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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Rotator Cuff Tears Clear all
Recruiting Not applicable Interventional

Use of the REGENETEN™ Bioinductive Implant System in High Grade Partial-thickness Tears

NCT05444465
View directory record Official record
Conditions
Rotator Cuff Injuries
Interventions
Isolated Bioinductive Repair, Completion and Repair
Device · Procedure
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
8
States / cities
Rome, Georgia • Rockford, Illinois • Baltimore, Maryland + 5 more
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Jul 23, 2026, 4:05 PM EDT
Terminated Not applicable Interventional

Tendon Transfer Rotator Cuff Tear

NCT04588506
View directory record Official record
Conditions
Rotator Cuff Tears
Interventions
Lower Trapezius Tendon Transfer Technique, Latissimus Dorsi Tendon Transfer Technique, Pectoralis Tendon Transfer Technique
Procedure
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 25, 2025 · Synced Jul 23, 2026, 4:05 PM EDT
Not listed No phase listed Observational

An Outcomes Study Utilizing Allomend(R) HD for Superior Capsular Reconstruction

NCT04615117
View directory record Official record
Conditions
Rotator Cuff Tear or Rupture, Not Specified as Traumatic
Interventions
Not listed
Lead sponsor
Western Orthopaedics Research and Education Foundation
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 11, 2021 · Synced Jul 23, 2026, 4:05 PM EDT
Withdrawn Not applicable Interventional

Effect of Postop Rehab Methods on Outcomes Following Reverse Shoulder Arthroplasty

NCT04285606
View directory record Official record
Conditions
Rotator Cuff Tear Arthropathy, Shoulder Osteoarthritis
Interventions
Patient-led rehab with short immobilization
Behavioral
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 20, 2022 · Synced Jul 23, 2026, 4:05 PM EDT
Recruiting No phase listed Observational

Perform Humeral System Study

NCT05067543
View directory record Official record
Conditions
Osteoarthritis Shoulder, Avascular Necrosis, Post-traumatic Arthrosis of Other Joints, Shoulder Region, Rotator Cuff Tear Arthropathy
Interventions
Tornier Perform Humeral - Stem
Device
Lead sponsor
Stryker Trauma and Extremities
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Timeline
2021 – 2036
U.S. locations
6
States / cities
Lexington, Kentucky • Eagan, Minnesota • Rochester, Minnesota + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Jul 23, 2026, 4:05 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Total Intravenous Anesthesia With Propofol vs. General Anesthesia in Outpatient Shoulder Arthroscopic Surgeries

NCT04793022
View directory record Official record
Conditions
Rotator Cuff Tears, Rotator Cuff Injuries, Orthopedic Disorder, Sports Injury, Anesthesia
Interventions
TIVA with Propofol, Inhaled Anesthesia
Drug
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years to 75 Years
Enrollment
192 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 7, 2023 · Synced Jul 23, 2026, 4:05 PM EDT
Recruiting Phase 2 Interventional

Efficacy and Safety Study of TPX-115 on Partial-thickness Rotator Cuff Tear

NCT07219654
View directory record Official record
Conditions
Partial Thickness Rotator Cuff Tears
Interventions
TPX-115, Cryopreserving hyaluronic acid medium, Saline
Biological · Other · Drug
Lead sponsor
Tego Science, Inc.
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
3
States / cities
La Mesa, California • Deerfield Beach, Florida • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Jul 23, 2026, 4:05 PM EDT
Recruiting Not applicable Interventional

Integrity Implant System Post Market Clinical Follow-Up Study

NCT06741527
View directory record Official record
Conditions
Rotator Cuff Tears of the Shoulder
Interventions
Integrity Implant System
Device
Lead sponsor
Anika Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
9
States / cities
Gilbert, Arizona • Pomona, California • Tampa, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Jul 23, 2026, 4:05 PM EDT
Terminated Not applicable Interventional Results available

Treatment of Partial-Thickness Rotator Cuff Tears

NCT03734536
View directory record Official record
Conditions
Arthroscopic Surgical Treatment of High-grade (>50%) Partialthickness
Interventions
REGENETEN™ Bioinductive Implant, Arthroscopic repair of the high-grade (>50%) partial-thickness
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
10
States / cities
Gainesville, Florida • Jacksonville Beach, Florida • Rome, Georgia + 7 more
Source: ClinicalTrials.gov public record
Updated Nov 18, 2024 · Synced Jul 23, 2026, 4:05 PM EDT
Completed No phase listed Observational Results available

PMCF Study on the Safety, Performance and Clinical Benefits Data of the ToggleLoc™ 2.9mm and JuggerLoc™ in the Shoulder

NCT05584553
View directory record Official record
Conditions
Bankart Lesions, SLAP Lesion, Acromioclavicular; Dislocation, Capsular Shift/Capsulolabral Reconstruction, Deltoid Repair, Rotator Cuff Tear Repair, Biceps Tendon Disorder
Interventions
ToggleLoc 2.9 mm soft tissue device, JuggerLoc soft tissue device
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
214 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
City of Saint Peters, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 27, 2025 · Synced Jul 23, 2026, 4:05 PM EDT
Recruiting No phase listed Observational

Dermal Allograft Augmentation of Large and Massive Rotator Cuff Tears

NCT05981833
View directory record Official record
Conditions
Full-thickness Rotator Cuff Tear
Interventions
Repair with DAA (dermal allograft augmentation)
Device
Lead sponsor
Arthrex, Inc.
Industry
Eligibility
30 Years to 75 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
4
States / cities
Scottsdale, Arizona • Greenwich, Connecticut • Medford, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 23, 2025 · Synced Jul 23, 2026, 4:05 PM EDT
Recruiting No phase listed Observational

Genetic Epidemiology of Rotator Cuff Tears: The cuffGEN Study

NCT04831164
View directory record Official record
Conditions
Rotator Cuff Tears
Interventions
NA (not an interventional study)
Other
Lead sponsor
University of Michigan
Other
Eligibility
40 Years to 85 Years
Enrollment
3,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2031
U.S. locations
10
States / cities
Iowa City, Iowa • Boston, Massachusetts • Ann Arbor, Michigan + 4 more
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Jul 23, 2026, 4:05 PM EDT
Not listed Not applicable Interventional

Subscapularis Repair in Reverse Shoulder Arthroplasty

NCT05438914
View directory record Official record
Conditions
Rotator Cuff Tear Arthropathy
Interventions
Repair of the subscapularis
Device
Lead sponsor
Arthrex, Inc.
Industry
Eligibility
18 Years to 100 Years
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
6
States / cities
Phoenix, Arizona • Denver, Colorado • Medford, Oregon + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 29, 2024 · Synced Jul 23, 2026, 4:05 PM EDT
Enrolling by invitation Not applicable Interventional

Randomized Study of an Analgesic Device Enabling Local Anesthetic Delivery and Neuromodulation After Shoulder/Foot Surgery

NCT07052721
View directory record Official record
Conditions
Rotator Cuff Tears, Shoulder Injuries, Hallux Valgus, Ankle Arthropathy, Clavicle Fracture
Interventions
Experimental Treatment, Sham Comparator
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Jul 23, 2026, 4:05 PM EDT
Completed No phase listed Observational

The Natural History of Asymptomatic Rotator Cuff Tears

NCT00923858
View directory record Official record
Conditions
Rotator Cuff Tear
Interventions
Not listed
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 75 Years
Enrollment
495 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2022
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 30, 2022 · Synced Jul 23, 2026, 4:05 PM EDT
Completed Not applicable Interventional

Interscalene Block With and Without Liposomal Bupivacaine in Shoulder Surgery

NCT03728946
View directory record Official record
Conditions
Rotator Cuff Tear, Postoperative Pain
Interventions
Liposomal Bupivacaine
Drug
Lead sponsor
Orthopaedic & Neurosurgery Specialists
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
6
States / cities
Greenwich, Connecticut • Stamford, Connecticut • Atlantis, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 23, 2020 · Synced Jul 23, 2026, 4:05 PM EDT
Completed No phase listed Observational

The Effects of Platelet Rich Plasma on the Integrity of Rotator Cuff Repair

NCT01424969
View directory record Official record
Conditions
Rotator Cuff Tear Arthropathy
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
50 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Feb 13, 2014 · Synced Jul 23, 2026, 4:05 PM EDT
Enrolling by invitation No phase listed Observational

Reverse Shoulder Arthroplasty vs Rotator Cuff Repair for 60+

NCT06848023
View directory record Official record
Conditions
Shoulder Injuries, Shoulder Pain
Interventions
Reverse Total Shoulder Arthroplasty, Rotator Cuff Repair
Procedure
Lead sponsor
Campbell Clinic
Other
Eligibility
60 Years to 95 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Germantown, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 27, 2025 · Synced Jul 23, 2026, 4:05 PM EDT
Completed Early Phase 1 Interventional

Rehabilitation: Closed-Chain Exercises for Rotator Cuff Tears

NCT02750176
View directory record Official record
Conditions
Full Thickness Rotator Cuff Tear
Interventions
Closed chain exercises
Other
Lead sponsor
University of Southern California
Other
Eligibility
40 Years to 85 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 24, 2018 · Synced Jul 23, 2026, 4:05 PM EDT
Completed No phase listed Observational

Comparison of the Accuracy of Telehealth Examination Versus Clinical Examination in the Detection of Rotator Cuff Tears

NCT03906630
View directory record Official record
Conditions
Rotator Cuff Tear
Interventions
Telehealth clinical exam, Standard clinical exam
Diagnostic Test
Lead sponsor
Duke University
Other
Eligibility
40 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Raleigh, North Carolina • Wake Forest, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 15, 2020 · Synced Jul 23, 2026, 4:05 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Vitamin D3 Supplementation for Vitamin D Deficiency in Rotator Cuff Repair Surgery

NCT05009498
View directory record Official record
Conditions
Vitamin D Deficiency, Rotator Cuff Tears
Interventions
Vitamin D3 supplementation, Placebo
Dietary Supplement · Other
Lead sponsor
Community Memorial Health System
Other
Eligibility
18 Years to 65 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
2
States / cities
Ventura, California
Source: ClinicalTrials.gov public record
Updated Aug 16, 2021 · Synced Jul 23, 2026, 4:05 PM EDT
Withdrawn Phase 4 Interventional

The Effect of NSAIDs After a Rotator Cuff Repair Surgery.

NCT02153177
View directory record Official record
Conditions
Rotator Cuff Tear
Interventions
Rotator cuff repair, Ibuprofen, Hydrocodone/Acetaminophen, Omeprazole, Hydrocodone/Acetaminophen
Procedure · Drug
Lead sponsor
University of Chicago
Other
Eligibility
45 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 22, 2023 · Synced Jul 23, 2026, 4:05 PM EDT
Withdrawn Phase 2 Interventional

Stromal Vascular Fraction (SVF) Cells for Non-Operative Treatment of Small Rotator Cuff Tears

NCT05264922
View directory record Official record
Conditions
Rotator Cuff Tears
Interventions
Tisseel Injectable Product, Stromal Vascular Fraction Cells
Drug · Biological
Lead sponsor
AdventHealth
Other
Eligibility
30 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Feb 14, 2023 · Synced Jul 23, 2026, 4:05 PM EDT
Not listed No phase listed Observational

Return to Play Checklist

NCT04278716
View directory record Official record
Conditions
Labral Tear, Glenoid
Interventions
Safe return to play checklist
Other
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
15 Years and older
Enrollment
1,000 participants
Timeline
2018 – 2021
U.S. locations
1
States / cities
Egg Harbor, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 19, 2020 · Synced Jul 23, 2026, 4:05 PM EDT