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ClinicalTrials.gov public records Last synced May 22, 2026, 4:13 AM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Transfemoral Amputation Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Amputation, Amputation; Traumatic, Leg, Lower, Limb; Absence, Congenital, Lower, Prosthesis User, Lower Limb Amputation Above Knee (Injury), Amputation; Traumatic, Leg: Thigh, Between Hip and Knee
Interventions
Power Knee
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
2
States / cities
Holliston, Massachusetts • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 25, 2025 · Synced May 22, 2026, 4:13 AM EDT
Not listed No phase listed Observational
View directory record Official record
Conditions
Amputation, Artificial Limbs, Energy Expenditure, Kinetics
Interventions
Lower Limb Powered Knee-Ankle Prosthesis
Device
Lead sponsor
Southern California Institute for Research and Education
Other
Eligibility
18 Years to 45 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Long Beach, California
Source: ClinicalTrials.gov public record
Updated Apr 4, 2019 · Synced May 22, 2026, 4:13 AM EDT
Withdrawn No phase listed Observational
View directory record Official record
Conditions
Diabetes
Interventions
Not listed
Lead sponsor
University of Toledo Health Science Campus
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 9, 2015 · Synced May 22, 2026, 4:13 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Amputation, Amputation, Traumatic, Amputation of Knee, Amputation; Traumatic, Limb
Interventions
Ottobock CLeg4 + Ottobock foot, SRALAB Hybrid Knee + Polycentric Ankle, SRALAB Hybrid Knee + Passive Ankle, Ottobock CLeg 4 + Polycentric Ankle
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 95 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 29, 2024 · Synced May 22, 2026, 4:13 AM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Amputation
Interventions
Robotic Knee/Ankle Prosthesis
Device
Lead sponsor
Georgia Institute of Technology
Other
Eligibility
18 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced May 22, 2026, 4:13 AM EDT
Completed No phase listed Observational Accepts healthy volunteers
View directory record Official record
Conditions
Lower Limb Amputation
Interventions
KinetiGait
Device
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 19, 2025 · Synced May 22, 2026, 4:13 AM EDT
Completed Phase 1 Interventional
View directory record Official record
Conditions
Amputation
Interventions
Vacuum assisted socket technology (Harmony System, Otto Bock Healthcare)
Device
Lead sponsor
Stony Brook University
Other
Eligibility
21 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
Stony Brook, New York • West Babylon, New York
Source: ClinicalTrials.gov public record
Updated May 11, 2014 · Synced May 22, 2026, 4:13 AM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Knee
Interventions
Revo-M, Taleo, Proflex XC
Device
Lead sponsor
Otto Bock Healthcare Products GmbH
Industry
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
4
States / cities
Mesa, Arizona • Linthicum, Maryland • Dayton, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 22, 2024 · Synced May 22, 2026, 4:13 AM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Wound Healing, Lower Extremity Amputation, Above Knee Amputation, Below Knee Amputation
Interventions
Lower Extremity Amputation, SPY Elite Imaging System, Indocyaine Green
Procedure · Device · Drug
Lead sponsor
Corewell Health West
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced May 22, 2026, 4:13 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Amputation
Interventions
Hybrid Leg, Prescribed Passive Prosthesis
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 95 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 16, 2024 · Synced May 22, 2026, 4:13 AM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Unilateral Transfemoral Amputation
Interventions
Level overground ambulation
Other
Lead sponsor
Southern California Institute for Research and Education
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Long Beach, California
Source: ClinicalTrials.gov public record
Updated May 2, 2017 · Synced May 22, 2026, 4:13 AM EDT
Completed No phase listed Observational Results available
View directory record Official record
Conditions
Transfemoral Amputation
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Feb 18, 2020 · Synced May 22, 2026, 4:13 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Amputation
Interventions
Northwestern University Flexible Sub-Ischial Suction Socket (NU-FlexSIS)
Device
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
21 Years to 85 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 9, 2024 · Synced May 22, 2026, 4:13 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Transfemoral Amputation, Amputation, Skin Health
Interventions
AeroFit Seal-In Liner / Socket, Seal-In Silicone Liner
Device
Lead sponsor
Össur Iceland ehf
Industry
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
7
States / cities
Gainesville, Florida • Indianapolis, Indiana • Bay City, Michigan + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 7, 2024 · Synced May 22, 2026, 4:13 AM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Lower Limb Amputation Above Knee (Injury)
Interventions
Microprocessor Knee (MPK), Non-Microprocessor Knee (NMPK)
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
55 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 11, 2018 · Synced May 22, 2026, 4:13 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Peripheral Arterial Disease, Peripheral Vascular Disease, Amputation, Lower Limb Amputation Knee, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury)
Interventions
Ischemic Conditioning Low - Sham Comparator, Ischemic Conditioning High - Active Comparator
Procedure
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced May 22, 2026, 4:13 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Amputation, Amputation; Traumatic, Leg, Lower, Limb; Absence, Congenital, Lower, Prosthesis User, Lower Limb Amputation Above Knee (Injury), Amputation; Traumatic, Leg: Thigh, Between Hip and Knee
Interventions
Ossur Power Knee, Reboocon Intuy Knee
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Sep 2, 2025 · Synced May 22, 2026, 4:13 AM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Amputation, Artificial Limbs
Interventions
Northwestern University Flexible Sub-Ischial Vacuum Socket, Ischial Containment Socket
Device
Lead sponsor
Northwestern University
Other
Eligibility
21 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
3
States / cities
Chicago, Illinois • Oakbrook Terrace, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 14, 2021 · Synced May 22, 2026, 4:13 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Transfemoral Amputation
Interventions
Northwestern University Flexible Subischial Suction Socket (NU-FlexSIS)
Device
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
3
States / cities
Minneapolis, Minnesota • Houston, Texas • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 14, 2025 · Synced May 22, 2026, 4:13 AM EDT
Active, not recruiting Not applicable Interventional
View directory record Official record
Conditions
Transfemoral Amputation
Interventions
MIT Powered Knee
Device
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
22 Years to 65 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2026
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced May 22, 2026, 4:13 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity
Interventions
Ischemic Preconditioning
Other
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 16, 2025 · Synced May 22, 2026, 4:13 AM EDT
Recruiting Phase 1 Interventional
View directory record Official record
Conditions
Transfemoral Amputation
Interventions
RISE guided personalization of prosthetic legs by tuning experts, RISE guided personalization of prosthetic legs by prosthetists, Manual personalization of the prosthetic leg by tuning experts
Device
Lead sponsor
North Carolina State University
Other
Eligibility
18 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced May 22, 2026, 4:13 AM EDT
Active, not recruiting Not applicable Interventional
View directory record Official record
Conditions
Lower Limb Amputation Above Knee (Injury), Congenital Amputation of Lower Limb, Lower Limb Amputation Knee
Interventions
Kenevo or C-Leg 4, Non microprocessor controlled knee (NMPK)
Device
Lead sponsor
Otto Bock Healthcare Products GmbH
Industry
Eligibility
65 Years and older
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
90
States / cities
Dothan, Alabama • Gilbert, Arizona • Phoenix, Arizona + 85 more
Source: ClinicalTrials.gov public record
Updated Feb 8, 2024 · Synced May 22, 2026, 4:13 AM EDT
Active, not recruiting No phase listed Observational
View directory record Official record
Conditions
Stroke, Parkinson Disease, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury)
Interventions
Database Entry
Other
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
Up to 99 Years
Enrollment
250 participants
Timeline
2022 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced May 22, 2026, 4:13 AM EDT