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ClinicalTrials.gov public records Last synced Oct 27, 2026, 8:14 AM EDT

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Showing 1–24 of 191 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Propofol Clear all
Completed Phase 4 Interventional Results available

Preventing Propofol-associated Injection Pain

NCT00864682
View directory record Official record
Conditions
Pain
Interventions
Saline, Lidocaine / propofol admixture, lidocaine pretreatment
Drug
Lead sponsor
Benaroya Research Institute
Other
Eligibility
18 Years to 80 Years
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 27, 2021 · Synced Oct 27, 2026, 8:14 AM EDT
Completed Phase 4 Interventional Results available

Comparison of Two Techniques of IV Lidocaine on Propofol Injection Pain

NCT03057704
View directory record Official record
Conditions
Injections, Intravenous
Interventions
Lidocaine injection flushed, Lidocaine injection tourniquet
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 10, 2018 · Synced Oct 27, 2026, 8:14 AM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Two Anesthetic Techniques in Magnetic Resonance Imaging (MRI)

NCT00894751
View directory record Official record
Conditions
Magnetic Resonance Imaging, Anesthesia
Interventions
dexmedetomidine, propofol
Drug
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
12 Months to 7 Years
Enrollment
98 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 21, 2020 · Synced Oct 27, 2026, 8:14 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effects of Sevoflurane and Propofol on Light Flash Evoked Pupillometry

NCT00695890
View directory record Official record
Conditions
Measurement of Pupil Diameter
Interventions
Not listed
Lead sponsor
University of Medicine and Dentistry of New Jersey
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Dec 19, 2014 · Synced Oct 27, 2026, 8:14 AM EDT
Completed Not applicable Interventional Results available

Effect of Nasal Positive Airway Pressure Versus Standard Care on Oxygenation and Ventilation During Propofol-based Sedation for Colonoscopy in Patients With High Risk of Airway Obstruction

NCT05524220
View directory record Official record
Conditions
Obstructive Sleep Apnea, Obesity
Interventions
Standard care with a facemask., SuperNO2VA™EtCO2 (Nasal Oxygenating Ventilating Apparatus)
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 22, 2025 · Synced Oct 27, 2026, 8:14 AM EDT
Completed No phase listed Observational

Propofol Sedation Study

NCT00597740
View directory record Official record
Conditions
Anesthesia
Interventions
Not listed
Lead sponsor
Scottsdale Healthcare
Other
Eligibility
18 Years to 80 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Dec 3, 2013 · Synced Oct 27, 2026, 8:14 AM EDT
Terminated Not applicable Interventional

Determining if the Buzzy® Personal Pain Relief Device Reduces Injection Pain of Propofol as Much as Intravenous Lidocaine in Children

NCT07770581
View directory record Official record
Conditions
Propofol Injection Pain in Children
Interventions
Buzzy device, Intravenous lidocaine
Device · Drug
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
12 Years to 17 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 18, 2026 · Synced Oct 27, 2026, 8:14 AM EDT
Completed Phase 3 Interventional Results available

Propofol in Obese Children

NCT01242241
View directory record Official record
Conditions
Pharmacodynamics, Obesity
Interventions
Propofol
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
3 Years to 17 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 21, 2020 · Synced Oct 27, 2026, 8:14 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Ketamine and Propofol NeuroImaging

NCT07294092
View directory record Official record
Conditions
Anesthesia, Pain
Interventions
Propofol, Ketamine, Peripheral Nerve Stimulation
Drug · Device
Lead sponsor
Keith M Vogt
Other
Eligibility
18 Years to 59 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Oct 27, 2026, 8:14 AM EDT
Terminated Phase 1Phase 2 Interventional

Effect of Intravenous Lidocaine, Used to Attenuate Pain With Propofol Injection, on Defibrillation Threshold Testing

NCT03117166
View directory record Official record
Conditions
Pain
Interventions
lidocaine, Placebo
Drug
Lead sponsor
Drexel University College of Medicine
Other
Eligibility
18 Years to 80 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 9, 2017 · Synced Oct 27, 2026, 8:14 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Memory & Conditioning Under Anesthesia

NCT04062123
View directory record Official record
Conditions
Anesthesia, Pain
Interventions
Dexmedetomidine, Propofol, Fentanyl, Peripheral Nerve Stimulation, Placebo
Drug · Device
Lead sponsor
Keith M Vogt
Other
Eligibility
18 Years to 39 Years
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 18, 2025 · Synced Oct 27, 2026, 8:14 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Driving Skills Recovery Following Procedural Sedation for Gastrointestinal Endoscopy

NCT04350424
View directory record Official record
Conditions
Anesthesia, Psychomotor Status
Interventions
Not listed
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 18, 2023 · Synced Oct 27, 2026, 8:14 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Dexmedetomidine Versus Propofol for Prolonged Sedation in Critically Ill Trauma and Surgical Patients

NCT02548923
View directory record Official record
Conditions
Delirium
Interventions
Dexmedetomidine
Drug
Lead sponsor
University of Tennessee Graduate School of Medicine
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 14, 2015 · Synced Oct 27, 2026, 8:14 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Efficacy and Safety of HSK3486 Compared to Propofol in Induction of General Anesthesia in Adults Having Elective Surgery

NCT04711837
View directory record Official record
Conditions
Anesthesia
Interventions
HSK3486, Propofol
Drug
Lead sponsor
Haisco-USA Pharmaceuticals, Inc.
Industry
Eligibility
18 Years and older
Enrollment
255 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
13
States / cities
Phoenix, Arizona • Pasadena, California • Tamarac, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Oct 10, 2025 · Synced Oct 27, 2026, 8:14 AM EDT
Completed Phase 3 Interventional Results available

Evaluate Use of Caudal Nerve Blocks in Adult Penile Prosthesis

NCT02740127
View directory record Official record
Conditions
Malignant Neoplasms of Male Genital Organs
Interventions
Caudal Nerve Block (CNB), Ropivacaine, Epinephrine, Decadron, Clonidine, Propofol, Phone Call
Procedure · Drug · Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older · Male only
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 24, 2022 · Synced Oct 27, 2026, 8:14 AM EDT
Completed Phase 1 Interventional Results available

Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) I

NCT04680910
View directory record Official record
Conditions
Treatment-resistant Depression
Interventions
Propofol, Electroencephalography (EEG), Slow-Wave Activity
Drug · Diagnostic Test
Lead sponsor
Washington University School of Medicine
Other
Eligibility
60 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Oct 27, 2026, 8:14 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Precedex Versus Propofol-Awakening for Reducing Brain Injury Expansion

NCT00538616
View directory record Official record
Conditions
Brain Injury, Intracranial Pressure
Interventions
Dexmedetomidine, Propofol
Drug
Lead sponsor
Carmelo Graffagnino
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 11, 2013 · Synced Oct 27, 2026, 8:14 AM EDT
Completed Phase 4 Interventional Results available

Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea

NCT01344759
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
Dexmedetomidine, Propofol
Drug
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
12 Months to 25 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 8, 2018 · Synced Oct 27, 2026, 8:14 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Efficacy and Safety of HSK3486 Compared to Propofol for Adults Undergoing Elective Surgery With General Anesthesia

NCT05478174
View directory record Official record
Conditions
General Anesthesia
Interventions
HSK3486, Propofol
Drug
Lead sponsor
Haisco-USA Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 99 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
23
States / cities
Sheffield, Alabama • Phoenix, Arizona • Davis, California + 19 more
Source: ClinicalTrials.gov public record
Updated Oct 10, 2025 · Synced Oct 27, 2026, 8:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Patient-Controlled Sedation Versus Anesthesiologist-Administered Sedation

NCT00868920
View directory record Official record
Conditions
Colonoscopy
Interventions
patient control of pump, anesthesiologist controlled sedation
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 30, 2017 · Synced Oct 27, 2026, 8:14 AM EDT
Completed Phase 3 Interventional Results available

Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU2)

NCT05327296
View directory record Official record
Conditions
Sedation
Interventions
Isoflurane, Propofol
Drug
Lead sponsor
Sedana Medical
Industry
Eligibility
18 Years and older
Enrollment
282 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
16
States / cities
Long Beach, California • Los Angeles, California • Redwood City, California + 12 more
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Oct 27, 2026, 8:14 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Comparison of Procedural Sedation in TEE

NCT06129188
View directory record Official record
Conditions
Anesthesia
Interventions
Remimazolam, Propofol
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 89 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Oct 27, 2026, 8:14 AM EDT
Completed No phase listed Observational

Efficacy and Safety of a Single Syringe Total Intravenous Anesthesia With Propofol and Remifentanil: A Prospective Cohort Study

NCT04987580
View directory record Official record
Conditions
Anesthesia
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 75 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 1, 2023 · Synced Oct 27, 2026, 8:14 AM EDT
Completed Phase 4 Interventional Results available

The Synergistic Effect of Dexmedetomidine on Propofol for Sedation for Pediatric Endoscopy

NCT02952222
View directory record Official record
Conditions
Anesthesia
Interventions
Dexmedetomidine, Propofol (Group P), Propofol (Group DP)
Drug
Lead sponsor
Keira Mason
Other
Eligibility
7 Years to 18 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 10, 2024 · Synced Oct 27, 2026, 8:14 AM EDT