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Showing 1–24 of 101 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Prolapse, Vaginal Clear all
Recruiting Phase 4 Interventional Accepts healthy volunteers

Paracervical Injection and Opioid Use After Vaginal Hysterectomy for Prolapse

NCT07213635
View directory record Official record
Conditions
Opioid Use, Surgical Recovery, Vaginal Hysterectomy, Prolapse Pelvic, Postoperative Pain
Interventions
Bupivacaine-epinephrine, Normal saline
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older · Female only
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 23, 2025 · Synced Jul 22, 2026, 10:00 AM EDT
Active, not recruiting Not applicable Interventional Results available

Apical Suspension Repair for Vault Prolapse In a Three-Arm Randomized Trial Design

NCT02676973
View directory record Official record
Conditions
Visceral Prolapse
Interventions
Open, Robotic, or Laparoscopic, Transvaginal Native Tissue Repair, Uphold™ LITE
Procedure
Lead sponsor
NICHD Pelvic Floor Disorders Network
Network
Eligibility
21 Years and older · Female only
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2026
U.S. locations
10
States / cities
Birmingham, Alabama • San Diego, California • Albuquerque, New Mexico + 6 more
Source: ClinicalTrials.gov public record
Updated Aug 25, 2025 · Synced Jul 22, 2026, 10:00 AM EDT
Completed Not applicable Interventional

Evaluating Sexual Function After Vaginal Repair With Perineorrhaphy

NCT01779739
View directory record Official record
Conditions
Sexual Function
Interventions
Perineorrhaphy
Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
19 Years to 105 Years · Female only
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
2
States / cities
Birmingham, Alabama • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 21, 2018 · Synced Jul 22, 2026, 10:00 AM EDT
Completed Phase 4 Interventional Results available

Preoperative Gabapentin vs Placebo for Vaginal Prolapse Surgery

NCT05658887
View directory record Official record
Conditions
Pelvic Organ Prolapse, Perioperative/Postoperative Complications
Interventions
Gabapentin, Gabapentin Placebo
Drug
Lead sponsor
Joseph Kowalski
Other
Eligibility
18 Years and older · Female only
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 11, 2025 · Synced Jul 22, 2026, 10:00 AM EDT
Terminated Not applicable Interventional

Pelvic Floor Support After Laparoscopic Hysterectomy for Benign Conditions: A Randomized Controlled Trial Comparing Vaginal Cuff Closure Techniques

NCT03753516
View directory record Official record
Conditions
Pelvic Organ Prolapse
Interventions
Laparoscopic - Vaginal Cuff Closure, Vaginal- Vaginal Cuff Closure
Procedure
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years and older · Female only
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Jul 22, 2026, 10:00 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Patient Experience and Bowel Preparation for Transvaginal Surgical Management of Vaginal Prolapse

NCT01431040
View directory record Official record
Conditions
Value of the Bowel Preparation and Diet Change Versus no Intervention, Preoperative Bowel Regimen
Interventions
No bowel prep, Clear liquid diet and 2 Fleet's enemas
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older · Female only
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 15, 2014 · Synced Jul 22, 2026, 10:00 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Outcomes of Anterior Colporrhaphy Versus Graft Reinforced Anterior Prolapse Repair

NCT00535301
View directory record Official record
Conditions
Cystocele, Uterine Prolapse, Urinary Incontinence
Interventions
grafted anterior prolapse repair, sutured anterior vaginal prolapse repair
Device · Procedure
Lead sponsor
Kaiser Permanente
Other
Eligibility
21 Years and older · Female only
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
Downey, California
Source: ClinicalTrials.gov public record
Updated Apr 21, 2015 · Synced Jul 22, 2026, 10:00 AM EDT
Completed No phase listed Observational

Vaginal Uphold Hysteropexy and Laparoscopic Sacral Hysteropexy for the Treatment of Uterovaginal Pelvic Organ Prolapse

NCT01377142
View directory record Official record
Conditions
Pelvic Organ Prolapse
Interventions
Laparoscopic sacral hysteropexy, Vaginal mesh hysteropexy
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
40 Years to 75 Years · Female only
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
7
States / cities
Stanford, California • Washington D.C., District of Columbia • Baltimore, Maryland + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 13, 2016 · Synced Jul 22, 2026, 10:00 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

PREPARE: Perioperative REhabilitation Around Vaginal Prolapse RepAir Surgery for Recovery Enhancement

NCT07265973
View directory record Official record
Conditions
Postoperative Physical Functioning
Interventions
Pelvic floor Home Exercise Program, this intervention is comprised of specific exercises that are easy to complete at home
Other
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older · Female only
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Jul 22, 2026, 10:00 AM EDT
Completed Phase 3 Interventional

The Effects of Local Vaginal Estrogen in Postmenopausal Women With Pelvic Organ Prolapse

NCT00803335
View directory record Official record
Conditions
Pelvic Organ Prolapse, Vaginal Atrophy
Interventions
Vaginal conjugated estrogen cream 0.5gm, Vaginal conjugated estrogen cream 1.0gm
Drug
Lead sponsor
TriHealth Inc.
Other
Eligibility
45 Years and older · Female only
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated May 26, 2015 · Synced Jul 22, 2026, 10:00 AM EDT
Completed Not applicable Interventional Results available

Feasibility Study of the Reia Vaginal Pessary

NCT04508335
View directory record Official record
Conditions
Pelvic Organ Prolapse
Interventions
Reia Vaginal Pessary
Device
Lead sponsor
Reia, LLC
Industry
Eligibility
18 Years and older · Female only
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
7
States / cities
Birmingham, Alabama • Cambridge, Massachusetts • Lebanon, New Hampshire + 4 more
Source: ClinicalTrials.gov public record
Updated Nov 26, 2024 · Synced Jul 22, 2026, 10:00 AM EDT
Completed No phase listed Observational Results available

Restorelle Direct Fix Anterior and Posterior (A&P) for Female Pelvic Organ Prolapse: A Prospective Post Market Study

NCT01378065
View directory record Official record
Conditions
Pelvic Organ Prolapse (POP)
Interventions
Restorelle Direct Fix A&P
Device
Lead sponsor
Coloplast A/S
Industry
Eligibility
18 Years and older · Female only
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
6
States / cities
Baltimore, Maryland • Grand Rapids, Michigan • Marshall, Missouri + 3 more
Source: ClinicalTrials.gov public record
Updated May 11, 2020 · Synced Jul 22, 2026, 10:00 AM EDT
Terminated Not applicable Interventional

Traditional vs. Graft-augmented Posterior Colporrhaphy

NCT00581594
View directory record Official record
Conditions
Pelvic Organ Prolapse, Posterior Vaginal Wall Defects
Interventions
Graft-augmented colporrhaphy, Traditional posterior colporrhaphy
Procedure
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older · Female only
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Jan 24, 2021 · Synced Jul 22, 2026, 10:00 AM EDT
Completed Not applicable Interventional Results available

The Extended Operations And Pelvic Muscle Training In The Management Of Apical Support Loss Study

NCT01166373
View directory record Official record
Conditions
Pelvic Organ Prolapse
Interventions
Enrollment video, SSLF, ULS, PMT, Usual Care
Behavioral · Procedure · Other
Lead sponsor
NICHD Pelvic Floor Disorders Network
Network
Eligibility
18 Years and older · Female only
Enrollment
285 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
7
States / cities
Birmingham, Alabama • La Jolla, California • Maywood, Illinois + 4 more
Source: ClinicalTrials.gov public record
Updated Sep 27, 2020 · Synced Jul 22, 2026, 10:00 AM EDT
Completed No phase listed Observational

Same Day Discharge Following Pelvic Reconstructive Surgery

NCT04804826
View directory record Official record
Conditions
Same Day Discharge, Pelvic Organ Prolapse, Total Vaginal Hysterectomy
Interventions
Pelvic Reconstructive Surgery
Procedure
Lead sponsor
TriHealth Inc.
Other
Eligibility
18 Years and older · Female only
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 4, 2024 · Synced Jul 22, 2026, 10:00 AM EDT
Completed No phase listed Observational

Permanent Versus Delayed-Absorbable Monofilament Suture

NCT04506177
View directory record Official record
Conditions
Hysterectomy, Sacrocolpopexy
Interventions
Not listed
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older · Female only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
5
States / cities
Augusta, Georgia • Chicago, Illinois • Chapel Hill, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 25, 2024 · Synced Jul 22, 2026, 10:00 AM EDT
Completed No phase listed Observational

Restorelle® Mesh Versus Native Tissue Repair for Prolapse

NCT02162615
View directory record Official record
Conditions
Pelvic Organ Prolapse
Interventions
Restorelle Direct Fix A, Restorelle Direct Fix P, Native Tissue Repair Anterior, Native Tissue Repair Posterior
Device · Procedure
Lead sponsor
Coloplast A/S
Industry
Eligibility
18 Years and older · Female only
Enrollment
810 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
33
States / cities
Agoura Hills, California • Stanford, California • Denver, Colorado + 30 more
Source: ClinicalTrials.gov public record
Updated Jan 26, 2022 · Synced Jul 22, 2026, 10:00 AM EDT
Active, not recruiting Not applicable Interventional

EASE: The Materna Prep Pivotal Study

NCT03973281
View directory record Official record
Conditions
Vaginal Delivery, Pelvic Organ Prolapse
Interventions
Materna Prep Device, Standard of Care (SOC)
Device · Other
Lead sponsor
Materna Medical
Industry
Eligibility
18 Years and older · Female only
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
22
States / cities
Birmingham, Alabama • Greenbrae, California • Los Angeles, California + 18 more
Source: ClinicalTrials.gov public record
Updated Sep 16, 2025 · Synced Jul 22, 2026, 10:00 AM EDT
Completed Phase 4 Interventional Results available

Lessons on Urethral Lidocaine in Urodynamics

NCT04038099
View directory record Official record
Conditions
Urethra Issue, Pelvic Organ Prolapse, Urinary Incontinence, Vaginal Vault Prolapse, Cystocele, Uterine Prolapse, Vaginal Prolapse, Pelvic Floor Disorders
Interventions
Water-Based Vaginal Lubricant, lidocaine topical
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 31, 2023 · Synced Jul 22, 2026, 10:00 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparing Force of Stream to Retrograde Fill Voiding Trial After Vaginal Apex Suspension

NCT02753920
View directory record Official record
Conditions
Vaginal Apical Prolapse
Interventions
voiding trial, Foley catheter
Other · Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 95 Years · Female only
Enrollment
184 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Great Neck, New York
Source: ClinicalTrials.gov public record
Updated Nov 4, 2018 · Synced Jul 22, 2026, 10:00 AM EDT
Terminated Phase 4 Interventional

Clinical Trial of Solifenacin Versus Placebo Plus Pessary for Women With Vaginal Prolapse

NCT01092624
View directory record Official record
Conditions
Pelvic Organ Prolapse
Interventions
Solifenacin, Placebo, Ring pessary with support, Cooper Surgical, Trumbell, CT Ref # MXPRS03 non-latex
Drug · Device
Lead sponsor
Hartford Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 3, 2011 · Synced Jul 22, 2026, 10:00 AM EDT
Active, not recruiting Not applicable Interventional

Barbed-suture Efficiency Study for Sacrocolpopexy

NCT05760794
View directory record Official record
Conditions
Prolapse; Female
Interventions
Non-barbed delayed absorbable suture, Barbed delayed absorbable suture
Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
21 Years to 80 Years · Female only
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 1, 2025 · Synced Jul 22, 2026, 10:00 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Will Cleaning the Bowel With an Enema Before Vaginal Prolapse Surgery Prevent Complications?

NCT00981539
View directory record Official record
Conditions
Colon Cleansing
Interventions
enema
Procedure
Lead sponsor
Illinois Urogynecology, Ltd.
Other
Eligibility
18 Years and older · Female only
Enrollment
310 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
2
States / cities
Oak Lawn, Illinois • Park Ridge, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 21, 2009 · Synced Jul 22, 2026, 10:00 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Chlorhexidine vs. Iodine for Vaginal Preparation in Urogynecologic Procedures

NCT04048356
View directory record Official record
Conditions
Pelvic Organ Prolapse, Urinary Incontinence, Pelvic Floor Disorders, Gynecologic Disease, Post-Op Infection, Surgical Site Infection, Urinary Tract Infections
Interventions
Vaginal scrub, to be applied vaginally and perineally immediately prior to surgery.
Drug
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older · Female only
Enrollment
137 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Jul 9, 2023 · Synced Jul 22, 2026, 10:00 AM EDT