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Showing 1–24 of 108 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Prescription Opioid Misuse Clear all
Completed Not applicable Interventional

Repeated-dose Brief Intervention to Reduce Overdose and Risk Behaviors Among Naloxone Recipients

NCT02093559
View directory record Official record
Conditions
Opioid-Related Disorders, Drug Overdose
Interventions
Brief counseling Intervention
Behavioral
Lead sponsor
San Francisco Department of Public Health
Government
Eligibility
18 Years to 65 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 21, 2023 · Synced Jul 20, 2026, 6:42 PM EDT
Active, not recruiting Not applicable Interventional

Evaluating an Intervention to Prevent Overdoses in Rural and Urban Counties

NCT05463341
View directory record Official record
Conditions
Opiate Overdose, Fentanyl Overdose, Harm Reduction
Interventions
Fentanyl Test Strips
Behavioral
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
18 Years and older
Enrollment
2,400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Jul 20, 2026, 6:42 PM EDT
Recruiting Not applicable Interventional

Social Network Overdose Prevention and Education Intervention

NCT06327061
View directory record Official record
Conditions
Drug Overdose
Interventions
Network overdose prevention, Standard of care health education
Behavioral
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Early Phase 1 Interventional

Feasibility of the Utilization of Buprenorphine in the Emergency Room to Treat Clinical Opioid Withdrawal

NCT03489161
View directory record Official record
Conditions
Drug Overdose, Opioid Withdrawal, Opioid-use Disorder
Interventions
Buprenorphine
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 65 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 12, 2018 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Not applicable Interventional

Recovery Initiation and Management After Overdose (RIMO) Experiment

NCT03895827
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Recovery Initiation and Management after Overdose (RIMO), Passive Referral to Treatment Control
Behavioral · Other
Lead sponsor
Chestnut Health Systems
Other
Eligibility
18 Years and older
Enrollment
251 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

iSTART: A Campus & Community Initiative for Services in Tec-health

NCT05362357
View directory record Official record
Conditions
Substance Use, Binge Drinking, Marijuana Use, Alcohol Drinking, Prescription Opioid Misuse, Illicit Drug Use
Interventions
iSTART Web-app
Behavioral
Lead sponsor
California State University, Northridge
Other
Eligibility
18 Years to 30 Years
Enrollment
1,100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Northridge, California
Source: ClinicalTrials.gov public record
Updated Feb 6, 2024 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Not applicable Interventional Results available

A Patient-Centered Intervention to Improve Opioid Safety

NCT02791399
View directory record Official record
Conditions
Opioid Safety, Prescription Opioid Misuse, Chronic Pain
Interventions
ISOP Intervention with the Nurse Care Manager
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
286 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 26, 2023 · Synced Jul 20, 2026, 6:42 PM EDT
Active, not recruiting Not applicable Interventional

Community-based Education, Navigation, and Support Intervention for Military Veterans

NCT05343169
View directory record Official record
Conditions
Overdose, Opioid Use Disorder, HIV Infections
Interventions
Overdose Education and Naloxone Distribution, Advanced Education in Safer Substance Use, Treatment, and Self-Care, Social Service and Health Navigation, Peer Social Support
Behavioral
Lead sponsor
New York University
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Jul 20, 2026, 6:42 PM EDT
Not yet recruiting Not applicable Interventional

The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study

NCT07216963
View directory record Official record
Conditions
Opioid Use Disorder, Overdose, Drug, Overdose, Substance Use (Drugs, Alcohol)
Interventions
Community Paramedic Standard of Care (CP SOC), CROSSROADS
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
4
States / cities
Miami, Florida • Boston, Massachusetts • Durham, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Not applicable Interventional Results available

Preventing Overdose Using Information and Data From the Environment

NCT05096429
View directory record Official record
Conditions
Opioid Overdose, Drug Overdose
Interventions
PROVIDENT
Behavioral
Lead sponsor
Brown University
Other
Eligibility
Not listed
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Preventing Opioid Overdose Mortality in the United States

NCT03924505
View directory record Official record
Conditions
Opioid Overdose
Interventions
Organize and Mobilize for Implementation Effectiveness, Dissemination
Other
Lead sponsor
RTI International
Other
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Dec 11, 2024 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Not applicable Interventional

Safety and Health Intervention Project

NCT02152397
View directory record Official record
Conditions
Drug Overdose, Opioid Related Disorders
Interventions
Therapist-led brief intervention (TBI)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Waterford, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 16, 2017 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Not applicable Interventional

More Individualized Care: Assessment and Recovery Through Engagement

NCT05122676
View directory record Official record
Conditions
Depression, Anxiety, Opioid-Related Disorders, Pain, Chronic
Interventions
More Individualized Care: Assessment and Recovery through Engagement (MI-CARE)
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
805 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Indianapolis, Indiana • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Jul 20, 2026, 6:42 PM EDT
Not listed Not applicable Interventional

Evaluation of a Medication Health Center to Promote Opioid Safety

NCT06456294
View directory record Official record
Conditions
Overdose
Interventions
MHC Outreach Intervention
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 13, 2024 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Pharmacodynamic Evaluation of Intramuscular Nalmefene Autoinjector 1.5 mg Compared to Intranasal Narcan 4 mg

NCT06719986
View directory record Official record
Conditions
Opioid Overdose
Interventions
Nalmefene HCl injection, Naloxone HCl intranasal
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
18 Years to 55 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Not applicable Interventional

The Impact of Co-Dispensing Naloxone to Patients Prescribed Chronic Opioid Therapy

NCT03337100
View directory record Official record
Conditions
Overdose, Risk Behavior
Interventions
Co-Dispensing
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 2, 2023 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Not applicable Interventional

Prescribe to Save Lives

NCT03175640
View directory record Official record
Conditions
Opioid-Related Disorders, Drug Overdose
Interventions
Implementation intervention
Behavioral
Lead sponsor
Baystate Medical Center
Other
Eligibility
Not listed
Enrollment
294 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
2
States / cities
Springfield, Massachusetts • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Dec 20, 2020 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Community Pharmacists and Opioid Misuse

NCT03149718
View directory record Official record
Conditions
Opioid Misuse
Interventions
Brief Intervention Medication Therapy Management, Standard Medication Counseling (SMC)
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania • Somerset, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 13, 2019 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Pupillary Unrest in Ambient Light, and Relationship to Opioid-Induced Respiratory Depression

NCT04301895
View directory record Official record
Conditions
Opioid; Intoxication, Perception Disturbance (Acute), Acute Pain, Overdose of Opiate, Respiratory Depression, Safety Issues
Interventions
Continuous conversational interaction, Remifentanil infusion
Behavioral · Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
20 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 9, 2020 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Not applicable Interventional

Effect of an Opioid Disposal Pouch Versus Usual Care on Post Discharge Disposal of Unused Medication

NCT04553588
View directory record Official record
Conditions
Drug Prescriptions
Interventions
Disposal pouch
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
313 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 16, 2020 · Synced Jul 20, 2026, 6:42 PM EDT
Recruiting Not applicable Interventional

Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level Data

NCT06768814
View directory record Official record
Conditions
Opioid Use Disorder, Opioid Use
Interventions
Sub-acute stabilization
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
40,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Jul 20, 2026, 6:42 PM EDT
Active, not recruiting Not applicable Interventional Results available

HEALing Communities Study

NCT04111939
View directory record Official record
Conditions
Opioid Use Disorder (OUD)
Interventions
Communities That HEAL, Wait-list control
Other
Lead sponsor
RTI International
Other
Eligibility
Not listed
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
4
States / cities
Lexington, Kentucky • Boston, Massachusetts • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated May 28, 2025 · Synced Jul 20, 2026, 6:42 PM EDT
Completed No phase listed Observational Results available

User Acceptability of a Device-Based Opioid Overdose Intervention

NCT04530591
View directory record Official record
Conditions
Opioid Overdose, Opioid-use Disorder, Substance Use Disorders
Interventions
Survey, Interview
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years and older
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 6, 2021 · Synced Jul 20, 2026, 6:42 PM EDT
Completed Not applicable Interventional Results available

A Tailored, Peer-delivered Intervention to Reduce Recurring Opioid Overdoses

NCT02922959
View directory record Official record
Conditions
Drug Overdose, Opioid-Related Disorders, Drug Addiction, Drug Abuse, Substance Abuse
Interventions
Peer Intervention, naloxone nasal spray kit, Personally-tailored opioid overdose prevention education (information packet)
Behavioral · Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 23, 2020 · Synced Jul 20, 2026, 6:42 PM EDT