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Showing 1–24 of 87 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Prehypertension Clear all
Terminated Not applicable Interventional

A Pivotal Study To Evaluate The Effectiveness of Isometric Handgrip Therapy In Prehypertensive And Hypertensive Patients

NCT04467879
View directory record Official record
Conditions
Hypertension, Systolic
Interventions
Zona Plus Device, Control Device
Device
Lead sponsor
Zona Health, Inc
Industry
Eligibility
18 Years to 80 Years
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
5
States / cities
St Louis, Missouri • Charlotte, North Carolina • Goldsboro, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2022 · Synced Sep 8, 2026, 8:28 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Personalized Blood Pressure Care Using IoMTs and Artificial Intelligence

NCT04543656
View directory record Official record
Conditions
Pre-hypertension
Interventions
AI-Based Lifestyle Recommendations, No Lifestyle Recommendations
Behavioral · Other
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Sep 27, 2021 · Synced Sep 8, 2026, 8:28 AM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Vascular Dysfunction in Human Obesity Hypertension

NCT01983462
View directory record Official record
Conditions
Obesity, Prehypertension, Hypertension
Interventions
Clonidine, Hydrochlorothiazide, Placebo
Drug
Lead sponsor
Gary L. Pierce
Other
Eligibility
18 Years to 79 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2020
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Apr 13, 2023 · Synced Sep 8, 2026, 8:28 AM EDT
Not listed Not applicable Interventional

Rice Vinegar as an Intervention to Lower Blood Pressure in Adults With Prehypertension and 10-year CVD Risk <10%

NCT03596099
View directory record Official record
Conditions
Prehypertension
Interventions
Mizkan rice vinegar with acetic acid, Mizkan rice vinegar without acetic acid
Dietary Supplement
Lead sponsor
Mizkan Holdings Co., Ltd.
Industry
Eligibility
30 Years to 65 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
2
States / cities
Atlanta, Georgia • Bellaire, Texas
Source: ClinicalTrials.gov public record
Updated Jul 29, 2019 · Synced Sep 8, 2026, 8:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of 7 Days of Grape Seed Extract Supplementation on Cold Pressor Test and Muscle Metaboreflex in Individuals With Elevated and Stage 1 Hypertension

NCT06428890
View directory record Official record
Conditions
Prehypertension
Interventions
Grape Seed Extract, Placebo
Dietary Supplement
Lead sponsor
California Baptist University
Other
Eligibility
18 Years to 30 Years · Male only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Riverside, California
Source: ClinicalTrials.gov public record
Updated May 23, 2024 · Synced Sep 8, 2026, 8:28 AM EDT
Completed Not applicable Interventional

Improving Physical Activity Through a mHealth Intervention in Cardio-metabolic Risk Patients

NCT02551640
View directory record Official record
Conditions
Diabetes Mellitus, Type 2, Prediabetic State, Hypertension, Prehypertension, Obesity
Interventions
FeatForward App (on study smartphone)
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
2
States / cities
Charlestown, Massachusetts • Revere, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 31, 2020 · Synced Sep 8, 2026, 8:28 AM EDT
Completed No phase listed Observational

ReNEW Clinic Cohort Study

NCT03816462
View directory record Official record
Conditions
Hypertension, Prehypertension, Obesity, Overweight, Left Ventricular Hypertrophy, Elevated Blood Pressure
Interventions
Not listed
Lead sponsor
Johns Hopkins University
Other
Eligibility
Up to 22 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 19, 2026 · Synced Sep 8, 2026, 8:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Low-intensity Resistance Exercise and Diet on Arterial Function and Blood Pressure

NCT01371370
View directory record Official record
Conditions
Obesity, Pre-hypertension, Hypertension
Interventions
Resistance exercise training, Hypocaloric diet, Resistance exercise training & diet
Other
Lead sponsor
Florida State University
Other
Eligibility
40 Years to 65 Years · Female only
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Aug 4, 2014 · Synced Sep 8, 2026, 8:28 AM EDT
Terminated Not applicable Interventional

Study of Hispanics to Assess Risk Prevention in Prehypertension

NCT01025323
View directory record Official record
Conditions
Pre-Hypertension
Interventions
Lifestyle modification
Behavioral
Lead sponsor
Florida Heart Research Institute
Other
Eligibility
18 Years to 75 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Mar 12, 2013 · Synced Sep 8, 2026, 8:28 AM EDT
Not yet recruiting Phase 3 Interventional

A Study of Orforglipron in Participants With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity

NCT07794579
View directory record Official record
Conditions
Overweight, Prediabetic State, Prehypertension, Obesity, Abdominal
Interventions
Orforglipron, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
2,001 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
79
States / cities
Anniston, Alabama • Birmingham, Alabama • Pelham, Alabama + 73 more
Source: ClinicalTrials.gov public record
Updated Aug 30, 2026 · Synced Sep 8, 2026, 8:28 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Nebivolol and Endothelial Regulation of Fibrinolysis (NERF)

NCT01595516
View directory record Official record
Conditions
Prehypertension, Hypertension
Interventions
Nebivolol, Metoprolol, Placebo, Bradykinin, Saline, Vitamin C
Drug · Other
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
45 Years to 65 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 24, 2019 · Synced Sep 8, 2026, 8:28 AM EDT
Terminated Phase 2 Interventional

Telephone-Based Lifestyle Intervention to Reduce Blood Pressure in Prehypertensive Patients

NCT00583310
View directory record Official record
Conditions
High Blood Pressure
Interventions
Telephone-based lifestyle counseling
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 18, 2013 · Synced Sep 8, 2026, 8:28 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Prehypertension Labeling

NCT01434953
View directory record Official record
Conditions
Prehypertension
Interventions
Labeled prehypertension, Unlabeled prehypertension
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 16, 2017 · Synced Sep 8, 2026, 8:28 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Efficacy of Coreg CR and Lisinopril on Markers for Cardiovascular Functional and Structural Disease

NCT00553969
View directory record Official record
Conditions
Pre-hypertension
Interventions
carvedilol phosphate, lisinopril, carvedilol phosphate and lisinopril, placebo and placebo
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
19 Years and older
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 23, 2018 · Synced Sep 8, 2026, 8:28 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

The Effect of Hibiscus Sabdariffa L. Tea on Blood Pressure

NCT00175110
View directory record Official record
Conditions
Hypertension
Interventions
herbal therapy/botanical therapy (Hibiscus sabdariffa)
Behavioral
Lead sponsor
Tufts University
Other
Eligibility
30 Years to 70 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Ends 2007
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 2, 2009 · Synced Sep 8, 2026, 8:28 AM EDT
Completed Not applicable Interventional

The Hypotensive Effects of Home-Based Isometric Handgrip Training in Older Adults With Pre-Hypertension and Hypertension - The HoldAge Trial

NCT04275037
View directory record Official record
Conditions
Hypertension, Pre-Hypertension
Interventions
Isometric Handgrip Training, Aerobic Exercise Training
Other
Lead sponsor
University Institute of Maia
Other
Eligibility
65 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated May 21, 2023 · Synced Sep 8, 2026, 8:28 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Community Park-Based Programs for Health Promotion: Fit2Play Prospective Cohort Study

NCT06595251
View directory record Official record
Conditions
Overweight, Obesity, Hypertension, Prehypertension, Anxiety, Well-being, Depression, Low Physical Fitness, Psychological
Interventions
Fit2Play curriculum
Other
Lead sponsor
Duke University
Other
Eligibility
6 Years to 14 Years
Enrollment
5,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Sep 3, 2025 · Synced Sep 8, 2026, 8:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Whey Protein on Blood Pressure

NCT00659672
View directory record Official record
Conditions
High Blood Pressure
Interventions
Whey Protein, Soy Protein, Control (carbohydrate)
Dietary Supplement
Lead sponsor
United States Department of Agriculture (USDA)
Federal
Eligibility
28 Years to 70 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Beltsville, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 8, 2011 · Synced Sep 8, 2026, 8:28 AM EDT
Completed Not applicable Interventional

Restoring Sleep Homeostasis to Lower Blood Pressure

NCT01008176
View directory record Official record
Conditions
Hypertension, Pre-hypertension
Interventions
Sleep extension
Behavioral
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
25 Years to 65 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 13, 2017 · Synced Sep 8, 2026, 8:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects and Mechanisms of Melatonin on Blood Pressure, Insulin Resistance, and Platelets

NCT03178396
View directory record Official record
Conditions
Prehypertension, Healthy
Interventions
melatonin
Dietary Supplement
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 7, 2017 · Synced Sep 8, 2026, 8:28 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Center of Research Translation (CORT) Project 2

NCT02038179
View directory record Official record
Conditions
Pre-hypertension, JNC 7 Stage I Hypertension
Interventions
Allopurinol, Placebo
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 40 Years
Enrollment
99 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 10, 2021 · Synced Sep 8, 2026, 8:28 AM EDT
Completed Not applicable Interventional

Heat & Aerobic Training (HEAT) Study

NCT02546726
View directory record Official record
Conditions
Pre-hypertension
Interventions
Heat & Aerobic Training (HEAT), Exercise Only
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
45 Years to 64 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 16, 2019 · Synced Sep 8, 2026, 8:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Diet and Whole-body Vibration Training on Cardiovascular and Autonomic Function

NCT01741779
View directory record Official record
Conditions
Obesity, Pre-hypertension, Hypertension
Interventions
Whole Body Vibration Training, Hypocaloric diet, Whole body vibration training & diet
Other
Lead sponsor
Florida State University
Other
Eligibility
45 Years to 65 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Dec 4, 2012 · Synced Sep 8, 2026, 8:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reducing Blood Pressure in Prehypertensive Older Rural Women Also Known as Wellness for Women: DASHing Toward Health

NCT00580528
View directory record Official record
Conditions
Pre-Hypertension
Interventions
Tailored Internet Newsletters, Tailored print newsletters delivered via mail
Behavioral
Lead sponsor
University of Nebraska
Other
Eligibility
40 Years to 69 Years · Female only
Enrollment
289 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2011
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Aug 31, 2023 · Synced Sep 8, 2026, 8:28 AM EDT