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Showing 1–24 of 58 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Tricuspid Valve Insufficiency Clear all
Active, not recruiting Not applicable Interventional

TTVR Early Feasibility Study

NCT04433065
View directory record Official record
Conditions
Tricuspid Regurgitation
Interventions
Intrepid™ TTVR System
Device
Lead sponsor
Medtronic Cardiovascular
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2031
U.S. locations
20
States / cities
Birmingham, Alabama • Phoenix, Arizona • Los Angeles, California + 16 more
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Sep 25, 2026, 5:53 AM EDT
Completed Not applicable Interventional

Staging Classification of Severe Tricuspid Regurgitation Using Novel Cardiac Imaging Techniques

NCT05006443
View directory record Official record
Conditions
Tricuspid Regurgitation
Interventions
Cardiac Magnetic Resonance
Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 99 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 12, 2025 · Synced Sep 25, 2026, 5:53 AM EDT
Completed Not applicable Interventional Results available

TRILUMINATE Study With Abbott Transcatheter Clip Repair System in Patients With Moderate or Greater TR

NCT03227757
View directory record Official record
Conditions
Tricuspid Valve Insufficiency
Interventions
Tricuspid Valve Repair System
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years to 90 Years
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
4
States / cities
Los Angeles, California • Detroit, Michigan • Minneapolis, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 5, 2024 · Synced Sep 25, 2026, 5:53 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Biomarkers in Aortic Stenosis - B.A.S.S.

NCT01334801
View directory record Official record
Conditions
Aortic Stenosis, Disorder of Prosthetic Cardiac Valve, Aortic Valve Insufficiency, Mitral Valve Insufficiency, Hypertrophic Cardiomyopathy, Tricuspid Valve Insufficiency
Interventions
Blood Draw
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
21 Years and older
Enrollment
378 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2020
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated May 4, 2022 · Synced Sep 25, 2026, 5:53 AM EDT
Recruiting Not applicable Interventional

CorMatrix Cor TRICUSPID ECM Valve Replacement - Pivotal Study

NCT05742906
View directory record Official record
Conditions
Tricuspid Valve Disease, Tricuspid Valve Insufficiency
Interventions
Tricuspid valve replacement with the Cor TRICUSPID ECM Valve
Device
Lead sponsor
Corvivo Cardiovascular, Inc.
Industry
Eligibility
Not listed
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
2
States / cities
Indianapolis, Indiana • New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 1, 2025 · Synced Sep 25, 2026, 5:53 AM EDT
Completed No phase listed Observational Results available

Contour 3D®/TriAd® Tricuspid Annuloplasty Ring Post-Market Clinical Trial

NCT01585779
View directory record Official record
Conditions
Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency
Interventions
Contour 3D® implant for tricuspid valve repair, Tri-Ad® implant for tricuspid valve repair
Device
Lead sponsor
Medtronic Cardiovascular
Industry
Eligibility
18 Years to 85 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
3
States / cities
Aventura, Florida • Ann Arbor, Michigan • Asheville, North Carolina
Source: ClinicalTrials.gov public record
Updated May 9, 2017 · Synced Sep 25, 2026, 5:53 AM EDT
Enrolling by invitation No phase listed Observational

Outcome of Patients With Severe Functional TR According to Medical, Transcatheter or Surgical Treatment

NCT05825898
View directory record Official record
Conditions
Tricuspid Regurgitation
Interventions
Surgery or Transcatheter tricuspid valve intervention
Procedure
Lead sponsor
Ottawa Heart Institute Research Corporation
Other
Eligibility
18 Years and older
Enrollment
3,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
4
States / cities
Rochester, Minnesota • New York, New York
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Sep 25, 2026, 5:53 AM EDT
Completed Not applicable Interventional Results available

Early Feasibility Study of the Edwards FORMA Tricuspid Transcatheter Repair System

NCT02471807
View directory record Official record
Conditions
Tricuspid Valve Regurgitation
Interventions
Edwards FORMA Tricuspid Transcatheter Repair System
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2023
U.S. locations
5
States / cities
Los Angeles, California • Atlanta, Georgia • Rochester, Minnesota + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 27, 2023 · Synced Sep 25, 2026, 5:53 AM EDT
Recruiting No phase listed Observational

DELINEATE-Prospective

NCT07197736
View directory record Official record
Conditions
Valve Disease, Aortic, Mitral Regurgitation (MR), Aortic Stenosis, Valvular Heart Disease, Tricuspid Regurgitation (TR), Aortic Regurgitation
Interventions
Not listed
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Sep 25, 2026, 5:53 AM EDT
Withdrawn No phase listed Observational

Measurement of Tricuspid Regurgitation Volume for Assessment of Tricuspid Regurgitation Using 3D Transesophageal Echocardiography

NCT05130775
View directory record Official record
Conditions
Tricuspid Regurgitation
Interventions
Transesophageal echocardiograpgy
Other
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older
Timeline
2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 4, 2024 · Synced Sep 25, 2026, 5:53 AM EDT
Recruiting Not applicable Interventional

Home-Based Cardiac Rehabilitation Using a Novel Mobile Health Exercise Regimen Following Transcatheter Heart Valve Interventions

NCT06077201
View directory record Official record
Conditions
Valvular Heart Disease
Interventions
HBCR hands-off, HBCR interactive
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Sep 25, 2026, 5:53 AM EDT
Active, not recruiting Not applicable Interventional

TRIcvalve biCAVal Valve System for Severe Tricuspid Regurgitation (TRICAV-I)

NCT06137807
View directory record Official record
Conditions
Tricuspid Regurgitation, Tricuspid Valve Disease
Interventions
TricValve® Transcatheter Bicaval Valve System
Device
Lead sponsor
P+F Products + Features USA Inc.
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
36
States / cities
Phoenix, Arizona • Tucson, Arizona • San Diego, California + 31 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 25, 2026, 5:53 AM EDT
Withdrawn No phase listed Observational

The Role of Echocardiographic Contrast (Optison) in Enhancing Tricuspid Regurgitation Spectral Doppler Signals

NCT02560116
View directory record Official record
Conditions
Hypertension, Pulmonary
Interventions
Not listed
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Jan 20, 2016 · Synced Sep 25, 2026, 5:53 AM EDT
Completed Not applicable Interventional

Tricuspid Annuloplasty for Moderate Tricuspid Regurgitation Associated With Miral Operation

NCT01246947
View directory record Official record
Conditions
Cardiac Surgery, Tricuspid Valve Regurgitation
Interventions
Tricuspid valve repair, Mitral surgery alone
Procedure · Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 7, 2023 · Synced Sep 25, 2026, 5:53 AM EDT
Recruiting Not applicable Interventional

EFS of the DUO System for Tricuspid Regurgitation

NCT05913908
View directory record Official record
Conditions
Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases
Interventions
DUO Transcatheter Tricuspid Coaptation Valve System
Device
Lead sponsor
CroiValve Limited
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
12
States / cities
Phoenix, Arizona • Thousand Oaks, California • Atlanta, Georgia + 9 more
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Sep 25, 2026, 5:53 AM EDT
Recruiting No phase listed Observational

Annuloplasty Rings and Band Post-Market Clinical Follow-Up Study

NCT04761120
View directory record Official record
Conditions
Mitral Regurgitation, Tricuspid Regurgitation, Valvular Heart Disease
Interventions
Abbott SJM Rigid Saddle Ring, Abbott SJM Séguin Ring, Abbott SJM Tailor Ring, Abbott SJM Tailor Band
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
550 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2031
U.S. locations
2
States / cities
Durham, North Carolina • Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Sep 25, 2026, 5:53 AM EDT
Active, not recruiting Not applicable Interventional

Clinical Study of Edwards Cardioband FIT Valve Repair System

NCT03382457
View directory record Official record
Conditions
Tricuspid Regurgitation
Interventions
Transcatheter Tricuspid Valve Repair
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2031
U.S. locations
9
States / cities
Chicago, Illinois • Rochester, Minnesota • Morristown, New Jersey + 6 more
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Sep 25, 2026, 5:53 AM EDT
Completed Phase 4 Interventional

Tricuspid Regurgitation Study

NCT01093001
View directory record Official record
Conditions
Tricuspid Regurgitation, Right Ventricular Dysfunction, Left Ventricular Dysfunction
Interventions
Echo
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 90 Years
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 2, 2016 · Synced Sep 25, 2026, 5:53 AM EDT
Terminated Not applicable Interventional

Early Feasibility Study of the Percutaneous 4Tech TriCinch Coil Tricuspid Valve Repair System

NCT03632967
View directory record Official record
Conditions
Functional Tricuspid Regurgitation, Heart Valve Diseases, Tricuspid Valve Insufficiency
Interventions
Tricinch Coil System Implantation
Device
Lead sponsor
4Tech Cardio Ltd.
Industry
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
9
States / cities
Los Angeles, California • Thousand Oaks, California • Atlanta, Georgia + 6 more
Source: ClinicalTrials.gov public record
Updated Jul 30, 2020 · Synced Sep 25, 2026, 5:53 AM EDT
Withdrawn Not applicable Interventional

Early Feasibility Study of the Cardiovalve System for Tricuspid Regurgitation

NCT04100720
View directory record Official record
Conditions
Tricuspid Regurgitation
Interventions
Cardiovalve Transfemoral Tricuspid Valve
Device
Lead sponsor
Cardiovalve Ltd.
Industry
Eligibility
18 Years to 84 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
3
States / cities
Chicago, Illinois • New York, New York • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Sep 25, 2026, 5:53 AM EDT
Not yet recruiting Not applicable Interventional

A Prospective, Randomized Multicenter Clinical Trial of the TricValve® Transcatheter Bicaval Valve System in Subjects With Severe Tricuspid Regurgitation.

NCT06458907
View directory record Official record
Conditions
Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure, Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency
Interventions
TricValve System, Optimal medical therapy
Device · Drug
Lead sponsor
P+F Products + Features USA Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
780 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2032
U.S. locations
34
States / cities
Birmingham, Alabama • Phoenix, Arizona • Sacramento, California + 29 more
Source: ClinicalTrials.gov public record
Updated Aug 2, 2026 · Synced Sep 25, 2026, 5:53 AM EDT
Recruiting Not applicable Interventional

Study of the Clinical Impact of Surgical Correction of Tricuspid Insufficiency in Implantable LVAD Patients

NCT02537769
View directory record Official record
Conditions
Tricuspid Regurgitation, Heart Failure NYHA Class III, Heart Failure NYHA Class IV
Interventions
Left ventricular assist device (LVAD), Tricuspid Valve Repair (TVR)
Device · Procedure
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2026
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 22, 2021 · Synced Sep 25, 2026, 5:53 AM EDT
Suspended Not applicable Interventional

NHLBI and Cook Trans-Atrial Intra-Pericardial Tricuspid Annuloplasty (TRAIPTA) Early Feasibility Study

NCT06479824
View directory record Official record
Conditions
Tricuspid Valve Insufficiency
Interventions
TRAIPTA (Trans-Atrial Intra-Pericardial Tricuspid Annuloplasty)
Device
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
21 Years to 100 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
2
States / cities
Atlanta, Georgia • Roslyn, New York
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 25, 2026, 5:53 AM EDT
Active, not recruiting Not applicable Interventional Results available

TRILUMINATE Pivotal Trial

NCT03904147
View directory record Official record
Conditions
Tricuspid Regurgitation
Interventions
TriClipTM Device
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
572 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2029
U.S. locations
63
States / cities
Birmingham, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 51 more
Source: ClinicalTrials.gov public record
Updated Dec 18, 2024 · Synced Sep 25, 2026, 5:53 AM EDT