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Showing 1–24 of 165 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Stress Reaction Clear all
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Depression, Epinephrine, and Platelet Function

NCT00166114
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Escitalopram, Desipramine
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years to 55 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2009
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 22, 2015 · Synced Jul 21, 2026, 10:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Stress Reactivity Study in Adolescents

NCT03997149
View directory record Official record
Conditions
Stress, Eating Behavior
Interventions
Acute Laboratory Stressor, Low affect video
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
14 Years to 19 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 24, 2019 · Synced Jul 21, 2026, 10:20 PM EDT
Recruiting Not applicable Interventional

Art Therapy and Emotional Well Being in Military Populations With Posttraumatic Stress Symptoms

NCT05414708
View directory record Official record
Conditions
PTSD, Military Activity, Post-Traumatic Headache, Posttraumatic Stress Disorder, Posttraumatic Stress Disorder, Delayed Onset, Sleep Disturbance, Nightmare, Irritable Mood, Anger, Combat and Operational Stress Reaction, Combat Stress Disorders, Military Family, Military Operations, Emotional Regulation, Emotion Processing
Interventions
Art Therapy
Behavioral
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years to 64 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
Bethesda, Maryland • Fort Belvoir, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Jul 21, 2026, 10:20 PM EDT
Completed Not applicable Interventional Results available

Morning Light Treatment for Traumatic Stress: The Role of Amygdala Reactivity

NCT04117347
View directory record Official record
Conditions
Stress
Interventions
Light therapy A via the Re-Timer®, Light therapy B via the Re-Timer®, Light therapy C via the Re-Timer®
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 26, 2024 · Synced Jul 21, 2026, 10:20 PM EDT
Recruiting No phase listed Observational

Effects of Brief Nature Exposure on Brain Functioning and Stress Reactivity

NCT07508800
View directory record Official record
Conditions
Stress (Psychology)
Interventions
Nature vs. Urban walks
Other
Lead sponsor
National Institutes of Health (NIH)
NIH
Eligibility
18 Years to 25 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Jul 21, 2026, 10:20 PM EDT
Completed Phase 2 Interventional Results available

Stress Response and Neurodevelopmental Outcome After Cardiac Surgery Utilizing CPB in Children: A Prospective, Double Blinded and Randomized Study

NCT02492269
View directory record Official record
Conditions
Congenital Heart Disease
Interventions
Dexmedetomidine, Placebo
Drug
Lead sponsor
Aymen N Naguib
Other
Eligibility
1 Month to 12 Months
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Jul 21, 2026, 10:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Sound Mind Warrior Study

NCT02328690
View directory record Official record
Conditions
Anxiety, Stress
Interventions
Binaural Beat Technology
Other
Lead sponsor
Fort Belvoir Community Hospital
Federal
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
2
States / cities
Bethesda, Maryland • Fort Belvoir, Virginia
Source: ClinicalTrials.gov public record
Updated May 29, 2017 · Synced Jul 21, 2026, 10:20 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

The Menopause Transition: Estrogen Variability, Stress Reactivity and Mood

NCT03003949
View directory record Official record
Conditions
Perimenopausal Disorder, Stress, Emotional
Interventions
Estradiol Patch, 0.1 Mg/24 Hours Weekly Transdermal Film, Extended Release, Placebo Patch, Progesterone Capsule, Placebo Oral Capsule
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
45 Years to 60 Years · Female only
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
2
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 25, 2021 · Synced Jul 21, 2026, 10:20 PM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

FHA: Characterization of Metabolic Status, Brain Circuitry, and Stress-Reactivity

NCT00453219
View directory record Official record
Conditions
Anovulation, FHA, Eumenorrhea, Polycystic Ovary Syndrome
Interventions
Screening evaluation, Meal Response, Blood Collection, Functional MRI, Endocrine Assessment
Procedure · Genetic
Lead sponsor
Emory University
Other
Eligibility
18 Years to 35 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2011
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 29, 2013 · Synced Jul 21, 2026, 10:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Self-Compassion Practice on Stress Reactivity Among Sexual Minority Women

NCT05949060
View directory record Official record
Conditions
Stress Reaction, Sexuality, Compassion
Interventions
Compassion Intervention
Behavioral
Lead sponsor
Syracuse University
Other
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Dec 26, 2024 · Synced Jul 21, 2026, 10:20 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Impact of OnabotulinumtoxinA (BOTOX®) on Stress

NCT06778421
View directory record Official record
Conditions
Stress (Psychology), Stress, Healthy Adult Female Participants, Stress, Psychologic, Stress, Psychological Cumulative, Stress, Physiological, Stress Response, Stress Levels, Stress Perception
Interventions
Intramuscular injection, OnabotulinumtoxinA (Botox®) Injections, Sodium Chloride
Procedure · Drug · Other
Lead sponsor
Center for Advanced Facial Plastic Surgery
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Beverly Hills, California
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Jul 21, 2026, 10:20 PM EDT
Enrolling by invitation Phase 4 Interventional

Fracture Recovery for Returning to Duty (Teriparatide STRONG)

NCT04589819
View directory record Official record
Conditions
Stress Fracture of Tibia or Fibula
Interventions
Teriparatide, Placebos
Drug
Lead sponsor
University of South Carolina
Other
Eligibility
Not listed
Enrollment
183 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 12, 2023 · Synced Jul 21, 2026, 10:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Can a Novel Manual Therapy Technique Help Relieve Stress? Assessing Effects of Primal Reflex Release on the Body's Stress Response

NCT06305585
View directory record Official record
Conditions
Psychological Stress
Interventions
Primal Reflex Release Technique (PRRT)
Other
Lead sponsor
University of Idaho
Other
Eligibility
18 Years to 64 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Moscow, Idaho
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Jul 21, 2026, 10:20 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

The Human Stress Response in a Simulated ED Setting

NCT04317482
View directory record Official record
Conditions
Stress Physiology, Stress Reaction, Substance Use Disorders, Methamphetamine-dependence, Stress, Emotional
Interventions
Standard social stress task, Stressful experience in the ED
Behavioral
Lead sponsor
University of Arkansas
Other
Eligibility
21 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Jul 21, 2026, 10:20 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Pregnancy-Specific Anxiety on Placental Inflammatory and Oxidative Stress Response and Birth Outcomes

NCT04993742
View directory record Official record
Conditions
Placental Dysfunction, Prenatal Stress
Interventions
MOMS Intervention
Behavioral
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years and older · Female only
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Jul 21, 2026, 10:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Functional Assessment of Ashwagandaha Root Extract During Weight Loss

NCT03112824
View directory record Official record
Conditions
Stress Reaction, Sleep Disturbance, Craving, Obesity
Interventions
Ashwagandha Root Extract Capsule, Placebo Capsule
Dietary Supplement · Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 70 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jan 29, 2023 · Synced Jul 21, 2026, 10:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Acute Plasma Abeta Responses to Stress

NCT05521919
View directory record Official record
Conditions
Stress Reaction, Stress Physiology
Interventions
Sympathetic Nervous System Activation, No-stress
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 65 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Jul 21, 2026, 10:20 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Cranberry Polyphenols and Stress Resilience During Multitasking in Healthy Adults

NCT07453537
View directory record Official record
Conditions
Stress Response, Mental Stress, Multitasking Behavior and Multitasking Ability, Physiological Stress, Cognitive Symptoms, Motor Activity
Interventions
Cranberry juice, Placebo juice
Other
Lead sponsor
University of Florida
Other
Eligibility
30 Years to 55 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Jul 21, 2026, 10:20 PM EDT
Completed Phase 1 Interventional

Effect of Polyunsaturated Fatty Acids on Cardiovascular and Motor Responses Under Stress

NCT00014027
View directory record Official record
Conditions
Healthy
Interventions
Docosahexaenoic acid (DHA), Eicosapentaenoic acid
Drug
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
18 Years and older
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2008
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Jul 21, 2026, 10:20 PM EDT
Completed Phase 2 Interventional Results available

Inhaled Oxytocin and HPA Axis Reactivity

NCT03593473
View directory record Official record
Conditions
Depression, Postpartum, Anxiety Disorders, Stress, Psychological
Interventions
Intranasal Oxytocin, Placebo
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older · Female only
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 7, 2025 · Synced Jul 21, 2026, 10:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Enhanced Recovery After Spine Surgery

NCT02949518
View directory record Official record
Conditions
Enhanced Recovery After Surgery, Spine Surgery
Interventions
Enhanced Recovery Pathway (ERP) for Spine
Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
21 Years and older
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 27, 2020 · Synced Jul 21, 2026, 10:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Stress & Resilience Study

NCT06063174
View directory record Official record
Conditions
Stress, Stress, Psychological, Stress, Physiological, Stress, Emotional, Stress Reaction
Interventions
Education Program, Think Well Program, Be Well Program, Eat Well Program, Sleep Well Program, Move Well Program
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
712 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 14, 2025 · Synced Jul 21, 2026, 10:20 PM EDT
Completed No phase listed Observational

US vs MRI for Stress Injuries

NCT05876897
View directory record Official record
Conditions
Stress Fracture
Interventions
Not listed
Lead sponsor
Ryan Kruse
Other
Eligibility
18 Years to 50 Years
Enrollment
25 participants
Timeline
2021 – 2024
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 30, 2024 · Synced Jul 21, 2026, 10:20 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Feasibility of Breathwork Intervention With Older Adults After Knee Surgery

NCT07464860
View directory record Official record
Conditions
Surgical Stress Response, Stress Physiological, Stress Physiology, Stress Psychological, Breathing Techniques, Breathing Exercises, Hypothalamic Pituitary Adrenal, Relaxation, Relaxation Therapy, Cortisol, Postoperative Pain, Postoperative Anxiety, Postoperative Depression, Quality of Recovery (QoR-15)
Interventions
A 5-minute Asynchronous Breathwork Intervention, A 5-minute Asynchronous Card Game Video
Behavioral
Lead sponsor
University of Arizona
Other
Eligibility
65 Years and older
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Jul 21, 2026, 10:20 PM EDT