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Conditions: Prenatal Care
Interventions: CenteringPregnancy; Behavioral
Lead sponsor: University of Arkansas; Other
Eligibility: 18 Years and older · Female only
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Springdale, Arkansas

Conditions: Alloimmune Thrombocytopenia, Fetal Alloimmune Thrombocytopenia
Interventions: IVIG (Intravenous Immunoglobulin), prednisone; Drug
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 102 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2015
U.S. locations: 1
States / cities: New York, New York

Conditions: Persistent Pulmonary Hypertension of the Newborn
Interventions: IV Remodulin, Placebo; Drug
Lead sponsor: United Therapeutics; Industry
Eligibility: 1 Hour to 14 Days
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2023
U.S. locations: 14
States / cities: Little Rock, Arkansas • Los Angeles, California • Palo Alto, California + 11 more

Conditions: Pregnancy, Preterm Labor, Maternal Fetal Factors, Preterm Birth
Interventions: Not listed
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: 18 Years to 45 Years
Enrollment: 746 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Fetal Growth Restriction (FGR), Placental Insufficiency, Preeclampsia, Still Births, Pregnancy, Pregnancy Complications, Pregnancy Outcomes, Ultrasound
Interventions: ultrafast power Doppler imaging (uPDI) / quantitative ultrasound (QUS); Device
Lead sponsor: Carilion Clinic; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Nonimmune Fetal Hydrops, Nonimmune Hydrops in Neonate, Genetic Disorders
Interventions: Whole Exome Sequencing, Whole Genome Sequencing; Diagnostic Test
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 16 Years to 55 Years
Enrollment: 55 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Congenital Heart Disease
Interventions: Not listed
Lead sponsor: Medical College of Wisconsin; Other
Eligibility: Up to 12 Weeks
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2016
U.S. locations: 2
States / cities: Madison, Wisconsin • Milwaukee, Wisconsin

Conditions: Lower Urinary Tract Obstructive Syndrome, Lower Urinary Tract Obstruction, Congenital, Bladder Outlet Obstruction, Bladder Outflow Obstruction
Interventions: Fetoscopes, Fetal Cystoscopy; Device · Procedure
Lead sponsor: Rodrigo Ruano; Other
Eligibility: 18 Years and older · Female only
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2028
U.S. locations: 2
States / cities: Miami, Florida • Rochester, Minnesota

Conditions: Fetal Development
Interventions: Not listed
Lead sponsor: University of Tennessee; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 2
States / cities: Memphis, Tennessee

Conditions: Fetal Alcohol Spectrum Disorders, Fetal Alcohol Syndrome, Partial Fetal Alcohol Syndrome, Alcohol-related Neurodevelopmental Disorder, Prenatal Alcohol Exposure
Interventions: Choline, placebo supplementation consisting of vegetable glycerin (50% by volume) and deionized water; Dietary Supplement
Lead sponsor: San Diego State University; Other
Eligibility: 5 Years to 10 Years
Enrollment: 55 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: San Diego, California

Conditions: Type 1 Diabetes, Pregnancy in Diabetic
Interventions: Not listed
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 0 Days to 99 Years
Enrollment: 6,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2032
U.S. locations: 4
States / cities: Aurora, Colorado • Boston, Massachusetts • New York, New York + 1 more

Conditions: Preterm Less Than 32wks With IVH, WMI/PVL, Late Preterm or Term (37-42wks) With Neonatal Encephalopathy Treated With Hypothermia for HIE
Interventions: Prospective Clinical and Neurodevelopmental Data Collection; Other
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 31 Weeks to 42 Weeks
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Deglutition Disorder, High Risk Pregnancy
Interventions: Not listed
Lead sponsor: National Institutes of Health Clinical Center (CC); NIH
Eligibility: Not listed
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2000 – 2004
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Cardiovascular Phenotype, Metabolic Phenotype, Hypertensive Disease, Psychological Phenotype, Audio
Interventions: Not listed
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: 18 Years to 99 Years · Female only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Methamphetamine Abuse, Newborn Complication &#X7C; Patient &#X7C; Neonatalology
Interventions: Not listed
Lead sponsor: University of California, Davis; Other
Eligibility: Not listed
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Marysville, California • Sacramento, California

Conditions: Atrial Flutter, Tachycardia, Supraventricular, Tachycardia, Atrial Ectopic, Tachycardia, Reciprocating, Tachycardia Atrial, Tachycardia, Atrioventricular Nodal Reentry, Tachycardia, Paroxysmal, Fetal Hydrops
Interventions: Prospective observational cohorts; Other
Lead sponsor: Edgar Jaeggi; Other
Eligibility: 16 Years to 50 Years · Female only
Enrollment: 330 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2025
U.S. locations: 18
States / cities: Phoenix, Arizona • San Francisco, California • Denver, Colorado + 15 more

Conditions: Kangaroo Care, Video, Prenatal Education, Skin-to-skin
Interventions: "Jumping into Kangaroo Care" - a video created by the Ohio Department of Health; Other
Lead sponsor: Kettering Health Network; Other
Eligibility: 18 Years and older · Female only
Enrollment: 240 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017
U.S. locations: 1
States / cities: Centerville, Ohio

Conditions: Prenatal Care, Maternal-child Health Services, Maternal Health Services, Perinatal Care, Midwifery
Interventions: Collaborative Care, Comparison Care- Usual Care + primary midwife; Behavioral
Lead sponsor: Vanderbilt University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 182 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Pregnancy, Child Development
Interventions: DHA, Sugar pill; Dietary Supplement
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years to 34 Years · Female only
Enrollment: 168 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Pregnancy
Interventions: Perelel Prenatal Vitamin, Generic Prenatal Vitamin; Dietary Supplement
Lead sponsor: University of Pittsburgh; Other
Eligibility: 14 Years and older · Female only
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Pregnancy Related, Substance Use, Mental Health Issue
Interventions: NEXUS intervention, Standardized Non-Medical fetal ultrasound; Behavioral
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years to 45 Years
Enrollment: 103 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature, Intracranial Hemorrhages, Leukomalacia, Periventricular, Cerebral Palsy
Interventions: Not listed
Lead sponsor: NICHD Neonatal Research Network; Network
Eligibility: Up to 14 Days
Enrollment: 1,339 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 1996 – 2000
U.S. locations: 15
States / cities: Birmingham, Alabama • Palo Alto, California • New Haven, Connecticut + 12 more

Conditions: High Risk Pregnancy, Congenital Heart Disease, Fetal Hydrops, Twin Monochorionic Monoamniotic Placenta, Gastroschisis, Fetal Demise, Stillbirth, Fetal Arrhythmia, Long QT Syndrome, Intrauterine Fetal Death, Sudden Infant Death, Pregnancy Loss, Twin Twin Transfusion Syndrome, Birth Defect, Fetal Cardiac Anomaly, Fetal Cardiac Disorder, Fetal Death, Brugada Syndrome, Fetal Tachycardia
Interventions: Fetal Magnetocardiogram and Neonatal Electrocardiogram, Substudy only: Maternal/Infant Pharmacogenomic assessment postnatally; Diagnostic Test · Genetic
Lead sponsor: Medical College of Wisconsin; Other
Eligibility: 18 Years and older · Female only
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2028
U.S. locations: 2
States / cities: Madison, Wisconsin • Milwaukee, Wisconsin

Conditions: Prenatal Care, Prenatal Diagnosis
Interventions: Not listed
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years and older · Female only
Enrollment: 78 participants
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Cleveland, Ohio

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Determine the Clinical Effectiveness of Mobile CenteringPregnancy to Improve Maternal and Infant Health Outcomes of Marshallese in Arkansas

A Trial of Antenatal Treatment of Alloimmune Thrombocytopenia

Remodulin as Add-on Therapy for the Treatment of Persistent Pulmonary Hypertension of the Newborn

Biomarkers in Obstetrical Complications

Placental Imaging Techniques

Whole Exome Sequencing and Whole Genome Sequencing for Nonimmune Fetal/Neonatal Hydrops

Parenting After Infant Congenital Heart Defect Diagnosis

Fetal Cystoscopy for Severe Lower Urinary Tract Obstruction

Biophysical Profile in Preterm Pregnancies

Choline Supplementation in Children With Fetal Alcohol Spectrum Disorders

PRenatal and Obstetric Maternal Exposures and ISlet Autoantibodies in Early Life

Cerebral/ Cortical Visual Impairment: Screening, Identification and Outcome Prediction in Neonates

Study of Fetal Swallowing

Implications of Maternal 45,X Mosaicism as a Secondary Genomic Finding Following Cell-Free DNA Sequencing During Pregnancy: A Deep Phenotype Study

Cardiovascular Effects of Prenatal Methamphetamine Exposure

Prospective Observational Cohort Study of Fetal Atrial Flutter & Supraventricular Tachycardia

The Effect of Video Education on Skin-to-Skin at the Time of Delivery

Collaboration for Antepartum Risk Evaluation

Improving Maternal and Child Health Through Prenatal Fatty Acid Supplementation

Perelel Prenatal Supplements vs. Generic Prenatal Supplements and Health of Mother and Baby (SUPPORT)

NEXUS - Next Generation Health Through 2D & 3D Fetal UltraSound; Building Connections to Support Maternal-fetal Health

In Utero Magnesium Sulfate Exposure: Effects on Extremely-Low-Birth-Weight Infants

Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise

Shifting Options Study