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Showing 1–24 of 26 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Thermogenesis Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Stimulation of Diet-Induced Thermogenesis by Cold-Exposure

NCT01898949
View directory record Official record
Conditions
Thermogenesis, Brown Adipose Tissue
Interventions
Cold Exposure
Other
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years to 35 Years · Male only
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Jan 7, 2016 · Synced Sep 7, 2026, 11:04 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure

NCT05545306
View directory record Official record
Conditions
Obesity, Normal Physiology, Healthy Volunteers
Interventions
+200% of dietary requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat, fasting, -50% of energy balance requirements. 50% of calories from carbohydrates, 20% from protein, and 30% from fat, +150% of energy balance requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat, +200% of dietary requirements, 51% of the calories from carbohydrates, 46%, from fat and 3% from protein, -25% of energy balance requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat, +150% of dietary requirements, 51% of the calories from carbohydrates, 46%, from fat and 3% from protein
Dietary Supplement
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 60 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 7, 2026, 11:04 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Food Intake and Thermogenesis in High Spinal Cord Injury

NCT07103993
View directory record Official record
Conditions
SCI - Spinal Cord Injury
Interventions
Low meal condition, Moderate meal condition, High meal condition, Ad-libitum control condition
Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Sep 7, 2026, 11:04 PM EDT
Recruiting No phase listed Observational

An Examination of Brown Adipose Tissue and Energy Expenditure in Infants

NCT05517967
View directory record Official record
Conditions
Cold Induced Thermogenesis
Interventions
Not listed
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
Up to 5 Weeks
Enrollment
60 participants
Timeline
2022 – 2025
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated May 30, 2025 · Synced Sep 7, 2026, 11:04 PM EDT
Completed Phase 2 Interventional

Predicting Weight Gain and Weight Loss Associated With Overeating or Fasting

NCT00687115
View directory record Official record
Conditions
Obesity, Diet Therapy, Weight Loss, Weight Gain, Nutrition Therapy
Interventions
Weight Loss, Overfeeding, Overfeeding Low Pro
Behavioral
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 60 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2023
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 30, 2026 · Synced Sep 7, 2026, 11:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Estrogen Deficiency on Energy Expenditure

NCT01846728
View directory record Official record
Conditions
Obesity
Interventions
Estrogen suppression
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
20 Years to 40 Years · Female only
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Nov 17, 2019 · Synced Sep 7, 2026, 11:04 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Non-Exercise Activity Thermogenesis (NEAT) in Children

NCT00315172
View directory record Official record
Conditions
Non-exercise Activity Thermogenesis
Interventions
Non-Exercise Activity Thermogenesis (NEAT)
Procedure
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
7 Years to 11 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Sep 7, 2026, 11:04 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Thermogenenic Responses to Fasting and Overfeeding in Women

NCT06610162
View directory record Official record
Conditions
Obesity
Interventions
Eucalaloric feeding, Acute Fasting, Acute Overfeeding
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 29, 2025 · Synced Sep 7, 2026, 11:04 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Energy Expenditure and Substrate Oxidation in a Whole Room Calorimeter

NCT04061369
View directory record Official record
Conditions
Overweight, Obesity, Body Weight
Interventions
Low fat meal, Moderate fat meal, High fat meal, High fat liquid meal
Other
Lead sponsor
USDA, Western Human Nutrition Research Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated May 14, 2023 · Synced Sep 7, 2026, 11:04 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Effects of b3-Adrenergic Receptor Agonists on Brown Adipose Tissue

NCT01783470
View directory record Official record
Conditions
Obesity
Interventions
beta3-adrenergic receptor agonist
Drug
Lead sponsor
Aaron Cypess
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 10, 2019 · Synced Sep 7, 2026, 11:04 PM EDT
Completed No phase listed Observational

Chronic Cold Exposure and Energy Metabolism in Humans

NCT01730105
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 40 Years · Male only
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated May 13, 2018 · Synced Sep 7, 2026, 11:04 PM EDT
Completed No phase listed Observational

Body Heat Content and Dissipation in Obese and Normal Weight Adults

NCT00266500
View directory record Official record
Conditions
Obesity
Interventions
Not listed
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2014
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 16, 2019 · Synced Sep 7, 2026, 11:04 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Can Food Timing Reduce Your Diabetes Risk?

NCT05862818
View directory record Official record
Conditions
Dietary Habits
Interventions
Day shift protocol - Diet order A-B, Day shift protocol - Diet order B-A, Night shift protocol - Diet order A-B, Night shift protocol - Diet order B-A
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 5, 2025 · Synced Sep 7, 2026, 11:04 PM EDT
Completed No phase listed Observational

Effects of Diet Changes on Metabolism

NCT00523627
View directory record Official record
Conditions
Obesity
Interventions
Not listed
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 55 Years
Enrollment
203 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2008
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 7, 2026, 11:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Acute Intake of Meals Containing Higher vs. Lower Energy From Protein on DIT

NCT06494449
View directory record Official record
Conditions
Healthy, Overweight and Obesity
Interventions
Higher protein, Lower protein
Other
Lead sponsor
Midwest Center for Metabolic and Cardiovascular Research
Other
Eligibility
18 Years to 55 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Addison, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 5, 2025 · Synced Sep 7, 2026, 11:04 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Mirabegron and Physiological Function in Cold Environments

NCT04766021
View directory record Official record
Conditions
Resting Energy Expenditure, Thermogenesis, Brown Adipose Tissue
Interventions
Mirabegron, Placebo
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 40 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 11, 2024 · Synced Sep 7, 2026, 11:04 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Evaluation of Safety, Efficacy and Thermogenesis-induction of RZL-012 in Overweight and Obese Volunteers

NCT03171415
View directory record Official record
Conditions
Obesity, Weight Loss, Overweight and Obesity
Interventions
RZL-012, Placebo
Drug
Lead sponsor
Raziel Therapeutics Ltd.
Industry
Eligibility
20 Years to 60 Years · Male only
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
West Bend, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 20, 2019 · Synced Sep 7, 2026, 11:04 PM EDT
Completed No phase listed Observational

Energy Expenditure and Weight Loss Maintenance

NCT03422380
View directory record Official record
Conditions
Obesity, Weight Change, Body, Weight Loss, Physical Activity
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 65 Years
Enrollment
112 participants
Timeline
2009 – 2012
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 4, 2018 · Synced Sep 7, 2026, 11:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Increased Dietary Protein and Meal Frequency Reduces Total and Abdominal Body Fat During Weight Maintenance and Weight Loss

NCT01749449
View directory record Official record
Conditions
Obesity
Interventions
protein and meal frequency
Other
Lead sponsor
Skidmore College
Other
Eligibility
30 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2007
U.S. locations
1
States / cities
Saratoga Springs, New York
Source: ClinicalTrials.gov public record
Updated Dec 12, 2012 · Synced Sep 7, 2026, 11:04 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Efficacy of ONE A DAY Weightsmart Advanced Versus Caffeine and Placebo on Energy Expenditure, Thermogenesis and Perceived Energy Levels in Women.

NCT00781586
View directory record Official record
Conditions
Energy Expenditure
Interventions
One-A-Day Weight S.A. (Multi-Vitamins, BAY94-9350), Caffeine, Placebo
Dietary Supplement · Drug
Lead sponsor
Bayer
Industry
Eligibility
25 Years to 45 Years · Female only
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 18, 2018 · Synced Sep 7, 2026, 11:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

mTORC1 and Autophagy in Human Brown Adipocytes

NCT04206124
View directory record Official record
Conditions
Obesity, Metabolic Disease
Interventions
Brown Fat Harvest During Anterior Neck Surgery
Procedure
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years to 60 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Oct 21, 2024 · Synced Sep 7, 2026, 11:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of 4-week Dihydrocapsiate Ingestion on Resting Metabolic Rate

NCT00999297
View directory record Official record
Conditions
Obesity, Weight
Interventions
Dihydrocapsiate
Other
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
20 Years to 60 Years
Enrollment
79 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2014
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Nov 19, 2015 · Synced Sep 7, 2026, 11:04 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

MIrabegron and Physiological Function in Cold Environments

NCT05990387
View directory record Official record
Conditions
Resting Energy Expenditure, Thermogenesis, Brown Adipose Tissue
Interventions
Mirabegron, Placebo
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 40 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Sep 7, 2026, 11:04 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Nutritional Restriction and Activity Thermogenesis

NCT00065338
View directory record Official record
Conditions
Obesity
Interventions
Exercise and behavior modification
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
25 Years to 55 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2007
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 4, 2011 · Synced Sep 7, 2026, 11:04 PM EDT