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Showing 1–24 of 116 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Skin Wrinkling Clear all
Completed Not applicable Interventional

Evaluation of the PlasmaJet Neutral Argon Plasma System to Treat Skin Ageing

NCT00761878
View directory record Official record
Conditions
Skin Aging
Interventions
Exposure to plasma energy
Procedure
Lead sponsor
Plasma Surgical Inc
Industry
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Fayetteville, New York
Source: ClinicalTrials.gov public record
Updated Jul 6, 2009 · Synced Sep 6, 2026, 6:49 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Poly-L-lactic Acid for Skin Quality

NCT02003833
View directory record Official record
Conditions
Skin Aging
Interventions
Poly-L-lactic acid, Placebo comparator
Device
Lead sponsor
Sadick Research Group
Other
Eligibility
30 Years to 60 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
2
States / cities
Carmel, Indiana • New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 19, 2015 · Synced Sep 6, 2026, 6:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Fractional Radiofrequency for Treatment of Acne Scars and Wrinkles

NCT05827510
View directory record Official record
Conditions
Acne, Wrinkle
Interventions
BTL-585F
Device
Lead sponsor
BTL Industries Ltd.
Industry
Eligibility
21 Years and older
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
2
States / cities
Davie, Florida • New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 1, 2024 · Synced Sep 6, 2026, 6:49 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Evaluation of Efficacy and Safety of the triLift™ System

NCT05773924
View directory record Official record
Conditions
Skin Laxity, Wrinkle
Interventions
triLift system
Device
Lead sponsor
Lumenis Be Ltd.
Industry
Eligibility
35 Years to 55 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 16, 2023 · Synced Sep 6, 2026, 6:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of the Benefits of FloraGLO™ Lutein on Skin Health

NCT03769779
View directory record Official record
Conditions
Aging, Wrinkle, Skin Elasticity, Healthy, Hydration
Interventions
FloraGLO Lutein, Safflower Oil
Dietary Supplement
Lead sponsor
Kemin Foods LC
Industry
Eligibility
30 Years to 65 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Port Chester, New York
Source: ClinicalTrials.gov public record
Updated Feb 2, 2021 · Synced Sep 6, 2026, 6:49 AM EDT
Not yet recruiting Phase 2 Interventional Accepts healthy volunteers

Assess Impact of Microdroplet Hyaluronic Acid Filler on Skin Quality in Patients on Glucagon-like Peptide-1 Agonists

NCT07221461
View directory record Official record
Conditions
Wrinkle
Interventions
Skinvive
Device
Lead sponsor
Goldman, Butterwick, Fitzpatrick and Groff
Other
Eligibility
25 Years to 50 Years · Female only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Sep 6, 2026, 6:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Procedure Pairing of a Post-Procedure Cream Versus a Comparator in Patients Treated With Fractional Ablative CO2 Laser for Facial Rejuvenation

NCT06366503
View directory record Official record
Conditions
Photoaging, Wrinkle, Skin Laxity
Interventions
Fractional Ablative CO2 Laser, Facial Cleanser, Facial Moisturizer, Sunscreen, Basic Ointment
Procedure · Other
Lead sponsor
Revision Skincare
Industry
Eligibility
35 Years to 65 Years · Female only
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Blue Ash, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 2, 2025 · Synced Sep 6, 2026, 6:49 AM EDT
Not yet recruiting Phase 4 Interventional Accepts healthy volunteers

Assess Injectable Hyaluronic Acid Gel for the Treatment of Volume Loss, Skin Laxity and Fine Lines

NCT07421544
View directory record Official record
Conditions
Fine Lines, Wrinkle, Facial Laxity, Volume Loss
Interventions
Obagi® Saypha® MagIQ™ Injectable Hyaluronic Acid
Other
Lead sponsor
Goldman, Butterwick, Fitzpatrick and Groff
Other
Eligibility
30 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Sep 6, 2026, 6:49 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Epidermal Delivery of Ani-Aging Ingredients

NCT01847066
View directory record Official record
Conditions
Wrinkles, Acne Scars, Pigmentation
Interventions
Erbium 2940 plus cosmetics plus Impact, Erbium 2940 plus cosmetics
Device
Lead sponsor
Alma Lasers Inc.
Industry
Eligibility
35 Years to 65 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 5, 2013 · Synced Sep 6, 2026, 6:49 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Investigating the Wrinkle Reduction Potential of a Novel Compounded Skin Care Cream

NCT03878381
View directory record Official record
Conditions
Skin Care
Interventions
Skin Care Cream, Placebo
Combination Product · Drug
Lead sponsor
Wayne State University
Other
Eligibility
20 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Dearborn, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 31, 2022 · Synced Sep 6, 2026, 6:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Multi-Center, Open-label Study Evaluate the Efficacy and Tolerability of a Dual Skincare Regimen Treatment for Facial Hyperpigmentation and Photodamaged Skin in Patients Exposed to Extrinsic Factors of Aging

NCT05423873
View directory record Official record
Conditions
Hyperpigmentation, Photodamaged Skin, Wrinkle, Fine Lines
Interventions
Gentle Cleansing Lotion, Revision Skincare
Other
Lead sponsor
Revision Skincare
Industry
Eligibility
35 Years to 60 Years · Female only
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
3
States / cities
Solana Beach, California • Greenwood Village, Colorado • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 20, 2022 · Synced Sep 6, 2026, 6:49 AM EDT
Completed Not applicable Interventional

Assessment of the Safety and Effectiveness of a Micro-RF Skin Treatment Device (nebulyft）

NCT06623214
View directory record Official record
Conditions
Wrinkle Reduction
Interventions
nebulyft
Device
Lead sponsor
Hangzhou Rebecca Medical Science and Technology Ltd.
Industry
Eligibility
25 Years to 65 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
San Gabriel, California
Source: ClinicalTrials.gov public record
Updated Oct 2, 2024 · Synced Sep 6, 2026, 6:49 AM EDT
Not listed Phase 1Phase 2 Interventional Accepts healthy volunteers

Safety Study of Bone Marrow Derived Stem Cells on Patients With Cutaneous Photoaging

NCT01771679
View directory record Official record
Conditions
Chronic Effect of Ultraviolet Radiation on Photoaged Skin, Dermatologic Disorders
Interventions
Allogeneic Mesenchymal Bone Marrow Cells
Biological
Lead sponsor
Stemedica Cell Technologies, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2024
U.S. locations
2
States / cities
La Mesa, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Oct 30, 2022 · Synced Sep 6, 2026, 6:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Healing Study of Fractional Skin Resurfacing and Tissue Histopathology After Ellacor Treatment

NCT06502470
View directory record Official record
Conditions
Wrinkle, Rhytides, Histopathology
Interventions
ellacor® Micro-Coring procedure
Device
Lead sponsor
Cytrellis Biosystems, Inc.
Industry
Eligibility
18 Years and older · Female only
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 15, 2024 · Synced Sep 6, 2026, 6:49 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Study to Evaluate the Safety and Efficacy of the Cytrellis Micro-Coring Device for the Treatment of Moderate to Severe Facial Wrinkles

NCT03793348
View directory record Official record
Conditions
Wrinkle
Interventions
MCD
Device
Lead sponsor
Cytrellis Biosystems, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
6
States / cities
Sacramento, California • Greenwood Village, Colorado • Miami, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 3, 2019 · Synced Sep 6, 2026, 6:49 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Application of the Apsara Thermal Wand System

NCT00662389
View directory record Official record
Conditions
Tightening of Skin Laxity
Interventions
Apsara Thermal Wand System
Device
Lead sponsor
Apsara Medical Corporation
Industry
Eligibility
40 Years to 65 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 27, 2009 · Synced Sep 6, 2026, 6:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Study to Evaluate the Performance of Fractional Radiofrequency for Improvement of Skin Texture Via Skin Resurfacing and Wrinkles Reduction

NCT00887913
View directory record Official record
Conditions
Skin Resurfacing, Wrinkle Reduction
Interventions
Fractional RF treatment with Matrix RF applicator
Device
Lead sponsor
Syneron Medical
Industry
Eligibility
21 Years and older
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
2
States / cities
Lincolnshire, Illinois • Chesterfield, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 29, 2010 · Synced Sep 6, 2026, 6:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Study of a Novel Microlens Array Device for Skin Rejuvenation

NCT02888626
View directory record Official record
Conditions
Wrinkles, Scars
Interventions
Microlens Array
Device
Lead sponsor
Cutera Inc.
Industry
Eligibility
20 Years to 75 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Brisbane, California
Source: ClinicalTrials.gov public record
Updated Aug 14, 2023 · Synced Sep 6, 2026, 6:49 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Anti-ageing Efficacy of a Cosmetic Formulation Containing NMN (2%) Versus Placebo

NCT04685096
View directory record Official record
Conditions
Wrinkle, Fatigue, Puffiness Around the Eyes
Interventions
Test product creme, Reference creme
Other
Lead sponsor
Seneque SA
Industry
Eligibility
40 Years to 65 Years · Female only
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Piscataway, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 22, 2021 · Synced Sep 6, 2026, 6:49 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The Effects of a 5-Step Skin Regimen on Pigmentation and Appearance Related Biophysical Properties

NCT05688527
View directory record Official record
Conditions
Wrinkle
Interventions
Cleansing Balm, Toning Essence, Facial Serum, Moisturizer, Eye Cream
Other
Lead sponsor
Integrative Skin Science and Research
Industry
Eligibility
35 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jul 24, 2023 · Synced Sep 6, 2026, 6:49 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Evaluation of the Ulthera® System for Treatment of the Face and Neck

NCT01713907
View directory record Official record
Conditions
Wrinkles, Rhytids, Skin Laxity
Interventions
Ulthera® Treatment
Device
Lead sponsor
Ulthera, Inc
Industry
Eligibility
30 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 23, 2017 · Synced Sep 6, 2026, 6:49 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Robotic Mechanical Coring for the Treatment of Moderate to Severe Facial Wrinkles

NCT05091788
View directory record Official record
Conditions
Wrinkle
Interventions
Venus Aime
Device
Lead sponsor
Venus Concept
Industry
Eligibility
22 Years to 75 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
2
States / cities
Chicago, Illinois • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 25, 2024 · Synced Sep 6, 2026, 6:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Investigation of Radiofrequency Device for Treatment of Wrinkles and Rhytides

NCT01279226
View directory record Official record
Conditions
Laxity of Skin
Interventions
Auralevée device
Device
Lead sponsor
Rocky Mountain Biosystems, Inc.
Industry
Eligibility
21 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Kirkland, Washington
Source: ClinicalTrials.gov public record
Updated Dec 2, 2012 · Synced Sep 6, 2026, 6:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Lutronic Genius System for Neck Treatment

NCT03534609
View directory record Official record
Conditions
Wrinkle, Skin Laxity, Skin Texture Disorder
Interventions
Lutronic Genius System
Device
Lead sponsor
CynosureLutronic
Industry
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 12, 2020 · Synced Sep 6, 2026, 6:49 AM EDT