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ClinicalTrials.gov public records Last synced Oct 24, 2026, 10:00 AM EDT

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Showing 1–24 of 28 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Second Stage Labor Clear all
Completed Phase 3 Interventional Results available

A Study to Learn How Well a Higher Amount of Aflibercept Given as an Injection Into the Eye Works and How Safe it is in People With Reduced Vision Due to Swelling in the Macula, Central Part of the Retina Caused by a Blocked Vein in the Retina (Macula Edema Secondary to Retinal Vein Occlusion)

NCT05850520
View directory record Official record
Conditions
Macular Edema Secondary to Retinal Vein Occlusion
Interventions
Aflibercept, VEGF Trap-Eye(Eylea, BAY86-5321)_higher dose, Aflibercept, VEGF Trap-Eye(Eylea, BAY86-5321)_2 mg, Sham, Fluorescein
Drug · Diagnostic Test
Lead sponsor
Bayer
Industry
Eligibility
18 Years and older
Enrollment
892 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
53
States / cities
Fullerton, California • Long Beach, California • Mountain View, California + 48 more
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Oct 24, 2026, 10:00 AM EDT
Recruiting Not applicable Interventional

Home-Based Brain Stimulation for Motoric Cognitive Risk Syndrome

NCT06821568
View directory record Official record
Conditions
Alzheimer Disease and Related Dementias, Cognition, Mobility Disability
Interventions
Personalized Transcranial Direct Current Stimulation (tDCS), Active-Sham
Other
Lead sponsor
Hebrew SeniorLife
Other
Eligibility
65 Years to 90 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Roslindale, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 24, 2026, 10:00 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Effects of Bupivacaine Induced Motor Blockade During the Second Stage of Labor

NCT01621230
View directory record Official record
Conditions
Pregnancy
Interventions
Epidural Bupivacaine plus fentanyl, Epidural fentanyl
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
16 Years to 44 Years · Female only
Enrollment
481 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 24, 2020 · Synced Oct 24, 2026, 10:00 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Rate and/or Presence of Dextrose on the Labor Course of Nulliparas

NCT01904617
View directory record Official record
Conditions
Length of Labor, Second Stage of Labor, Intravenous Hydration of Labor
Interventions
Dextrose, Normal Saline
Other
Lead sponsor
MemorialCare Health System
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Long Beach, California
Source: ClinicalTrials.gov public record
Updated Jan 8, 2015 · Synced Oct 24, 2026, 10:00 AM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

Caffeine in the Second Stage of Labor in Low-risk Nulliparous Mothers at Term

NCT05906303
View directory record Official record
Conditions
Second Stage of Labor
Interventions
Caffeine and Sodium Benzoate Injection, Normal Saline
Drug
Lead sponsor
The Reading Hospital and Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
West Reading, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 14, 2023 · Synced Oct 24, 2026, 10:00 AM EDT
Terminated Not applicable Interventional

PROphylactic Manual RotatIon in the Second stagE of Labor

NCT05175040
View directory record Official record
Conditions
Labor Complication, Pregnancy Related
Interventions
Prophylactic manual rotation, Sham rotation
Procedure
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 26, 2024 · Synced Oct 24, 2026, 10:00 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Early Initiation of Milk Expression in Mothers of Very Low Birth Weight Infants

NCT01892085
View directory record Official record
Conditions
Breast Milk Expression
Interventions
Early initiation, Intermediate expression, Late initiation
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 24, 2023 · Synced Oct 24, 2026, 10:00 AM EDT
Terminated Phase 4 Interventional

Epidural Fentanyl for 2nd Stage Labor Analgesia

NCT03120780
View directory record Official record
Conditions
Labor Pain
Interventions
Fentanyl 20 mcg, Fentanyl 100 mcg
Drug
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older · Female only
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 27, 2025 · Synced Oct 24, 2026, 10:00 AM EDT
Completed Not applicable Interventional

Video Education for Labor and Delivery

NCT04766099
View directory record Official record
Conditions
Pregnancy Related, Educational Problems
Interventions
Childbirth Educational Video
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older · Female only
Enrollment
161 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 12, 2022 · Synced Oct 24, 2026, 10:00 AM EDT
Terminated Phase 1Phase 2 Interventional Results available

Study to See How Safe Curcumin is and How Well it Works When Used to Treat Mucositis in Patients Getting Chemotherapy

NCT02300727
View directory record Official record
Conditions
Mucositis
Interventions
Curcumin-MTD, Mouthwash-standard pharmacy preparation, Curcumin
Drug
Lead sponsor
Amy Beres
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Green Bay, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 31, 2019 · Synced Oct 24, 2026, 10:00 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Evaluation of Maternal Feedback to Shorten Pushing Efforts During Labor

NCT02648867
View directory record Official record
Conditions
Prolonged Second Stage of Labor
Interventions
Continuous Maternal Feedback
Device
Lead sponsor
Clinical Innovations, LLC
Industry
Eligibility
Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
3
States / cities
Galveston, Texas • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 21, 2017 · Synced Oct 24, 2026, 10:00 AM EDT
Completed Not applicable Interventional

Duration of Second Stage of Labor Wearing a Dental Occlusion Device

NCT00629369
View directory record Official record
Conditions
Pregnancy
Interventions
Extra 3 mouth guard, Shock doctor mouth guard v3.0
Device
Lead sponsor
Mercy Medical Center
Other
Eligibility
16 Years to 45 Years · Female only
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 13, 2008 · Synced Oct 24, 2026, 10:00 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

The Association Between Decreasing Labor Analgesia Epidural Infusion and Forceps Delivery

NCT00443560
View directory record Official record
Conditions
Labor Pain, Pregnancy
Interventions
Case controlled analysis of epidural labor analgesia patterns
Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
2,162 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 14, 2014 · Synced Oct 24, 2026, 10:00 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mouth Guard Use in the Second Stage of Labor

NCT03520530
View directory record Official record
Conditions
Dystocia; Fetal, Labor Long, Cesarean Section, Affecting Fetus or Newborn
Interventions
Mouth Guard
Device
Lead sponsor
Christiana Care Health Services
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
154 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Aug 4, 2020 · Synced Oct 24, 2026, 10:00 AM EDT
Completed No phase listed Observational

Nurse Perspectives Regarding Use of the Labor Mirror

NCT04900883
View directory record Official record
Conditions
Second Stage Labor
Interventions
survey
Other
Lead sponsor
Mount Carmel Health System
Other
Eligibility
Not listed
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 18, 2023 · Synced Oct 24, 2026, 10:00 AM EDT
Not listed Not applicable Interventional

Passive Descent in Obese Nulliparous Gravidae

NCT02080429
View directory record Official record
Conditions
Management of the Second Stage of Labor in Obese Nulliparous Women by Either Passive Descent or Immediate Pushing.
Interventions
Passive Descent, Pushing
Procedure
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
Female only
Enrollment
540 participants
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 6, 2014 · Synced Oct 24, 2026, 10:00 AM EDT
Recruiting Phase 1Phase 2 Interventional

A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body

NCT06413680
View directory record Official record
Conditions
Melanoma, Clear-Cell Renal-Cell Carcinoma (ccRCC), Advanced Solid Tumors
Interventions
REGN10597, Cemiplimab
Drug
Lead sponsor
Regeneron Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
11
States / cities
Los Angeles, California • San Francisco, California • North Haven, Connecticut + 7 more
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Oct 24, 2026, 10:00 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Role of Oxytocin in the Second Stage of Labor

NCT04303702
View directory record Official record
Conditions
Labor Complication
Interventions
Continue Oxytocin, Discontinue Oxytocin
Drug · Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
Female only
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 5, 2026 · Synced Oct 24, 2026, 10:00 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Use of an Occlusal Support Device During the Second Stage of Labor

NCT02807493
View directory record Official record
Conditions
Pregnancy
Interventions
Occlusal Support Device, Control
Device · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
347 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 21, 2022 · Synced Oct 24, 2026, 10:00 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Optimizing Management of the 2nd Stage of Labor: Multicenter Randomized Trial

NCT02137200
View directory record Official record
Conditions
Pregnancy
Interventions
Immediate pushing, Delayed pushing
Procedure
Lead sponsor
Washington University School of Medicine
Other
Eligibility
Female only
Enrollment
2,414 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
6
States / cities
Birmingham, Alabama • St Louis, Missouri • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 4, 2019 · Synced Oct 24, 2026, 10:00 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Promoting Effective Recovery From Labor Urinary Incontinence (PERL)

NCT00506116
View directory record Official record
Conditions
Urinary Incontinence, Pelvic Organ Prolapse, Perinatal Laceration, Second Stage Labor
Interventions
Videotape, routine care, PME instruction, PME practice and record keeping (in diaries), Non-directed or directed,spontaneous or sustained pushing, Data collection
Behavioral · Procedure
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older · Female only
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1996 – 2006
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 31, 2007 · Synced Oct 24, 2026, 10:00 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Randomized Control Trial of Second Stage of Labor

NCT02101515
View directory record Official record
Conditions
Labor Complications
Interventions
Length of Second Stage
Other
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older · Female only
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 26, 2018 · Synced Oct 24, 2026, 10:00 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Goal-directed Labor Epidural Analgesia Maintenance

NCT05255263
View directory record Official record
Conditions
Labor Onset and Length Abnormalities
Interventions
PIEB, CEI
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 14, 2022 · Synced Oct 24, 2026, 10:00 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Trial of IV NTG for CD After Second Stage Arrest for the Prevention of Uterine Extension

NCT02265965
View directory record Official record
Conditions
Prolonged Second Stage of Labor
Interventions
intravenous nitroglycerin
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 19, 2020 · Synced Oct 24, 2026, 10:00 AM EDT