Adults

NCT00220441
View directory record Official record
Conditions
Impaired Glucose Tolerance
Interventions
Aerobic exercise
Behavioral
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
55 Years to 90 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
2
States / cities
Seattle, Washington • Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Jul 29, 2008 · Synced Jul 23, 2026, 8:13 PM EDT
Completed Not applicable Interventional

Effects of Lean Pork, High Protein Breakfast on Satiety and Metabolic Health in Pre-diabetes

NCT02934425
View directory record Official record
Conditions
Pre-diabetes
Interventions
Refined carbohydrate-rich breakfast, High pork protein breakfast
Other
Lead sponsor
Midwest Center for Metabolic and Cardiovascular Research
Other
Eligibility
18 Years to 74 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 14, 2018 · Synced Jul 23, 2026, 8:13 PM EDT
Completed Not applicable Interventional

Pathobiology and Reversibility of Prediabetes in a Biracial Cohort

NCT02027571
View directory record Official record
Conditions
Prediabetes, Type 2 Diabetes, Obesity
Interventions
Intensive Lifestyle Intervention (ILI)
Behavioral
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years to 65 Years
Enrollment
223 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 14, 2018 · Synced Jul 23, 2026, 8:13 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Study of the Function of Hormones Present In Taste Buds

NCT00233298
View directory record Official record
Conditions
Diabetes, Obesity, Pre-Diabetes, Metabolic Syndrome
Interventions
Not listed
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
12 Years to 50 Years
Enrollment
225 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 4, 2018 · Synced Jul 23, 2026, 8:13 PM EDT
Completed No phase listed Observational

Novel Therapy for Glucose Intolerance in HIV Disease

NCT02006914
View directory record Official record
Conditions
Insulin Resistance
Interventions
Chromium Picolinate
Dietary Supplement
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years and older
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2012
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Dec 9, 2013 · Synced Jul 23, 2026, 8:13 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

NCT06007404
View directory record Official record
Conditions
Type 2 Diabetes, Insulin Resistance, Obesity, Metabolic Disease, PreDiabetes
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
14 Years to 18 Years
Enrollment
175 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Jul 23, 2026, 8:13 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effects of Liraglutide on Hippocampal Structure and Function in Aging Adults With Prediabetes

NCT02140983
View directory record Official record
Conditions
Insulin Resistance, Dementia
Interventions
Liraglutide, Placebo
Drug
Lead sponsor
Stanford University
Other
Eligibility
50 Years to 70 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jan 24, 2018 · Synced Jul 23, 2026, 8:13 PM EDT
Completed Phase 2 Interventional Results available

To Compare the Effect of a Subcutaneous Canakinumab Administration to Placebo in Patients With Impaired Glucose Tolerance or Patients With Type 2 Diabetes With Differing Baseline Diabetes Therapies

NCT01068860
View directory record Official record
Conditions
Type 2 Diabetes Mellitus, Impaired Glucose Tolerance
Interventions
Canakinumab 150 mg, Placebo to Canakinumab
Drug
Lead sponsor
Novartis
Industry
Eligibility
18 Years to 74 Years
Enrollment
246 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
11
States / cities
Los Angeles, California • Santa Ana, California • Spring Valley, California + 7 more
Source: ClinicalTrials.gov public record
Updated Sep 4, 2011 · Synced Jul 23, 2026, 8:13 PM EDT
Completed No phase listed Observational Results available

Antihypertensive Medication Exposure as Risk for Impaired Glucose Tolerance: A PEAR Sub-Study

NCT01099397
View directory record Official record
Conditions
Prediabetic State
Interventions
Oral glucose tolerance test
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 2, 2018 · Synced Jul 23, 2026, 8:13 PM EDT
Completed Not applicable Interventional

Nutri Diet Goal Setting Software Pilot Trial

NCT05436041
View directory record Official record
Conditions
Type 2 Diabetes, Pre-diabetes, Metabolic Syndrome
Interventions
Collaborative Diet Goal Setting Clinical Decision Support
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 65 Years
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Oct 11, 2023 · Synced Jul 23, 2026, 8:13 PM EDT
Completed Phase 2 Interventional

Rosiglitazone to Reverse Metabolic Defects in Diabetes

NCT00094796
View directory record Official record
Conditions
Diabetes Mellitus, Type II, Insulin Resistance
Interventions
Exercise cardiopulmonary metabolic testing, Skeletal muscle biopsy, Brachial artery reactivity testing
Procedure
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
22 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
2
States / cities
Bethesda, Maryland • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Jul 23, 2026, 8:13 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Composition & Function of Sarcoplasmic Reticulum in Persons With the Metabolic Syndrome

NCT02122666
View directory record Official record
Conditions
Metabolic Syndrome
Interventions
muscle biopsy
Procedure
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2024
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 25, 2024 · Synced Jul 23, 2026, 8:13 PM EDT
Completed Not applicable Interventional

Women's Lifestyle Balance Study

NCT03184337
View directory record Official record
Conditions
PreDiabetes, Metabolic Syndrome, Overweight
Interventions
CDC's PreventT2 Program, CDC's PreventT2 Program with Added Sleep Content
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
30 Years to 70 Years · Female only
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 24, 2018 · Synced Jul 23, 2026, 8:13 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Insulin Sensitivity Using Aerobic Interval Conditioning

NCT01286922
View directory record Official record
Conditions
Pre-diabetes
Interventions
Behavioral: exercise
Other
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
30 Years to 60 Years · Male only
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Sep 14, 2022 · Synced Jul 23, 2026, 8:13 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Northern Manhattan Study of Metabolism and Mind

NCT02470260
View directory record Official record
Conditions
Diabetes, Pre-diabetes, Cognition - Other, Depressive Symptoms, Metabolic Syndrome
Interventions
Not listed
Lead sponsor
Columbia University
Other
Eligibility
50 Years to 64 Years
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 6, 2025 · Synced Jul 23, 2026, 8:13 PM EDT
Terminated No phase listed Interventional Results available

Vestibular Stimulation to Trigger Adipose Loss Clinical Trial

NCT03138369
View directory record Official record
Conditions
Obesity, Obesity, Abdominal, Metabolic Syndrome, Weight Loss
Interventions
Vestibular nerve stimulator, Sham vestibular stimulation
Device
Lead sponsor
Neurovalens Ltd.
Industry
Eligibility
22 Years to 80 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 26, 2022 · Synced Jul 23, 2026, 8:13 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Mood and Insulin Resistance in Adolescents At-Risk for Diabetes

NCT01425905
View directory record Official record
Conditions
Depression, Impaired Glucose Tolerance
Interventions
The Blues Program, Hey Durham
Other
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
12 Years to 17 Years · Female only
Enrollment
174 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 15, 2019 · Synced Jul 23, 2026, 8:13 PM EDT