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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Substance Use Treatment Clear all
Active, not recruiting Not applicable Interventional Accepts healthy volunteers Results available

The Substance Abuse Treatment to HIV Care II (SAT2HIV-II) Project

NCT04687917
View directory record Official record
Conditions
Substance Use
Interventions
The facilitation, training, feedback, and consultation (FTFC) Strategy, The facilitation, training, feedback, consultation, and incentivization (FTFCI) Strategy
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
428 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 12, 2025 · Synced Sep 24, 2026, 2:42 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Imaging Biomarker for Addiction Treatment Outcome

NCT03427424
View directory record Official record
Conditions
Opioid-Related Disorders, Alcohol-Related Disorders
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 65 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 30, 2024 · Synced Sep 24, 2026, 2:42 PM EDT
Completed Phase 4 Interventional Results available

Health Education Counseling With or Without Bupropion in Helping African Americans Stop Smoking

NCT00666978
View directory record Official record
Conditions
Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer, Head and Neck Cancer, Kidney Cancer, Leukemia, Liver Cancer, Lung Cancer, Pancreatic Cancer, Tobacco Use Disorder
Interventions
smoking cessation intervention, bupropion hydrochloride, gene expression analysis, polymerase chain reaction, counseling intervention, educational intervention, psychosocial assessment and care
Behavioral · Drug · Genetic + 2 more
Lead sponsor
Lisa Sanderson Cox, PhD
Other
Eligibility
18 Years and older
Enrollment
540 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
2
States / cities
Kansas City, Kansas • Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 12, 2017 · Synced Sep 24, 2026, 2:42 PM EDT
Completed Not applicable Interventional Results available

Testing a Community-Friendly Risk Reduction Intervention for Injection Drug Users

NCT01741350
View directory record Official record
Conditions
HIV, Opioid Dependence
Interventions
Community-friendly Health Recovery Program, Time-and-Attention-Matched Control Condition
Behavioral
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years and older
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Sep 24, 2026, 2:42 PM EDT
Not yet recruiting Phase 1 Interventional

Cannabis Effects on Opioid Self-Administration

NCT07668635
View directory record Official record
Conditions
Opioid Use Disorder, Cannabis Use
Interventions
Cannabis, Placebo Cannabis, Intranasal Opioid Agonist, Oral Opioid Agonist
Drug
Lead sponsor
Shanna Babalonis, PhD
Other
Eligibility
18 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Sep 24, 2026, 2:42 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The IMPROV Project: Improving Mental Health and Substance Use Treatment Provision (IMPROV) Among People Living With HIV (Human Immunodeficiency Virus) in Atlanta

NCT05415891
View directory record Official record
Conditions
Mental Health Disorder, Substance Use Disorder, Stigmatization, Implementation Science
Interventions
Modified Health Policy Project (HPP) HIV-Stigma and Discrimination Reduction Training Curriculum, You℞ Decision prescribing platform
Behavioral · Device
Lead sponsor
RTI International
Other
Eligibility
18 Years and older
Enrollment
333 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
2
States / cities
Decatur, Georgia • Duluth, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 12, 2022 · Synced Sep 24, 2026, 2:42 PM EDT
Enrolling by invitation Not applicable Interventional

Developing and Testing Innovative Care Pathways for Screening and Treatment of OUD/PTSD in Jails

NCT07490717
View directory record Official record
Conditions
Post-traumatic Stress Disorder (PTSD), Post-traumatic Stress Symptoms, Opioid Use Disorder (OUD), Stimulant Use Disorder, Stimulant Use & Co-occuring Opioid Use Disorders, Co-occurring Mental and Substance Use Disorders, Medications for Opioid Use Disorder
Interventions
Cognitive Processing Therapy (CPT), Written Exposure Therapy (WET)
Other
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years and older
Enrollment
338 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
2
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Sep 24, 2026, 2:42 PM EDT
Completed Not applicable Interventional Results available

Piloting an Internet-based Therapy for Insomnia in a Population of Veterans With Substance Use Disorders

NCT01949389
View directory record Official record
Conditions
Chronic Insomnia
Interventions
Internet-based Cognitive Behavioral Therapy for Insomnia
Behavioral
Lead sponsor
VA Connecticut Healthcare System
Federal
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 12, 2016 · Synced Sep 24, 2026, 2:42 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Effectiveness of Various Smoking Cessation Therapies in Reducing Smoking in Adolescents - 1

NCT00158171
View directory record Official record
Conditions
Smoking Cessation, Tobacco Use Disorder
Interventions
Nicotine Replacement Therapies, Nicotine patch, Folic Acid
Drug · Dietary Supplement
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
13 Years to 18 Years
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2004
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 9, 2017 · Synced Sep 24, 2026, 2:42 PM EDT
Recruiting Not applicable Interventional

Supporting Treatment Access and Recovery in COD

NCT05138614
View directory record Official record
Conditions
Opioid Use Disorder, Mental Health Disorder
Interventions
Medication for Opioid Use Disorder, MISSION Critical Time Intervention, MISSION Peer Support, MISSION Dual Recovery Therapy
Other · Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
5
States / cities
Holyoke, Massachusetts • Orange, Massachusetts • Springfield, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Sep 24, 2026, 2:42 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Cocaine Use Reduction With Buprenorphine

NCT01402492
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Buprenorphine + Naltrexone, Placebo + Naltrexone
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
302 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
11
States / cities
Los Angeles, California • San Francisco, California • Denver, Colorado + 8 more
Source: ClinicalTrials.gov public record
Updated Oct 28, 2021 · Synced Sep 24, 2026, 2:42 PM EDT
Recruiting Not applicable Interventional

A Clinical Trial of Telehealth Treatment for Opioid Use Disorders

NCT07362082
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
RecoveryPad platform
Device
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
470 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 20, 2026 · Synced Sep 24, 2026, 2:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Real Time fMRI and Quitting Smoking

NCT03302026
View directory record Official record
Conditions
Nicotine Use Disorder
Interventions
Realtime biofeedback using fMRI
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 15, 2019 · Synced Sep 24, 2026, 2:42 PM EDT
Completed Phase 2 Interventional Results available

Gender Differences in Response to Nicotine Replacement Therapy and De-Nicotinized Cigarettes

NCT00960778
View directory record Official record
Conditions
Nicotine Dependence
Interventions
nicotine patch (Nicoderm Committed Quitter (CQ), Habitrol), denicotinized cigarettes (Quest 3 cigarettes)
Drug · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years to 60 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 22, 2018 · Synced Sep 24, 2026, 2:42 PM EDT
Recruiting Not applicable Interventional

Disclosure Intervention for People in Treatment for Opioid Use Disorder

NCT06458985
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Disclosing Recovery: A Decision Aid and Toolkit
Behavioral
Lead sponsor
University of Delaware
Other
Eligibility
18 Years and older
Enrollment
480 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Wilmington, Delaware
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Sep 24, 2026, 2:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mobile Application to Improve Care Coordination Among HIV Clinic and Substance Use Treatment Providers

NCT02906215
View directory record Official record
Conditions
HIV, Substance Use, Care Coordination
Interventions
Care Coordination Intervention
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jul 24, 2022 · Synced Sep 24, 2026, 2:42 PM EDT
Completed Not applicable Interventional

Advancing STOP: Self-regulation Therapy for Opioid Addiction and Pain

NCT03363243
View directory record Official record
Conditions
Opioid-use Disorder, Chronic Pain
Interventions
STOP Therapy Treatment group, Treatment as usual (TAU) group
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 65 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 26, 2025 · Synced Sep 24, 2026, 2:42 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Effects of Remote Motivational Enhancement & MySafeRx on Post-Detox Engagement in B/N Treatment -RCT

NCT04822168
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
MySafeRx™, Standard Care
Other
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Dec 6, 2021 · Synced Sep 24, 2026, 2:42 PM EDT
Completed Phase 2 Interventional Results available

Evaluation of Moclobemide, a Reversible MAO-A Inhibitor, as an Adjunct to Nicotine Replacement Therapy in Female Smokers

NCT01926626
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine Patch, Moclobemide
Drug
Lead sponsor
Jed E. Rose
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
3
States / cities
Charlotte, North Carolina • Durham, North Carolina • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 22, 2017 · Synced Sep 24, 2026, 2:42 PM EDT
Completed Not applicable Interventional Results available

Start Treatment and Recovery for Opioid Use Disorder

NCT04505540
View directory record Official record
Conditions
Opioid-use Disorder, Mental Disorder, Opioid Medication Assisted Treatment
Interventions
Bridge Clinic
Other
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Dec 10, 2023 · Synced Sep 24, 2026, 2:42 PM EDT
Completed Not applicable Interventional Results available

Secondary HIV Prevention and Adherence Among HIV-infected Drug Users

NCT01741311
View directory record Official record
Conditions
Risk Behavior, Medication Adherence, HIV
Interventions
3H+ (Holistic Health for HIV), HHRP+ (Holistic Health Recovery Program)
Behavioral
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years and older
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 7, 2025 · Synced Sep 24, 2026, 2:42 PM EDT
Completed Not applicable Interventional Results available

A Study to Help People Quit Smoking.

NCT01880099
View directory record Official record
Conditions
Nicotine Dependence
Interventions
placebo, Galantamine 8mg, Galantamine 16mg
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 55 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 22, 2020 · Synced Sep 24, 2026, 2:42 PM EDT
Completed Phase 2 Interventional

Combination Pharmacotherapy for Smoking Cessation Among Methadone Patients

NCT00060814
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Combined intervention
Other
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 70 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 24, 2026, 2:42 PM EDT
Terminated Phase 4 Interventional Results available

Topiramate Treatment of Alcohol Use Disorders in African Americans

NCT03018704
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Topiramate, placebo
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
2
States / cities
Decatur, Georgia • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Sep 24, 2026, 2:42 PM EDT