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Showing 1–24 of 240 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Spine Pain Clear all
Enrolling by invitation No phase listed Observational

Influence of Flexion Distraction Manipulation on Measures of Performance and Postural Control

NCT06965920
View directory record Official record
Conditions
Spine Condition, Low Back Pain
Interventions
Not listed
Lead sponsor
Keiser University College of Chiropractic Medicine
Other
Eligibility
18 Years to 100 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
West Palm Beach, Florida
Source: ClinicalTrials.gov public record
Updated May 17, 2025 · Synced Jul 23, 2026, 10:07 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

An Observational Study of Integrated Chronic Pain Management in a Community Health Center

NCT04490291
View directory record Official record
Conditions
Chronic Pain, Spine Disease
Interventions
chronic pain team, chiropractic team
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 28, 2020 · Synced Jul 23, 2026, 10:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Optimizing Mental Health in Orthopedic Care

NCT05194722
View directory record Official record
Conditions
Anxiety, Depression, Back Pain, Neck Pain
Interventions
Wysa mobile app
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Jul 23, 2026, 10:07 AM EDT
Withdrawn Not applicable Interventional

Methadone Versus Placebo in Spine Fusion

NCT01125059
View directory record Official record
Conditions
Postoperative Pain
Interventions
Methadone, Saline
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 21, 2015 · Synced Jul 23, 2026, 10:07 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Multimodal Analgesia Versus Routine Care Pain Management

NCT01861743
View directory record Official record
Conditions
Degenerative Disc Disease Lumbar, Spinal Stenosis, Lumbar Spondylolisthesis
Interventions
Multimodal Analgesia, Patient controlled analgesia
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
Not listed
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 28, 2018 · Synced Jul 23, 2026, 10:07 AM EDT
Active, not recruiting Not applicable Interventional

Non-pharmacological Treatment for Pain After Spine Surgery

NCT04770480
View directory record Official record
Conditions
Low Back Pain, Chronic Pain, Surgery, Back Pain, Low, Back Pain Lower Back Chronic
Interventions
Standard Care (SC), Enriched Pain Management Pathway (EPM)
Behavioral
Lead sponsor
Dan Rhon
Federal
Eligibility
18 Years to 75 Years
Enrollment
267 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
3
States / cities
Honolulu, Hawaii • San Antonio, Texas • Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated May 25, 2026 · Synced Jul 23, 2026, 10:07 AM EDT
Completed Phase 3 Interventional Results available

Analgesic Efficacy of Repeated Doses of Intravenous (IV) Acetaminophen in Post-operative Pediatric Spine Fusion Patients

NCT01394718
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Intravenous Acetaminophen, Placebo
Drug · Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
10 Years to 18 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 17, 2016 · Synced Jul 23, 2026, 10:07 AM EDT
Terminated Not applicable Interventional Results available

Dexamethasone Versus Depo Medrol in Lumbar Epidurals

NCT01397552
View directory record Official record
Conditions
Lumbar Spine Disc Herniation, Lumbar Radiculitis, Lumbar Back Pain
Interventions
Dexamethasone, methylprednisolone acetate
Drug
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
21 Years to 89 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
East Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Nov 21, 2023 · Synced Jul 23, 2026, 10:07 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Tissue Collection for Understanding Intervertebral Disc Degeneration and Back Pain

NCT01633034
View directory record Official record
Conditions
Intervertebral Disc Degeneration, Back Pain
Interventions
Not listed
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2025
U.S. locations
2
States / cities
Manhasset, New York • Manhattan, New York
Source: ClinicalTrials.gov public record
Updated Mar 19, 2024 · Synced Jul 23, 2026, 10:07 AM EDT
Not listed Phase 4 Interventional

Dronabinol for Post-operative Pain After Lumbar Fusion

NCT04346407
View directory record Official record
Conditions
Post-operative Pain
Interventions
Dronabinol 2.5mg Cap, Placebo
Drug
Lead sponsor
Jeffrey L Gum MD
Other
Eligibility
18 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Feb 11, 2021 · Synced Jul 23, 2026, 10:07 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Postoperative subQ Pain Control for Spinal Fusion Surgery

NCT03476811
View directory record Official record
Conditions
Spine Fusion, Surgery, Pain, Postoperative
Interventions
0.25% Marcaine at 2ml/hr and pain medications, Placement of OnQ Drug pump
Drug · Device
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated May 25, 2022 · Synced Jul 23, 2026, 10:07 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

The Role of Disc Nutrition in the Etiology and Clinical Treatment of Disc Degeneration

NCT04134910
View directory record Official record
Conditions
Back Pain, Intervertebral Disc Degeneration
Interventions
Physical Therapy
Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
30 Years to 70 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Jul 23, 2026, 10:07 AM EDT
Completed Phase 1 Interventional

Patients With Neck Pain Likely to Benefit From Thoracic Spine Thrust Mobilization

NCT00504686
View directory record Official record
Conditions
Neck Pain
Interventions
manual therapy, exercise
Other
Lead sponsor
Franklin Pierce University
Other
Eligibility
18 Years to 60 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Concord, New Hampshire
Source: ClinicalTrials.gov public record
Updated Feb 2, 2009 · Synced Jul 23, 2026, 10:07 AM EDT
Completed Not applicable Interventional

Short-Term Effects of Combined Manual Therapy to the Cervical and Thoracic Spine

NCT01318720
View directory record Official record
Conditions
Neck Pain
Interventions
Manual Therapy
Other
Lead sponsor
Masefield and Cavallaro Physical Therapy
Other
Eligibility
18 Years to 60 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
2
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Apr 6, 2015 · Synced Jul 23, 2026, 10:07 AM EDT
Not listed Phase 1Phase 2 Interventional

Safety Evaluation of ART352-L in Subjects Undergoing Posterolateral Spinal Fusion

NCT04378543
View directory record Official record
Conditions
Degenerative Spondylolisthesis
Interventions
ART352-L
Biological
Lead sponsor
Ankasa Regenerative Therapeutics, Inc.
Industry
Eligibility
50 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
3
States / cities
Los Angeles, California • Rochester, Minnesota • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 11, 2020 · Synced Jul 23, 2026, 10:07 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Occupational Exposure to Whole Body Vibration Among U.S. Military Veterans: Acute and Chronic Contributions to Musculoskeletal Disorders and Spine-Area Pain

NCT07367139
View directory record Official record
Conditions
Spine Health, Spine Injuries and Disorders, Spine Degeneration, Whole Body Vibration
Interventions
Water
Other
Lead sponsor
Milwaukee VA Medical Center
Federal
Eligibility
20 Years to 45 Years
Enrollment
112 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 25, 2026 · Synced Jul 23, 2026, 10:07 AM EDT
Completed Early Phase 1 Interventional

Improving Pain and Reducing Opioid Use (IPaRO) in Lumbar Spine Surgery Patients

NCT03088306
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Lumbar Spinal Instability, Lumbar Spine Degeneration
Interventions
Standard analgesia use [Oxygen], Standard analgesia use [Hydromorphone], Standard analgesia use [Volatile Anesthesia], Standard analgesia use [Fentanyl], Multi-modal pain management [Acetaminophen + Gabapentin], Multi-modal pain management [Fentanyl], Multi-modal pain management [Intravenous Ketamine], Multi-modal pain management [Valium + Gabapentin]
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 100 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 15, 2018 · Synced Jul 23, 2026, 10:07 AM EDT
Completed Not applicable Interventional

The RELIEF Study - Researching the Effectiveness of Lumbar Interventions for Enhancing Function

NCT01854892
View directory record Official record
Conditions
Low Back Pain
Interventions
Manipulation, Mobilization, Laser Therapy
Other
Lead sponsor
Ohio University
Other
Eligibility
18 Years to 45 Years
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Athens, Ohio
Source: ClinicalTrials.gov public record
Updated May 11, 2017 · Synced Jul 23, 2026, 10:07 AM EDT
Enrolling by invitation Phase 4 Interventional

The MDK Study: Using a Combination of Methadone-dexmedetomidine-ketamine for Postoperative Pain Control in Patients Undergoing Complex Spine Surgeries.

NCT07365800
View directory record Official record
Conditions
Spine Surgery
Interventions
Methadone-dexmedetomidine-ketamine combination
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 79 Years
Enrollment
248 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Jul 23, 2026, 10:07 AM EDT
Completed Not applicable Interventional Results available

Study of Opioid Use After Lumbar and Cervical Spine Surgery

NCT02674711
View directory record Official record
Conditions
Low Back Pain, Opiate Addiction, Neck Pain
Interventions
Educational Video
Behavioral
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 18, 2023 · Synced Jul 23, 2026, 10:07 AM EDT
Withdrawn Phase 2 Interventional

Analgesic Effects of Perioperative Propranolol Administration for Spine Surgery

NCT04421209
View directory record Official record
Conditions
Lumbar Disc Disease, Spinal Fusion, Degenerative Disc Disease
Interventions
Propranolol Hcl 40mg Tab, Placebo oral tablet
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 15, 2021 · Synced Jul 23, 2026, 10:07 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Neural Control and Mechanosensation in Spine Muscle

NCT07003802
View directory record Official record
Conditions
Low Back Pain and Core Muscle, Disc Herniation
Interventions
Resistance exercise
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 60 Years
Enrollment
152 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Jul 23, 2026, 10:07 AM EDT
Terminated Phase 2 Interventional

A Study Comparing the Safety and Effectiveness of Cartilage Cell Injected Into the Lumbar Disc as Compared to a Placebo

NCT01771471
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
NuQu, Placebo
Biological · Other
Lead sponsor
ISTO Technologies, Inc.
Industry
Eligibility
21 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2020
U.S. locations
10
States / cities
Birmingham, Alabama • San Francisco, California • Santa Monica, California + 7 more
Source: ClinicalTrials.gov public record
Updated Aug 30, 2017 · Synced Jul 23, 2026, 10:07 AM EDT
Recruiting Phase 4 Interventional

Depo-Medrol on Psoas After LLIF

NCT05929755
View directory record Official record
Conditions
Muscle Weakness, Pain, Postoperative, Paresthesia, Pain, Muscle
Interventions
Depo-Medrol, Gel-Flow NT
Drug
Lead sponsor
Hardeep Singh
Other
Eligibility
18 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Jul 23, 2026, 10:07 AM EDT