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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Tooth Extraction Clear all
Completed Phase 2 Interventional

Rofecoxib and Bupivacaine to Prevent Pain After Third Molar (Wisdom Tooth) Extraction

NCT00050362
View directory record Official record
Conditions
Pain, Tooth Extraction
Interventions
Rofecoxib and Bupivacaine
Drug
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2004
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 9, 2026, 9:05 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Variability in Analgesic Response to Ibuprofen

NCT06539741
View directory record Official record
Conditions
Impacted Third Molar Tooth, Pain, Acute
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 9, 2026, 9:05 AM EDT
Completed Phase 2 Interventional

Bradykinin Receptors and Pain

NCT00083356
View directory record Official record
Conditions
Tooth, Impacted
Interventions
Wisdom tooth extraction
Procedure
Lead sponsor
National Institute of Nursing Research (NINR)
NIH
Eligibility
Not listed
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 9, 2026, 9:05 AM EDT
Terminated Phase 4 Interventional

Comparison of Straumann BoneCeramic vs. Allograft Bone in Extraction Sockets

NCT00782236
View directory record Official record
Conditions
Tooth Loss
Interventions
Bone Graft Material
Device
Lead sponsor
Institut Straumann AG
Industry
Eligibility
18 Years to 80 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Yardley, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 3, 2016 · Synced Sep 9, 2026, 9:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Histologic Comparison of Healing After Tooth Extraction With Ridge Preservation Using Two Different Xenografts

NCT03769376
View directory record Official record
Conditions
Partial Edentulism
Interventions
Bio-Oss®, Salvin-Oss®
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 100 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 14, 2021 · Synced Sep 9, 2026, 9:05 AM EDT
Withdrawn Phase 4 Interventional

Use of Remimazolam and Fentanyl for Procedural Sedation in Patients Undergoing Dental Extraction

NCT06793358
View directory record Official record
Conditions
Dental Extraction
Interventions
fentanyl and Remimazolam
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Sep 9, 2026, 9:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Clinical Trial to Test the Effect of a Marketed Mouth Rinse on Stain Removal

NCT02151058
View directory record Official record
Conditions
Tooth Stain
Interventions
Colgate® Regular Cavity Protection, Experimental Mouth Rinse, Crest® 3D White Multi-Care Whitening Rinse, Glamorous White, Fresh Mint
Drug · Other
Lead sponsor
Johnson & Johnson Consumer and Personal Products Worldwide
Industry
Eligibility
18 Years to 65 Years
Enrollment
227 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated May 31, 2015 · Synced Sep 9, 2026, 9:05 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Evaluation of OSSIX-Plus Resorbable Collagen Membranes for Alveolar Ridge Preservation Following Exodontia

NCT00639860
View directory record Official record
Conditions
Alveolar Bone Loss, Loss of Teeth Due to Extraction, Edentulous Alveolar Ridge
Interventions
OSSIX-Plus
Device
Lead sponsor
William Giannobile
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 30, 2016 · Synced Sep 9, 2026, 9:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Periodontal Phenotype Study (Tooth Extraction)

NCT02668289
View directory record Official record
Conditions
Tooth Extraction Status Nos
Interventions
consent, Screening, Xray, PVS Impressions, Photographs, CBCT, Anesthesia, Extraction, Clinical measurements
Other · Procedure
Lead sponsor
Gustavo Avila-Ortiz DDS, MS, PhD
Other
Eligibility
18 Years to 75 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Nov 6, 2022 · Synced Sep 9, 2026, 9:05 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Mix of Demineralized Freeze-Dried Bone Allograft and Deproteinized Bovine Bone Mineral: a Possible Solution for Alveolar Ridge Preservation?

NCT06275789
View directory record Official record
Conditions
Alveolar Ridge Preservation, Dental Extraction, Bone Graft
Interventions
Alveolar ridge preservation
Procedure
Lead sponsor
Nova Southeastern University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Sep 11, 2025 · Synced Sep 9, 2026, 9:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Healing Time on New Bone Formation Following Tooth Extraction and Ridge Preservation With Demineralized Freeze-Dried Bone Allograft

NCT02154386
View directory record Official record
Conditions
Bone Augmentation
Interventions
Ridge preservation using DFDBA
Device
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 89 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Dec 2, 2015 · Synced Sep 9, 2026, 9:05 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Evaluation of Implants Placed Immediately or Delayed Into Extraction Sites

NCT01244997
View directory record Official record
Conditions
Dental Caries
Interventions
Dental Implant
Procedure
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
21 Months to 65 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2009
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Nov 21, 2010 · Synced Sep 9, 2026, 9:05 AM EDT
Completed Phase 2 Interventional Results available

Phase 2 Study of Indomethacin Capsules to Treat Dental Pain

NCT00964431
View directory record Official record
Conditions
Dental Pain
Interventions
Celecoxib 400 mg, Placebo, Indomethacin Test (lower dose), Indomethacin Test (upper dose)
Drug
Lead sponsor
Iroko Pharmaceuticals, LLC
Industry
Eligibility
18 Years to 50 Years
Enrollment
203 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated May 21, 2012 · Synced Sep 9, 2026, 9:05 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Ridge Preservation With FDBA (Freeze Dried Bone Allograft) Using Dexamethasone vs. Saline

NCT06556095
View directory record Official record
Conditions
Bone Graft, Tooth Extraction
Interventions
Dexamethasone 4mg/ml solution
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 89 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Sep 9, 2026, 9:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Comparison Between Primary and Secondary Flap Coverage in Extraction Sites: A Pilot Study

NCT03136913
View directory record Official record
Conditions
Loss of Teeth Due to Extraction
Interventions
Cytoplast® TXT-200, MinerOss® Cortical and Cancellous Chips (FDBA), Open Flap Technique, Closed Flap Technique
Device · Procedure
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 11, 2021 · Synced Sep 9, 2026, 9:05 AM EDT
Completed Phase 2 Interventional

Capsaicin to Control Pain Following Third Molar Extraction

NCT00008476
View directory record Official record
Conditions
Facial Pain
Interventions
Capsaicin
Drug
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 9, 2026, 9:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparison of Post Tooth Extraction Healing Using Different Xenograft Materials

NCT03149172
View directory record Official record
Conditions
Alveolar Bone Loss
Interventions
Equimatrix®, Bio-Oss®, Endobon®
Device
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 24, 2020 · Synced Sep 9, 2026, 9:05 AM EDT
Recruiting Not applicable Interventional

Effect of Collagen Membrane on Ridge Preservation

NCT07580495
View directory record Official record
Conditions
Dehiscence, Tooth Extraction, Alveolar Bone Loss
Interventions
Minimally Invasive tooth extraction, Alveolar ridge preservation with ABCC, Resorbable collagen membrane (InterCollagen® Guide)
Procedure · Device
Lead sponsor
Debora Dias
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Sep 9, 2026, 9:05 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Genetic Basis For Variation In NSAID Analgesia In A Clinical Model Of Acute Pain

NCT00115752
View directory record Official record
Conditions
Pain
Interventions
Valdecoxib, COX Inhibitor
Drug
Lead sponsor
National Institute of Nursing Research (NINR)
NIH
Eligibility
7 Years to 35 Years
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2006
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Sep 9, 2026, 9:05 AM EDT
Completed Phase 2 Interventional

Analgesic Efficacy and Safety of ADL5859 in Subjects With Acute Dental Pain After Third Molar Extraction

NCT00993863
View directory record Official record
Conditions
Acute Pain
Interventions
Placebo, ADL5859 30 mg, ADL5859 100 mg, ADL5859 200 mg, ibuprofen 400 mg
Drug
Lead sponsor
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Industry
Eligibility
18 Years to 50 Years
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jul 16, 2015 · Synced Sep 9, 2026, 9:05 AM EDT
Not listed Not applicable Interventional

A Comparison of Two Socket Sealing Collagen Matrices for Extraction Socket Management

NCT03003819
View directory record Official record
Conditions
Tooth Loss
Interventions
Control Collagen Wound Dressing, Test Collagen Matrix
Device
Lead sponsor
McGuire Institute
Industry
Eligibility
18 Years to 75 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Fenton, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 19, 2020 · Synced Sep 9, 2026, 9:05 AM EDT
Completed No phase listed Observational

Diagnosis and Evaluation of Patients Needing Third Molar (Wisdom Tooth) Extraction and Patients With Chronic Facial Pain

NCT00001600
View directory record Official record
Conditions
Facial Pain, Temporomandibular Joint Disorder
Interventions
Not listed
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
4,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 9, 2026, 9:05 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Plaque Removal Efficacy of Four Dentifrices Following a Single Brushing

NCT04794439
View directory record Official record
Conditions
Plaque, Dental
Interventions
Dentifrices
Drug
Lead sponsor
Church & Dwight Company, Inc.
Industry
Eligibility
18 Years to 69 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 11, 2021 · Synced Sep 9, 2026, 9:05 AM EDT
Completed Phase 2 Interventional

Capsaicin to Control Pain Following Third Molar Extraction

NCT00088686
View directory record Official record
Conditions
Healthy, Tooth Extraction
Interventions
Capsaicin (Intramucosal Injection)
Drug
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 9, 2026, 9:05 AM EDT