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Showing 1–24 of 208 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Substance Use Risk Clear all
Completed Not applicable Interventional Results available

Integrated Treatment for Posttraumatic Stress Disorder and Substance Abuse in Young Adults

NCT02667119
View directory record Official record
Conditions
Substance Use Disorder, Posttraumatic Stress Disorder
Interventions
Prolonged Exposure with Contingency Management, Standard Care
Behavioral
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 25 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
3
States / cities
Farmington, Connecticut • Hartford, Connecticut • New Britain, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 21, 2022 · Synced Sep 7, 2026, 3:33 PM EDT
Recruiting Not applicable Interventional

Optimizing Smart Technology for Addiction Recovery

NCT07573540
View directory record Official record
Conditions
Alcohol Use Disorder, Alcohol Use Disorder (AUD)
Interventions
STAR
Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
416 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Sep 7, 2026, 3:33 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Neural and Hormonal Influences on Sex Differences in Risk for AUD

NCT04929288
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Alcohol
Drug
Lead sponsor
Jessica Weafer
Other
Eligibility
21 Years to 26 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 7, 2026, 3:33 PM EDT
Not listed Phase 2 Interventional

The Aim of This Study is to Determine the Effectiveness of a Motivational Enhancement Intervention in Reducing Risk Behaviors (Drug and Alcohol Use, Sexual Risk Behavior, Poor Adherence to Medications) Among HIV+ Youth. - 1

NCT00227825
View directory record Official record
Conditions
Adherence, HIV Risk Behaviors, Alcohol & Drug Use, Health Behaviors, Sexual Risk Behaviors
Interventions
Motivational interviewing
Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
16 Years to 24 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 10, 2017 · Synced Sep 7, 2026, 3:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Preventing HIV Among Native Americans Through the Treatment PTSD & Substance Use

NCT03112369
View directory record Official record
Conditions
HIV Prevention, PTSD and Substance Use Disorder
Interventions
Narrative Exposure Therapy (NET), Motivational Interviewing w/Skills Training (MIST)
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
16 Years and older
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2024
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 7, 2026, 3:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Gender-Responsive Drug Use Treatment for Juvenile Justice Girls

NCT02293057
View directory record Official record
Conditions
Drug Use
Interventions
VOICES Group, Girl Health Group
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
12 Years to 24 Years · Female only
Enrollment
132 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 22, 2020 · Synced Sep 7, 2026, 3:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Project UNITY - HIV Risk Reduction and Vaccine Education Interventions

NCT00150098
View directory record Official record
Conditions
HIV Infections, Hepatitis B
Interventions
Enhanced HIV risk reduction and HIV vaccine education
Behavioral
Lead sponsor
New York Blood Center
Other
Eligibility
18 Years and older · Female only
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2010
U.S. locations
2
States / cities
New York, New York • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Apr 7, 2014 · Synced Sep 7, 2026, 3:33 PM EDT
Completed Phase 2 Interventional Results available

Onsite Buprenorphine Treatment at Syringe Exchange Programs

NCT03150173
View directory record Official record
Conditions
Opiate Addiction
Interventions
Onsite treatment, Enhanced referral, Buprenorphine
Behavioral · Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
3
States / cities
New York, New York • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Dec 10, 2025 · Synced Sep 7, 2026, 3:33 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Altering Memories That Increase Risk of Relapse in Alcohol Use Disorders

NCT03732248
View directory record Official record
Conditions
Alcohol Use Disorder, Alcohol Dependence
Interventions
Rapamycin, Placebo
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 26, 2021 · Synced Sep 7, 2026, 3:33 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Acute Alcohol Response In Bipolar Disorder: a Longitudinal Alcohol Administration/fMRI Study

NCT05838274
View directory record Official record
Conditions
Bipolar Disorder, Alcohol Drinking, Alcohol Use Disorder
Interventions
Alcohol vs. Placebo beverage conditions
Other
Lead sponsor
University of Texas at Austin
Other
Eligibility
21 Years to 26 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jan 11, 2026 · Synced Sep 7, 2026, 3:33 PM EDT
Completed Phase 1 Interventional

Intensive Outpatient Services for Teens

NCT01732601
View directory record Official record
Conditions
Depression, Suicide
Interventions
Intensive Outpatient CBT, Standard Care
Behavioral
Lead sponsor
Brown University
Other
Eligibility
12 Years to 18 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 22, 2018 · Synced Sep 7, 2026, 3:33 PM EDT
Completed No phase listed Observational

Effect of Heroin Use on Immune Activation and Cardiovascular Risk in HIV

NCT03976258
View directory record Official record
Conditions
HIV Infection, Opioid-use Disorder, Cardiovascular Diseases
Interventions
buprenorphine/naloxone, Methadone, Naltrexone Injection, Heroin
Drug
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
190 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
2
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 1, 2023 · Synced Sep 7, 2026, 3:33 PM EDT
Completed Not applicable Interventional

Providing PrEP, Hepatitis C Treatment, and MOUD Through Telemedicine at Greensboro SSP

NCT05108935
View directory record Official record
Conditions
Opioid Use, Opioid Use Disorder, Risk Reduction, Hiv, Hepatitis C
Interventions
Suboxone, Truvada, Mavyret
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
2
States / cities
Durham, North Carolina • Greensboro, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 26, 2023 · Synced Sep 7, 2026, 3:33 PM EDT
Completed Not applicable Interventional

International Latino Research Partnership

NCT02038855
View directory record Official record
Conditions
Substance Use (Drugs, Alcohol)
Interventions
Integrated Intervention for Dual Problems and Early Action
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Somerville, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 30, 2017 · Synced Sep 7, 2026, 3:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Rapid Self-Testing to Prevent Fentanyl Overdose Among Young People Who Use Drugs

NCT03373825
View directory record Official record
Conditions
Accidental Overdose of Opiate
Interventions
Take home rapid drug test
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 35 Years
Enrollment
93 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 23, 2018 · Synced Sep 7, 2026, 3:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Web Intervention for Concerned Partners to Prevent Service Member Alcohol Abuse Abuse

NCT02073825
View directory record Official record
Conditions
Alcohol Abuse
Interventions
Web Brief Intervention (WBI)
Behavioral
Lead sponsor
RAND
Other
Eligibility
18 Years and older
Enrollment
312 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Sep 28, 2017 · Synced Sep 7, 2026, 3:33 PM EDT
Enrolling by invitation Not applicable Interventional

Optimizing and Advancing SBIRT in Schools

NCT06206161
View directory record Official record
Conditions
Adolescent Drinking, Adolescent Substance Use, Risk Behavior, Health
Interventions
Indicated Prevention, Clinical Staff, Selective Prevention, Expanded Paraprofessional Workforce
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
14 Years to 19 Years
Enrollment
21,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Sep 7, 2026, 3:33 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Family Risk Analysis of Substance Use in Attention Deficit Hyperactivity Disorder (ADHD) Youth Treated With Concerta

NCT00181792
View directory record Official record
Conditions
ADHD, Smoking
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
6 Years to 55 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 3, 2012 · Synced Sep 7, 2026, 3:33 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Qungasvik (Toolbox): Prevention of Alcohol/Suicide Risk in Alaska Native Youth

NCT05400135
View directory record Official record
Conditions
Suicide, Alcohol Use Disorder
Interventions
Qungasvik (Tools for Life)
Behavioral
Lead sponsor
University of Alaska Fairbanks
Other
Eligibility
12 Years to 21 Years
Enrollment
542 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
1
States / cities
Fairbanks, Alaska
Source: ClinicalTrials.gov public record
Updated May 31, 2022 · Synced Sep 7, 2026, 3:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Computerized Risk Assessment in an Employee Population

NCT00153335
View directory record Official record
Conditions
Healthy
Interventions
patient-provider interaction
Behavioral
Lead sponsor
Centers for Disease Control and Prevention
Federal
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2007
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Feb 25, 2010 · Synced Sep 7, 2026, 3:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Prevention of Substance Use in At-Risk Students: A Family-Centered Web Program

NCT03060291
View directory record Official record
Conditions
Substance Use, Conduct Disorders in Adolescence, Depression, Anxiety
Interventions
FCU-Online, web/ mobile only, FCU-Online, web/ mobile + coach
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
Not listed
Enrollment
322 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 18, 2023 · Synced Sep 7, 2026, 3:33 PM EDT
Completed Not applicable Interventional Results available

Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start Study

NCT04043728
View directory record Official record
Conditions
Copd, Smoking Cessation, Nicotine Dependence, Tobacco Use, Cigarette Smoking
Interventions
Unified Protocol adapted for smoking cessation
Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 16, 2021 · Synced Sep 7, 2026, 3:33 PM EDT
Completed Not applicable Interventional Results available

Boston ARCH 4F Intervention to Reduce Fall Risk in People With HIV and Alcohol Use

NCT04804579
View directory record Official record
Conditions
HIV Infection, Alcohol Consumption, Falls, Accidental, Falls
Interventions
Fall Prevention Intervention
Behavioral
Lead sponsor
Boston University
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 28, 2023 · Synced Sep 7, 2026, 3:33 PM EDT
Completed Not applicable Interventional Results available

Calcitriol in Preventing Lung Cancer in Smokers and Former Smokers at High Risk of Lung Cancer

NCT00690924
View directory record Official record
Conditions
Lung Cancer, Precancerous Condition, Tobacco Use Disorder
Interventions
calcitriol, laboratory biomarker analysis, pharmacological study
Drug · Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
40 Years to 79 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2018
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jun 3, 2018 · Synced Sep 7, 2026, 3:33 PM EDT