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Showing 1–17 of 17 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Sleep Fragmentation Clear all
Recruiting Not applicable Interventional

Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease (Aim 2)

NCT05070013
View directory record Official record
Conditions
Parkinson's Disease, Sleep Fragmentation
Interventions
Deep Brain Stimulation
Device
Lead sponsor
University of Nebraska
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Omaha, Nebraska • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 21, 2025 · Synced Jul 22, 2026, 6:49 AM EDT
Not yet recruiting Phase 4 Interventional Accepts healthy volunteers

Light and Sleep Fragmentation

NCT06009289
View directory record Official record
Conditions
Sleep, Mild Cognitive Impairment, Mood Disorders
Interventions
Light therapy
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
65 Years to 99 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Aug 24, 2023 · Synced Jul 22, 2026, 6:49 AM EDT
Completed Phase 2 Interventional Results available

Sleep Laboratory Study to Investigate the Safety and Efficacy of Neu-P11 in Primary Insomnia Patients

NCT01489969
View directory record Official record
Conditions
Primary Insomnia
Interventions
Neu-P11
Drug
Lead sponsor
Neurim Pharmaceuticals Ltd.
Industry
Eligibility
18 Years to 80 Years
Enrollment
137 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
9
States / cities
San Diego, California • Hallandale, Florida • South Miami, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Jun 5, 2018 · Synced Jul 22, 2026, 6:49 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Obstructive Sleep Apnea (OSA) and Metabolic Syndrome: Role of Oxidative Stress

NCT00177892
View directory record Official record
Conditions
Obstructive Sleep Apnea, Metabolic Syndrome X
Interventions
sleep disruption, sleep with and without positive pressure
Procedure
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
18 Years to 65 Years
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2008
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 2, 2008 · Synced Jul 22, 2026, 6:49 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Sleep Disruption in Post-operative Patients in the Neurocritical Care Unit

NCT02997839
View directory record Official record
Conditions
Sleep Fragmentation
Interventions
sleep disruption
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 100 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 2, 2018 · Synced Jul 22, 2026, 6:49 AM EDT
Completed Not applicable Interventional

Inspiratory Muscle Strength Training for Sleep-related Breathing Disorders

NCT02709941
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Inspiratory muscle strength training, Placebo
Other
Lead sponsor
University of Arizona
Other
Eligibility
30 Years to 75 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 28, 2017 · Synced Jul 22, 2026, 6:49 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Improving Sleep Quality During Pregnancy Using an Oral Appliance

NCT03646214
View directory record Official record
Conditions
Snoring, Sleep Fragmentation
Interventions
Midline traction oral appliance
Device
Lead sponsor
Texas A&M University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2026
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 6, 2025 · Synced Jul 22, 2026, 6:49 AM EDT
Completed Not applicable Interventional

Effects of Earplugs on Sleep and Sleep Apnea

NCT01062854
View directory record Official record
Conditions
Sleep Disordered Breathing
Interventions
Soft earplugs are worn during sleep study
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
407 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 5, 2016 · Synced Jul 22, 2026, 6:49 AM EDT
Terminated Not applicable Interventional Results available

Direct Noise Reduction in the Intensive Care Units (ICU) Using Earplugs and Noise Canceling Headphones

NCT01343095
View directory record Official record
Conditions
Delirium, Sleep Fragmentation
Interventions
Foam Earplugs, Noise Canceling Headphones
Device
Lead sponsor
Wake Forest University
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 11, 2018 · Synced Jul 22, 2026, 6:49 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Menopausal Sleep Fragmentation and Body Fat Gain

NCT03047330
View directory record Official record
Conditions
Menopause
Interventions
Estradiol withdrawal, Fragmented sleep
Drug · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 7, 2024 · Synced Jul 22, 2026, 6:49 AM EDT
Recruiting Not applicable Interventional

Sleepless at Scripps: An Inpatient White Noise Study

NCT05475262
View directory record Official record
Conditions
White Noise, Sleep, Sleep Fragmentation, Sleep Duration
Interventions
Active white noise, Inactive white noise
Device
Lead sponsor
Scripps Health
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Jul 22, 2026, 6:49 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Effects of Experimental Sleep Disturbances on Receptor Function of Study Drug

NCT04299490
View directory record Official record
Conditions
Sleep Disorder, Healthy
Interventions
Sleep Fragmentation, Within-Subject test of blinded study medication (stimulant, benzodiazepine, opioid, cannabinoid, over-the-counter pain medication, or placebo), Sleep Continuity Disruption, Undisturbed Sleep
Behavioral · Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 48 Years
Enrollment
148 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 23, 2025 · Synced Jul 22, 2026, 6:49 AM EDT
Completed Phase 4 Interventional Results available

Suvorexant and Sleep/Delirium in ICU Patients

NCT04092894
View directory record Official record
Conditions
Insomnia, Sleep Fragmentation, Sleep Initiation and Maintenance Disorders, Postoperative Delirium
Interventions
Suvorexant 20 mg, Placebo oral tablet
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
60 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
2
States / cities
Boston, Massachusetts • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Oct 26, 2025 · Synced Jul 22, 2026, 6:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Impact of Behavioral Treatment of Insomnia on Nighttime Urine Production

NCT03883724
View directory record Official record
Conditions
Sleep Fragmentation, Poor Quality Sleep, Nocturia, Nocturnal Enuresis
Interventions
Brief behavioral treatment of insomnia (BBTI), Information-only control (IC)
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
65 Years and older
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 21, 2022 · Synced Jul 22, 2026, 6:49 AM EDT
Completed Phase 4 Interventional

Nasal Budesonide in Children With Rhinitis and/or Mild Obstructive Sleep Apnea Syndrome

NCT00560586
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Budesonide, placebo
Drug
Lead sponsor
University of Louisville
Other
Eligibility
6 Years to 12 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 10, 2017 · Synced Jul 22, 2026, 6:49 AM EDT
Completed No phase listed Observational

Understanding Sleep in Hospitalized Older Patients

NCT01057823
View directory record Official record
Conditions
Sleep Deprivation, Sleep Fragmentation
Interventions
Not listed
Lead sponsor
University of Chicago
Other
Eligibility
50 Years and older
Enrollment
771 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 16, 2021 · Synced Jul 22, 2026, 6:49 AM EDT
Active, not recruiting Not applicable Interventional

Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease

NCT04620551
View directory record Official record
Conditions
Parkinson Disease, Sleep Fragmentation
Interventions
Sub-clinical stimulation
Device
Lead sponsor
University of Nebraska
Other
Eligibility
21 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Aug 18, 2025 · Synced Jul 22, 2026, 6:49 AM EDT