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Showing 1–20 of 20 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Spinal Instability Clear all
Terminated Phase 3 Interventional

A Clinical Study of the Dynesys(R) Spinal System

NCT00759057
View directory record Official record
Conditions
Degenerative Spondylolisthesis or Retrolisthesis, Spinal Stenosis, Stenosing Lesion.
Interventions
Posterior Pedicle Screw System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
20 Years to 80 Years
Enrollment
399 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2015
U.S. locations
26
States / cities
Scottsdale, Arizona • Tucson, Arizona • Los Angeles, California + 23 more
Source: ClinicalTrials.gov public record
Updated Jun 27, 2012 · Synced Jul 22, 2026, 1:42 AM EDT
Completed Early Phase 1 Interventional

Improving Pain and Reducing Opioid Use (IPaRO) in Lumbar Spine Surgery Patients

NCT03088306
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Lumbar Spinal Instability, Lumbar Spine Degeneration
Interventions
Standard analgesia use [Oxygen], Standard analgesia use [Hydromorphone], Standard analgesia use [Volatile Anesthesia], Standard analgesia use [Fentanyl], Multi-modal pain management [Acetaminophen + Gabapentin], Multi-modal pain management [Fentanyl], Multi-modal pain management [Intravenous Ketamine], Multi-modal pain management [Valium + Gabapentin]
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 100 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 15, 2018 · Synced Jul 22, 2026, 1:42 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Home Program Education for Patients With Low Back Pain

NCT02427438
View directory record Official record
Conditions
Low Back Pain, Lumbago, Spinal Instability
Interventions
Video, Handout
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 50 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 25, 2017 · Synced Jul 22, 2026, 1:42 AM EDT
Terminated Phase 2 Interventional Results available

CopiOs Posterolateral Fusion Procedure

NCT01123850
View directory record Official record
Conditions
Spondylolisthesis, Stenosis
Interventions
Copios
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
21 Years to 85 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
6
States / cities
Orlando, Florida • Belleville, Illinois • Indianapolis, Indiana + 3 more
Source: ClinicalTrials.gov public record
Updated May 26, 2015 · Synced Jul 22, 2026, 1:42 AM EDT
Not listed Not applicable Interventional

OSTEOAMP Lumbar Fusion Intra-Patient Controlled Study

NCT05405374
View directory record Official record
Conditions
Lumbar Spine Disease, Lumbar Spondylolisthesis, Lumbar Spine Instability, Lumbar Spondylosis, Degenerative Disc Disease
Interventions
OSTEOAMP, Infuse
Other · Device
Lead sponsor
Bioventus LLC
Industry
Eligibility
21 Years to 80 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
9
States / cities
New Haven, Connecticut • Wichita, Kansas • Paducah, Kentucky + 6 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2023 · Synced Jul 22, 2026, 1:42 AM EDT
Not listed No phase listed Observational

Prospective SPINE Registry

NCT04176562
View directory record Official record
Conditions
Sacroiliac; Fusion, Sacroiliac, Joint Diseases, Musculoskeletal Diseases, Spinal Disease, Spinal Stenosis, Spinal Instability, Fusion of Joint, Fusion of Spine, Spinal Fusion, Spine
Interventions
RTI Spine products
Device
Lead sponsor
Xtant Medical
Industry
Eligibility
18 Years and older
Enrollment
5,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
7
States / cities
Hartford, Connecticut • Boca Raton, Florida • Delray Beach, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 11, 2024 · Synced Jul 22, 2026, 1:42 AM EDT
Recruiting Phase 4 Interventional

Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery

NCT05029726
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Spondylolisthesis, Lumbar Spondylosis, Lumbar Radiculopathy, Lumbar Spine Instability, Synovial Cyst, Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Intervertebral Discs
Interventions
Bupivacaine-Epinephrine 0.25%-1:200,000 Injectable Solution plus clonidine, normal saline
Drug
Lead sponsor
John O'Toole
Other
Eligibility
18 Years to 80 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Jul 22, 2026, 1:42 AM EDT
Active, not recruiting No phase listed Observational

Incomplete Cervical SCI Without Instability

NCT05653206
View directory record Official record
Conditions
Cervical Spinal Cord Injury
Interventions
Nonsurgical treatment, Surgical treatment
Procedure
Lead sponsor
AO Foundation, AO Spine
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
3
States / cities
San Francisco, California • Baltimore, Maryland • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Jul 22, 2026, 1:42 AM EDT
Completed No phase listed Observational

Evaluation Of Spinelink® Fixation In The Treatment Of Degenerative Spondylolisthesis And Spinal Instability

NCT00726310
View directory record Official record
Conditions
Degenerative Disc Disease, Degenerative Spondylolisthesis
Interventions
SpineLink® , SpineLink® II
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
Not listed
Enrollment
202 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2009
U.S. locations
2
States / cities
San Diego, California • Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 12, 2020 · Synced Jul 22, 2026, 1:42 AM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Treatment of One and/or Two Level Cervical Degenerative Disc Disease

NCT05812092
View directory record Official record
Conditions
Cervical Radiculopathy
Interventions
CONDUIT Interbody Cervical System with DePuy Synthes Cervical Plating System
Device
Lead sponsor
Research Source
Network
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Aug 21, 2025 · Synced Jul 22, 2026, 1:42 AM EDT
Terminated Phase 3 Interventional Results available

INFUSE®Bone Graft in Transforaminal Lumbar Interbody Fusion for Degenerative Disease of Lumbosacral Spine

NCT01415908
View directory record Official record
Conditions
Lumbar Spine Degeneration
Interventions
INFUSE Bone Graft, Iliac Crest Bone Graft
Device · Other
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
5
States / cities
Mesa, Arizona • Los Angeles, California • Gulf Breeze, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 17, 2016 · Synced Jul 22, 2026, 1:42 AM EDT
Completed Not applicable Interventional

Prevention of Arthritis-Related Work Disability

NCT00000416
View directory record Official record
Conditions
Rheumatoid Arthritis, Systemic Lupus Erythematosus, Osteoarthritis, Knee, Ankylosing Spondylitis
Interventions
Rehabilitation counseling
Other
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years to 65 Years
Enrollment
242 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2001
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 25, 2017 · Synced Jul 22, 2026, 1:42 AM EDT
Recruiting No phase listed Observational

Intraoperative Monitoring for the Lateral Lumbar Interbody Fusion Procedure

NCT05648474
View directory record Official record
Conditions
Intervertebral Disc Degeneration, Stenosis, Spinal, Spondylolisthesis, Spinal Deformity, Spinal Instability
Interventions
Somatosensory evoked potential [SSEP] intraoperative monitoring
Diagnostic Test
Lead sponsor
Alphatec Spine, Inc.
Industry
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Carlsbad, California
Source: ClinicalTrials.gov public record
Updated Oct 23, 2024 · Synced Jul 22, 2026, 1:42 AM EDT
Recruiting Not applicable Interventional

The NOTICE Study: Neurosurgery and OrThopedIcs Communication Evaluation Study Following Lumbar Fusions

NCT04140344
View directory record Official record
Conditions
Lumbar Spine Degeneration, Lumbar Spine Instability, Lumbar Spondylosis
Interventions
Text Message Group
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
224 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Jul 22, 2026, 1:42 AM EDT
Not yet recruiting Phase 1Phase 2 Interventional

Stimulation-based Therapy to Improve Balance in DCM

NCT07298460
View directory record Official record
Conditions
Degenerative Cervical Myelopathy
Interventions
Transcutaneous spinal cord stimulation, Balance and Gait Training
Device · Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
50 Years to 90 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Jul 22, 2026, 1:42 AM EDT
Recruiting Not applicable Interventional

ARC-IM System to Manage Symptomatic Blood Pressure Instability Secondary to Chronic Spinal Cord Injury

NCT07147296
View directory record Official record
Conditions
Spinal Cord Injuries, Blood Pressure Disorders
Interventions
ARC-IM System Implantation, ARC-IM Therapy (Group 1), ARC-IM Therapy (Group 2)
Procedure · Device
Lead sponsor
ONWARD Medical, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
12
States / cities
Little Rock, Arkansas • Englewood, Colorado • Miami, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Jul 22, 2026, 1:42 AM EDT
Terminated Not applicable Interventional Results available

Clinical Outcomes of the Trinica(R) Anterior Lumbar Plate: Fixed Screws vs. Variable Screws

NCT00762723
View directory record Official record
Conditions
Degenerative Disc Disease, Spinal Stenosis, Spondylolisthesis
Interventions
Trinica Anterior Lumbar Plate System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
Not listed
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
3
States / cities
Daphne, Alabama • Mobile, Alabama • San Bernardino, California
Source: ClinicalTrials.gov public record
Updated Apr 16, 2014 · Synced Jul 22, 2026, 1:42 AM EDT
Enrolling by invitation No phase listed Observational

Cervical Interbody Implant Study

NCT04689854
View directory record Official record
Conditions
Degenerative Disc Disease, Cervical Spinal Instability
Interventions
Not listed
Lead sponsor
NuVasive
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
7
States / cities
Orange, California • Hartford, Connecticut • Somerville, Massachusetts + 4 more
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Jul 22, 2026, 1:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Joint Mobilization in the Treatment of Chronic Ankle Instability

NCT01438905
View directory record Official record
Conditions
Ankle Sprain
Interventions
Small amplitude (Grade IV) mobilization, High velocity, low amplitude (Grade V) mobilization
Other
Lead sponsor
Creighton University
Other
Eligibility
19 Years to 45 Years · Male only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Feb 22, 2018 · Synced Jul 22, 2026, 1:42 AM EDT
Completed No phase listed Observational

Streamline Occipito-Cervico-Thoracic System Post-Market Clinical Follow-up

NCT04171544
View directory record Official record
Conditions
Spinal Stenosis Occipito-Atlanto-Axial, Spinal Disease, Spinal Stenosis Cervical, Spinal Stenosis Cervicothoracic Region, Spinal Instability
Interventions
Streamline Occipito-Cervico-Thoracic Spinal Fixation System
Device
Lead sponsor
RTI Surgical
Industry
Eligibility
Not listed
Enrollment
60 participants
Timeline
2019 – 2020
U.S. locations
2
States / cities
Las Vegas, Nevada • Reno, Nevada
Source: ClinicalTrials.gov public record
Updated Oct 26, 2020 · Synced Jul 22, 2026, 1:42 AM EDT