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Showing 25–46 of 22 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Prosthesis User Clear all
Completed Not applicable Interventional

Connect TF - An Investigation of Function and Usability of a New Adaptable Socket System

NCT04388488
View directory record Official record
Conditions
Prosthesis User, Amputation
Interventions
CONNECT TF adaptable socket system, Any conventional handmade socket
Device
Lead sponsor
Össur Iceland ehf
Industry
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
2
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 7, 2024 · Synced Jul 21, 2026, 6:07 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

GaMA Metric to Quantify Functional Importance of Various Upper Limb Prosthetic Devices

NCT06420687
View directory record Official record
Conditions
Amputation, Amputation, Traumatic, Amputation; Traumatic, Hand, Amputation; Traumatic, Limb
Interventions
Clinically prescribed prosthesis, Experimental prosthesis - Wrist rotation + 1-DOF, Experimental prosthesis - Wrist rotation + Wrist flexion +1-DOF, Experimental prosthesis - Wrist rotation + Multi DOF hand, Experimental prosthesis - Wrist rotation + wrist flexion + Multi DOF hand
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 70 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 13, 2025 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Results available

An Investigation of Functional Improvements in the RHEO KNEE Compared to Hydraulic Microprocessor Controlled Knees (MPKs)

NCT04023578
View directory record Official record
Conditions
Prosthesis User, Amputation
Interventions
RHEO KNEE XC
Device
Lead sponsor
Össur Iceland ehf
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
4
States / cities
Orlando, Florida • Flowood, Mississippi • Fort Worth, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 5, 2020 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Results available

Lower Limb Prostheses for Individuals Who Carry Infants, Toddlers, and Other Loads

NCT07159490
View directory record Official record
Conditions
Amputation, Prosthesis User
Interventions
Standard-of-care prosthetic foot, Standard-of-care prosthetic foot with heel-stiffening wedge, Standard-of-care prosthetic foot of one category greater stiffness, Dual keel prosthetic foot, Powered ankle-foot
Device
Lead sponsor
VA Puget Sound Health Care System
Federal
Eligibility
18 Years to 70 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Jul 21, 2026, 6:07 PM EDT
Recruiting Not applicable Interventional

Functional and Neuroprotective Effects of Restoring Lower Limb Sensation After Diabetic Peripheral Neuropathy

NCT04658693
View directory record Official record
Conditions
Lower Extremity Amputee, Diabetic Peripheral Neuropathy
Interventions
Implanted Multi contact stimulating electrode and intramuscular electromyography recording electrode
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Jul 21, 2026, 6:07 PM EDT
Recruiting Not applicable Interventional

Effects of Myoelectric Channel Count and Targeting for Upper Limb Prosthetic Control

NCT07011420
View directory record Official record
Conditions
Amputation, Amputation, Traumatic, Amputation, Congenital, Prosthesis User, Upper Limb Amputation Below Elbow (Injury), Amputation; Traumatic, Arm: Forearm, Between Elbow and Wrist
Interventions
Experimental socket with 4 untargeted channels active, Experimental socket with 8 untargeted channels active, Experimental socket with up to 16 untargeted channels active, Experimental socket with 8 targeted channels active, Coapt EMG Cuff
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Chicago, Illinois • Holliston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 2, 2025 · Synced Jul 21, 2026, 6:07 PM EDT
Not listed Early Phase 1 Interventional

Biofeedback Retention in Individuals With AKA

NCT05126485
View directory record Official record
Conditions
Amputation of Knee, Back Pain, Osteo Arthritis Knee
Interventions
Haptic Biofeedback from SageMotion Biofeedback System
Device
Lead sponsor
San Jose State University
Other
Eligibility
18 Years to 70 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
2
States / cities
Palo Alto, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 1, 2023 · Synced Jul 21, 2026, 6:07 PM EDT
Recruiting No phase listed Observational

Evaluating the Experience of Upper Limb Prosthesis Use

NCT04855214
View directory record Official record
Conditions
Prosthesis User, Amputation, Upper Limb Amputation at the Wrist, Upper Limb Amputation Above Elbow (Injury), Upper Limb Amputation Below Elbow (Injury)
Interventions
Qualitative Analysis
Other
Lead sponsor
Louis Stokes VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 3, 2025 · Synced Jul 21, 2026, 6:07 PM EDT
Active, not recruiting Not applicable Interventional

Optimizing Prosthetic Prescription to Mitigate the Effects of Perspiration

NCT07024342
View directory record Official record
Conditions
Amputation, Prosthesis User
Interventions
Liner perforated with very small diameter holes, Liner perforated with somewhat larger diameter holes, Liner-liner, As-prescribed liner
Device
Lead sponsor
VA Puget Sound Health Care System
Federal
Eligibility
18 Years to 70 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Results available

Digital Weight Bearing Shape Capture Socket Technology

NCT05749952
View directory record Official record
Conditions
Amputation, Prosthesis User, Residual Limbs
Interventions
Symphonie Aqua Digital System mediated sh
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Outcomes With Passive MPKs vs. Powered Prosthetic Knees

NCT05267639
View directory record Official record
Conditions
Amputation, Amputation; Traumatic, Leg, Lower, Limb; Absence, Congenital, Lower, Prosthesis User, Lower Limb Amputation Above Knee (Injury), Amputation; Traumatic, Leg: Thigh, Between Hip and Knee
Interventions
Power Knee
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
2
States / cities
Holliston, Massachusetts • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 25, 2025 · Synced Jul 21, 2026, 6:07 PM EDT
Withdrawn Not applicable Interventional

An Osseoanchored Percutaneous Prosthesis Study Evaluating Stable Neural Signal Transmission in Subjects With Transhumeral Amputations

NCT03957226
View directory record Official record
Conditions
Amputation Neuroma, Amputation, Prosthesis User
Interventions
e-OPRA (electronic-Osseoanchored Prosthese for the Rehabilitation of Amputees)
Device
Lead sponsor
University of Michigan
Other
Eligibility
22 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 3, 2024 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Perceptual Experience of Argus II Users

NCT05285618
View directory record Official record
Conditions
Retinitis Pigmentosa
Interventions
Argus II
Device
Lead sponsor
University of California, Santa Barbara
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
3
States / cities
Santa Barbara, California • Baltimore, Maryland • Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 31, 2024 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

EMG-Based Hand-Wrist Control: Study B Mirrored

NCT04692571
View directory record Official record
Conditions
Amputation, Amputation; Traumatic, Hand, Amputation, Congenital, Prosthesis User
Interventions
PSICON Measurement Apparatus
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
2
States / cities
Holliston, Massachusetts • Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 4, 2021 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Results available

Clinical Investigation (Beta) of Power Knee Mainstream - Dynamic

NCT04787627
View directory record Official record
Conditions
Prosthesis User, Amputation
Interventions
Power Knee
Device
Lead sponsor
Össur Iceland ehf
Industry
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Silver Spring, Maryland • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 21, 2025 · Synced Jul 21, 2026, 6:07 PM EDT
Active, not recruiting Not applicable Interventional

Personalized Mobility Interventions Using Smart Sensor Resources for Lower-Limb Prosthesis Users

NCT03930199
View directory record Official record
Conditions
Amputation
Interventions
Needs-based intervention (physical, psychological, or both)
Other
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 89 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
3
States / cities
Chicago, Illinois • Bethesda, Maryland • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Jul 21, 2026, 6:07 PM EDT
Recruiting Not applicable Interventional

Effects of Microprocessor-controlled Prosthetic Knees on Fall-related Health Outcomes in Limited Community Ambulators

NCT06937242
View directory record Official record
Conditions
Amputation, Prosthesis User, Amputation; Traumatic, Leg: Thigh, Between Hip and Knee, Limb; Absence, Congenital, Lower, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Above Knee
Interventions
Ottobock C-Leg 4 Microprocessor Knee, Ottobock Kenevo
Device
Lead sponsor
Hanger Institute for Clinical Research and Education, LLC
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Jul 21, 2026, 6:07 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers Results available

3D X-ray Motion Analysis of Ankle-foot Motion After Total Ankle Arthroplasty

NCT03575975
View directory record Official record
Conditions
Ankle Arthroplasty, Prosthesis User, Joint Disease
Interventions
Total Ankle Replacement Prosthesis
Device
Lead sponsor
Georgia Institute of Technology
Other
Eligibility
18 Years to 79 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated May 27, 2021 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional

Pattern Recognition Prosthetic Control

NCT04272489
View directory record Official record
Conditions
Prosthesis User, Congenital Amputation of Upper Limb, Amputation; Traumatic, Limb
Interventions
EMG-Pattern Recognition Controller
Device
Lead sponsor
Coapt, LLC
Industry
Eligibility
18 Years to 70 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 19, 2022 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Results available

Assist-Knee: Energy-Harvesting Knee Prosthesis

NCT04023045
View directory record Official record
Conditions
Transfemoral Amputation, Artificial Limbs
Interventions
Assist-Knee, Habitual Prosthesis
Device
Lead sponsor
Orthocare Innovations, LLC
Industry
Eligibility
21 Years to 80 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Edmonds, Washington
Source: ClinicalTrials.gov public record
Updated Oct 17, 2023 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Myoelectric Game Training and Outcomes

NCT04354493
View directory record Official record
Conditions
Amputation, Prosthesis User, Prosthesis
Interventions
Myo-electric Gaming Interface
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Holliston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 18, 2022 · Synced Jul 21, 2026, 6:07 PM EDT
Active, not recruiting Not applicable Interventional

Transfemoral Powered Foot and Physical Therapy Study

NCT03625921
View directory record Official record
Conditions
Lower Extremity Problem, Prosthesis User
Interventions
Powered device with physical therapy, Powered device with standard of practice
Behavioral
Lead sponsor
VA New York Harbor Healthcare System
Federal
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 5, 2025 · Synced Jul 21, 2026, 6:07 PM EDT