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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Withdrawn Phase 3 Interventional

The Use of Anticonvulsants for Treatment of Patients With Alcohol Dependence and Post Traumatic Stress Disorder

NCT00571246
View directory record Official record
Conditions
Alcohol Dependence, Post Traumatic Stress Disorder
Interventions
Topiramate, lamotrigine, Placebo
Drug · Other
Lead sponsor
Yale University
Other
Eligibility
21 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 15, 2020 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional Results available

Smoking Cessation for Smokers With Sleep Problems

NCT01277887
View directory record Official record
Conditions
Nicotine Dependence, Cigarette Smoking, Insomnia
Interventions
Cognitive-Behavioral Counseling, Smoking Cessation Counseling
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 75 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 20, 2017 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pharmacotherapy and Mechanisms of Sleep Disturbance in Alcohol Dependence

NCT01014533
View directory record Official record
Conditions
Alcohol Dependence, Insomnia
Interventions
Placebo dispensed to subject., Gabapentin dispensed to subject.
Drug
Lead sponsor
Dr. Kirk Brower
Other
Eligibility
18 Years to 65 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 5, 2017 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Imaging the Neurobiology of a Behavioral Treatment for Cocaine Dependence

NCT00376558
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Community Reinforcement Approach
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 45 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2011
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 30, 2016 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Topiramate Alone and in Combination With the Nicotine Patch for Smoking Cessation: A Pilot Study

NCT00755716
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Placebo (sugar pill), Topiramate, Nicotine patch
Drug
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 65 Years
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2013
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 15, 2017 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Phase 4 Interventional Results available

Buprenorphine Maintenance vs. Detoxification in Prescription Opioid Dependence

NCT00555425
View directory record Official record
Conditions
Opiate Dependence
Interventions
Behavioral: Buprenorphine/naloxone maintenance (Mtn), Behavioral: Buprenorphine/naloxone detoxification (Dtx)
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
113 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 13, 2019 · Synced Sep 19, 2026, 4:53 AM EDT
Completed No phase listed Observational Results available

Characterizing Methamphetamine Withdrawal in Recently Abstinent Methamphetamine Users: A Pilot Study

NCT00653263
View directory record Official record
Conditions
Methamphetamine Dependence, Methamphetamine Withdrawal
Interventions
Not listed
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 65 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jun 27, 2021 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Personalized Feedback for Smokers With Elevated Anxiety Sensitivity

NCT03382093
View directory record Official record
Conditions
Anxiety Disorders, Anxiety, Tobacco Dependence, Smoking, Cigarette, Smoking, Tobacco
Interventions
Personalized Feedback Intervention, Smoking Information Control
Behavioral
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
95 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 18, 2019 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Baclofen Effects on Marijuana Dependence

NCT02011516
View directory record Official record
Conditions
Marijuana Dependence
Interventions
Baclofen, Psychosocial, Placebo
Drug · Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 60 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 13, 2017 · Synced Sep 19, 2026, 4:53 AM EDT
Completed No phase listed Observational

A Naturalistic Study of Adolescents and Young Adults in Treatment for Opioid Dependence

NCT02718352
View directory record Official record
Conditions
Opioid Dependence
Interventions
Naturalistic Prospective Cohort
Other
Lead sponsor
Yale University
Other
Eligibility
16 Years to 25 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 26, 2018 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Phase 1 Interventional Results available

Pharmaco-Magnetic Resonance Spectroscopy (MRS) Study of Clavulanic Acid

NCT04411914
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Clavulanic Acid, Placebo
Drug · Other
Lead sponsor
Temple University
Other
Eligibility
18 Years to 70 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 21, 2023 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Phase 2 Interventional Results available

Effects of Ibudilast on Oxycodone Self-administration in Opioid Abusers

NCT01740414
View directory record Official record
Conditions
Opioid Abuse, Opioid Dependence
Interventions
MN-166 (50 mg) First, Placebo First
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 55 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 16, 2017 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Phase 2 Interventional Results available

Mirtazapine for Treating Cocaine Dependent Individuals Who Also Suffer From Depression

NCT00249444
View directory record Official record
Conditions
Cocaine Dependence, Depression
Interventions
Mirtazapine, Placebo
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 60 Years
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 24, 2017 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional Results available

RCT of Web-Based Behavioral Sleep Intervention for Individuals With Alcohol Use Disorder

NCT03493958
View directory record Official record
Conditions
Alcohol Use Disorder, Alcohol Dependence, Insomnia
Interventions
Sleep Healthy Using the Internet (SHUTi)
Behavioral
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
18 Years to 65 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Phase 2 Interventional

Topiramate to Reduce Cocaine Dependence

NCT00223626
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Topiramate
Drug
Lead sponsor
Bankole Johnson
Other
Eligibility
18 Years to 45 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
2
States / cities
Charlottesville, Virginia • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 18, 2012 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Phase 2 Interventional Results available

Treatment of Smoking Among Individuals With PTSD

NCT00937235
View directory record Official record
Conditions
Cigarette Smoking, Nicotine Dependence, Post-traumatic Stress Disorder, Tobacco Use Disorder
Interventions
Varenicline, Medication Management Counseling, Prolonged Exposure
Drug · Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 75 Years
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 13, 2017 · Synced Sep 19, 2026, 4:53 AM EDT
Completed No phase listed Observational

Alcoholism Assessment and Treatment

NCT00106093
View directory record Official record
Conditions
Alcoholism, Alcohol Dependence, Alcohol Drinking Related Problems
Interventions
Not listed
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
18 Years and older
Enrollment
1,192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2015
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 26, 2018 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional Results available

Smartphone Based Continuing Care for Alcohol

NCT02681406
View directory record Official record
Conditions
Alcohol Abuse
Interventions
ACHESS, TMC
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 75 Years
Enrollment
262 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 8, 2022 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Phase 1 Interventional

Agonist Replacement Therapy for Cocaine Dependence

NCT00697138
View directory record Official record
Conditions
Cocaine Dependence
Interventions
d-Amphetamine; Atomoxetine
Drug
Lead sponsor
University of Kentucky
Other
Eligibility
18 Years to 50 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Feb 29, 2012 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Phase 2 Interventional

Role of Metabolites in Nicotine Dependence (2) - 5

NCT00000288
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Cotinine fumarate
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 45 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1995 – 2002
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Varenicline on Brain Activity During Nicotine Abstinence

NCT00602927
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Varenicline, Placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 9, 2011 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional Results available

Assessing E-Cigarettes for Tobacco Harm Reduction in the Context of Lung Cancer Screening

NCT06472869
View directory record Official record
Conditions
Electronic Cigarette Use, Smoking, Cigarette, Nicotine Dependence
Interventions
NJOY ACE e-cigarette
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
50 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional Results available

Modafinil, Sleep, and Cognition in Cocaine Dependence

NCT00582491
View directory record Official record
Conditions
Cocaine Dependence, Substance-induced Sleep Disorder, Substance-induced Cognitive Disorder
Interventions
Modafinil, Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 13, 2012 · Synced Sep 19, 2026, 4:53 AM EDT
Recruiting Not applicable Interventional

Preoperative Opioid Tapering Before Spine Surgery

NCT07221786
View directory record Official record
Conditions
Opioid Consumption, Postoperative, Pain After Surgery, Opioid Dependency
Interventions
Opioid tapering with CBT and education, Opioid tapering with education alone
Other
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Philadephia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Sep 19, 2026, 4:53 AM EDT