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ClinicalTrials.gov public records Last synced Oct 20, 2026, 5:38 PM EDT

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Showing 25–48 of 83 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Traumatic Amputation Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Vacuum Suspension: Effects on Tissue Oxygenation, Activity and Fit

NCT00117793
View directory record Official record
Conditions
Amputation, Diabetes, Leg Injuries, Traumatic Amputations
Interventions
Total Surface Bearing Suction Socket, Vacuum assisted socket system
Device
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 15, 2014 · Synced Oct 20, 2026, 5:38 PM EDT
Recruiting Not applicable Interventional

DExterous Hand Control Through Fascicular Targeting (DEFT) - (Human Subjects)

NCT02994160
View directory record Official record
Conditions
Amputation; Traumatic, Hand
Interventions
Fast electrode
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 95 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2028
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Oct 20, 2026, 5:38 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

GaMA Metric to Quantify Functional Importance of Various Upper Limb Prosthetic Devices

NCT06420687
View directory record Official record
Conditions
Amputation, Amputation, Traumatic, Amputation; Traumatic, Hand, Amputation; Traumatic, Limb
Interventions
Clinically prescribed prosthesis, Experimental prosthesis - Wrist rotation + 1-DOF, Experimental prosthesis - Wrist rotation + Wrist flexion +1-DOF, Experimental prosthesis - Wrist rotation + Multi DOF hand, Experimental prosthesis - Wrist rotation + wrist flexion + Multi DOF hand
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 70 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 14, 2025 · Synced Oct 20, 2026, 5:38 PM EDT
Recruiting Not applicable Interventional

Optimizing Gait Rehabilitation for Veterans With Non-traumatic Lower Limb Amputation

NCT03995238
View directory record Official record
Conditions
Transtibial Amputation, Peripheral Artery Disease, Diabetes Mellitus
Interventions
Error-augmentation gait training, Error-correction gait training, Supervised walking
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
40 Years to 89 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
2
States / cities
Aurora, Colorado • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 20, 2026, 5:38 PM EDT
Recruiting No phase listed Observational

Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain

NCT06908538
View directory record Official record
Conditions
Amputation, Amputation of Lower Limb, Amputation of Upper Limb, Amputation, Limb Loss, Amputation, Traumatic/Surgery, Cryo Analgesia
Interventions
cryoablation
Device
Lead sponsor
AtriCure, Inc.
Industry
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2035
U.S. locations
6
States / cities
Pittsfield, Massachusetts • Manchester, New Hampshire • New York, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Oct 20, 2026, 5:38 PM EDT
Withdrawn No phase listed Observational

Hand Transplantation: Functional and Quality of Life Outcomes

NCT02331355
View directory record Official record
Conditions
Amputation; Traumatic, Arm, Upper, Between Shoulder and Elbow, Amputation; Traumatic, Hand, Amputation; Traumatic, Hand, Both, Amputation; Traumatic, Arm: Forearm, at Elbow Level, Amputation; Traumatic, Arm, Upper
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 16, 2020 · Synced Oct 20, 2026, 5:38 PM EDT
Recruiting Not applicable Interventional

Transtibial Osseointegration

NCT06636136
View directory record Official record
Conditions
Amputation; Traumatic, Leg, Lower
Interventions
OPRA
Device
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
22 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
2
States / cities
Bethesda, Maryland • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 20, 2026, 5:38 PM EDT
Recruiting Not applicable Interventional

Pilot Trial for WounDx™ Clinical Decision Support Tool

NCT06921707
View directory record Official record
Conditions
Wounds, Wounds and Injuries, Extremity Injury, Traumatic Wounds and Injuries, Amputation, Traumatic/Surgery, Amputation, Wound, Open Fracture Wounds
Interventions
Clinical Decision Support Tool, Standard of Care (SOC)
Device · Procedure
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
5
States / cities
Birmingham, Alabama • Atlanta, Georgia • Indianapolis, Indiana + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Oct 20, 2026, 5:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Prosthetic Components and Stability in Amputee Gait

NCT00167778
View directory record Official record
Conditions
Diabetes Mellitus, Leg Injuries, Traumatic Amputation
Interventions
Transverse plane rotation adaptor pylon, Rigid pylon
Device
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 70 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 15, 2014 · Synced Oct 20, 2026, 5:38 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The Effect of Gait Training Using Virtual Reality and Real-Time Feedback on Physiological and Functional Gait Performance in Persons With a Traumatic Lower Extremity Amputation

NCT01225432
View directory record Official record
Conditions
Elevated Metabolic Cost
Interventions
Gait Training
Other
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 45 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2007
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 21, 2010 · Synced Oct 20, 2026, 5:38 PM EDT
Recruiting No phase listed Observational

A Real-World Registry of Chronic Wounds and Ulcers

NCT02280733
View directory record Official record
Conditions
Diabetic Foot, Pressure Ulcer, Surgical Wound Dehiscence, Vasculitis, Skin Ulcer, Leg Ulcer, Pyoderma, Peripheral Arterial Disease, Lymphedema, Surgical Complication, Venous Leg Ulcers (VLUs), Calciphylaxis, Sickle Cell Ulcer, Pressure Ulcer (PU), Diabetic Foot Ulcers (DFUs), Pressure Injury, Arterial Ulcers, Soft Tissue Radionecrosis (STRN), Traumatic Wounds, Chronic Ulcer
Interventions
Usual care
Other
Lead sponsor
U.S. Wound Registry
Other
Eligibility
Not listed
Enrollment
300,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2030
U.S. locations
1
States / cities
The Woodlands, Texas
Source: ClinicalTrials.gov public record
Updated Jul 16, 2025 · Synced Oct 20, 2026, 5:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Socket Cooling Effectiveness Take Home Study

NCT04484805
View directory record Official record
Conditions
Amputation, Amputation; Traumatic, Leg, Lower, Amputation Stump, Limb; Absence, Congenital, Lower, Prosthesis User, Lower Limb Amputation Below Knee (Injury)
Interventions
ICE Condition, Sham Condition
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years to 89 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
2
States / cities
Holliston, Massachusetts • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 22, 2024 · Synced Oct 20, 2026, 5:38 PM EDT
Terminated Not applicable Interventional Results available

Spinal Cord Stimulation for Restoration of Function in Lower-Limb Amputees, 90-Day

NCT04547582
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity, Phantom Limb Pain
Interventions
Spinal cord stimulator
Device
Lead sponsor
Lee Fisher, PhD
Other
Eligibility
22 Years to 70 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Oct 20, 2026, 5:38 PM EDT
Completed Not applicable Interventional Results available

To Assess the Utility of the Point Digit in a Clinical Take-home Study

NCT04755790
View directory record Official record
Conditions
Amputation; Traumatic, Hand
Interventions
Point Digit
Device
Lead sponsor
Point Designs
Industry
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
7
States / cities
Lafayette, Colorado • Overland Park, Kansas • Maple Grove, Minnesota + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 24, 2024 · Synced Oct 20, 2026, 5:38 PM EDT
Recruiting Not applicable Interventional

Effects of Microprocessor-controlled Prosthetic Knees on Fall-related Health Outcomes in Limited Community Ambulators

NCT06937242
View directory record Official record
Conditions
Amputation, Prosthesis User, Amputation; Traumatic, Leg: Thigh, Between Hip and Knee, Limb; Absence, Congenital, Lower, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Above Knee
Interventions
Ottobock C-Leg 4 Microprocessor Knee, Ottobock Kenevo
Device
Lead sponsor
Hanger Institute for Clinical Research and Education, LLC
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Oct 20, 2026, 5:38 PM EDT
Not listed Not applicable Interventional

External Compression Therapy for Secondary Prevention of Lower-Limb Loss and Cardiovascular Mortality

NCT02054416
View directory record Official record
Conditions
Critical Limb Ischemia
Interventions
ArtAssist© Device
Device
Lead sponsor
Temple University
Other
Eligibility
21 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 8, 2016 · Synced Oct 20, 2026, 5:38 PM EDT
Terminated Not applicable Interventional

The Impact of Sexual Health and Amputation Focused Education on Regulation of Glucose and Amputation Prevention

NCT04078854
View directory record Official record
Conditions
Diabetic Ulcers on Both Feet, Amputation; Traumatic, Limb, Sexual Dysfunction, Diabetic Foot Ulcer Ischemic
Interventions
Diabetes education
Behavioral
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Sep 11, 2023 · Synced Oct 20, 2026, 5:38 PM EDT
Completed Not applicable Interventional Results available

Limb Health and Socket Pressure in Response to Powered Ankle Protheses

NCT05112679
View directory record Official record
Conditions
Pressure Ulcer, Ankle, Prosthesis User, Prosthesis Durability, Mobility Limitation, Skin Wound, Amputation; Traumatic, Foot, Amputation, Limb Deficiencies
Interventions
PROPRIO FOOT® by Ossur & Empower ankle by Ottobock
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Oct 20, 2026, 5:38 PM EDT
Completed Not applicable Interventional

Treatment of Chronic Pain After Spinal Cord Injury (SCI) or Amputation

NCT00006448
View directory record Official record
Conditions
Spinal Cord Injuries, Amputation, Traumatic, Pain
Interventions
cognitive therapy, Physical Therapy, Methadone
Behavioral · Procedure · Drug
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years to 75 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 1996
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 26, 2016 · Synced Oct 20, 2026, 5:38 PM EDT
Not listed Phase 1 Interventional

Acupuncture for the Treatment of Phantom Limb and Residual Limb Pain After Amputation

NCT00388752
View directory record Official record
Conditions
Phantom Limb, Residual Limb Pain, Traumatic Amputation, Amputation
Interventions
Acupuncture
Procedure
Lead sponsor
Walter Reed Army Medical Center
Federal
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2006
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jun 6, 2007 · Synced Oct 20, 2026, 5:38 PM EDT
Withdrawn No phase listed Observational

A Comparison of the Outcomes of Distal Fingertip Amputations Treated With Either Artificial (Xeroform) or Biological Dressings

NCT03968835
View directory record Official record
Conditions
Finger Injuries, Amputation, Traumatic
Interventions
Bacitracin, Skin Graft
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
Up to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 29, 2020 · Synced Oct 20, 2026, 5:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Design, Prototyping, and Testing of a Robotic Prosthetic Leg

NCT04616378
View directory record Official record
Conditions
Amputation; Traumatic, Leg, Lower
Interventions
Phase 2 Prescribed Prosthesis, Phase 2 Robotic Prosthetic Leg, Phase 3 No Prosthesis, Phase 3 Robotic Prosthetic Leg, Phase 3 Prescribed Prosthesis
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Aug 29, 2022 · Synced Oct 20, 2026, 5:38 PM EDT
Recruiting Not applicable Interventional

Evaluation of Myoelectric Implantable Recording Array (MIRA) in Participants With Transradial Amputation

NCT05768802
View directory record Official record
Conditions
Amputation, Amputation; Traumatic, Hand
Interventions
Myoelectric Implantable Recording Array (MIRA)
Device
Lead sponsor
Boninger, Michael, MD
Other
Eligibility
22 Years to 70 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Oct 20, 2026, 5:38 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Human Upper Extremity (Hand and Forearm) Allotransplantation

NCT00722280
View directory record Official record
Conditions
Amputation, Traumatic
Interventions
Hand Transplantation
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 60 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2017
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 16, 2018 · Synced Oct 20, 2026, 5:38 PM EDT