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ClinicalTrials.gov public records Last synced Oct 20, 2026, 7:45 PM EDT

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Showing 1–24 of 46 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Procedural Anxiety Clear all
Not yet recruiting Phase 2 Interventional

Investigating Pre-Procedural Anxiety and Effect of Analgesia on Intrauterine Device Placement and Endometrial Biopsy

NCT07031206
View directory record Official record
Conditions
Anxiety, Pain
Interventions
Paracervical block- Lidocaine without epinephrine, Benzocaine Gel applied to the cervix, Hydroxyzine Hydrochloride
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older · Female only
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 22, 2025 · Synced Oct 20, 2026, 7:45 PM EDT
Completed Not applicable Interventional

Distracting Through Procedural Pain and Distress

NCT04892160
View directory record Official record
Conditions
Chronic Illness, Hematologic Malignancy, Bone Marrow Transplant Infection, Oncology, Sickle Cell Disease
Interventions
Guided Imagery, Virtual Reality
Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
8 Years to 25 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
2
States / cities
Milwaukee, Wisconsin • Wauwatosa, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 19, 2021 · Synced Oct 20, 2026, 7:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparing Virtual Reality (VR) to Non-VR for Decreasing Preoperative/Procedural Anxiety

NCT05094141
View directory record Official record
Conditions
Preoperative Anxiety
Interventions
Virtual reality
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
5 Years to 12 Years
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 11, 2025 · Synced Oct 20, 2026, 7:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Nitrous Oxide Use in Minor Procedures

NCT01911351
View directory record Official record
Conditions
Laceration, Abscess
Interventions
Nitrous Oxide
Drug
Lead sponsor
New York City Health and Hospitals Corporation
Other
Eligibility
3 Years to 12 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Apr 11, 2016 · Synced Oct 20, 2026, 7:45 PM EDT
Not yet recruiting Not applicable Interventional

Virtual Reality (VR) Audiovisual Distraction to Reduce Pain and Anxiety for Prone Pain Procedures

NCT07779083
View directory record Official record
Conditions
Procedural Pain, Procedural Anxiety
Interventions
Virtual Reality (VR) Audiovisual Distraction
Behavioral
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
230 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Aug 21, 2026 · Synced Oct 20, 2026, 7:45 PM EDT
Recruiting Not applicable Interventional

Effect of Music on Pain and Anxiety During Nail Biopsies

NCT07518953
View directory record Official record
Conditions
Procedural Anxiety, Pain
Interventions
Music intervention, Local anesthesia injections
Behavioral · Procedure
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Oct 20, 2026, 7:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pain, Anxiety During Interventional Spine Procedures

NCT04257019
View directory record Official record
Conditions
Pain, Low Back Pain, Procedural Pain, Procedural Anxiety
Interventions
Lavender oil, Almond oil, Water
Other
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 23, 2020 · Synced Oct 20, 2026, 7:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Virtual Reality Goggle Utilization for Venipuncture Distraction

NCT04479735
View directory record Official record
Conditions
Pain, Procedural
Interventions
Virtual Reality Goggles
Device
Lead sponsor
Montefiore Medical Center
Other
Eligibility
5 Years to 21 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Oct 20, 2026, 7:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluating the Feasibility of VR for Pediatric Renal Biopsies

NCT05267704
View directory record Official record
Conditions
Pain, Procedural, Procedural Anxiety, Sedation Complication
Interventions
Oculus Go Virtual Reality Headset
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
5 Years to 17 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 12, 2026 · Synced Oct 20, 2026, 7:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Online Mindfulness-Based Intervention to Decrease Pre-Procedural Anxiety Before a First-Time Screening Colonoscopy

NCT06233253
View directory record Official record
Conditions
Colorectal Carcinoma
Interventions
Best Practice, Medical Chart Review, Online Mindfulness Meditation, Survey Administration
Other · Behavioral
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
45 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 24, 2025 · Synced Oct 20, 2026, 7:45 PM EDT
Completed Not applicable Interventional

Lavender Aromatherapy Spine Procedure Study

NCT04156009
View directory record Official record
Conditions
Spine Injuries and Disorders, Pain, Back
Interventions
Activated Lavender Elequil aromatabs® (#372), Unactivated Lavender Elequil aromatabs® (#372)
Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 85 Years
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 2, 2021 · Synced Oct 20, 2026, 7:45 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Self-Adjusted Nitrous Oxide: A Feasibility Study in the Setting of Vasectomy

NCT05895383
View directory record Official record
Conditions
Procedural Pain, Pain Catastrophizing, Procedural Anxiety
Interventions
Nitrous oxide
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
21 Years to 85 Years · Male only
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 6, 2026 · Synced Oct 20, 2026, 7:45 PM EDT
Completed Not applicable Interventional Results available

A Single Blinded Randomized Controlled Trial Testing the Efficacy of a Pediatric Interactive Relational Agent vs. Standard Preoperative Education

NCT04586569
View directory record Official record
Conditions
Anesthesia, Anesthesia Emergence Delirium, Procedural Anxiety
Interventions
Pediatric Interactive Relational Agent (PIRA)
Other
Lead sponsor
Boston Children's Hospital
Other
Eligibility
4 Years to 10 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Waltham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Oct 20, 2026, 7:45 PM EDT
Recruiting No phase listed Observational

Virtual Reality (VR) for Interventional Radiology (IR) Procedures

NCT07427862
View directory record Official record
Conditions
Pain, Procedural Anxiety
Interventions
Meta Oculus Quest Pro, Pico 4, Pico G3
Device
Lead sponsor
Children's Hospital Los Angeles
Other
Eligibility
8 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Oct 20, 2026, 7:45 PM EDT
Recruiting Not applicable Interventional

Virtual Reality as a Method for Pain and Anxiety Control During First Trimester Procedural Abortion

NCT07288047
View directory record Official record
Conditions
Abortion, First Trimester, Pain Management, Pain After Surgery, Satisfaction, Satisfaction With Care, Anxiety After Surgery
Interventions
VR headset, Usual Care
Device · Other
Lead sponsor
Study Investigator
Other
Eligibility
18 Years and older · Female only
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 20, 2026, 7:45 PM EDT
Not yet recruiting Phase 4 Interventional

Remimazolam Versus Dexmedetomidine for Sedation During Neuraxial

NCT07651956
View directory record Official record
Conditions
Pregnant People, Anxiety
Interventions
Remimazolam, Dexmedetomidine
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older · Female only
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 20, 2026, 7:45 PM EDT
Completed Phase 2 Interventional Results available

A Study to Evaluate the Clinical Efficacy, Safety and Tolerability of ARX-F03 Sublingual Sufentanil/Triazolam NanoTab™ in Patients Undergoing an Elective Abdominal Liposuction Procedure

NCT00894699
View directory record Official record
Conditions
Sedation, Anxiety, Pain
Interventions
Sublingual Sufentanil/Triazolam NanoTab™ (ARX-F03), Placebo NanoTab™
Drug
Lead sponsor
Talphera, Inc
Industry
Eligibility
18 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Pasadena, California
Source: ClinicalTrials.gov public record
Updated Jun 25, 2014 · Synced Oct 20, 2026, 7:45 PM EDT
Not listed Not applicable Interventional

Cognitive Behavioral Intervention to Reduce Procedural Anxiety Among Woman With High Risk Pregnancies With Scheduled Cesarean Deliveries

NCT04203082
View directory record Official record
Conditions
Procedural Anxiety, High Risk Pregnancy, Fetal Complications
Interventions
Exposure Intervention, Usual Care
Behavioral · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
4
States / cities
Aurora, Colorado • Kansas City, Missouri • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 22, 2024 · Synced Oct 20, 2026, 7:45 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Remimazolam Sedation for Nerve Blocks

NCT05415202
View directory record Official record
Conditions
Procedural Anxiety, Procedural Pain
Interventions
Remimazolam 20 MG [Byfavo]
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Sep 28, 2023 · Synced Oct 20, 2026, 7:45 PM EDT
Withdrawn Not applicable Interventional

Technology-Based Distractions for Minor Procedures

NCT06924814
View directory record Official record
Conditions
Anxiety, Procedural Anxiety
Interventions
Standard of Care, Immersive technology
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
4 Years to 17 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Oct 20, 2026, 7:45 PM EDT
Enrolling by invitation Not applicable Interventional

VR-PAT for Pain and Anxiety Management During Pediatric Dermatologic Laser Procedures

NCT05645224
View directory record Official record
Conditions
Procedural Anxiety, Procedural Pain
Interventions
VR-PAT
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
5 Years to 25 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Oct 20, 2026, 7:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Can Virtual Reality Reduce Pain and Anxiety During Blood Draw

NCT04449341
View directory record Official record
Conditions
Procedural Anxiety, Procedural Pain
Interventions
Oculus Go headset with Ocean Rift application
Device
Lead sponsor
C.R.Darnall Army Medical Center
Federal
Eligibility
18 Years to 50 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Fort Hood, Texas
Source: ClinicalTrials.gov public record
Updated Jul 13, 2021 · Synced Oct 20, 2026, 7:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Breathwork Training Reduces Anxiety In Outpatient Gastrointestinal Procedures

NCT07647341
View directory record Official record
Conditions
Anxiety
Interventions
paced breathwork
Behavioral
Lead sponsor
Calm and Sense Technologies LLC
Industry
Eligibility
18 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Jupiter, Florida
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Oct 20, 2026, 7:45 PM EDT
Enrolling by invitation Not applicable Interventional

Little NIRVANA for Pediatric Pain and Anxiety

NCT06795126
View directory record Official record
Conditions
Acute Pain, Procedural Anxiety, Pediatric ALL, Emergency Medicine, IV Access
Interventions
Little NIRVANA
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
2 Years to 8 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 20, 2026, 7:45 PM EDT