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Showing 1–17 of 17 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Residual Limb Pain Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

AMI Construction in Lower Extremity Residual Limbs

NCT04063592
View directory record Official record
Conditions
Amputation
Interventions
Residual limb revision
Procedure
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
3
States / cities
Bethesda, Maryland • Boston, Massachusetts • Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Jul 21, 2026, 6:07 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Detecting Change in Muscle Parameters, Pain, and Function With NMES for TTA

NCT06830876
View directory record Official record
Conditions
Amputation
Interventions
Chattanooga Continuum Device
Device
Lead sponsor
Sara Peterson-Snyder
Industry
Eligibility
18 Years to 100 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 16, 2025 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Results available

Pulsed Electromagnetic Fields for Post-Amputation Pain

NCT05392803
View directory record Official record
Conditions
Phantom Limb Pain, Residual Limb Pain
Interventions
Active then Sham Treatment, Sham then Active Treatment
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Results available

Electrical Stimulation for the Treatment of Post-Amputation Pain Using the SPRINT System

NCT01996254
View directory record Official record
Conditions
Post-Amputation Pain, Phantom Limb Pain, Residual Limb Pain
Interventions
SPRINT Peripheral Nerve Stimulation (PNS) System
Device
Lead sponsor
SPR Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
10
States / cities
Scottsdale, Arizona • La Jolla, California • Denver, Colorado + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 25, 2020 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Results available

C-RFA of Residual Limb Neuroma

NCT04538417
View directory record Official record
Conditions
Phantom Limb Pain, Neuroma Amputation
Interventions
Cooled Radiofrequency Ablation
Device
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jan 7, 2025 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Results available

Postoperative Peripheral Nerve Stimulation for Management of Post-amputation Pain

NCT03484429
View directory record Official record
Conditions
Phantom Limb Pain, Postoperative Pain, Neuroma, Acute Pain, Chronic Pain, Residual Limbs, Amputation
Interventions
Peripheral nerve stimulation, Standard Medical Therapy
Device · Other
Lead sponsor
Hunter Holmes Mcguire Veteran Affairs Medical Center
Federal
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 20, 2021 · Synced Jul 21, 2026, 6:07 PM EDT
Recruiting Not applicable Interventional

Target Muscle Re-innervation and Regenerative Peripheral Nerve Interfaces Alone and in Combination for the Treatment of Residual and Phantom Limb Pain in Cancer Patients Who Have Received an Amputation

NCT06840262
View directory record Official record
Conditions
Amputation
Interventions
Questionnaire Administration, Regenerative Peripheral Nerve Interface Surgery, Targeted Muscle Reinnervation
Other · Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 4, 2025 · Synced Jul 21, 2026, 6:07 PM EDT
Not listed Phase 1 Interventional

Acupuncture for the Treatment of Phantom Limb and Residual Limb Pain After Amputation

NCT00388752
View directory record Official record
Conditions
Phantom Limb, Residual Limb Pain, Traumatic Amputation, Amputation
Interventions
Acupuncture
Procedure
Lead sponsor
Walter Reed Army Medical Center
Federal
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2006
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jun 5, 2007 · Synced Jul 21, 2026, 6:07 PM EDT
Recruiting Phase 4 Interventional

A Study of Contralateral Limb Block

NCT06045936
View directory record Official record
Conditions
Limb Pain, Phantom
Interventions
Lidocaine, Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Mankato, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 5, 2026 · Synced Jul 21, 2026, 6:07 PM EDT
Recruiting No phase listed Observational

Pain and Disability Outcomes in Post Amputation Patients

NCT05716321
View directory record Official record
Conditions
Limb Pain, Phantom, Residual Limbs Pain, Disability Physical
Interventions
Not listed
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Jul 21, 2026, 6:07 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluation of Ultrasonic Neuroma Size With Residual Limb Pain in Above-Knee Amputees

NCT00686764
View directory record Official record
Conditions
Neuroma Amputation
Interventions
Observational
Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 99 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 13, 2015 · Synced Jul 21, 2026, 6:07 PM EDT
Recruiting Not applicable Interventional

Surgical Treatments for Postamputation Pain

NCT05009394
View directory record Official record
Conditions
Residual Limb Pain, Amputation Neuroma, Phantom Limb Pain, Pain, Neuropathic, Pain, Nerve
Interventions
Targeted Muscle Reinnervation (TMR), Regenerative Peripheral Nerve Interface (RPNI), Standard neuroma treatment, neuroma excision, and muscle burying
Procedure
Lead sponsor
Prometei Pain Rehabilitation Center
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
3
States / cities
Chicago, Illinois • Boston, Massachusetts • Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 8, 2025 · Synced Jul 21, 2026, 6:07 PM EDT
Active, not recruiting Not applicable Interventional Results available

Electrical Nerve Block for Amputation Pain

NCT02221934
View directory record Official record
Conditions
Post-Amputation Pain, Phantom Limb Pain, Residual Limb Pain, Stump Pain
Interventions
Altius
Device
Lead sponsor
Neuros Medical, Inc.
Industry
Eligibility
21 Years and older
Enrollment
607 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2025
U.S. locations
22
States / cities
Scottsdale, Arizona • Little Rock, Arkansas • Denver, Colorado + 18 more
Source: ClinicalTrials.gov public record
Updated Jun 5, 2025 · Synced Jul 21, 2026, 6:07 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Perioperative Mirror Therapy and Phantom Limb Pain

NCT02383979
View directory record Official record
Conditions
Phantom Limb Pain, Phantom Pain, Phantom Sensation, Pseudomelia
Interventions
Sham (Comparator) Plasma Ball, Mirror
Device
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years to 30 Years
Enrollment
115 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2019
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 27, 2019 · Synced Jul 21, 2026, 6:07 PM EDT
Terminated Phase 4 Interventional Results available

Sciatic Block in Contralateral Limb Phantom and Residual Limb Pain

NCT05046639
View directory record Official record
Conditions
Pain, Amputation
Interventions
10 mL 2% lidocaine, 10 mL preservative free saline
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 2, 2025 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Study to Assess the Efficacy of Botulinum Toxin B (Myobloc) for the Treatment of Prosthesis-associated Sweating

NCT01671800
View directory record Official record
Conditions
Hyperhidrosis
Interventions
Botulinum Type B, Placebo
Drug
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 9, 2013 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Pain in Amputees Reduced by Administration of Diet Examination

NCT05460845
View directory record Official record
Conditions
Amputation, Phantom Limb Pain, Residual Limb Pain
Interventions
Low-Carbohydrate Diet
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 65 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 29, 2023 · Synced Jul 21, 2026, 6:07 PM EDT