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Showing 1–24 of 139 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Presbyopia Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Clinical Trial of The VisAbility Micro Insert System for Presbyopic Patients

NCT02374671
View directory record Official record
Conditions
Presbyopia
Interventions
VisAbility Micro Insert
Device
Lead sponsor
Refocus Group, Inc.
Industry
Eligibility
45 Years to 60 Years
Enrollment
365 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
14
States / cities
Orange, California • San Diego, California • Honolulu, Hawaii + 10 more
Source: ClinicalTrials.gov public record
Updated Jan 5, 2020 · Synced Jul 21, 2026, 7:06 AM EDT
Completed Phase 4 Interventional

Evaluation of the Tecnis™ Multifocal and Crystalens™ Accommodating Intraocular Lenses

NCT01061281
View directory record Official record
Conditions
Aphakia
Interventions
Tecnis MF IOL, Crystalens AO IOL
Device
Lead sponsor
Innovative Medical
Industry
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Cape Coral, Florida
Source: ClinicalTrials.gov public record
Updated Jan 17, 2012 · Synced Jul 21, 2026, 7:06 AM EDT
Completed Not applicable Interventional

MULTICENTER, DOUBLE-ARM, PATIENT AND ASSESSOR-MASKED, PROSPECTIVE, RANDOMIZED CLINICAL TRIAL TO COMPARE VISUAL PERFORMANCE OF NEGATIVE AND NEUTRAL ASPHERIC MONOFOCAL INTRAOCULAR LENSES

NCT07385014
View directory record Official record
Conditions
Cataract, Presbyopia
Interventions
Neutral Aspheric Monofocal IOL, Negative Aspheric Monofocal IOL
Device
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years to 95 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Jul 21, 2026, 7:06 AM EDT
Completed Not applicable Interventional Results available

Clinical Validation Study of Comfilcon A Multifocal Toric Contact Lenses

NCT03417557
View directory record Official record
Conditions
Presbyopia
Interventions
Comfilcon A lens (test), Omafilcon B lens (control)
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
40 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated May 3, 2020 · Synced Jul 21, 2026, 7:06 AM EDT
Completed Not applicable Interventional Results available

Post Approval Study of the AcrySof® IQ ReSTOR® Toric IOLs

NCT03733730
View directory record Official record
Conditions
Aphakia, Presbyopia, Astigmatism
Interventions
ACRYSOF IQ RESTOR +3.0 Multifocal Toric IOL, ACRYSOF IQ RESTOR +2.5 D Multifocal Toric IOL, ACRYSOF IQ RESTOR +2.5 D Multifocal IOL, Cataract Surgery
Device · Procedure
Lead sponsor
Alcon Research
Industry
Eligibility
22 Years and older
Enrollment
2,449 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
37
States / cities
Dothan, Alabama • Phoenix, Arizona • Fresno, California + 32 more
Source: ClinicalTrials.gov public record
Updated Oct 31, 2023 · Synced Jul 21, 2026, 7:06 AM EDT
Recruiting Phase 4 Interventional

Quality of Life in Presbyopic Patients Who Are Treated With Qlosi

NCT07113210
View directory record Official record
Conditions
Presbyopia, Glasses, Dry Eye
Interventions
pilocarpine HCL ophthalmic solution
Drug
Lead sponsor
Southern College of Optometry
Other
Eligibility
45 Years to 64 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
2
States / cities
Medina, Minnesota • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 11, 2025 · Synced Jul 21, 2026, 7:06 AM EDT
Terminated Phase 2 Interventional Results available

A Dose-ranging Study to Evaluate the Safety and Efficacy of UNR844 in Subjects With Presbyopia.

NCT04806503
View directory record Official record
Conditions
Presbyopia
Interventions
UNR844, Placebo
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
45 Years to 55 Years
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
12
States / cities
Laguna Hills, California • Newport Beach, California • Largo, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Jun 19, 2024 · Synced Jul 21, 2026, 7:06 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Impact of a Novel Extended Depth of Focus Intraocular Lens on Visual and Lifestyle Enhancement

NCT04570579
View directory record Official record
Conditions
Cataract, Cataract Senile, Presbyopia
Interventions
Vivity Extended Depth of Focus Intraocular Lens
Device
Lead sponsor
Alanna Nattis, DO
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Babylon, New York
Source: ClinicalTrials.gov public record
Updated May 13, 2025 · Synced Jul 21, 2026, 7:06 AM EDT
Completed No phase listed Observational Results available

Synergy Lens Outcomes Evaluation

NCT05418153
View directory record Official record
Conditions
Presbyopia, Pseudophakia
Interventions
Tecnis Synergy IOL
Device
Lead sponsor
Center For Sight
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
2
States / cities
Venice, Florida • Mt. Pleasant, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 17, 2024 · Synced Jul 21, 2026, 7:06 AM EDT
Completed Not applicable Interventional Results available

Evaluation of Product Performance of a New Silicone Hydrogel Multifocal Contact Lens

NCT05660577
View directory record Official record
Conditions
Myopia and Hyperopia and Presbyopia
Interventions
new silicone hydrogel daily disposable multifocal contact lens, the Bausch + Lomb (kalifilcon A) Daily Disposable Multifocal Contact Lens
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
40 Years and older
Enrollment
301 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
20
States / cities
San Diego, California • San Francisco, California • Denver, Colorado + 16 more
Source: ClinicalTrials.gov public record
Updated Apr 8, 2024 · Synced Jul 21, 2026, 7:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assessment of Three Basic Progressive Lens Designs

NCT05252871
View directory record Official record
Conditions
Presbyopia
Interventions
Progressive Additional Lenses (PAL), pre calibrated and made of polymeric material with anti-reflection coating
Device
Lead sponsor
Western University of Health Sciences
Other
Eligibility
45 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Pomona, California
Source: ClinicalTrials.gov public record
Updated Aug 14, 2024 · Synced Jul 21, 2026, 7:06 AM EDT
Completed Not applicable Interventional Results available

Comparison of Two Soft Bifocal Contact Lenses

NCT00724945
View directory record Official record
Conditions
Presbyopia
Interventions
balafilcon A, senofilcon A
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
35 Years to 70 Years
Enrollment
113 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
6
States / cities
Jacksonville, Florida • Winter Park, Florida • East Lansing, Michigan + 1 more
Source: ClinicalTrials.gov public record
Updated May 20, 2015 · Synced Jul 21, 2026, 7:06 AM EDT
Completed Not applicable Interventional Results available

Clinical Evaluation of a Multifocal Contact Lens on Symptomatic Patients

NCT01016652
View directory record Official record
Conditions
Presbyopia
Interventions
etafilcon A multifocal contact lens, etafilcon A Contact Lens
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
35 Years to 47 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
8
States / cities
North Little Rock, Arkansas • Blue Springs, Missouri • Lake Ozark, Missouri + 5 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2018 · Synced Jul 21, 2026, 7:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Pilot Study to Test the Safety and Feasibility of a Brillouin Ocular Analyzer

NCT01775007
View directory record Official record
Conditions
Measurement of the Elasticity of the Anterior Eye Segment
Interventions
Brillouin Ocular Analyser
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
20 Years to 60 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2017
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 1, 2022 · Synced Jul 21, 2026, 7:06 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Safety and Efficacy Study BRIMOCHOL™ PF and Carbachol PF in Subjects With Emmetropic Phakic or Pseudophakic Presbyopia

NCT05270863
View directory record Official record
Conditions
Presbyopia
Interventions
BRIMOCHOL™ PF, Carbachol PF, Brimonidine tartrate
Drug
Lead sponsor
Visus Therapeutics
Other
Eligibility
45 Years to 80 Years
Enrollment
182 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
15
States / cities
Glendale, California • Rancho Cordova, California • Jacksonville, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Jul 21, 2026, 7:06 AM EDT
Completed Not applicable Interventional Results available

Comparison of Three Soft Bifocal Contact Lenses

NCT00808340
View directory record Official record
Conditions
Presbyopia
Interventions
balafilcon A, senofilcon A production, senofilcon A test
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
35 Years to 70 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 18, 2018 · Synced Jul 21, 2026, 7:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Handling Comparison Between Two Contact Lens Types

NCT02310126
View directory record Official record
Conditions
Presbyopia
Interventions
etafilcon A (multi-focal), etafilcon A (sphere)
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
195 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
8
States / cities
Jacksonville, Florida • Sarasota, Florida • Winter Park, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2018 · Synced Jul 21, 2026, 7:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

VisionApp - Refraction and Presbyopia

NCT07570602
View directory record Official record
Conditions
Presbyopia, Refractive Errors
Interventions
VisionApp
Device
Lead sponsor
Indiana University
Other
Eligibility
40 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Jul 21, 2026, 7:06 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Evaluation of the Safety and Effectiveness of Aceclidine/Brimonidine (LNZ101) and Aceclidine (LNZ100) in the Treatment of Presbyopia

NCT05294328
View directory record Official record
Conditions
Presbyopia, Refractive Errors, Eye Diseases
Interventions
Aceclidine+Brimonidine combination ophthalmic solution, Aceclidine ophthalmic solution, Vehicle Proprietary Ophthalmic Solution
Drug
Lead sponsor
LENZ Therapeutics, Inc
Other
Eligibility
45 Years to 75 Years
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
5
States / cities
Glendale, California • Indianapolis, Indiana • Andover, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 4, 2024 · Synced Jul 21, 2026, 7:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

APIOC for Presbyopia and APIOC for Presbyopia With Astigmatism

NCT04883099
View directory record Official record
Conditions
Presbyopia, Myopia, Hyperopia, Astigmatism
Interventions
APIOC for Presbyopia and APIOC for Presbyopia for Astigmatism
Device
Lead sponsor
Lentechs, LLC
Industry
Eligibility
40 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
6
States / cities
San Diego, California • Orlando, Florida • Lexington, Kentucky + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 18, 2022 · Synced Jul 21, 2026, 7:06 AM EDT
Completed Phase 3 Interventional Results available

Efficacy Study of Pilocarpine HCl Ophthalmic Solution (AGN-190584) in Participants With Presbyopia

NCT03804268
View directory record Official record
Conditions
Presbyopia
Interventions
Vehicle, Pilocarpine HCl Ophthalmic Solution
Other · Drug
Lead sponsor
Allergan
Industry
Eligibility
40 Years to 55 Years
Enrollment
323 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
36
States / cities
Chandler, Arizona • Scottsdale, Arizona • Beverly Hills, California + 32 more
Source: ClinicalTrials.gov public record
Updated Dec 27, 2021 · Synced Jul 21, 2026, 7:06 AM EDT
Completed Early Phase 1 Interventional

Evaluation of NV701 (Pilocarpine 1.25%) Compared With Vuity (Pilocarpine 1.25%) on Pupil Size in Subjects With Presbyopia

NCT06783686
View directory record Official record
Conditions
Pupil Constriction
Interventions
NV701, Pilocarpine 1.25% Eye drop
Drug
Lead sponsor
Novus Vision LLC
Industry
Eligibility
40 Years to 55 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
2
States / cities
Chandler, Arizona • Glendale, California
Source: ClinicalTrials.gov public record
Updated Sep 4, 2025 · Synced Jul 21, 2026, 7:06 AM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers

Investigation of the Presbia Flexivue Microlens™

NCT02110472
View directory record Official record
Conditions
Presbyopia
Interventions
Corneal inlay
Device
Lead sponsor
PresbiBio, LLC
Industry
Eligibility
45 Years to 60 Years
Enrollment
412 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
11
States / cities
Beverly Hills, California • La Jolla, California • Los Angeles, California + 8 more
Source: ClinicalTrials.gov public record
Updated Sep 27, 2016 · Synced Jul 21, 2026, 7:06 AM EDT
Completed Not applicable Interventional Results available

Clinical Evaluation of a Manufacturing Process for a Frequent Replacement Silicone Hydrogel Multifocal Contact Lens

NCT05765227
View directory record Official record
Conditions
Refractive Ametropia
Interventions
Lehfilcon A multifocal contact lenses, Lotrafilcon B multifocal contact lenses, Hydrogen peroxide-based cleaning and disinfection system
Device
Lead sponsor
Alcon Research
Industry
Eligibility
40 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Johns Creek, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 15, 2024 · Synced Jul 21, 2026, 7:06 AM EDT