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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Primary Insomnia Clear all
Completed Not applicable Interventional Results available

Making Better Lives: Patient-Focused Care for Low Back Pain (LBP)

NCT02697435
View directory record Official record
Conditions
Chronic Low Back Pain, Hip Ostearthritis, Myofascial Pain Syndrome, Fibromyalgia, Depression, Maladaptive Coping, Lumbar Spinal Stenosis, Insomnia, Sacroiliac Joint Pain, Lateral Hip and Thigh Pain, Anxiety, Dementia, Recent Leg Length Discrepancy
Interventions
Patient-Centered Care, Imaging-Directed Care
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
60 Years to 89 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 18, 2019 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Phase 3 Interventional

Evaluation of the Hypnotic Properties of Zolpidem-MR 12.5 mg and Zolpidem 10 mg Marketed Product Compared to Placebo in Patients With Primary Insomnia

NCT00630175
View directory record Official record
Conditions
Sleep Initiation and Maintenance Disorders
Interventions
zolpidem-MR (modified release), zolpidem (SL800750), placebo
Drug
Lead sponsor
Sanofi
Industry
Eligibility
18 Years to 64 Years
Enrollment
113 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2004
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated May 17, 2009 · Synced Jul 22, 2026, 2:27 PM EDT
Not yet recruiting Phase 4 Interventional

Doxepin Alone or Combined With Ramelteon Versus Placebo for Improving Sleep Quality After Primary Total Knee Arthroplasty

NCT07598734
View directory record Official record
Conditions
Sleep Quality Post-TKA, Postoperative Knee Function, Quality of Life After Primary TKA
Interventions
Doxepin 6 mg, Ramelteon 8 mg, Placebo Tablets
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 80 Years
Enrollment
129 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Phase 4 Interventional Results available

A Long-Term Safety and Efficacy Study of Eszopiclone in Elderly With Primary Chronic Insomnia

NCT00386334
View directory record Official record
Conditions
Insomnia
Interventions
Eszopiclone, Placebo
Drug
Lead sponsor
Sumitomo Pharma America, Inc.
Industry
Eligibility
65 Years to 85 Years
Enrollment
388 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
82
States / cities
Birmingham, Alabama • Chandler, Arizona • Glendale, Arizona + 69 more
Source: ClinicalTrials.gov public record
Updated Mar 13, 2016 · Synced Jul 22, 2026, 2:27 PM EDT
Not listed Not applicable Interventional

The Effect of Mindfulness Training Before Primary Total Joint Arthroplasty on Sleep Quality

NCT05295004
View directory record Official record
Conditions
Sleep Disturbance, Arthropathy
Interventions
Mindfulness Meditation Training
Behavioral
Lead sponsor
Colorado Joint Replacement
Other
Eligibility
18 Years to 90 Years
Enrollment
282 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 9, 2023 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Phase 2 Interventional

A Study to Evaluate the Effects of GW679769 on Sleep and Cognitive Function in Subjects With Primary Insomnia

NCT00650871
View directory record Official record
Conditions
Sleep Initiation and Maintenance Disorders
Interventions
GW679769, Placebo
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 64 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
7
States / cities
San Diego, California • Atlanta, Georgia • New York, New York + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 7, 2017 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Not applicable Interventional

Intervention for Sleep and Pain in Youth

NCT03137147
View directory record Official record
Conditions
Headache Disorders, Migraine Disorders, Insomnia
Interventions
Intervention for Sleep and Pain in Youth
Behavioral
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
11 Years to 17 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 18, 2018 · Synced Jul 22, 2026, 2:27 PM EDT
Not listed Not applicable Interventional

Integrating Behavioral Health and Primary Care for Comorbid Behavioral and Medical Problems

NCT02868983
View directory record Official record
Conditions
Arthritis, Asthma, Chronic Obstructive Lung Disease, Diabetes, Heart Failure, Hypertension, Anxiety, Chronic Pain, Depression, Fibromyalgia, Insomnia, Irritable Bowel Syndrome, Problem Drinking, Substance Use Disorder
Interventions
Integration
Other
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
4,025 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Oct 4, 2021 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Phase 4 Interventional Results available

Total Joint Arthroplasty and Sleep

NCT03968939
View directory record Official record
Conditions
Primary Total Hip Arthroplasty, Primary Total Knee Arthroplasty
Interventions
Diphenhydramine (Benadryl), Melatonin, Sleep Hygiene Education
Drug · Dietary Supplement · Behavioral
Lead sponsor
James A. Keeney
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 15, 2024 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Not applicable Interventional Results available

RCT of Brief CBT-I in Primary Care Veterans With Suicidal Thoughts

NCT03603717
View directory record Official record
Conditions
Insomnia, Suicidal Ideation
Interventions
Cognitive Behavioral Therapy for Insomnia, Sleep Hygiene
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
283 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
3
States / cities
Buffalo, New York • Canandaigua, New York • Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Jun 16, 2024 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Not applicable Interventional

CBT for Insomnia in Primary Brain Tumor Patients

NCT04919993
View directory record Official record
Conditions
Primary Brain Tumor, PBT
Interventions
Cognitive Behavioral Therapy-Insomnia
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 12, 2023 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Not applicable Interventional

Effect of Parathyroidectomy on Sleep

NCT00501215
View directory record Official record
Conditions
Hyperparathyroidism
Interventions
Parathyroid Surgery, Telephone Interview, Polysomnography (PSG)
Procedure · Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
21 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 17, 2017 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Phase 2 Interventional

A Dose-ranging, Multicenter Polysomnography Trial of PD 0200390 in Adults With Primary Insomnia

NCT00551148
View directory record Official record
Conditions
Primary Insomnia
Interventions
PD 0200390, Placebo
Drug · Other
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 64 Years
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
16
States / cities
Glendale, Arizona • Phenoix, Arizona • Phoenix, Arizona + 12 more
Source: ClinicalTrials.gov public record
Updated Jul 24, 2012 · Synced Jul 22, 2026, 2:27 PM EDT
Recruiting Not applicable Interventional

Cereset Research Exploratory Study

NCT03777267
View directory record Official record
Conditions
Neurological Diseases or Conditions, Cardiovascular Conditions After Birth, Psychophysiologic Disorders
Interventions
Active CR
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
11 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2028
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Jul 22, 2026, 2:27 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Information Processing at Sleep Onset and During Sleep in Patients With Insomnia

NCT00680199
View directory record Official record
Conditions
Primary Insomnia
Interventions
Not listed
Lead sponsor
University of Rochester
Other
Eligibility
25 Years to 45 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 27, 2015 · Synced Jul 22, 2026, 2:27 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pilot Trial in Sleep Laboratory Setting to Compare the Physiology of Night Time Bladder Function in Subjects With Overactive Bladder (OAB) Versus Subjects That Have Insomnia and Healthy Normal Subjects

NCT01029015
View directory record Official record
Conditions
Bladder Function
Interventions
cystometry, polysomnography
Procedure
Lead sponsor
Astellas Pharma Inc
Industry
Eligibility
45 Years and older
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 6, 2011 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Not applicable Interventional

30 Days in Home Use and Home Use Patterns Over 6 Months

NCT01882699
View directory record Official record
Conditions
Primary Insomnia
Interventions
Cereve Sleep System
Device
Lead sponsor
Cereve, Inc.
Industry
Eligibility
22 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
4
States / cities
Saint Petersburgh, Florida • Atlanta, Georgia • Crestview Hills, Kentucky
Source: ClinicalTrials.gov public record
Updated May 21, 2015 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Phase 2 Interventional

Effects Of GW679769 On Sleep Onset And Maintenance And Next Day Functioning In Subjects With Primary Insomnia

NCT00280423
View directory record Official record
Conditions
Sleep Initiation and Maintenance Disorders, Insomnia
Interventions
GW679769
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 64 Years
Enrollment
342 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
61
States / cities
Birmingham, Alabama • Phoenix, Arizona • Tucson, Arizona + 50 more
Source: ClinicalTrials.gov public record
Updated Apr 14, 2015 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Phase 3 Interventional

Efficacy and Safety of Eplivanserin Treatment for Sleep Maintenance Insomnia Followed by Optional Extension up to 1 Year

NCT00253903
View directory record Official record
Conditions
Sleep Initiation and Maintenance Disorders, Insomnia
Interventions
eplivanserin (SR46349), placebo
Drug
Lead sponsor
Sanofi
Industry
Eligibility
18 Years and older
Enrollment
1,155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated Nov 29, 2010 · Synced Jul 22, 2026, 2:27 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Comparison of Efficacy of Behavioral Approaches for Treatment of Insomnia

NCT03461666
View directory record Official record
Conditions
Primary Insomnia
Interventions
Cognitive Behavior Therapy-Insomnia, Focus of Attention, Combined-CBT-I and FOA Group, Sleep Hygiene
Behavioral
Lead sponsor
Pacific Institute of Medical Sciences
Other
Eligibility
18 Years to 72 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
2
States / cities
Bothell, Washington
Source: ClinicalTrials.gov public record
Updated Apr 4, 2023 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Two Contrasting Interventions for Sleep Management

NCT01804036
View directory record Official record
Conditions
Primary Insomnia, Secondary Insomnia
Interventions
Zolpidem, Mind-Body Bridging
Drug · Behavioral
Lead sponsor
University of Utah
Other
Eligibility
17 Years to 40 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
2
States / cities
Colorado Springs, Colorado • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 29, 2017 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Not applicable Interventional Results available

Sustainable Methods, Algorithms, and Research Tools for Delivering Optimal Care Study

NCT02037438
View directory record Official record
Conditions
Obstructive Sleep Apnea of Adult, Insomnia, Circadian Rhythm Sleep Disorder, Sleep Related Movement Disorders, Narcolepsy and Hypersomnia, Parasomnia
Interventions
CONV care for the diagnosis and treatment of sleep disorders, PCCM for the diagnosis and treatment of sleep disorders
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
1,836 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Mar 3, 2019 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Not applicable Interventional Results available

The Role of Partial Reinforcement in the Long Term Management of Insomnia

NCT00662155
View directory record Official record
Conditions
Primary Insomnia
Interventions
Zolpidem, Placebos
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 55 Years
Enrollment
129 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 6, 2017 · Synced Jul 22, 2026, 2:27 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

The Psychoneuroimmunology of Insomnia

NCT00680771
View directory record Official record
Conditions
Primary Insomnia
Interventions
Not listed
Lead sponsor
University of Rochester
Other
Eligibility
30 Years to 50 Years · Female only
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 16, 2012 · Synced Jul 22, 2026, 2:27 PM EDT