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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:57 AM EST

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Showing 1–24 of 123 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Smoking (Tobacco) Addiction Clear all

Conditions: Smoking
Interventions: Mindfulness, Quit Line; Behavioral
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 93 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Nicotine Addiction
Interventions: transcranial direct current stimulation (tDCS); Device
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 60 Years
Enrollment: 172 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Nicotine Dependence, Opiate Dependence
Interventions: Intensive, tailored intervention, NJ Quitline Referral; Behavioral
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 18 Years and older
Enrollment: 87 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Conditions: Smoking Cessation, Tobacco Use Disorder
Interventions: Usual Care, Smoking Reduction; Drug · Other
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 13 Years to 19 Years
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Nicotine Addiction, Vaping
Interventions: Nicotine pod, Placebo pod; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 30 Years
Enrollment: 8 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Nicotine Use Disorder
Interventions: Retrieval Extinction Training (RET), Control Retrieval Extinction Training (RET); Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 25 Years to 65 Years
Enrollment: 191 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Smoking, Smoking Behaviors, Nicotine Dependence
Interventions: E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 2.4% Nicotine with Tobacco Flavor Only, E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 5% Nicotine with Tobacco Flavor Only, Tobacco Pouches with 3mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 3mg Nicotine with Tobacco Flavor Only, Tobacco Pouches with 6mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 6mg Nicotine with Tobacco Flavor Only; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 21 Years and older
Enrollment: 256 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Nicotine Dependence, Tobacco Use Disorder
Interventions: Not listed
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 70 Years
Enrollment: 135 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2010
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Tobacco Use, Tobacco Use Cessation, Smoking Cessation, Nicotine Addiction, Tobacco Smoking
Interventions: ELEVATE, ELEVATE-S; Behavioral
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years and older
Enrollment: 3,543 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Nicotine Dependence
Interventions: Transcranial Magnetic Stimulation; Device
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 65 Years
Enrollment: 75 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2013
U.S. locations: 2
States / cities: Baltimore, Maryland • Catonsville, Maryland

Conditions: Nicotine Addiction
Interventions: Standard smoking cessation counseling; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 119 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2024
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking, Smoking Cessation, Smoking Reduction, Smoking Habit, Smoking Behaviors, Smoking, Tobacco, Smoking, Cigarette, Smoking (Tobacco) Addiction, Tobacco Use, Tobacco Smoking
Interventions: Indoor Air Quality Monitor AirGradient ONE; Other
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 8
States / cities: Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more

Conditions: Cigarette Smoking, Addiction, E Cig Use
Interventions: E cigarettes, Nicotine Replacement Therapy; Other
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 65 Years
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: New York, New York

Conditions: Cigarette Smoking, Tobacco Smoking, Nicotine Dependence, Smoking Cessation
Interventions: Mindfulness Training, Smoking Cessation Therapy; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: Nicotine Dependence
Interventions: E-cigarettes; Combination Product
Lead sponsor: Duke University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Alcoholism, Nicotine Dependence
Interventions: Varenicline; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 70 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Nicotine Use Disorder
Interventions: Practice Quit Attempt; Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 45 Years
Enrollment: 82 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Nicotine Dependence
Interventions: pregabalin, cigarettes; Drug · Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Nicotine Addiction
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 50 Years
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2011
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Nicotine Addiction, Smoking Cessation
Interventions: Nicotine polacrilex, STAM 1100mAh CE4 eGo Clearomizer; Drug · Other
Lead sponsor: Creighton University; Other
Eligibility: 19 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Nicotine Dependence
Interventions: lorcaserin, nicotine patch, placebo lorcaserin; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 97 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking, Smoking Cessation, Craving, Addiction, Addiction Nicotine, Nicotine Dependence, Cigarette Smoking
Interventions: Real TBS to the vmPFC, Sham cTBS to the vmPFC; Device
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years to 75 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Smoking Cessation, Smoking, Tobacco, Smoking (Tobacco) Addiction, Cessation, Tobacco, Cigarette Smoking
Interventions: Bupropion Hydrochloride; Drug
Lead sponsor: University of Southern California; Other
Eligibility: 21 Years to 65 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Nicotine Addiction, Cigarette Smoking
Interventions: Smoking research cigarettes with e-cigarette, Nicotine discrimination thresholds; Drug
Lead sponsor: Rose Research Center, LLC; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 2
States / cities: Charlotte, North Carolina • Raleigh, North Carolina

Search by objective public record fields.

Meriter Mindfulness Training for Smokers Program and Study

tDCS Effects on Resisting Smoking: Dose Ranging Study

Developing a Smoking Cessation Intervention for Methadone Maintained Smokers

Effectiveness of Reducing Smoking in Facilitating Smoking Cessation in Adolescents - 2

Acute Effects of Vaping Nicotine on Cognition in Young Adults

Behavioral Memory Modulation in Nicotine Addiction

Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction

Effectiveness of Using Reduced Nicotine Cigarettes in Men and Women Smokers to Combat Nicotine Addiction

CONNECT Cancer Survivors With Tobacco Treatment

Pilot Study of Transcranial Magnetic Stimulation (TMS) in Nicotine Addiction

Neural Mechanisms Associated With Risk of Smoking Relapse

A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home

Electronic Cigarettes as a Harm Reduction Strategy in Individuals With Substance Use Disorder

Mindfulness Training for Smoking Cessation

The Role of Nicotine and Non-Nicotine Alkaloids in E-Cigarette Use and Dependence

Varenicline and Alcohol in Inpatient Addictions Program (IAP)

Neural Basis of Eating Behavior in Abstinent Smokers

GABA (Gamma Amino Butyric Acid) Medication for Tobacco

Quantitation of Human Cerebral Nicotinie Receptors With 2[18F]FA-85380 and PET Healthy Non-smokers and Ex-Smokers and in Heavy and Light Situational Smokers

e-Cigarettes Versus NRT Gum for Smoking Cessation

Combination Nicotine Patch / Lorcaserin for Smoking Cessation

QuitFast: Evaluating Transcranial Magnetic Stimulation as a Tool to Reduce Smoking Directly Following a Quit Attempt

High Dose Bupropion for Smoking Cessation - Pilot Study

Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use