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Showing 1–24 of 58 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Transtibial Amputation Clear all
Recruiting Early Phase 1 Interventional

Feasibility Study Evaluating the Safety and Effectiveness of Magnetic Bead Tracking System When Used With a Bionic External Prosthesis

NCT07195461
View directory record Official record
Conditions
Transtibial Amputee, Transtibial Amputation
Interventions
Magnetic Bead Tracking System
Device
Lead sponsor
MuscleMetrix, LLC
Industry
Eligibility
22 Years to 65 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 25, 2025 · Synced Jul 22, 2026, 8:30 AM EDT
Active, not recruiting Not applicable Interventional

Magnetic Bead Tracking System and eOPRA Implant System With Bionic Prosthesis for Transtibial Amputees

NCT06391697
View directory record Official record
Conditions
Amputation
Interventions
eOPRA Implant System for Transtibial Amputees and Magnetic Bead Tracking System
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
22 Years to 65 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
Boston, Massachusetts • Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Jul 22, 2026, 8:30 AM EDT
Enrolling by invitation Not applicable Interventional

Comparison of Various Prosthetic Foot-Ankle Mechanisms

NCT05964855
View directory record Official record
Conditions
Transtibial Amputation - Unilateral
Interventions
MIT Variable Stiffness Prosthesis, MIT Variable Equilibrium Angle Prosthesis, MIT Sliding Beam Passive Prosthesis, Ossur Pro-flex XC, Blatchford Elan Variable-Dampening Prosthesis
Device
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 12, 2025 · Synced Jul 22, 2026, 8:30 AM EDT
Completed No phase listed Observational

Outcomes Following Severe Distal Tibia, Ankle and/or Foot Trauma: Comparison of Limb Salvage Versus Transtibial Amputation Protocol

NCT01606501
View directory record Official record
Conditions
Severe Distal Tibia Injury, Severe Ankle Injury, Severe Foot Injury, Major Soft Tissue Loss, Major Bone Articular Surface Loss, Major Ankle Articular Surface Loss
Interventions
Not listed
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 60 Years
Enrollment
664 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
33
States / cities
Birmingham, Alabama • San Diego, California • San Francisco, California + 26 more
Source: ClinicalTrials.gov public record
Updated Mar 23, 2021 · Synced Jul 22, 2026, 8:30 AM EDT
Recruiting Not applicable Interventional

Transtibial Osseointegration

NCT06636136
View directory record Official record
Conditions
Amputation; Traumatic, Leg, Lower
Interventions
OPRA
Device
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
22 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
2
States / cities
Bethesda, Maryland • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Jul 22, 2026, 8:30 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Falls in Older Persons With Limb Loss

NCT03670004
View directory record Official record
Conditions
Amputation, Elderly
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
65 Years to 85 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 6, 2022 · Synced Jul 22, 2026, 8:30 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Transtibial Pin Lock Suspension at Varying Distraction Values Using a Modified Air Bladder Casting System

NCT04248907
View directory record Official record
Conditions
Amputation
Interventions
0 pound tension, 2 pound tension, 4 pound tension
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Apr 30, 2020 · Synced Jul 22, 2026, 8:30 AM EDT
Completed Early Phase 1 Interventional

Virtual Reality Rehabilitation for Individuals With Lower Limb Amputation

NCT02328859
View directory record Official record
Conditions
Transtibial Amputation
Interventions
Virtual Reality Gait Training, Treadmill Gait Training
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 23, 2019 · Synced Jul 22, 2026, 8:30 AM EDT
Completed Not applicable Interventional

Post Market Clinical Protocol - Xtremity Polymer Prosthetic Socket System

NCT05190354
View directory record Official record
Conditions
Amputation, Prosthesis User
Interventions
Xtremity Polymer Prosthetic Socket
Device
Lead sponsor
Medical Creations, Inc.
Industry
Eligibility
19 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Aug 23, 2022 · Synced Jul 22, 2026, 8:30 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Physical Activity in Adults With Amputation

NCT03722797
View directory record Official record
Conditions
Amputees
Interventions
Metabolic Cost Testing Procedures
Procedure
Lead sponsor
University of Delaware
Other
Eligibility
18 Years to 60 Years
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Mar 3, 2022 · Synced Jul 22, 2026, 8:30 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Detecting Change in Muscle Parameters, Pain, and Function With NMES for TTA

NCT06830876
View directory record Official record
Conditions
Amputation
Interventions
Chattanooga Continuum Device
Device
Lead sponsor
Sara Peterson-Snyder
Industry
Eligibility
18 Years to 100 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 16, 2025 · Synced Jul 22, 2026, 8:30 AM EDT
Completed No phase listed Observational

Improved Training Program for Fall Prevention of War Fighters

NCT03446131
View directory record Official record
Conditions
Limb Injury
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 55 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
4
States / cities
San Diego, California • Bethesda, Maryland • Rochester, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 6, 2021 · Synced Jul 22, 2026, 8:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Comparison of External Mechanical Work Between Different Prosthetic Feet

NCT01340807
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity
Interventions
Specialized Functional Prosthetic Training
Other
Lead sponsor
Miami VA Healthcare System
Federal
Eligibility
40 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 24, 2011 · Synced Jul 22, 2026, 8:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Socket Cooling Effectiveness Take Home Study

NCT04484805
View directory record Official record
Conditions
Amputation, Amputation; Traumatic, Leg, Lower, Amputation Stump, Limb; Absence, Congenital, Lower, Prosthesis User, Lower Limb Amputation Below Knee (Injury)
Interventions
ICE Condition, Sham Condition
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years to 89 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
2
States / cities
Holliston, Massachusetts • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 21, 2024 · Synced Jul 22, 2026, 8:30 AM EDT
Recruiting Not applicable Interventional

Automatic Prosthetic Foot Stiffness Modulation to Improve Balance

NCT06711588
View directory record Official record
Conditions
Lower Limb Amputation Below Knee
Interventions
As-prescribed stiffness, Two categories stiffer than the as-prescribed stiffness, Two categories less stiff than the as-prescribed stiffness
Device
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Jul 22, 2026, 8:30 AM EDT
Recruiting Not applicable Interventional

Fuzzy Wale Compression Stockinet to Promote Healing Following Transtibial Amputation for Peripheral Arterial Disease

NCT06308562
View directory record Official record
Conditions
Peripheral Arterial Disease
Interventions
Fuzzy Wale Compression Stockinet
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced Jul 22, 2026, 8:30 AM EDT
Terminated Not applicable Interventional Results available

Effects of Shrinker Use on Healing and Volume

NCT00693628
View directory record Official record
Conditions
Transtibial Amputation
Interventions
compression shrinker
Device
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 4, 2017 · Synced Jul 22, 2026, 8:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Measures of Gait Efficiency of Three Multi-Axial, Vertical Shock and Energy Storing-Return Prosthetic Feet During Simple & Complex Mobility Activities

NCT01404559
View directory record Official record
Conditions
Amputation
Interventions
Ossur Variflex prosthetic foot, Ossur Ceterus prosthetic foot, Endolite Elite Blade prosthetic foot
Device
Lead sponsor
University of South Florida
Other
Eligibility
21 Years to 45 Years · Male only
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Dec 14, 2014 · Synced Jul 22, 2026, 8:30 AM EDT
Not listed Not applicable Interventional

Enhancement of Residual Limb Proprioception and Rehabilitation Training Methods With a Vibrotactile Device.

NCT02026570
View directory record Official record
Conditions
Transtibial Amputation
Interventions
Internal Focus of Attention, External Focus of Attention
Behavioral
Lead sponsor
Southern California Institute for Research and Education
Other
Eligibility
18 Years to 70 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Long Beach, California
Source: ClinicalTrials.gov public record
Updated Apr 4, 2019 · Synced Jul 22, 2026, 8:30 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Optimizing Prosthetic and Bicycle Fit for Veterans With Transtibial Amputations

NCT03828331
View directory record Official record
Conditions
Amputation
Interventions
Prosthetic/Bicycle Configuration
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 55 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 9, 2024 · Synced Jul 22, 2026, 8:30 AM EDT
Not listed Not applicable Interventional

Prosthetic Smart Socket Technology to Improve Patient Interaction, Usability, Comfort, Fit, and Function.

NCT03199222
View directory record Official record
Conditions
Complications of the Amputated Limb
Interventions
Prosthetic smart socket technology with patient prompting
Device
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Mar 19, 2019 · Synced Jul 22, 2026, 8:30 AM EDT
Not listed Not applicable Interventional

Osseointegrated Transtibial Prosthesis With Neural Interface

NCT05249049
View directory record Official record
Conditions
Amputation
Interventions
e-OPRA Implant System for Transtibial Amputees
Device
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
22 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
2
States / cities
Boston, Massachusetts • Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 20, 2022 · Synced Jul 22, 2026, 8:30 AM EDT
Completed Not applicable Interventional Results available

Evaluation of a Modified Running-specific Prosthetic Foot

NCT02440711
View directory record Official record
Conditions
Transtibial Amputation
Interventions
Energy storing foot (ESF), Modified running specific foot (mRSF)
Device
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 1, 2023 · Synced Jul 22, 2026, 8:30 AM EDT
Withdrawn Not applicable Interventional

Energy-Harvesting Mesofluidic Impulse Prosthesis: e-MIP

NCT04157608
View directory record Official record
Conditions
Transtibial Amputation, Artificial Limbs
Interventions
Habitual Prosthesis, Energy-Harvesting Mesofluidic Impulse Prosthesis
Device
Lead sponsor
Orthocare Innovations, LLC
Industry
Eligibility
21 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Edmonds, Washington
Source: ClinicalTrials.gov public record
Updated Oct 9, 2023 · Synced Jul 22, 2026, 8:30 AM EDT