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Showing 1–17 of 17 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Prolonged Mechanical Ventilation Clear all
Completed Not applicable Interventional

Informing Decisions in Chronic Critical Illness: A Randomized Control Trial (RCT)

NCT01230099
View directory record Official record
Conditions
Chronic Critical Illness, Prolonged Mechanical Ventilation
Interventions
Supportive Information Team Group
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
21 Years and older
Enrollment
622 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
4
States / cities
New York, New York • Chapel Hill, North Carolina • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 28, 2015 · Synced Jul 21, 2026, 10:25 PM EDT
Completed Not applicable Interventional Results available

Improving Decision Making for Patients With Prolonged Mechanical Ventilation

NCT01751061
View directory record Official record
Conditions
Surrogate Decision Makers, Prolonged Mechanical Ventilation
Interventions
Decision aid, Usual care
Behavioral · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
416 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
4
States / cities
Chapel Hill, North Carolina • Durham, North Carolina • Pittsburgh, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated May 1, 2019 · Synced Jul 21, 2026, 10:25 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Personalized Decision-Aid to Guide Tracheostomy and Prolonged Mechanical Ventilation Decision-Making

NCT07223918
View directory record Official record
Conditions
Acute Respiratory Failure, Mechanical Ventilation, Tracheostomy
Interventions
TRACH-Support
Behavioral
Lead sponsor
Denver Health and Hospital Authority
Other
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Nov 2, 2025 · Synced Jul 21, 2026, 10:25 PM EDT
Completed No phase listed Observational

Prediction of Functional Outcomes From Chronic Critical Illness

NCT03159208
View directory record Official record
Conditions
Chronic Critical Illness, Prolonged Mechanical Ventilation
Interventions
Not listed
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
589 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
6
States / cities
Denver, Colorado • The Bronx, New York • Chapel Hill, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 27, 2021 · Synced Jul 21, 2026, 10:25 PM EDT
Completed Not applicable Interventional

Mechanical Ventilator Weaning in Chronically Ventilated Patients

NCT06976554
View directory record Official record
Conditions
Mechanical Ventilation Complication
Interventions
weaning
Procedure
Lead sponsor
University of California, Los Angeles
Other
Eligibility
Not listed
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 2, 2025 · Synced Jul 21, 2026, 10:25 PM EDT
Completed Not applicable Interventional

Weaning From Prolonged Mechanical Ventilation

NCT01541462
View directory record Official record
Conditions
Acute Mechanical Ventilatory Failure
Interventions
Weaning
Other
Lead sponsor
RML Specialty Hospital
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2011
U.S. locations
1
States / cities
Hinsdale, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 29, 2012 · Synced Jul 21, 2026, 10:25 PM EDT
Completed Not applicable Interventional

Electrical Stimulation to Strengthen Muscles in the Lower Legs in Patients Requiring Prolonged Mechanical Ventilation

NCT01825135
View directory record Official record
Conditions
Muscle Weakness
Interventions
Neuromuscular electrical stimulation, sham stimulation
Device
Lead sponsor
RML Specialty Hospital
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Hinsdale, Illinois
Source: ClinicalTrials.gov public record
Updated May 2, 2017 · Synced Jul 21, 2026, 10:25 PM EDT
Withdrawn Phase 4 Interventional

Automated Ventilator Controlled Weaning vs Daily Spontaneous Breathing Trial in Difficult to Wean ICU Patients

NCT00813839
View directory record Official record
Conditions
Mechanical Ventilation, Weaning
Interventions
daily weaning trails
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 7, 2015 · Synced Jul 21, 2026, 10:25 PM EDT
Completed Phase 4 Interventional Results available

Preventing Depression in People Receiving Mechanical Ventilation in an Intensive Care Unit

NCT00872027
View directory record Official record
Conditions
Depression
Interventions
Escitalopram, Placebo
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
25 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 18, 2017 · Synced Jul 21, 2026, 10:25 PM EDT
Completed Phase 1Phase 2 Interventional

A Pilot Clinical Trial to Evaluate the Effects of Acupuncture in Patients on Prolonged Mechanical Ventilation

NCT01621139
View directory record Official record
Conditions
Mechanical Ventilation Complication
Interventions
Acupuncture
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 12, 2013 · Synced Jul 21, 2026, 10:25 PM EDT
Recruiting Not applicable Interventional

Prognostic Estimates Among ICU Clinicians

NCT06452797
View directory record Official record
Conditions
Mechanical Ventilation
Interventions
ProVent-14 score
Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
Not listed
Enrollment
238 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
3
States / cities
Chicago, Illinois • Oak Park, Illinois • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 16, 2025 · Synced Jul 21, 2026, 10:25 PM EDT
Not listed Not applicable Interventional

Facilitating Functional Independence in Patients Receiving Prolonged Mechanical Ventilation

NCT02847988
View directory record Official record
Conditions
Muscle Weakness
Interventions
Neuromuscular electrical Stimulation (NMES), Sham Stimulation
Device
Lead sponsor
RML Specialty Hospital
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Hinsdale, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 10, 2021 · Synced Jul 21, 2026, 10:25 PM EDT
Terminated Phase 4 Interventional Results available

Impact of Methadone on Prolonged Mechanical Ventilation in Patients on Continuous Treatment With Opioids

NCT06110546
View directory record Official record
Conditions
Effect of Methadone on the Duration on Mechanical Ventilation
Interventions
Methadone group, Usual care
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 31, 2025 · Synced Jul 21, 2026, 10:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pilot Study of TransAeris® System in Surgical Patients at Risk of Prolonged Mechanical Ventilation

NCT04309123
View directory record Official record
Conditions
Ventilator-Induced Diaphragm Dysfunction
Interventions
TransAeris System
Device
Lead sponsor
Synapse Biomedical
Industry
Eligibility
22 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 7, 2021 · Synced Jul 21, 2026, 10:25 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Randomized Study of TransAeris® System in Cardiac Surgery Patients at Risk of Prolonged Mechanical Ventilation

NCT04899856
View directory record Official record
Conditions
Ventilator Induced Diaphragm Dysfunction
Interventions
TransAeris
Device
Lead sponsor
Synapse Biomedical
Industry
Eligibility
22 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 17, 2023 · Synced Jul 21, 2026, 10:25 PM EDT
Completed Not applicable Interventional

The SOMNUS Study: Sedative Optimization Via Monitoring Neurological Status

NCT00469482
View directory record Official record
Conditions
Delirium, Cognitive Impairment, Critically Ill
Interventions
Sedation,RASS Targeted plus BIS Monitoring, Sedation, RASS Targeted
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2016
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 7, 2018 · Synced Jul 21, 2026, 10:25 PM EDT
Completed No phase listed Observational

Variability Analysis as a Predictor of Liberation From Mechanical Ventilation

NCT01140750
View directory record Official record
Conditions
Mechanical Ventilation, Autonomic Nervous System Diseases
Interventions
Not listed
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 8, 2010 · Synced Jul 21, 2026, 10:25 PM EDT