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Showing 25–40 of 16 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Preterm Premature Ruptured Membranes Clear all
Recruiting Phase 4 Interventional

Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT)

NCT06396078
View directory record Official record
Conditions
Preterm Premature Rupture of Membrane, Pregnancy, High Risk, Preterm Birth
Interventions
Ceftriaxone 1000 MG, Clarithromycin 500mg, Metronidazole 500 mg, Ampicillin 2 GM Injection, Amoxicillin 250 MG, Azithromycin, Erythromycin
Drug
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older · Female only
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Columbus, Ohio • Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Jul 23, 2026, 11:46 PM EDT
Recruiting Phase 4 Interventional

Oxytocin/Foley vs. Oxytocin for Induction in Patients With PPROM

NCT07119398
View directory record Official record
Conditions
Preterm PROM (Pregnancy)
Interventions
Oxytocin plus Foley Catheter, Oxytocin
Combination Product · Drug
Lead sponsor
Eastern Virginia Medical School
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 12, 2025 · Synced Jul 23, 2026, 11:46 PM EDT
Terminated Not applicable Interventional Results available

Use of Placental Alpha Microglobulin-1(PAMG-1) to Diagnose Premature Rupture of Membranes in Pregnant Women

NCT03715530
View directory record Official record
Conditions
Preterm Labor, Preterm Birth
Interventions
PAMG-1 immunoassay
Device
Lead sponsor
Mark Santillan
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Oct 2, 2019 · Synced Jul 23, 2026, 11:46 PM EDT
Withdrawn Phase 3 Interventional

Erythromycin Versus Azithromycin in Preterm Premature Rupture of Membranes

NCT01556334
View directory record Official record
Conditions
Preterm Premature Ruptured Membranes
Interventions
Azithromycin, Erythromycin
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Jul 23, 2026, 11:46 PM EDT
Not listed No phase listed Observational

The Accuracy of Amniotic Fluid Ferning in the Second Trimester in the Diagnosis of Preterm Prelabor Rupture of Membranes

NCT04963465
View directory record Official record
Conditions
Preterm Premature Rupture of Membrane, Amniotic Fluid Leakage
Interventions
Ferning on microscopy
Diagnostic Test
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Apr 17, 2023 · Synced Jul 23, 2026, 11:46 PM EDT
Terminated Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Does a Rescue Course of Betamethasone in Pregnant Women With PPROM Decrease Neonatal Morbidity?

NCT02939742
View directory record Official record
Conditions
PPROM, Respiratory Distress Syndrome in Premature Infants
Interventions
Betamethasone, Placebo
Drug
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2023
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Jul 23, 2026, 11:46 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Outpatient Antibiotics Following Previable Rupture of Membranes (pPPROM) Between 18 0/7 and 22 6/7 Weeks Gestational Age

NCT05345457
View directory record Official record
Conditions
Pregnancy Preterm, Pregnancy Prom, PROM, Preterm (Pregnancy), PROM (Pregnancy), Premat Rupture Membranes Preterm Unspec to Length of Time Between Rupture/Labor, Premature Birth
Interventions
Azithromycin Pill, Amoxicillin Pill
Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
3
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Jul 23, 2026, 11:46 PM EDT
Terminated Not applicable Interventional Results available

Foley Catheter for Labor Induction in Women With Term and Near Term Membrane Rupture

NCT00290199
View directory record Official record
Conditions
Fetal Membranes, Premature Rupture, Labor, Induced/IS
Interventions
Transcervical Foley catheter
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
12 Years to 55 Years · Female only
Enrollment
169 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
3
States / cities
Birmingham, Alabama • Newark, Delaware • Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated May 22, 2017 · Synced Jul 23, 2026, 11:46 PM EDT
Not yet recruiting Phase 4 Interventional

Extended Azithromycin Treatment in Prelabor Rupture of Membranes

NCT07669207
View directory record Official record
Conditions
Preterm Prelabor Rupture of Membranes, PPROM
Interventions
Azithromycin (Azithro), Standard Azithromycin Dosing
Drug
Lead sponsor
Alexa Henderson
Other
Eligibility
Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Jul 23, 2026, 11:46 PM EDT
Active, not recruiting No phase listed Observational

Dilapan-S®: A Multicenter US E-registry

NCT04451109
View directory record Official record
Conditions
Post Term Pregnancy, Premature Rupture of Membrane, Fetal Growth Retardation, Oligohydramnios, Gestational Diabetes, High Blood Pressure in Pregnancy
Interventions
Dilapan-S
Device
Lead sponsor
Medicem Technology s.r.o.
Other
Eligibility
18 Years and older · Female only
Enrollment
1,200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 21, 2024 · Synced Jul 23, 2026, 11:46 PM EDT
Completed No phase listed Observational

Clinical, Biochemical, Histological and Biophysical Parameters in the Prediction of Cerebral Palsy in Patients With Preterm Labor and Premature Rupture of Membranes

NCT00342667
View directory record Official record
Conditions
Preterm Birth, Pregnancy
Interventions
Not listed
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
Up to 45 Years
Enrollment
4,673 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2014
U.S. locations
2
States / cities
Bethesda, Maryland • Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 23, 2023 · Synced Jul 23, 2026, 11:46 PM EDT
Terminated Not applicable Interventional

A Comparison of Bed Rest Versus Moderate Activity in Preterm Premature Rupture of Membranes (PPROM)

NCT02327637
View directory record Official record
Conditions
Preterm Premature Rupture of the Membranes, Physical Activity
Interventions
Moderate Activity
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Female only
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 5, 2019 · Synced Jul 23, 2026, 11:46 PM EDT
Completed No phase listed Observational

Biomarkers of Intra-amniotic Infection in Women With Preterm Premature Ruptured Amniotic Membranes

NCT00701350
View directory record Official record
Conditions
Intra-amniotic Infection, Preterm Birth
Interventions
Not listed
Lead sponsor
ProteoGenix, Inc.
Industry
Eligibility
18 Years and older · Female only
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
4
States / cities
Phoenix, Arizona • Tucson, Arizona • San Jose, California + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 20, 2010 · Synced Jul 23, 2026, 11:46 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

PROMMO Trial: Oral Misoprostol vs IV Oxytocin

NCT04478942
View directory record Official record
Conditions
Premature Rupture of Membrane, Induction of Labor Affected Fetus / Newborn
Interventions
Misoprostol Oral Product, Intravenous Oxytocin
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older · Female only
Enrollment
138 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 27, 2025 · Synced Jul 23, 2026, 11:46 PM EDT
Completed No phase listed Observational

Repeat Antenatal Corticosteroids

NCT03133104
View directory record Official record
Conditions
Antenatal Corticosteroids
Interventions
Antenatal corticosteroids
Other
Lead sponsor
St. Louis University
Other
Eligibility
13 Years to 55 Years · Female only
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 28, 2017 · Synced Jul 23, 2026, 11:46 PM EDT
Not listed Phase 2 Interventional Accepts healthy volunteers

Indomethacin Versus Placebo in Women With Preterm Premature Rupture of Membranes (PPROM)

NCT00466128
View directory record Official record
Conditions
Preterm Premature Rupture of Membranes
Interventions
indomethacin
Drug
Lead sponsor
Thomas Jefferson University
Other
Eligibility
15 Years to 50 Years · Female only
Enrollment
116 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 17, 2015 · Synced Jul 23, 2026, 11:46 PM EDT