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Showing 1–24 of 245 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Shortness of Breath/Dyspnea Clear all
Withdrawn Early Phase 1 Interventional

S-Nitrosylation Therapy of COVID-19

NCT04528771
View directory record Official record
Conditions
SARS-CoV2 Infection, Covid19
Interventions
SNO, Nitrogen gas
Drug
Lead sponsor
James Reynolds
Other
Eligibility
18 Years to 89 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 6, 2025 · Synced Sep 24, 2026, 2:03 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Antibiotics and the Prolongation of Pregnancy in Preterm Labor With an Advanced Cervical Exam

NCT00589329
View directory record Official record
Conditions
Length of Pregnancy Prolongation in Hours
Interventions
erythromycin and metronidazole (antibiotics), placebo
Drug
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2012
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 3, 2019 · Synced Sep 24, 2026, 2:03 AM EDT
Withdrawn Not applicable Interventional

Fatigue in Patients With Amyotrophic Lateral Sclerosis

NCT04468191
View directory record Official record
Conditions
Amyotrophic Lateral Sclerosis, Dysphagia, Dyspnea, Respiration Disorders
Interventions
Experimental expiratory muscle strength training (EMST), Sham expiratory muscle strength training (EMST)
Device
Lead sponsor
Cara Donohue
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 14, 2021 · Synced Sep 24, 2026, 2:03 AM EDT
Completed No phase listed Observational

Autonomic Monitoring in Neurocardiogenic Syncope

NCT05907018
View directory record Official record
Conditions
Syncope, Chest Pain, Dyspnea
Interventions
Not listed
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
7 Years to 24 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 28, 2025 · Synced Sep 24, 2026, 2:03 AM EDT
Completed Not applicable Interventional

Home-Based Respiratory Muscle Strength Training Program for Individuals With Post-COVID-19 Persistent Dyspnea

NCT06091280
View directory record Official record
Conditions
Post-COVID-19 Syndrome, Dyspnea
Interventions
Respiratory Muscle Strength Trainers
Device
Lead sponsor
University of South Florida
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Apr 14, 2025 · Synced Sep 24, 2026, 2:03 AM EDT
Completed Not applicable Interventional

Improving Management of Breathlessness in Patients With Lung Cancer

NCT01937637
View directory record Official record
Conditions
Breathlessness, Dyspnea, Lung Cancer
Interventions
Cognitive Behavioral Intervention for Breathlessness
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 20, 2015 · Synced Sep 24, 2026, 2:03 AM EDT
Recruiting Not applicable Interventional

Determinants of Cardiorespiratory Fitness and Effects of HIIT in Patients With ANOCA Obstructive Coronary Artery Disease(ANOCA)

NCT07182955
View directory record Official record
Conditions
MINOCA, Shortness of Breath, Atherosclerotic Heart Disease of Native Coronary Artery
Interventions
EXERCISE TRAINING WITH OR WITHOUT MEDICATION
Behavioral
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 85 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 18, 2025 · Synced Sep 24, 2026, 2:03 AM EDT
Recruiting No phase listed Observational

Phrenic Nerve Reconstruction for the Treatment of Diaphragmatic Paralysis: Patient Experiences and Reported Outcomes.

NCT06243718
View directory record Official record
Conditions
Diaphragmatic Paralysis, Pain, Chest, Breath Shortness
Interventions
Not listed
Lead sponsor
Advanced Reconstructive Surgery Alliance
Government
Eligibility
18 Years to 70 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
Red Bank, New Jersey • Shrewsbury, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 5, 2024 · Synced Sep 24, 2026, 2:03 AM EDT
Completed Not applicable Interventional

Palliative Care Coaching for Families With Rare Advanced Lung Diseases

NCT03813667
View directory record Official record
Conditions
Lung Diseases, Rare Non-Neoplastic Disorder
Interventions
Intervention FamPALcare
Behavioral
Lead sponsor
West Virginia University
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Oct 20, 2019 · Synced Sep 24, 2026, 2:03 AM EDT
Completed Phase 1 Interventional

Acupuncture Feasibility Trial for Dyspnea in Lung Cancer

NCT02094950
View directory record Official record
Conditions
Lung Cancer, Dyspnea
Interventions
Acupuncture
Procedure
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 22, 2019 · Synced Sep 24, 2026, 2:03 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Buspirone in Reducing Shortness of Breath in Patients With Cancer

NCT00053846
View directory record Official record
Conditions
Dyspnea, Pulmonary Complications, Unspecified Adult Solid Tumor, Protocol Specific
Interventions
buspirone hydrochloride, Placebo
Drug
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 120 Years
Enrollment
432 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2011
U.S. locations
15
States / cities
Chicago, Illinois • Decatur, Illinois • Evanston, Illinois + 12 more
Source: ClinicalTrials.gov public record
Updated Nov 23, 2015 · Synced Sep 24, 2026, 2:03 AM EDT
Terminated No phase listed Observational

Treatment of Dyspnea in Do-not-intubate Patients

NCT02114944
View directory record Official record
Conditions
Acute Respiratory Failure, Acute on Chronic Respiratory Failure, Dyspnea
Interventions
NIV, CPAP, Standard oxygen, HFNC
Device
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 12, 2025 · Synced Sep 24, 2026, 2:03 AM EDT
Completed Not applicable Interventional

Preventing Dyspnea During Speech in Older Speakers

NCT05029986
View directory record Official record
Conditions
Dyspnea
Interventions
Socialization phase, Speech breathing intervention
Behavioral
Lead sponsor
University of Delaware
Other
Eligibility
50 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Jun 28, 2022 · Synced Sep 24, 2026, 2:03 AM EDT
Recruiting Phase 2 Interventional

Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH

NCT05937854
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease, Pulmonary Hypertension, Dyspnea
Interventions
Tadalafil, Placebo
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
35 Years to 89 Years
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
5
States / cities
Aurora, Colorado • Decatur, Georgia • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Sep 24, 2026, 2:03 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

The Role of Heliox in Respiratory Control

NCT07424014
View directory record Official record
Conditions
Work of Breathing
Interventions
Heliox inspirate
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 40 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Sep 24, 2026, 2:03 AM EDT
Completed Not applicable Interventional

Virtual Reality at End-of-life

NCT06149429
View directory record Official record
Conditions
End of Life, Pain, Nausea, Fatigue, Well-Being, Psychological, Depression, Dyspnea, Appetite Loss, Anxiety
Interventions
Personalized virtual reality experience
Behavioral
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
Not listed
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Cheektowaga, New York
Source: ClinicalTrials.gov public record
Updated Dec 18, 2024 · Synced Sep 24, 2026, 2:03 AM EDT
Completed Not applicable Interventional

Inspiratory Muscle Training and Behavioral Support to Alleviate Dyspnea and Promote Walking in Lung Cancer Survivors: A Pilot Study

NCT05059132
View directory record Official record
Conditions
Lung Neoplasm
Interventions
Tele-rehabilitation, Education only
Behavioral · Other
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 12, 2023 · Synced Sep 24, 2026, 2:03 AM EDT
Withdrawn Phase 3 Interventional

Clevidipine vs Placebo or Standard of Care for Dyspnea and Blood Pressure Control in AHF

NCT04592380
View directory record Official record
Conditions
Dyspnea, Hypertension, Acute Heart Failure
Interventions
Stage 1: Clevidipine (double-blinded), Stage 1: Placebo (double-blinded), Stage 2: Clevidipine (open-label), Stage 2: Standard of Care (open-label)
Drug
Lead sponsor
The Medicines Company
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
9
States / cities
Montgomery, Alabama • Tucson, Arizona • St Louis, Missouri + 5 more
Source: ClinicalTrials.gov public record
Updated Oct 18, 2020 · Synced Sep 24, 2026, 2:03 AM EDT
Completed Not applicable Interventional

Impact of Immediate Point-of-Care Ultrasound on Patients With Cardiopulmonary Symptoms in the Emergency Department

NCT02861508
View directory record Official record
Conditions
Chest Pain, Dyspnea, Syncope, Hypotension
Interventions
Point-of-care ultrasound, Usual care
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 27, 2020 · Synced Sep 24, 2026, 2:03 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Epinephrine Inhalation Aerosol USP, a HFA-MDI Study for Assessment of Pharmacokinetics

NCT01188577
View directory record Official record
Conditions
Asthma, Bronchospasm, Wheezing, Shortness of Breath
Interventions
Epinephrine Inhalation Aerosol, HFA, Epinephrine Inhalation Aerosol
Drug
Lead sponsor
Amphastar Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 30 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Cypress, California
Source: ClinicalTrials.gov public record
Updated Jul 24, 2017 · Synced Sep 24, 2026, 2:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study to Evaluate the Effects of a Supplement on Mucus Clearance and Respiratory Symptoms

NCT07740746
View directory record Official record
Conditions
Mucus Clearance, Respiratory Symptoms, Breathlessness, Chest Mucus Accumulation, Low Energy Levels
Interventions
BetterLungs, Placebo
Dietary Supplement
Lead sponsor
The Better Brand Inc.
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Aug 2, 2026 · Synced Sep 24, 2026, 2:03 AM EDT
Completed No phase listed Observational

Pain Assessment, Incidence & Nature in Heart Failure

NCT00444301
View directory record Official record
Conditions
Heart Diseases
Interventions
Not listed
Lead sponsor
PC-HEART
Other
Eligibility
18 Years and older
Enrollment
349 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
14
States / cities
San Diego, California • Washington D.C., District of Columbia • Palm Beach, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Jun 10, 2008 · Synced Sep 24, 2026, 2:03 AM EDT
Completed No phase listed Observational

The U.K. Embryologist Fatigue Study

NCT05708963
View directory record Official record
Conditions
Fatigue, Stress, Burnout, Professional, Musculoskeletal Pain, Back Pain, Neck Pain, Headache, Dizziness, Sleep Disturbance, Chest Pain, Syncope, Cardiovascular Diseases, Shortness of Breath, Gastrointestinal Diseases
Interventions
Not listed
Lead sponsor
TMRW Life Sciences
Industry
Eligibility
22 Years to 65 Years
Enrollment
123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 7, 2023 · Synced Sep 24, 2026, 2:03 AM EDT
Completed Phase 2 Interventional Results available

Lisinopril in Reducing Shortness of Breath Caused by Radiation Therapy in Patients With Lung Cancer

NCT01880528
View directory record Official record
Conditions
Dyspnea, Non-small Cell Lung Cancer, Small Cell Lung Cancer
Interventions
lisinopril, placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
3
States / cities
Scottsdale, Arizona • Rochester, Minnesota • Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Jan 1, 2020 · Synced Sep 24, 2026, 2:03 AM EDT