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ClinicalTrials.gov public records Last synced May 22, 2026, 12:49 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Single Ventricle Defect Clear all
Withdrawn No phase listed Observational
View directory record Official record
Conditions
Hypoplastic Left Heart Syndrome, Obstructive Sleep Apnea Syndrome, Single Ventricle Physiology
Interventions
Not listed
Lead sponsor
University of Rochester
Other
Eligibility
1 Month to 2 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2004
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 29, 2015 · Synced May 22, 2026, 12:49 AM EDT
Active, not recruiting Phase 2 Interventional Results available
View directory record Official record
Conditions
Hypoplastic Left Heart Syndrome
Interventions
Autologous (self) mononuclear cells derived from umbilical cord blood, Stage II Surgical repair
Biological · Procedure
Lead sponsor
Timothy J Nelson, MD, PhD
Other
Eligibility
Up to 12 Months
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
8
States / cities
Birmingham, Alabama • Los Angeles, California • Aurora, Colorado + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 7, 2025 · Synced May 22, 2026, 12:49 AM EDT
Terminated Phase 4 Interventional Results available
View directory record Official record
Conditions
Tetralogy of Fallot, Transposition of the Great Vessels With an Arterial Switch, Single Ventricle With a Fontan Palliation
Interventions
Eplerenone
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 80 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 3, 2018 · Synced May 22, 2026, 12:49 AM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Fontan Physiology Patients With PB or PLE, Fontan Physiology Patients Without PB or PLE
Interventions
Not listed
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
6 Months and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 28, 2013 · Synced May 22, 2026, 12:49 AM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Hypoplastic Left Heart Syndrome
Interventions
Not listed
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 60 Years
Enrollment
187 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
10
States / cities
Los Angeles, California • Wilmington, Delaware • St. Petersburg, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Jan 21, 2020 · Synced May 22, 2026, 12:49 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Single-ventricle
Interventions
Near infrared spectroscopy
Diagnostic Test
Lead sponsor
Advocate Hospital System
Other
Eligibility
Up to 6 Months
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Oak Lawn, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 6, 2024 · Synced May 22, 2026, 12:49 AM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Hypoplastic Left Heart, Congenital Heart Disease, Cyanotic Congenital Heart Disease, Cardiac Disease
Interventions
Norwood Palliation / DKS / Damus-Kaye-Stansel procedure
Procedure
Lead sponsor
Baylor College of Medicine
Other
Eligibility
Up to 2 Months
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 2, 2020 · Synced May 22, 2026, 12:49 AM EDT
Completed Phase 1Phase 2 Interventional Results available
View directory record Official record
Conditions
Single Ventricle Heart Disease After Fontan Surgery
Interventions
Udenafil
Drug
Lead sponsor
Mezzion Pharma Co. Ltd
Industry
Eligibility
14 Years to 18 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
5
States / cities
Indianapolis, Indiana • Ann Arbor, Michigan • Cincinnati, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated May 5, 2025 · Synced May 22, 2026, 12:49 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Single-ventricle
Interventions
Live-Video-Supervised Exercise Intervention, Usual Care then Live-Video Supervised Exercise Intervention
Other
Lead sponsor
Stanford University
Other
Eligibility
8 Years to 19 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced May 22, 2026, 12:49 AM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Single-ventricle, Congenital Heart Disease
Interventions
Not listed
Lead sponsor
University of Texas at Austin
Other
Eligibility
6 Years and older
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 27, 2021 · Synced May 22, 2026, 12:49 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Heart Failure Congenital, Single-ventricle
Interventions
Cardiac rehabilitation, Usual care
Behavioral · Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Stanford, California • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 4, 2026 · Synced May 22, 2026, 12:49 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Congenital Heart Disease, Single-ventricle
Interventions
Transthoracic Echocardiogram or Cardiac MRI, Ventripoint Echocardiogram
Device
Lead sponsor
Duke University
Other
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced May 22, 2026, 12:49 AM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Heart Defects, Congenital
Interventions
Blalock-Taussig pulmonary artery shunt, Right ventricular to pulmonary artery shunt
Procedure
Lead sponsor
Carelon Research
Other
Eligibility
Not listed
Enrollment
555 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
12
States / cities
Los Angeles, California • Wilmington, Delaware • St. Petersburg, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Mar 10, 2025 · Synced May 22, 2026, 12:49 AM EDT
Recruiting Phase 1Phase 2 Interventional
View directory record Official record
Conditions
Single-ventricle
Interventions
Spironolactone
Drug
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
1 Year to 6 Years
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 7, 2025 · Synced May 22, 2026, 12:49 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Single-ventricle
Interventions
Fortini formula, Standard Nutritional Care
Other
Lead sponsor
Driscoll Children's Hospital
Other
Eligibility
0 Months to 6 Months
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Corpus Christi, Texas
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced May 22, 2026, 12:49 AM EDT
Active, not recruiting No phase listed Observational
View directory record Official record
Conditions
Single-ventricle, Pulmonary Vascular Resistance Abnormality, Superior Cavo-Pulmonary Anastomosis, Endothelin, Metabolomics
Interventions
Research Blood Sampling
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
1 Month to 2 Years
Enrollment
50 participants
Timeline
2018 – 2027
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced May 22, 2026, 12:49 AM EDT
Completed Phase 2 Interventional Results available
View directory record Official record
Conditions
Hypoplastic Left Heart Syndrome, Hypoplastic Right-sided Heart Complex
Interventions
Ambrisentan, Placebo
Drug · Other
Lead sponsor
Kevin Hill
Other
Eligibility
24 Months to 120 Months
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 11, 2019 · Synced May 22, 2026, 12:49 AM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Congenital Heart Disease, Hypoplastic Left Heart Syndrome, Hypoplastic Right Heart Syndrome, d-Transposition of the Great Arteries
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
Up to 30 Days
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
4
States / cities
Atlanta, Georgia • Ann Arbor, Michigan • Charleston, South Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 9, 2021 · Synced May 22, 2026, 12:49 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Single-ventricle, Myocardial Fibrosis
Interventions
Exercise
Behavioral
Lead sponsor
Maria Bano
Other
Eligibility
10 Years to 40 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2025
U.S. locations
1
States / cities
Irving, Texas
Source: ClinicalTrials.gov public record
Updated Sep 4, 2021 · Synced May 22, 2026, 12:49 AM EDT
Completed Phase 3 Interventional Results available
View directory record Official record
Conditions
Functional Single Ventricle Heart Disease
Interventions
Udenafil
Drug
Lead sponsor
Mezzion Pharma Co. Ltd
Industry
Eligibility
12 Years to 18 Years
Enrollment
301 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
21
States / cities
Phoenix, Arizona • Los Angeles, California • San Diego, California + 18 more
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced May 22, 2026, 12:49 AM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Congenital Heart Disease
Interventions
Digoxin
Drug
Lead sponsor
Christoph P Hornik, MD MPH
Other
Eligibility
Up to 6 Months
Enrollment
50 participants
Timeline
2019 – 2022
U.S. locations
11
States / cities
Los Angeles, California • San Diego, California • Aurora, Colorado + 8 more
Source: ClinicalTrials.gov public record
Updated Oct 11, 2022 · Synced May 22, 2026, 12:49 AM EDT
Completed No phase listed Observational Results available
View directory record Official record
Conditions
Congenital Heart Disease
Interventions
Not listed
Lead sponsor
Emory University
Other
Eligibility
Not listed
Enrollment
224 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated May 1, 2012 · Synced May 22, 2026, 12:49 AM EDT
Withdrawn No phase listed Observational
View directory record Official record
Conditions
Congenital Heart Disease, Single Ventricle
Interventions
NIRS
Device
Lead sponsor
Roby Sebastian
Other
Eligibility
Not listed
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 5, 2018 · Synced May 22, 2026, 12:49 AM EDT
Recruiting Phase 3 Interventional
View directory record Official record
Conditions
Single Ventricle Heart Disease
Interventions
Udenafil, Placebo
Drug
Lead sponsor
Mezzion Pharma Co. Ltd
Industry
Eligibility
12 Years to 18 Years
Enrollment
436 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
37
States / cities
Phoenix, Arizona • Little Rock, Arkansas • Los Angeles, California + 32 more
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced May 22, 2026, 12:49 AM EDT