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ClinicalTrials.gov public records Last synced Nov 8, 2026, 6:48 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 112 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Prescription Opioid Misuse Clear all

Conditions: Prescription Drug Abuse
Interventions: MyHealthyChoices, Health Risk Assessment; Behavioral · Other
Lead sponsor: Johns Hopkins Bloomberg School of Public Health; Other
Eligibility: 18 Years and older
Enrollment: 123 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 2
States / cities: Baltimore, Maryland • Morgantown, West Virginia

Conditions: Opioid Misuse
Interventions: CPMRx; Behavioral
Lead sponsor: Jessica Morgan; Industry
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Opioid Overdose
Interventions: Enhanced Overdose Education (EOE), Standard education; Behavioral
Lead sponsor: Hartford Hospital; Other
Eligibility: 21 Years to 65 Years
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 2
States / cities: Hartford, Connecticut

Conditions: Opioids; Harmful Use
Interventions: Mobile Phone Application; Behavioral
Lead sponsor: Drexel University; Other
Eligibility: 18 Years and older
Enrollment: 110 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Opioid; Intoxication, Perception Disturbance (Acute), Acute Pain, Overdose of Opiate, Respiratory Depression, Safety Issues
Interventions: Continuous conversational interaction, Remifentanil infusion; Behavioral · Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 20 Years to 55 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Opioid Overdose
Interventions: Observation only; Other
Lead sponsor: Member Companies of the Opioid PMR Consortium; Industry
Eligibility: 18 Years to 79 Years
Enrollment: 808,455 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 4
States / cities: Wilmington, Delaware • Boston, Massachusetts • Portland, Oregon + 1 more

Conditions: Opioid Use, Stimulant Use
Interventions: harm reduction intervention; Behavioral
Lead sponsor: Brittany Miller-Roenigk; Other
Eligibility: 18 Years to 65 Years
Enrollment: 63 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 3
States / cities: Louisville, Kentucky • Cincinnati, Ohio

Conditions: Pain, Opioid Abuse, Pregnancy
Interventions: CBT for Chronic Pain in Pregnancy; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Opioid Use Disorder, Opioid Overdose
Interventions: Bundled intervention (Experimental), control group, Buprenorphine (Experimental), Scheduled Peer Support Specialist (Experimental), Telemedicine Buprenorphine Treatment; Other · Drug · Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 19 Years and older
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Computer + Fluency, Computer Only, Treatment as Usual
Interventions: Computer + Fluency, Computer Only, Treatment as Usual; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Pain, Postoperative, Opioid Misuse, Opioid Use, Pain
Interventions: OxyCODONE 5 mg Oral Tablet, Acetaminophen 500 mg Tab, Ibuprofen 600 mg; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Opioid Overdose
Interventions: Organize and Mobilize for Implementation Effectiveness, Dissemination; Other
Lead sponsor: RTI International; Other
Eligibility: 18 Years and older
Enrollment: 105 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Berkeley, California

Conditions: Opiate Overdose, Opioid-Related Disorders, Narcotic-Related Disorders, Substance-related Disorders, Chemically-Induced Disorders, Mental Disorders
Interventions: Machine Learning-Based Clinical Decision Support: Overdose Prevention Alert (OPA) Intervention; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 674 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Chronic Pain, Opioid Use Disorders
Interventions: Mindfulness-Oriented Recovery Enhancement, Support Group; Behavioral
Lead sponsor: University of Utah; Other
Eligibility: 18 Years to 100 Years
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Opioid Use Disorder, Overdose, Drug, Overdose, Substance Use (Drugs, Alcohol)
Interventions: Community Paramedic Standard of Care (CP SOC), CROSSROADS; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2030
U.S. locations: 4
States / cities: Miami, Florida • Boston, Massachusetts • Durham, North Carolina + 1 more

Conditions: Opioid-Related Disorders, Drug Overdose
Interventions: Brief counseling Intervention; Behavioral
Lead sponsor: San Francisco Department of Public Health; Government
Eligibility: 18 Years to 65 Years
Enrollment: 63 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Overdose, Opioid Use Disorder, HIV Infections
Interventions: Overdose Education and Naloxone Distribution, Advanced Education in Safer Substance Use, Treatment, and Self-Care, Social Service and Health Navigation, Peer Social Support; Behavioral
Lead sponsor: New York University; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Substance Use Disorder (SUD), Opioid Use Disorder, Alcohol Use Disorder (AUD), Drug Use, Overdose
Interventions: Not listed
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years and older
Enrollment: 1,200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Opioid Overdose
Interventions: Educational Webinar, Resources, Reminders; Behavioral
Lead sponsor: Auburn University; Other
Eligibility: 18 Years and older
Enrollment: 55 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Auburn, Alabama

Conditions: Overdose
Interventions: Peer Education, Narcan Nasal Product; Behavioral · Drug
Lead sponsor: Johns Hopkins Bloomberg School of Public Health; Other
Eligibility: 18 Years and older
Enrollment: 614 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Drug Overdose, Opioid-Related Disorders, Drug Addiction, Drug Abuse, Substance Abuse
Interventions: Peer Intervention, naloxone nasal spray kit, Personally-tailored opioid overdose prevention education (information packet); Behavioral · Drug
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Substance Use, Binge Drinking, Marijuana Use, Alcohol Drinking, Prescription Opioid Misuse, Illicit Drug Use
Interventions: iSTART Web-app; Behavioral
Lead sponsor: California State University, Northridge; Other
Eligibility: 18 Years to 30 Years
Enrollment: 1,100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Northridge, California

Conditions: Surgery, Opioid Use, Opioid Misuse, Prescription Opioid Misuse
Interventions: Opioid Prescribing Report Cards; Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: Not listed
Enrollment: 26,562 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Alcohol Use, Cannabis Use, Nicotine Use, Illicit Drug Use, Prescription Opioid Misuse
Interventions: MATAspire Web-app; Behavioral
Lead sponsor: California State University, Northridge; Other
Eligibility: 18 Years and older
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Northridge, California

Search by objective public record fields.

Using m-Health Tools to Reduce the Misuse of Opioid Pain Relievers

Decreasing Opioid Misuse and Habit-forming Behaviors Following Prescription in Patients Undergoing Cesarean Section

Improving Availability of Intranasal Naloxone

Piloting a Naloxone Intervention in Philadelphia

Pupillary Unrest in Ambient Light, and Relationship to Opioid-Induced Respiratory Depression

Incidence and Predictors of Opioid Overdose and Death Among Long-Term Users of Opioid Analgesics

THRIVE: Culturally AdapTed Harm Reduction Intervention

Program for Pain & Prescription Opioid Use in Pregnancy

A Bundled Intervention to End Opioid Overdoses

Evaluation of a Computerized Opioid Overdose Prevention Program

Reduced Opioid Prescription After Laparoscopic Hysterectomy

Preventing Opioid Overdose Mortality in the United States

Developing and Evaluating a Machine-Learning Opioid Overdose Prediction & Risk-Stratification Tool in Primary Care

Mindfulness-Oriented Recovery Enhancement For Chronic Pain and Prescription Opioid Misuse in Primary Care

The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study

Repeated-dose Brief Intervention to Reduce Overdose and Risk Behaviors Among Naloxone Recipients

Community-based Education, Navigation, and Support Intervention for Military Veterans

Disease Intervention Specialist (DIS) for SUD

Preventing Opioid Overdose Deaths by Empowering Pharmacists to Dispense Naloxone

An Evaluation of a Social Network Intervention for Primary and Secondary Prevention of Opioid Overdoses

A Tailored, Peer-delivered Intervention to Reduce Recurring Opioid Overdoses

iSTART: A Campus & Community Initiative for Services in Tec-health

Increasing Implementation of Post-Operative Opioid Prescribing Guidelines

MATAspire: Mental Health Awareness Tailored App for Substance Prevention and Integrated Resilience Education